A global strategy to mitigate the environmental impact of China's ruminant consumption boom.

abstract：:Understanding human cooperation is of major interest across the natural and social sciences. But it is unclear to what extent cooperation is actually a general concept. Most research on cooperation has implicitly assumed that a person's behaviour in one cooperative context is related to their behaviour in other settin...

journal_title：Nature communications

authors： Peysakhovich A,Nowak MA,Rand DG

更新日期：2014-09-16 00:00:00

abstract：:Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics. Here we describe the design and development of the Alphabody, a protein scaffold featuring a single-chain antiparallel triple-helix coiled-coil fold. We report affinity-...

journal_title：Nature communications

authors： Desmet J,Verstraete K,Bloch Y,Lorent E,Wen Y,Devreese B,Vandenbroucke K,Loverix S,Hettmann T,Deroo S,Somers K,Henderikx P,Lasters I,Savvides SN

更新日期：2014-10-30 00:00:00

abstract：:Neurons communicate through chemical synapses and electrical synapses (gap junctions). Although these two types of synapses often coexist between neurons, little is known about whether they interact, and whether any interactions between them are important to controlling synaptic strength and circuit functions. By stud...

journal_title：Nature communications

authors： Liu P,Chen B,Mailler R,Wang ZW

更新日期：2017-03-20 00:00:00

abstract：:Compartmentalization of the gut microbiota is thought to be important to system function, but the extent of spatial organization in the gut ecosystem remains poorly understood. Here, we profile the murine colonic microbiota along longitudinal and lateral axes using laser capture microdissection. We found fine-scale sp...

journal_title：Nature communications

authors： Riva A,Kuzyk O,Forsberg E,Siuzdak G,Pfann C,Herbold C,Daims H,Loy A,Warth B,Berry D

更新日期：2019-09-25 00:00:00

abstract：:Of the many challenges in building a wireless network at terahertz frequencies, link discovery remains one of the most critical and least explored. In a network of mobile receivers using narrow directional beams, how do the nodes rapidly locate each other? This direction information is crucial for beam forming and ste...

journal_title：Nature communications

authors： Ghasempour Y,Shrestha R,Charous A,Knightly E,Mittleman DM

更新日期：2020-04-24 00:00:00

abstract：:The original version of this article contained an error in the author affiliations. Oliver J. Furzer was incorrectly associated with Department of Plant Sciences, College of Life Sciences, Wuhan University, 430072, Wuhan, China.This has now been corrected in the HTML version of the article. The PDF version of the arti...

journal_title：Nature communications

authors： Asai S,Furzer OJ,Cevik V,Kim DS,Ishaque N,Goritschnig S,Staskawicz BJ,Shirasu K,Jones JDG

更新日期：2019-01-08 00:00:00

abstract：:Hydrogen can facilitate the detachment of protective oxide layer off metals and alloys. The degradation is usually exacerbated at elevated temperatures in many industrial applications; however, its origin remains poorly understood. Here by heating hydrogenated aluminium inside an environmental transmission electron mi...

journal_title：Nature communications

authors： Li M,Xie DG,Ma E,Li J,Zhang XX,Shan ZW

更新日期：2017-02-20 00:00:00

abstract：:Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemne...

journal_title：Nature communications

authors： Jiang H,Zhou C,Zhang Z,Wang Q,Wei H,Shi W,Li J,Wang Z,Ou Y,Wang W,Wang H,Zhang Q,Sun W,Sun P,Yang S

更新日期：2020-10-12 00:00:00

abstract：:Artificial photosynthesis is a vibrant field of research aiming at converting abundant, low energy molecules such as water, nitrogen or carbon dioxide into fuels or useful chemicals by means of solar energy input. Photo-electrochemical reduction of carbon dioxide is an appealing strategy, aiming at reducing the greenh...

journal_title：Nature communications

authors： Pati PB,Wang R,Boutin E,Diring S,Jobic S,Barreau N,Odobel F,Robert M

更新日期：2020-07-13 00:00:00

abstract：:Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience network, are key functional networks of the human brain. Here we show that the rapid evolutionary cortical expansion of cognitive networks in the human brain, and most pronounced the DMN, runs parallel with high expre...

