Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses.

abstract：:Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP...

journal_title：Nature communications

authors： Kang H,Yang B,Zhang K,Pan Q,Yuan W,Li G,Bian L

更新日期：2019-04-12 00:00:00

abstract：:Photo-activated resin composites are widely used in industry and medicine. Despite extensive chemical characterisation, the micro-scale pattern of resin matrix reactive group conversion between filler particles is not fully understood. Using an advanced synchrotron-based wide-field IR imaging system and state-of-the-a...

journal_title：Nature communications

authors： Sirovica S,Solheim JH,Skoda MWA,Hirschmugl CJ,Mattson EC,Aboualizadeh E,Guo Y,Chen X,Kohler A,Romanyk DL,Rosendahl SM,Morsch S,Martin RA,Addison O

更新日期：2020-04-15 00:00:00

abstract：:The effects of high-fat diet (HFD) and postprandial endotoxemia on the development of type 2 diabetes are not fully understood. Here we show that the serine protease prostasin (PRSS8) regulates hepatic insulin sensitivity by modulating Toll-like receptor 4 (TLR4)-mediated signalling. HFD triggers the suppression of PR...

journal_title：Nature communications

authors： Uchimura K,Hayata M,Mizumoto T,Miyasato Y,Kakizoe Y,Morinaga J,Onoue T,Yamazoe R,Ueda M,Adachi M,Miyoshi T,Shiraishi N,Ogawa W,Fukuda K,Kondo T,Matsumura T,Araki E,Tomita K,Kitamura K

更新日期：2014-03-11 00:00:00

abstract：:The hydroxyl radical (OH) removes most atmospheric pollutants from air. The loss frequency of OH radicals due to the combined effect of all gas-phase OH reactive species is a measureable quantity termed total OH reactivity. Here we present total OH reactivity observations in pristine Amazon rainforest air, as a functi...

journal_title：Nature communications

authors： Nölscher AC,Yañez-Serrano AM,Wolff S,de Araujo AC,Lavrič JV,Kesselmeier J,Williams J

更新日期：2016-01-22 00:00:00

abstract：:The realization that mitigation efforts to reduce carbon dioxide emissions have, until now, been relatively ineffective has led to an increasing interest in climate engineering as a possible means of preventing the potentially catastrophic consequences of climate change. While many studies have addressed the potential...

journal_title：Nature communications

authors： Keller DP,Feng EY,Oschlies A

更新日期：2014-02-25 00:00:00

abstract：:Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we perform a comprehensive unbiased characterisation of LNCaP cells chronically exposed to multiple AR inhibitors (...

journal_title：Nature communications

authors： Blomme A,Ford CA,Mui E,Patel R,Ntala C,Jamieson LE,Planque M,McGregor GH,Peixoto P,Hervouet E,Nixon C,Salji M,Gaughan L,Markert E,Repiscak P,Sumpton D,Blanco GR,Lilla S,Kamphorst JJ,Graham D,Faulds K,MacKay GM,

更新日期：2020-05-19 00:00:00

abstract：:Photovoltaic devices based on metal halide perovskites are rapidly improving in efficiency. Once the Shockley-Queisser limit is reached, charge-carrier extraction will be limited only by radiative bimolecular recombination of electrons with holes. Yet, this fundamental process, and its link with material stoichiometry...

journal_title：Nature communications

authors： Davies CL,Filip MR,Patel JB,Crothers TW,Verdi C,Wright AD,Milot RL,Giustino F,Johnston MB,Herz LM

更新日期：2018-01-18 00:00:00

abstract：:EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell-cell adhesion via intercellular oligomerization and proliferative signalling via proteolytic cleavage. Despite its use as a diagnostic marker and being a drug target, structural details of ...

journal_title：Nature communications

authors： Pavšič M,Gunčar G,Djinović-Carugo K,Lenarčič B

更新日期：2014-08-28 00:00:00

abstract：:Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based flu...

journal_title：Nature communications

authors： Yang Q,Dong Y,Wu W,Zhu C,Chong H,Lu J,Yu D,Liu L,Lv F,Wang S

更新日期：2012-01-01 00:00:00

abstract：:Nanophotonics is becoming invaluable for an expanding range of applications, from controlling the spontaneous emission rate and the directionality of quantum emitters, to reducing material requirements of solar cells by an order of magnitude. These effects are highly dependent on the near field of the nanostructure, w...

journal_title：Nature communications

authors： Johlin E,Solari J,Mann SA,Wang J,Shimizu TS,Garnett EC

更新日期：2016-12-20 00:00:00

abstract：:Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1-FOXO1 cascade is essential for directional migration of tip cells towards hypoxic regions. In mice, endothelial-specific deletion of either...

