ARMMs as a versatile platform for intracellular delivery of macromolecules.

abstract：:Recent years have witnessed the growing interest in the remote functionalization of alkenes for it offers a strategy to activate the challenging C-H bonds distant from the initiation point via alkene isomerization/functionalization. However, the catalytic enantioselective isomerization/functionalization with one singl...

journal_title：Nature communications

authors： Chen X,Cheng Z,Guo J,Lu Z

更新日期：2018-09-26 00:00:00

abstract：:In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost...

journal_title：Nature communications

authors： Chelo IM,Nédli J,Gordo I,Teotónio H

更新日期：2013-01-01 00:00:00

abstract：:Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in mice heterozygous f...

journal_title：Nature communications

authors： Brina D,Miluzio A,Ricciardi S,Clarke K,Davidsen PK,Viero G,Tebaldi T,Offenhäuser N,Rozman J,Rathkolb B,Neschen S,Klingenspor M,Wolf E,Gailus-Durner V,Fuchs H,Hrabe de Angelis M,Quattrone A,Falciani F,Biffo S

更新日期：2015-09-18 00:00:00

abstract：:The alloy-design strategy of combining multiple elements in near-equimolar ratios has shown great potential for producing exceptional engineering materials, often known as 'high-entropy alloys'. Understanding the elemental distribution, and, thus, the evolution of the configurational entropy during solidification, is ...

journal_title：Nature communications

authors： Santodonato LJ,Zhang Y,Feygenson M,Parish CM,Gao MC,Weber RJ,Neuefeind JC,Tang Z,Liaw PK

更新日期：2015-01-20 00:00:00

abstract：:Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety of immune responses...

journal_title：Nature communications

authors： Helou DG,Shafiei-Jahani P,Lo R,Howard E,Hurrell BP,Galle-Treger L,Painter JD,Lewis G,Soroosh P,Sharpe AH,Akbari O

更新日期：2020-08-10 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common focal seizure disorder in adults. In many patients, transient brain insults, including status epilepticus (SE), are followed by a latent period of epileptogenesis, preceding the emergence of clinical seizures. In experimental animals, transcriptional upregulation of CaV3...

journal_title：Nature communications

authors： van Loo KM,Schaub C,Pitsch J,Kulbida R,Opitz T,Ekstein D,Dalal A,Urbach H,Beck H,Yaari Y,Schoch S,Becker AJ

更新日期：2015-10-26 00:00:00

abstract：:Two-dimensional electron systems have attracted attention as thermoelectric materials, which can directly convert waste heat into electricity. It has been theoretically predicted that thermoelectric power factor can be largely enhanced when the two-dimensional electron layer is far narrower than the de Broglie wavelen...

journal_title：Nature communications

authors： Zhang Y,Feng B,Hayashi H,Chang CP,Sheu YM,Tanaka I,Ikuhara Y,Ohta H

更新日期：2018-06-20 00:00:00

abstract：:Chiral magnets are an emerging class of topological matter harboring localized and topologically protected vortex-like magnetic textures called skyrmions, which are currently under intense scrutiny as an entity for information storage and processing. Here, on the level of micromagnetics we rigorously show that chiral ...

journal_title：Nature communications

authors： Hoffmann M,Zimmermann B,Müller GP,Schürhoff D,Kiselev NS,Melcher C,Blügel S

更新日期：2017-08-21 00:00:00

abstract：:Conventional interferometers usually utilize beam splitters for wave splitting and recombination. These interferometers are widely used for precision measurement. Their sensitivity for phase measurement is limited by the shot noise, which can be suppressed with squeezed states of light. Here we study a new type of int...

journal_title：Nature communications

authors： Hudelist F,Kong J,Liu C,Jing J,Ou ZY,Zhang W

更新日期：2014-01-01 00:00:00

abstract：:The current study uses big data to study prosocial behavior by analyzing donations made on the GoFundMe platform. In a dataset of more than $44 million in online donations, we find that 21% were made while opting to be anonymous to the public, with survey results indicating that 11% of these anonymous donations (2.3% ...

journal_title：Nature communications

authors： Sisco MR,Weber EU

更新日期：2019-09-03 00:00:00

abstract：:Microbiome-derived metabolites influence intestinal homeostasis and regulate graft-versus-host disease (GVHD), but the molecular mechanisms remain unknown. Here we show the metabolite sensor G-protein-coupled receptor 43 (GPR43) is important for attenuation of gastrointestinal GVHD in multiple clinically relevant muri...

