Compact genome of the Antarctic midge is likely an adaptation to an extreme environment.

abstract：:The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a regio...

journal_title：Nature communications

authors： Duffy DL,Zhu G,Li X,Sanna M,Iles MM,Jacobs LC,Evans DM,Yazar S,Beesley J,Law MH,Kraft P,Visconti A,Taylor JC,Liu F,Wright MJ,Henders AK,Bowdler L,Glass D,Ikram MA,Uitterlinden AG,Madden PA,Heath AC,Nelson EC,

更新日期：2018-11-14 00:00:00

abstract：:Despite their importance as mechanistic models for heterogeneous Haber Bosch ammonia synthesis from dinitrogen and dihydrogen, homogeneous molecular terminal metal-nitrides are notoriously unreactive towards dihydrogen, and only a few electron-rich, low-coordinate variants demonstrate any hydrogenolysis chemistry. Her...

journal_title：Nature communications

authors： Chatelain L,Louyriac E,Douair I,Lu E,Tuna F,Wooles AJ,Gardner BM,Maron L,Liddle ST

更新日期：2020-01-17 00:00:00

abstract：:Carbon-based three-dimensional aerographite networks, built from interconnected hollow tubular tetrapods of multilayer graphene, are ultra-lightweight materials recently discovered and ideal for advanced multifunctional applications. In order to predict the bulk mechanical behaviour of networks it is very important to...

journal_title：Nature communications

authors： Meija R,Signetti S,Schuchardt A,Meurisch K,Smazna D,Mecklenburg M,Schulte K,Erts D,Lupan O,Fiedler B,Mishra YK,Adelung R,Pugno NM

更新日期：2017-04-12 00:00:00

abstract：:Membrane-bound pyrophosphatases (M-PPases), which couple proton/sodium ion transport to pyrophosphate synthesis/hydrolysis, are important in abiotic stress resistance and in the infectivity of protozoan parasites. Here, three M-PPase structures in different catalytic states show that closure of the substrate-binding p...

journal_title：Nature communications

authors： Li KM,Wilkinson C,Kellosalo J,Tsai JY,Kajander T,Jeuken LJ,Sun YJ,Goldman A

更新日期：2016-12-06 00:00:00

abstract：:The Mott metal-insulator transition-a manifestation of Coulomb interactions among electrons-is known as a discontinuous transition. Recent theoretical studies, however, suggest that the transition is continuous if the Mott insulator carries a spin liquid with a spinon Fermi surface. Here, we demonstrate the case of a ...

journal_title：Nature communications

authors： Furukawa T,Kobashi K,Kurosaki Y,Miyagawa K,Kanoda K

更新日期：2018-01-22 00:00:00

abstract：:The miniaturization of integrated optical circuits below the diffraction limit for high-speed manipulation of information is one of the cornerstones in plasmonics research. By coupling to surface plasmons supported on nanostructured metallic surfaces, light can be confined to the nanoscale, enabling the potential inte...

journal_title：Nature communications

authors： Raza S,Esfandyarpour M,Koh AL,Mortensen NA,Brongersma ML,Bozhevolnyi SI

更新日期：2016-12-16 00:00:00

abstract：:Synthetic genetic circuits allow us to modify the behavior of living cells. However, changes in environmental conditions and unforeseen interactions with the host cell can cause deviations from a desired function, resulting in the need for time-consuming reassembly to fix these issues. Here, we use a regulatory motif ...

journal_title：Nature communications

authors： Bartoli V,Meaker GA,di Bernardo M,Gorochowski TE

更新日期：2020-04-29 00:00:00

abstract：:Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients,...

journal_title：Nature communications

authors： Wang S,Wang J,Kumar V,Karnell JL,Naiman B,Gross PS,Rahman S,Zerrouki K,Hanna R,Morehouse C,Holoweckyj N,Liu H,Autoimmunity Molecular Medicine Team.,Manna Z,Goldbach-Mansky R,Hasni S,Siegel R,Sanjuan M,Streicher K,Ca

更新日期：2018-05-01 00:00:00

abstract：:Astrocytes migrate from the optic nerve into the inner retina, forming a template upon which retinal vessels develop. In the Nuc1 rat, mutation in the gene encoding βA3/A1-crystallin disrupts both Notch signalling in astrocytes and formation of the astrocyte template. Here we show that loss of βA3/A1-crystallin in ast...

journal_title：Nature communications

authors： Valapala M,Hose S,Gongora C,Dong L,Wawrousek EF,Samuel Zigler J Jr,Sinha D

更新日期：2013-01-01 00:00:00

abstract：:A 'pseudogap' was introduced by Mott to describe a state of matter that has a minimum in the density of states at the Fermi level, deep enough for states to become localized. It can arise either from Coulomb repulsion between electrons, and/or incipient charge or spin order. Here we employ ultrafast spectroscopy to st...