journal_title：Nature communications

authors： Wei Y,de Lange SC,Scholtens LH,Watanabe K,Ardesch DJ,Jansen PR,Savage JE,Li L,Preuss TM,Rilling JK,Posthuma D,van den Heuvel MP

更新日期：2019-10-24 00:00:00

abstract：:MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell p...

journal_title：Nature communications

authors： Alivernini S,Kurowska-Stolarska M,Tolusso B,Benvenuto R,Elmesmari A,Canestri S,Petricca L,Mangoni A,Fedele AL,Di Mario C,Gigante MR,Gremese E,McInnes IB,Ferraccioli G

更新日期：2016-09-27 00:00:00

abstract：:The nucleotidyl cyclase toxin ExoY is one of the virulence factors injected by the Pseudomonas aeruginosa type III secretion system into host cells. Inside cells, it is activated by an unknown eukaryotic cofactor to synthesize various cyclic nucleotide monophosphates. ExoY-like adenylate cyclases are also found in Mul...

journal_title：Nature communications

authors： Belyy A,Raoux-Barbot D,Saveanu C,Namane A,Ogryzko V,Worpenberg L,David V,Henriot V,Fellous S,Merrifield C,Assayag E,Ladant D,Renault L,Mechold U

更新日期：2016-12-05 00:00:00

abstract：:Linking microbial metabolomics and carbon sequestration in the ocean via refractory organic molecules has been hampered by the chemical complexity of dissolved organic matter (DOM). Here, using bioassay experiments and ultra-high resolution metabolic profiling, we demonstrate that marine bacteria rapidly utilize simpl...

journal_title：Nature communications

authors： Lechtenfeld OJ,Hertkorn N,Shen Y,Witt M,Benner R

更新日期：2015-03-31 00:00:00

abstract：:Ligand-induced receptor dimerization has traditionally been viewed as the key event in transmembrane signalling by epidermal growth factor receptors (EGFRs). Here we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet responds to its ligand LIN-3 without changing oligomerization ...

journal_title：Nature communications

authors： Freed DM,Alvarado D,Lemmon MA

更新日期：2015-06-10 00:00:00

abstract：:Synthetic genetic circuits allow us to modify the behavior of living cells. However, changes in environmental conditions and unforeseen interactions with the host cell can cause deviations from a desired function, resulting in the need for time-consuming reassembly to fix these issues. Here, we use a regulatory motif ...

journal_title：Nature communications

authors： Bartoli V,Meaker GA,di Bernardo M,Gorochowski TE

更新日期：2020-04-29 00:00:00

abstract：:Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, the mechanism of lipid accumulation and the corresponding function in tumor-associated macrophages (TAMs) remain unclear. With primary investigation in colon cancer and confirmation in other cancer models, here we determin...

journal_title：Nature communications

authors： Xiang W,Shi R,Kang X,Zhang X,Chen P,Zhang L,Hou A,Wang R,Zhao Y,Zhao K,Liu Y,Ma Y,Luo H,Shang S,Zhang J,He F,Yu S,Gan L,Shi C,Li Y,Yang W,Liang H,Miao H

更新日期：2018-07-03 00:00:00

abstract：:Berry phase associated with energy bands in crystals can lead to quantised observables like quantised dipole polarizations in one-dimensional topological insulators. Recent theories have generalised the concept of quantised dipoles to multipoles, resulting in the discovery of multipole topological insulators which exh...

journal_title：Nature communications

authors： Xue H,Ge Y,Sun HX,Wang Q,Jia D,Guan YJ,Yuan SQ,Chong Y,Zhang B

更新日期：2020-05-15 00:00:00

abstract：:The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular ...

journal_title：Nature communications

authors： Ghosh D,Pinto S,Danglot L,Vandewauw I,Segal A,Van Ranst N,Benoit M,Janssens A,Vennekens R,Vanden Berghe P,Galli T,Vriens J,Voets T

