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Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination.

Abstract：

:Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence supports NK cell antiviral immunity in HIV-1 infection, further knowledge of their response is necessary. Here we show that NK cells responding to models of direct cell recognition, ADCC, and cytokine activation have unique transcriptional fingerprints. Compared with healthy volunteers, individuals with chronic HIV-1 infection have higher expression of genes commonly associated with activation, and lower expression of genes associated with direct cell recognition and cytokine stimulation in their NK cells. By contrast, NK cell transcriptional profiles of individuals receiving a modified vaccinia Ankara (MVA) vectored HIV-1 vaccine show upregulation of genes associated with direct cell recognition. These findings demonstrate that targeted transcriptional profiling provides a sensitive assessment of NK cell activity, which helps understand how NK cells respond to viral infections and vaccination.

journal_name

Nat Commun

journal_title

Nature communications

authors

Costanzo MC,Kim D,Creegan M,Lal KG,Ake JA,Currier JR,Streeck H,Robb ML,Michael NL,Bolton DL,Steers NJ,Eller MA

doi

10.1038/s41467-018-03618-w

subject

Has Abstract

pub_date

2018-03-23 00:00:00

pages

1212

issue

1

issn

2041-1723

pii

10.1038/s41467-018-03618-w

journal_volume

9

pub_type

杂志文章

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