journal_title：Nature communications

authors： Madan I,Kurosawa T,Toda Y,Oda M,Mertelj T,Mihailovic D

更新日期：2015-04-20 00:00:00

abstract：:Accurate prediction of an individual's phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful individual-level data Bayesian multiple regression model (BayesR) to one that utilises summary statistics from genome-wide association studies (GWAS), SBayesR. ...

journal_title：Nature communications

authors： Lloyd-Jones LR,Zeng J,Sidorenko J,Yengo L,Moser G,Kemper KE,Wang H,Zheng Z,Magi R,Esko T,Metspalu A,Wray NR,Goddard ME,Yang J,Visscher PM

更新日期：2019-11-08 00:00:00

abstract：:Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual cytokines. Searching for better cardiac inflammation targets, here we link T cells with HF developmen...

journal_title：Nature communications

authors： Kallikourdis M,Martini E,Carullo P,Sardi C,Roselli G,Greco CM,Vignali D,Riva F,Ormbostad Berre AM,Stølen TO,Fumero A,Faggian G,Di Pasquale E,Elia L,Rumio C,Catalucci D,Papait R,Condorelli G

更新日期：2017-03-06 00:00:00

abstract：:Polar van der Waals chalcogenophosphates exhibit unique properties, such as negative electrostriction and multi-well ferrielectricity, and enable combining dielectric and 2D electronic materials. Using low temperature piezoresponse force microscopy, we revealed coexistence of piezoelectric and non-piezoelectric phases...

journal_title：Nature communications

authors： Dziaugys A,Kelley K,Brehm JA,Tao L,Puretzky A,Feng T,O'Hara A,Neumayer S,Chyasnavichyus M,Eliseev EA,Banys J,Vysochanskii Y,Ye F,Chakoumakos BC,Susner MA,McGuire MA,Kalinin SV,Ganesh P,Balke N,Pantelides ST,Morozo

更新日期：2020-07-17 00:00:00

abstract：:Random numbers are commonly used in many different fields, ranging from simulations in fundamental science to security applications. In some critical cases, as Bell's tests and cryptography, the random numbers are required to be both private and to be provided at an ultra-fast rate. However, practical generators are u...

journal_title：Nature communications

authors： Avesani M,Marangon DG,Vallone G,Villoresi P

更新日期：2018-12-18 00:00:00

abstract：:'Ideal' transparent p-type semiconductors are required for the integration of high-performance thin-film transistors (TFTs) and circuits. Although CuI has recently attracted attention owing to its excellent opto-electrical properties, solution processability, and low-temperature synthesis, the uncontrolled copper vaca...

journal_title：Nature communications

authors： Liu A,Zhu H,Park WT,Kim SJ,Kim H,Kim MG,Noh YY

更新日期：2020-08-27 00:00:00

abstract：:Exosomes are nanometer-sized lipid vesicles present in liquid biopsies and used as biomarkers for several diseases including cancer, Alzheimer's, and central nervous system diseases. Purification and subsequent size and surface characterization are essential to exosome-based diagnostics. Sample purification is, howeve...

journal_title：Nature communications

authors： Rasmussen MK,Pedersen JN,Marie R

更新日期：2020-05-11 00:00:00

abstract：:Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). Considered as an early event in tumour development, this form of genome instability plays a prominent role in tumour onset. Chromothri...

journal_title：Nature communications

authors： Voronina N,Wong JKL,Hübschmann D,Hlevnjak M,Uhrig S,Heilig CE,Horak P,Kreutzfeldt S,Mock A,Stenzinger A,Hutter B,Fröhlich M,Brors B,Jahn A,Klink B,Gieldon L,Sieverling L,Feuerbach L,Chudasama P,Beck K,Kroiss M,H

更新日期：2020-05-08 00:00:00

abstract：:Autophagy is the major cellular pathway by which macromolecules are degraded, and amino acid depletion powerfully activates autophagy. MAP4K3, or germinal-center kinase-like kinase, is required for robust cell growth in response to amino acids, but the basis for MAP4K3 regulation of cellular metabolic disposition rema...

journal_title：Nature communications

authors： Hsu CL,Lee EX,Gordon KL,Paz EA,Shen WC,Ohnishi K,Meisenhelder J,Hunter T,La Spada AR

更新日期：2018-03-05 00:00:00

abstract：:Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of a single major capsid protein (MCP). Here, by high-resolution cryo-EM analysis, we show that a class of archaeal viruses possess hetero-hexameric MCPs which mi...

journal_title：Nature communications

authors： De Colibus L,Roine E,Walter TS,Ilca SL,Wang X,Wang N,Roseman AM,Bamford D,Huiskonen JT,Stuart DI

