Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum.

abstract：:Diet is commonly assumed to affect the evolution of species, but few studies have directly tested its effect at macroevolutionary scales. Here we use Bayesian models of trait-dependent diversification and a comprehensive dietary database of all birds worldwide to assess speciation and extinction dynamics of avian diet...

journal_title：Nature communications

authors： Burin G,Kissling WD,Guimarães PR Jr,Şekercioğlu ÇH,Quental TB

更新日期：2016-04-07 00:00:00

abstract：:Autophagosomes are double-membrane vesicles that sequester cytoplasmic material for lysosomal degradation. Their biogenesis is initiated by recruitment of Atg9-vesicles to the phagophore assembly site. This process depends on the regulated activation of the Atg1-kinase complex. However, the underlying molecular mechan...

journal_title：Nature communications

authors： Rao Y,Perna MG,Hofmann B,Beier V,Wollert T

更新日期：2016-01-12 00:00:00

abstract：:Field-effect transistors based on carbon nanotubes have been shown to be faster and less energy consuming than their silicon counterparts. However, ensuring these advantages are maintained for integrated circuits is a challenge. Here we demonstrate that a significant reduction in the use of field-effect transistors ca...

journal_title：Nature communications

authors： Ding L,Zhang Z,Liang S,Pei T,Wang S,Li Y,Zhou W,Liu J,Peng LM

更新日期：2012-02-14 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms14778. ...

journal_title：Nature communications

authors： Li B,Bian K,Lane JMD,Salerno KM,Grest GS,Ao T,Hickman R,Wise J,Wang Z,Fan H

更新日期：2017-05-24 00:00:00

abstract：:The immunogenic heat shock proteins (HSPs) gp96, hsp70 and calreticulin (CRT) bind to CD91 on antigen-presenting cells (APCs) for cross-presentation of the HSP-chaperoned peptides. This event leads to priming of T-cell responses. Here we show that CD91 serves as a signalling receptor for these HSPs, allowing for the m...

journal_title：Nature communications

authors： Pawaria S,Binder RJ

更新日期：2011-11-01 00:00:00

abstract：:Rising demand for ruminant meat and dairy products in developing countries is expected to double anthropogenic greenhouse gas and ammonia emissions from livestock by 2050. Mitigation strategies are urgently needed to meet demand while minimizing environmental impacts. Here, we develop scenarios for mitigating emission...

journal_title：Nature communications

authors： Du Y,Ge Y,Ren Y,Fan X,Pan K,Lin L,Wu X,Min Y,Meyerson LA,Heino M,Chang SX,Liu X,Mao F,Yang G,Peng C,Qu Z,Chang J,Didham RK

更新日期：2018-10-08 00:00:00

abstract：:The process of crystallization is difficult to observe for transported, out-of-equilibrium systems, as the continuous energy injection increases activity and competes with ordering. In emerging fields such as microfluidics and active matter, the formation of long-range order is often frustrated by the presence of hydr...

journal_title：Nature communications

authors： Massana-Cid H,Meng F,Matsunaga D,Golestanian R,Tierno P

更新日期：2019-06-04 00:00:00

abstract：:Post-transcriptional RNA modifications play a critical role in the pathogenesis of human mitochondrial disorders, but the mechanisms by which specific modifications affect mitochondrial protein synthesis remain poorly understood. Here we used a quantitative RNA sequencing approach to investigate, at nucleotide resolut...

journal_title：Nature communications

authors： Richter U,Evans ME,Clark WC,Marttinen P,Shoubridge EA,Suomalainen A,Wredenberg A,Wedell A,Pan T,Battersby BJ

更新日期：2018-09-27 00:00:00

abstract：:The occurrence of Oceanic Anoxic Event 2 (OAE2) 94 million years ago is considered to be one of the largest carbon cycle perturbations in the Earth's history. The marked increase in the spatial extent of the anoxic conditions in the world's oceans associated with OAE2 resulted in the mass accumulation of organic-rich ...

journal_title：Nature communications

authors： Takashima R,Nishi H,Yamanaka T,Tomosugi T,Fernando AG,Tanabe K,Moriya K,Kawabe F,Hayashi K

更新日期：2011-01-01 00:00:00

abstract：:Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current stimulation (tACS) can entrain and enhance neural rhythms related to memory, but the evidence ...

journal_title：Nature communications

authors： Lafon B,Henin S,Huang Y,Friedman D,Melloni L,Thesen T,Doyle W,Buzsáki G,Devinsky O,Parra LC,A Liu A

更新日期：2017-10-31 00:00:00

abstract：:Avoiding repeated mistakes and learning to reinforce rewarding decisions is critical for human survival and adaptive actions. Yet, the neural underpinnings of the value systems that encode different decision-outcomes remain elusive. Here coupling single-trial electroencephalography with simultaneously acquired functio...

