Abstract:
:The ventral striatum has long been proposed as an integrator of biologically significant associative information to drive actions. Although inputs from the amygdala and hippocampus have been much studied, the role of prominent inputs from orbitofrontal cortex (OFC) are less well understood. Here, we recorded single-unit activity from ventral striatum core in rats with sham or ipsilateral neurotoxic lesions of lateral OFC, as they performed an odour-guided spatial choice task. Consistent with prior reports, we found that spiking activity recorded in sham rats during cue sampling was related to both reward magnitude and reward identity, with higher firing rates observed for cues that predicted more reward. Lesioned rats also showed differential activity to the cues, but this activity was unbiased towards larger rewards. These data support a role for OFC in shaping activity in the ventral striatum to represent the biological significance of associative information in the environment.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Cooch NK,Stalnaker TA,Wied HM,Bali-Chaudhary S,McDannald MA,Liu TL,Schoenbaum Gdoi
10.1038/ncomms8195subject
Has Abstractpub_date
2015-05-21 00:00:00pages
7195issn
2041-1723pii
ncomms8195journal_volume
6pub_type
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