更新日期：2019-03-29 00:00:00

abstract：:Osteoderms are bones embedded within the dermis, and are common to select members of most major tetrapod lineages. The largest known animals that bear osteoderms are members of Titanosauria, a diverse clade of sauropod dinosaurs. Here we report on two titanosaur osteoderms recovered from the Upper Cretaceous Maevarano...

journal_title：Nature communications

authors： Curry Rogers K,D'Emic M,Rogers R,Vickaryous M,Cagan A

更新日期：2011-11-29 00:00:00

abstract：:Pollinators tend to be preferentially attracted to large floral displays that may comprise more than one plant in a patch. Attracting pollinators thus not only benefits individuals investing in advertising, but also other plants in a patch through a 'magnet' effect. Accordingly, there could be an indirect fitness adva...

journal_title：Nature communications

authors： Torices R,Gómez JM,Pannell JR

更新日期：2018-05-22 00:00:00

abstract：:Iminium catalysis, involving the transformation of iminium ions to enamines, has been extensively studied in the context of a number of organic processes. However, the reverse of this process involving conversion of enamines to iminium species has not been realized. Here, we describe a new transformation-'oxidative en...

journal_title：Nature communications

authors： Zhang SL,Xie HX,Zhu J,Li H,Zhang XS,Li J,Wang W

更新日期：2011-01-01 00:00:00

abstract：:Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is essential for development, wound healing and disease. Membrane-localized vascular endothelial growth factor receptor-1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis. ...

journal_title：Nature communications

authors： Boucher JM,Clark RP,Chong DC,Citrin KM,Wylie LA,Bautch VL

更新日期：2017-06-07 00:00:00

abstract：:The immunogenic heat shock proteins (HSPs) gp96, hsp70 and calreticulin (CRT) bind to CD91 on antigen-presenting cells (APCs) for cross-presentation of the HSP-chaperoned peptides. This event leads to priming of T-cell responses. Here we show that CD91 serves as a signalling receptor for these HSPs, allowing for the m...

journal_title：Nature communications

authors： Pawaria S,Binder RJ

更新日期：2011-11-01 00:00:00

abstract：:In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to prevent damaging collisions. Gram-positive bacteria contain a transcription factor HelD that is able to remove and recycle stalled complexes, but it was not know...

journal_title：Nature communications

authors： Newing TP,Oakley AJ,Miller M,Dawson CJ,Brown SHJ,Bouwer JC,Tolun G,Lewis PJ

更新日期：2020-12-18 00:00:00

abstract：:The removal of dying neurons by microglia has a key role during both development and in several diseases. To date, little is known about the cellular and molecular processes underlying neuronal engulfment in the brain. Here we took a live imaging approach to quantify neuronal cell death progression in embryonic zebraf...

journal_title：Nature communications

authors： Mazaheri F,Breus O,Durdu S,Haas P,Wittbrodt J,Gilmour D,Peri F

更新日期：2014-06-05 00:00:00

abstract：:Two hundred years ago, Ampère discovered that electric loops in which currents of electrons are generated by a penetrating magnetic field can mutually interact. Here we show that Ampère's observation can be transferred to the quantum realm of interactions between triangular plaquettes of spins on a lattice, where the ...

journal_title：Nature communications

authors： Grytsiuk S,Hanke JP,Hoffmann M,Bouaziz J,Gomonay O,Bihlmayer G,Lounis S,Mokrousov Y,Blügel S

更新日期：2020-01-24 00:00:00

abstract：:Extracellular vesicles have an important function in cellular communication. Here, we show that human and mouse monocytes release TGF-β1-transporting vesicles in response to the pathogenic fungus Candida albicans. Soluble β-glucan from C. albicans binds to complement receptor 3 (CR3, also known as CD11b/CD18) on monoc...

journal_title：Nature communications

authors： Halder LD,Jo EAH,Hasan MZ,Ferreira-Gomes M,Krüger T,Westermann M,Palme DI,Rambach G,Beyersdorf N,Speth C,Jacobsen ID,Kniemeyer O,Jungnickel B,Zipfel PF,Skerka C

更新日期：2020-05-11 00:00:00

abstract：:Biological tissues have the remarkable ability to remodel and repair in response to disease, injury and mechanical stresses. Synthetic materials lack the complexity of biological tissues, and man-made materials that respond to external stresses through a permanent increase in stiffness are uncommon. Here we report tha...

journal_title：Nature communications

authors： Agrawal A,Chipara AC,Shamoo Y,Patra PK,Carey BJ,Ajayan PM,Chapman WG,Verduzco R

更新日期：2013-01-01 00:00:00

abstract：:Interactions between absorbers and plasmonic metasurfaces can give rise to unique optical properties not present for either of the individual materials and can influence the performance of a host of optical sensing and thin-film optoelectronic applications. Here we identify three distinct mode types of absorber-coated...

journal_title：Nature communications

authors： Petoukhoff CE,O'Carroll DM

更新日期：2015-08-14 00:00:00