journal_title：Nature communications

authors： Fouragnan E,Retzler C,Mullinger K,Philiastides MG

更新日期：2015-09-08 00:00:00

abstract：:Phospholipase C is a key enzyme in phosphoinositide turnover. Although its functions have been extensively studied at the cellular level, many questions remain concerning its functions at the organ and individual animal levels. Here we demonstrate that mice lacking phospholipase Cδ1 develop granulocytosis associated w...

journal_title：Nature communications

authors： Kanemaru K,Nakamura Y,Sato K,Kojima R,Takahashi S,Yamaguchi M,Ichinohe M,Kiyonari H,Shioi G,Kabashima K,Nakahigashi K,Asagiri M,Jamora C,Yamaguchi H,Fukami K

更新日期：2012-07-17 00:00:00

abstract：:The concept of spin-torque-driven high-frequency magnetization dynamics, allows the potential construction of complex networks of non-linear dynamical nanoscale systems, combining the field of spintronics and the study of non-linear systems. In the few previous demonstrations of synchronization of several spin-torque ...

journal_title：Nature communications

authors： Lebrun R,Tsunegi S,Bortolotti P,Kubota H,Jenkins AS,Romera M,Yakushiji K,Fukushima A,Grollier J,Yuasa S,Cros V

更新日期：2017-06-12 00:00:00

abstract：:Researchers strive to produce nanoparticles with complexity in composition and structure. Although traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, scientists seek more complicated geometries for potential functionality. Here we report the simple solution construction of mul...

journal_title：Nature communications

authors： Zhu J,Zhang S,Zhang K,Wang X,Mays JW,Wooley KL,Pochan DJ

更新日期：2013-01-01 00:00:00

abstract：:Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic ...

journal_title：Nature communications

authors： Muthana M,Kennerley AJ,Hughes R,Fagnano E,Richardson J,Paul M,Murdoch C,Wright F,Payne C,Lythgoe MF,Farrow N,Dobson J,Conner J,Wild JM,Lewis C

更新日期：2015-08-18 00:00:00

abstract：:Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of proviral integration sites. However, the source of the proliferation of HIV-infected cells remains unclear. Here, we analyze the TCR repertoire of single HIV-infected cells harboring translation-competent proviruses in longitudinal ...

journal_title：Nature communications

authors： Gantner P,Pagliuzza A,Pardons M,Ramgopal M,Routy JP,Fromentin R,Chomont N

更新日期：2020-08-14 00:00:00

abstract：:Tunneling is a fundamental quantum process with no classical equivalent, which can compete with Coulomb interactions to give rise to complex phenomena. Phosphorus dopants in silicon can be placed with atomic precision to address the different regimes arising from this competition. However, they exploit wavefunctions r...

journal_title：Nature communications

authors： Voisin B,Bocquel J,Tankasala A,Usman M,Salfi J,Rahman R,Simmons MY,Hollenberg LCL,Rogge S

更新日期：2020-11-30 00:00:00

abstract：:Optical super-resolution microscopy allows nanoscale imaging of protein molecules in intact biological tissues. However, it is still challenging to perform large volume super-resolution imaging for entire animal organs. Here we develop a single-wavelength Bessel lightsheet method, optimized for refractive-index matchi...

journal_title：Nature communications

authors： Chu LA,Lu CH,Yang SM,Liu YT,Feng KL,Tsai YC,Chang WK,Wang WC,Chang SW,Chen P,Lee TK,Hwu YK,Chiang AS,Chen BC

更新日期：2019-10-18 00:00:00

abstract：:5-Methylfurfural (MF) is a very useful chemical. Selective hydrogenation of biomass platform molecule 5-(hydroxymethyl)furfural (HMF) to MF using H2 as the reducing agent is very attractive, but challenging because hydrogenation of C=O bond in HMF is more favourable than C-OH both kinetically and thermodynamically, an...

journal_title：Nature communications

authors： Li S,Dong M,Yang J,Cheng X,Shen X,Liu S,Wang ZQ,Gong XQ,Liu H,Han B

更新日期：2021-01-26 00:00:00

abstract：:Plant halogenated natural products are rare and harbor various interesting bioactivities, yet the biochemical basis for the involved halogenation chemistry is unknown. While a handful of Fe(II)- and 2-oxoglutarate-dependent halogenases (2ODHs) have been found to catalyze regioselective halogenation of unactivated C-H ...

journal_title：Nature communications

authors： Kim CY,Mitchell AJ,Glinkerman CM,Li FS,Pluskal T,Weng JK

更新日期：2020-04-20 00:00:00

abstract：:Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they are remodelled upon developmental transitions remain poorly understood. Here, we report the existence of two types of enhancer units within SEs typified by distin...

journal_title：Nature communications

authors： Bell E,Curry EW,Megchelenbrink W,Jouneau L,Brochard V,Tomaz RA,Mau KHT,Atlasi Y,de Souza RA,Marks H,Stunnenberg HG,Jouneau A,Azuara V