journal_title：Nature communications

authors： Fujiwara H,Docampo MD,Riwes M,Peltier D,Toubai T,Henig I,Wu SJ,Kim S,Taylor A,Brabbs S,Liu C,Zajac C,Oravecz-Wilson K,Sun Y,Núñez G,Levine JE,van den Brink MRM,Ferrara JLM,Reddy P

更新日期：2018-09-10 00:00:00

abstract：:Third generation sequencing technologies provide the opportunity to improve genome assemblies by generating long reads spanning most repeat sequences. However, current analysis methods require substantial amounts of sequence data and computational resources to overcome the high error rates. Furthermore, they can only ...

journal_title：Nature communications

authors： Cao MD,Nguyen SH,Ganesamoorthy D,Elliott AG,Cooper MA,Coin LJ

更新日期：2017-02-20 00:00:00

abstract：:In the original version of this Article, Supplementary Table 10 contained incorrect primer sequences for the mobility shift assay for SNP rs4776984. These errors have now been fixed and the corrected version of the Supplementary Information PDF is available to download from the HTML version of the Article. ...

journal_title：Nature communications

authors： Pan DZ,Garske KM,Alvarez M,Bhagat YV,Boocock J,Nikkola E,Miao Z,Raulerson CK,Cantor RM,Civelek M,Glastonbury CA,Small KS,Boehnke M,Lusis AJ,Sinsheimer JS,Mohlke KL,Laakso M,Pajukanta P,Ko A

更新日期：2018-08-22 00:00:00

abstract：:Propagation behaviors of electromagnetic waves are governed by the equifrequency surface of the medium. Up to now, ordinary materials, including the medium exist in nature and the man-made metamaterials, always have an equifrequency surface (ellipsoid or hyperboloid) centered at zero k-point. Here we propose a new typ...

journal_title：Nature communications

authors： Chen WJ,Hou B,Zhang ZQ,Pendry JB,Chan CT

更新日期：2018-05-25 00:00:00

abstract：:Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown...

journal_title：Nature communications

authors： Kim DH,Park ES,Lee AR,Park S,Park YK,Ahn SH,Kang HS,Won JH,Ha YN,Jae B,Kim DS,Chung WC,Song MJ,Kim KH,Park SH,Kim SH,Kim KH

更新日期：2018-08-16 00:00:00

abstract：:Hydride transfers play a crucial role in a multitude of biological redox reactions and are mediated by flavin, deazaflavin or nicotinamide adenine dinucleotide cofactors at standard redox potentials ranging from 0 to -340 mV. 2-Naphthoyl-CoA reductase, a key enzyme of oxygen-independent bacterial naphthalene degradati...

journal_title：Nature communications

authors： Willistein M,Bechtel DF,Müller CS,Demmer U,Heimann L,Kayastha K,Schünemann V,Pierik AJ,Ullmann GM,Ermler U,Boll M

更新日期：2019-05-06 00:00:00

abstract：:Chemical synthesis of amino acids from renewable sources is an alternative route to the current processes based on fermentation. Here, we report visible-light-driven amination of biomass-derived α-hydroxyl acids and glucose into amino acids using NH3 at 50 °C. Ultrathin CdS nanosheets are identified as an efficient an...

journal_title：Nature communications

authors： Song S,Qu J,Han P,Hülsey MJ,Zhang G,Wang Y,Wang S,Chen D,Lu J,Yan N

更新日期：2020-09-29 00:00:00

abstract：:Plasma membrane Ca2+-ATPases (PMCAs) are key regulators of global Ca2+ homeostasis and local intracellular Ca2+ dynamics. Recently, Neuroplastin (NPTN) and basigin were identified as previously unrecognized obligatory subunits of PMCAs that dramatically increase the efficiency of PMCA-mediated Ca2+ clearance. Here, we...

journal_title：Nature communications

authors： Gong D,Chi X,Ren K,Huang G,Zhou G,Yan N,Lei J,Zhou Q

更新日期：2018-09-06 00:00:00

abstract：:The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived infl...

journal_title：Nature communications

authors： Davies LC,Rosas M,Jenkins SJ,Liao CT,Scurr MJ,Brombacher F,Fraser DJ,Allen JE,Jones SA,Taylor PR

更新日期：2013-01-01 00:00:00

abstract：:Potassium-ion batteries are a compelling technology for large scale energy storage due to their low-cost and good rate performance. However, the development of potassium-ion batteries remains in its infancy, mainly hindered by the lack of suitable cathode materials. Here we show that a previously known frustrated magn...

journal_title：Nature communications

authors： Ji B,Yao W,Zheng Y,Kidkhunthod P,Zhou X,Tunmee S,Sattayaporn S,Cheng HM,He H,Tang Y