journal_title：Nature communications

authors： Kim YH,Choi J,Yang MJ,Hong SP,Lee CK,Kubota Y,Lim DS,Koh GY

更新日期：2019-02-19 00:00:00

abstract：:The shift from maternal to embryonic control is a critical developmental milestone in preimplantation development. Widespread transcriptomic and epigenetic remodeling facilitate this transition from terminally differentiated gametes to totipotent blastomeres, but the identity of transcription factors (TF) and genomic ...

journal_title：Nature communications

authors： Halstead MM,Ma X,Zhou C,Schultz RM,Ross PJ

更新日期：2020-09-17 00:00:00

abstract：:The challenge of monitoring in planta dynamic changes of NADP(H) and NAD(H) redox states at the subcellular level is considered a major obstacle in plant bioenergetics studies. Here, we introduced two circularly permuted yellow fluorescent protein sensors, iNAP and SoNar, into Arabidopsis thaliana to monitor the dynam...

journal_title：Nature communications

authors： Lim SL,Voon CP,Guan X,Yang Y,Gardeström P,Lim BL

更新日期：2020-06-26 00:00:00

abstract：:Although a hydrophobic microtexture at a solid surface most often reflects rain owing to the presence of entrapped air within the texture, it is much more challenging to repel hot water. As it contacts a colder material, hot water generates condensation within the cavities at the solid surface, which eventually builds...

journal_title：Nature communications

authors： Mouterde T,Lecointre P,Lehoucq G,Checco A,Clanet C,Quéré D

更新日期：2019-03-29 00:00:00

abstract：:Saccharomyces cerevisiae is a Crabtree-positive eukaryal model organism. It is believed that the Crabtree effect has evolved as a competition mechanism by allowing for rapid growth and production of ethanol at aerobic glucose excess conditions. This inherent property of yeast metabolism and the multiple mechanisms und...

journal_title：Nature communications

authors： Dai Z,Huang M,Chen Y,Siewers V,Nielsen J

更新日期：2018-08-03 00:00:00

abstract：:Subduction zone magmas are more oxidised on eruption than those at mid-ocean ridges. This is attributed either to oxidising components, derived from subducted lithosphere (slab) and added to the mantle wedge, or to oxidation processes occurring during magma ascent via differentiation. Here we provide direct evidence f...

journal_title：Nature communications

authors： Bénard A,Klimm K,Woodland AB,Arculus RJ,Wilke M,Botcharnikov RE,Shimizu N,Nebel O,Rivard C,Ionov DA

更新日期：2018-08-29 00:00:00

abstract：:Species-specific gamete recognition is a key premise to ensure reproductive success and the maintenance of species boundaries. During plant pollen tube (PT) reception, gametophyte interactions likely allow the species-specific recognition of signals from the PT (male gametophyte) by the embryo sac (female gametophyte)...

journal_title：Nature communications

authors： Müller LM,Lindner H,Pires ND,Gagliardini V,Grossniklaus U

更新日期：2016-03-11 00:00:00

abstract：:Mammalian female meiosis is error prone, with rates of meiotic chromosome missegregations strongly increasing towards the end of the reproductive lifespan. A strong reduction of BubR1 has been observed in oocytes of women approaching menopause and in ovaries of aged mice, which led to the hypothesis that a gradual dec...

journal_title：Nature communications

authors： Touati SA,Buffin E,Cladière D,Hached K,Rachez C,van Deursen JM,Wassmann K

更新日期：2015-04-21 00:00:00

abstract：:Oxidation of bromide in aqueous environments initiates the formation of molecular halogen compounds, which is important for the global tropospheric ozone budget. In the aqueous bulk, oxidation of bromide by ozone involves a [Br•OOO-] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy m...

journal_title：Nature communications

authors： Artiglia L,Edebeli J,Orlando F,Chen S,Lee MT,Corral Arroyo P,Gilgen A,Bartels-Rausch T,Kleibert A,Vazdar M,Andres Carignano M,Francisco JS,Shepson PB,Gladich I,Ammann M

更新日期：2017-09-26 00:00:00

abstract：:Cytosolic HSP90 requires multiple cochaperones in folding client proteins. However, the function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed to be independent of cochaperones. Here, we demonstrate that gp96 chaperones multiple Toll-like receptors (TLRs), but not TLR3, in...

journal_title：Nature communications

authors： Liu B,Yang Y,Qiu Z,Staron M,Hong F,Li Y,Wu S,Li Y,Hao B,Bona R,Han D,Li Z

更新日期：2010-09-21 00:00:00

abstract：:Many volcanoes erupt compositionally homogeneous magmas over timescales ranging from decades to millennia. This monotonous activity is thought to reflect a high degree of chemical homogeneity in their magmatic systems, leading to predictable eruptive behaviour. We combine petrological analyses of erupted crystals with...