更新日期：2020-02-28 00:00:00

abstract：:CrAss-like phages are double-stranded DNA viruses that are prevalent in human gut microbiomes. Here, we analyze gut metagenomic data from mother-infant pairs and patients undergoing fecal microbiota transplantation to evaluate the patterns of acquisition, transmission and strain diversity of crAss-like phages. We find...

journal_title：Nature communications

authors： Siranosian BA,Tamburini FB,Sherlock G,Bhatt AS

更新日期：2020-01-15 00:00:00

abstract：:The isolation of the two-dimensional semiconductor molybdenum disulphide introduced a new optically active material possessing a band gap that can be facilely tuned via elastic strain. As an atomically thin membrane with exceptional strength, monolayer molybdenum disulphide subjected to biaxial strain can embed wide b...

journal_title：Nature communications

authors： Li H,Contryman AW,Qian X,Ardakani SM,Gong Y,Wang X,Weisse JM,Lee CH,Zhao J,Ajayan PM,Li J,Manoharan HC,Zheng X

更新日期：2015-06-19 00:00:00

abstract：:Increased vascular permeability contributes to many diseases, including acute respiratory distress syndrome, cancer and inflammation. Most past work on vascular barrier function has focused on soluble regulators, such as tumour-necrosis factor-α. Here we show that lung vascular permeability is controlled mechanically ...

journal_title：Nature communications

authors： Mammoto A,Mammoto T,Kanapathipillai M,Wing Yung C,Jiang E,Jiang A,Lofgren K,Gee EP,Ingber DE

更新日期：2013-01-01 00:00:00

abstract：:Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms. Here we apply dual RNA-seq to Orientia tsutsugamushi (Ot), an obligate...

journal_title：Nature communications

authors： Mika-Gospodorz B,Giengkam S,Westermann AJ,Wongsantichon J,Kion-Crosby W,Chuenklin S,Wang LC,Sunyakumthorn P,Sobota RM,Subbian S,Vogel J,Barquist L,Salje J

更新日期：2020-07-03 00:00:00

abstract：:Intestinal intraepithelial T cells contribute to the regulation of inflammatory responses in the intestine; however, the molecular basis for their development and maintenance is unknown. The aryl hydrocarbon receptor complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and senses environmental fact...

journal_title：Nature communications

authors： Nakajima K,Maekawa Y,Kataoka K,Ishifune C,Nishida J,Arimochi H,Kitamura A,Yoshimoto T,Tomita S,Nagahiro S,Yasutomo K

更新日期：2013-01-01 00:00:00

abstract：:X-linked lymphoproliferative syndrome type-2 (XLP-2) is a primary immunodeficiency disease attributed to XIAP mutation and is triggered by infection. Here, we show that mouse Xiap-/- regulatory T (Treg) cells and human XIAP-deficient Treg cells are defective in suppressive function. The Xiap-/- Treg cell defect is lin...

journal_title：Nature communications

authors： Hsieh WC,Hsu TS,Chang YJ,Lai MZ

更新日期：2018-01-31 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Yang C,Eleftheriadou M,Kelaini S,Morrison T,González MV,Caines R,Edwards N,Yacoub A,Edgar K,Moez A,Ivetic A,Zampetaki A,Zeng L,Wilkinson FL,Lois N,Stitt AW,Grieve DJ,Margariti A

更新日期：2020-09-16 00:00:00

abstract：:Vertical transmission accounts for most human immunodeficiency virus (HIV) infection in children, and treatments for newborns are needed to abrogate infection or limit disease progression. We showed previously that short-term broadly neutralizing antibody (bNAb) therapy given 24 h after oral exposure cleared simian-hu...

journal_title：Nature communications

authors： Shapiro MB,Cheever T,Malherbe DC,Pandey S,Reed J,Yang ES,Wang K,Pegu A,Chen X,Siess D,Burke D,Henderson H,Lewinsohn R,Fischer M,Stanton JJ,Axthelm MK,Kahl C,Park B,Lewis AD,Sacha JB,Mascola JR,Hessell AJ,Haigw

更新日期：2020-01-07 00:00:00

abstract：:Serial X-ray crystallography allows macromolecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for serial synchrotron crystallography experiments has been limited to millisecond timescales with monochromatic beams. The polychromatic, "...

journal_title：Nature communications

authors： Meents A,Wiedorn MO,Srajer V,Henning R,Sarrou I,Bergtholdt J,Barthelmess M,Reinke PYA,Dierksmeyer D,Tolstikova A,Schaible S,Messerschmidt M,Ogata CM,Kissick DJ,Taft MH,Manstein DJ,Lieske J,Oberthuer D,Fischetti RF,C

更新日期：2017-11-03 00:00:00