更新日期：2020-03-06 00:00:00

abstract：:Liquid crystalline network (LCN) actuator normally deforms upon thermally or optically induced order-disorder phase transition, switching once between two shapes (shape 1 in LC phase and shape 2 in isotropic state) for each stimulation on/off cycle. Herein, we report an LCN actuator that deforms from shape 1 to shape ...

journal_title：Nature communications

authors： Xiao YY,Jiang ZC,Hou JB,Zhao Y

更新日期：2021-01-27 00:00:00

abstract：:Antibiotic resistance poses rapidly increasing global problems in combatting multidrug-resistant (MDR) infectious diseases like MDR tuberculosis, prompting for novel approaches including host-directed therapies (HDT). Intracellular pathogens like Salmonellae and Mycobacterium tuberculosis (Mtb) exploit host pathways t...

journal_title：Nature communications

authors： Korbee CJ,Heemskerk MT,Kocev D,van Strijen E,Rabiee O,Franken KLMC,Wilson L,Savage NDL,Džeroski S,Haks MC,Ottenhoff THM

更新日期：2018-01-24 00:00:00

abstract：:The emergence of larger brains with large numbers of neurons is an evolutionary innovation in mammals and birds. However, the corresponding changes in cortical developmental programmes during amniote evolution are poorly understood. Here we examine the cortical development of Madagascar ground geckos, and report uniqu...

journal_title：Nature communications

authors： Nomura T,Gotoh H,Ono K

更新日期：2013-01-01 00:00:00

abstract：:As influenza A viruses remain a major threat to human health worldwide, the discovery of broadly neutralizing monoclonal antibodies that recognize conserved epitopes would facilitate the development of antibody-based therapeutic strategies. Here we report that a VH4-4-encoded human mAb named 3E1 could neutralize H1 an...

journal_title：Nature communications

authors： Wang W,Sun X,Li Y,Su J,Ling Z,Zhang T,Wang F,Zhang H,Chen H,Ding J,Sun B

更新日期：2016-12-02 00:00:00

abstract：:BRCA2 is essential for maintaining genomic integrity. BRCA2-deficient primary cells are either not viable or exhibit severe proliferation defects. Yet, BRCA2 deficiency contributes to tumorigenesis. It is believed that mutations in genes such as TRP53 allow BRCA2 heterozygous cells to overcome growth arrest when they ...

journal_title：Nature communications

authors： Biswas K,Philip S,Yadav A,Martin BK,Burkett S,Singh V,Babbar A,North SL,Chang S,Sharan SK

更新日期：2018-02-07 00:00:00

abstract：:Protein function and dynamics are closely related; however, accurate dynamics information is difficult to obtain. Here based on a carefully assembled data set derived from experimental data for proteins in solution, we quantify backbone dynamics properties on the amino-acid level and develop DynaMine--a fast, high-qua...

journal_title：Nature communications

authors： Cilia E,Pancsa R,Tompa P,Lenaerts T,Vranken WF

更新日期：2013-01-01 00:00:00

abstract：:Human pressures on the ocean are thought to be increasing globally, yet we know little about their patterns of cumulative change, which pressures are most responsible for change, and which places are experiencing the greatest increases. Managers and policymakers require such information to make strategic decisions and...

journal_title：Nature communications

authors： Halpern BS,Frazier M,Potapenko J,Casey KS,Koenig K,Longo C,Lowndes JS,Rockwood RC,Selig ER,Selkoe KA,Walbridge S

更新日期：2015-07-14 00:00:00

abstract：:Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy triplet excited states. Here, a facile strategy to realize the efficient deep-blue organic afterglow is proposed via host molecule...

journal_title：Nature communications

authors： Xu S,Wang W,Li H,Zhang J,Chen R,Wang S,Zheng C,Xing G,Song C,Huang W

更新日期：2020-09-23 00:00:00

abstract：:Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We...

journal_title：Nature communications

authors： Zhao LH,Liu X,Yan HX,Li WY,Zeng X,Yang Y,Zhao J,Liu SP,Zhuang XH,Lin C,Qin CJ,Zhao Y,Pan ZY,Huang G,Liu H,Zhang J,Wang RY,Yang Y,Wen W,Lv GS,Zhang HL,Wu H,Huang S,Wang MD,Tang L,Cao HZ,Wang L,Lee TL

更新日期：2016-10-05 00:00:00

abstract：:The dynamics of many natural and artificial systems are well described as random walks on a network: the stochastic behaviour of molecules, traffic patterns on the internet, fluctuations in stock prices and so on. The vast literature on random walks provides many tools for computing properties such as steady-state pro...

journal_title：Nature communications

authors： Perkins TJ,Foxall E,Glass L,Edwards R

更新日期：2014-10-14 00:00:00