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Honey bee Royalactin unlocks conserved pluripotency pathway in mammals.

Abstract：

:Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species.

journal_name

Nat Commun

journal_title

Nature communications

authors

Wan DC,Morgan SL,Spencley AL,Mariano N,Chang EY,Shankar G,Luo Y,Li TH,Huh D,Huynh SK,Garcia JM,Dovey CM,Lumb J,Liu L,Brown KV,Bermudez A,Luong R,Zeng H,Mascetti VL,Pitteri SJ,Wang J,Tu H,Quarta M,Sebastiano

doi

10.1038/s41467-018-06256-4

subject

Has Abstract

pub_date

2018-12-04 00:00:00

pages

5078

issue

1

issn

2041-1723

pii

10.1038/s41467-018-06256-4

journal_volume

9

pub_type

杂志文章

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