journal_title：Nature communications

authors： Stock MJ,Geist D,Neave DA,Gleeson MLM,Bernard B,Howard KA,Buisman I,Maclennan J

更新日期：2020-07-28 00:00:00

abstract：:Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...

journal_title：Nature communications

authors： Qi H,Zhang H,Zhao Y,Chen C,Long JJ,Chung WK,Guan Y,Shen Y

更新日期：2021-01-21 00:00:00

abstract：:Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here ...

journal_title：Nature communications

authors： Wan DC,Morgan SL,Spencley AL,Mariano N,Chang EY,Shankar G,Luo Y,Li TH,Huh D,Huynh SK,Garcia JM,Dovey CM,Lumb J,Liu L,Brown KV,Bermudez A,Luong R,Zeng H,Mascetti VL,Pitteri SJ,Wang J,Tu H,Quarta M,Sebastiano

更新日期：2018-12-04 00:00:00

abstract：:Device performance and in particular device stability for blue perovskite light-emitting diodes (PeLEDs) remain considerable challenges for the whole community. In this manuscript, we conceive an approach by tuning the 'A-site' cation composition of perovskites to develop blue-emitters. We herein report a Rubidium-Ces...

journal_title：Nature communications

authors： Jiang Y,Qin C,Cui M,He T,Liu K,Huang Y,Luo M,Zhang L,Xu H,Li S,Wei J,Liu Z,Wang H,Kim GH,Yuan M,Chen J

更新日期：2019-04-23 00:00:00

abstract：:Epistasis emerges when the effects of an amino acid depend on the identities of interacting residues. This phenomenon shapes fitness landscapes, which have the power to reveal evolutionary paths and inform evolution of desired functions. However, there is a need for easily implemented, high-throughput methods to captu...

journal_title：Nature communications

authors： Yoo JI,Daugherty PS,O'Malley MA

更新日期：2020-02-04 00:00:00

abstract：:Epitaxy is widely employed to create highly oriented crystalline films. A less appreciated, but nonetheless powerful means of creating such films is via topotactic transformation, in which a chemical reaction transforms a single crystal of one phase into a single crystal of a different phase, which inherits its orient...

journal_title：Nature communications

authors： Mairoser T,Mundy JA,Melville A,Hodash D,Cueva P,Held R,Glavic A,Schubert J,Muller DA,Schlom DG,Schmehl A

更新日期：2015-07-16 00:00:00

abstract：:Control of the collective response of plasma particles to intense laser light is intrinsic to relativistic optics, the development of compact laser-driven particle and radiation sources, as well as investigations of some laboratory astrophysics phenomena. We recently demonstrated that a relativistic plasma aperture pr...

journal_title：Nature communications

authors： Gonzalez-Izquierdo B,King M,Gray RJ,Wilson R,Dance RJ,Powell H,Maclellan DA,McCreadie J,Butler NMH,Hawkes S,Green JS,Murphy CD,Stockhausen LC,Carroll DC,Booth N,Scott GG,Borghesi M,Neely D,McKenna P

更新日期：2016-09-14 00:00:00

abstract：:Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome interactions. Here, we report a single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling. scNMT-seq (single-cell nucleosome, met...

journal_title：Nature communications

authors： Clark SJ,Argelaguet R,Kapourani CA,Stubbs TM,Lee HJ,Alda-Catalinas C,Krueger F,Sanguinetti G,Kelsey G,Marioni JC,Stegle O,Reik W

更新日期：2018-02-22 00:00:00

abstract：:Epigenetic control of enhancers alters neuronal functions and may be involved in Alzheimer's disease (AD). Here, we identify enhancers in neurons contributing to AD by comprehensive fine-mapping of DNA methylation at enhancers, genome-wide. We examine 1.2 million CpG and CpH sites in enhancers in prefrontal cortex neu...

journal_title：Nature communications

authors： Li P,Marshall L,Oh G,Jakubowski JL,Groot D,He Y,Wang T,Petronis A,Labrie V

更新日期：2019-05-21 00:00:00

abstract：:In Drosophila, a complex consisting of Calypso and ASX catalyzes H2A deubiquitination and has been reported to act as part of the Polycomb machinery in transcriptional silencing. The mammalian homologs of these proteins (BAP1 and ASXL1/2/3, respectively), are frequently mutated in various cancer types, yet their preci...

journal_title：Nature communications

authors： Campagne A,Lee MK,Zielinski D,Michaud A,Le Corre S,Dingli F,Chen H,Shahidian LZ,Vassilev I,Servant N,Loew D,Pasmant E,Postel-Vinay S,Wassef M,Margueron R

更新日期：2019-01-21 00:00:00