Orbitofrontal lesions eliminate signalling of biological significance in cue-responsive ventral striatal neurons.

Abstract:

:The ventral striatum has long been proposed as an integrator of biologically significant associative information to drive actions. Although inputs from the amygdala and hippocampus have been much studied, the role of prominent inputs from orbitofrontal cortex (OFC) are less well understood. Here, we recorded single-unit activity from ventral striatum core in rats with sham or ipsilateral neurotoxic lesions of lateral OFC, as they performed an odour-guided spatial choice task. Consistent with prior reports, we found that spiking activity recorded in sham rats during cue sampling was related to both reward magnitude and reward identity, with higher firing rates observed for cues that predicted more reward. Lesioned rats also showed differential activity to the cues, but this activity was unbiased towards larger rewards. These data support a role for OFC in shaping activity in the ventral striatum to represent the biological significance of associative information in the environment.

journal_name

Nat Commun

journal_title

Nature communications

authors

Cooch NK,Stalnaker TA,Wied HM,Bali-Chaudhary S,McDannald MA,Liu TL,Schoenbaum G

doi

10.1038/ncomms8195

subject

Has Abstract

pub_date

2015-05-21 00:00:00

pages

7195

issn

2041-1723

pii

ncomms8195

journal_volume

6

pub_type

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