更新日期：2016-02-04 00:00:00

abstract：:India is located at a critical geographic crossroads for understanding the dispersal of Homo sapiens out of Africa and into Asia and Oceania. Here we report evidence for long-term human occupation, spanning the last ~80 thousand years, at the site of Dhaba in the Middle Son River Valley of Central India. An unchanging...

journal_title：Nature communications

authors： Clarkson C,Harris C,Li B,Neudorf CM,Roberts RG,Lane C,Norman K,Pal J,Jones S,Shipton C,Koshy J,Gupta MC,Mishra DP,Dubey AK,Boivin N,Petraglia M

更新日期：2020-02-25 00:00:00

abstract：:Proton conduction is a fundamental process in biology and in devices such as proton exchange membrane fuel cells. To maximize proton conduction, three-dimensional conduction pathways are preferred over one-dimensional pathways, which prevent conduction in two dimensions. Many crystalline porous solids to date show one...

journal_title：Nature communications

authors： Liu M,Chen L,Lewis S,Chong SY,Little MA,Hasell T,Aldous IM,Brown CM,Smith MW,Morrison CA,Hardwick LJ,Cooper AI

更新日期：2016-09-13 00:00:00

abstract：:Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator of signalling following DNA double-strand breaks (DSBs) has been dissected in extraordinary detai...

journal_title：Nature communications

authors： Álvarez-Quilón A,Serrano-Benítez A,Lieberman JA,Quintero C,Sánchez-Gutiérrez D,Escudero LM,Cortés-Ledesma F

更新日期：2014-02-27 00:00:00

abstract：:β-Adrenergic receptor (β-AR) signaling is a pathway controlling adaptive thermogenesis in brown or beige adipocytes. Here we investigate the biological roles of the transcription factor Foxp1 in brown/beige adipocyte differentiation and thermogenesis. Adipose-specific deletion of Foxp1 leads to an increase of brown ad...

journal_title：Nature communications

authors： Liu P,Huang S,Ling S,Xu S,Wang F,Zhang W,Zhou R,He L,Xia X,Yao Z,Fan Y,Wang N,Hu C,Zhao X,Tucker HO,Wang J,Guo X

更新日期：2019-11-07 00:00:00

abstract：:Enhancers are critical for developmental stage-specific gene expression, but their dynamic regulation in plants remains poorly understood. Here we compare genome-wide localization of H3K27ac, chromatin accessibility and transcriptomic changes during flower development in Arabidopsis. H3K27ac prevalently marks promoter...

journal_title：Nature communications

authors： Yan W,Chen D,Schumacher J,Durantini D,Engelhorn J,Chen M,Carles CC,Kaufmann K

更新日期：2019-04-12 00:00:00

abstract：:A nest of begging chicks invites an intuitive explanation: needy chicks want to be fed and parents want to feed them. Surprisingly, however, in a quarter of species studied, parents ignore begging chicks. Furthermore, parents in some species even neglect smaller chicks that beg more, and preferentially feed the bigges...

journal_title：Nature communications

authors： Caro SM,Griffin AS,Hinde CA,West SA

更新日期：2016-03-29 00:00:00

abstract：:With its light weight, low cost and high efficiency even at low operation frequency, the triboelectric nanogenerator is considered a potential solution for self-powered sensor networks and large-scale renewable blue energy. As an energy harvester, its output power density and efficiency are dictated by the triboelectr...

journal_title：Nature communications

authors： Wang J,Wu C,Dai Y,Zhao Z,Wang A,Zhang T,Wang ZL

更新日期：2017-07-20 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcripto...

journal_title：Nature communications

authors： Arthur SE,Jiang A,Grande BM,Alcaide M,Cojocaru R,Rushton CK,Mottok A,Hilton LK,Lat PK,Zhao EY,Culibrk L,Ennishi D,Jessa S,Chong L,Thomas N,Pararajalingam P,Meissner B,Boyle M,Davidson J,Bushell KR,Lai D,Farinha

更新日期：2018-10-01 00:00:00

abstract：:Humans survive and thrive through social exchange. Yet, social dependency also comes at a cost. Perceived social isolation, or loneliness, affects physical and mental health, cognitive performance, overall life expectancy, and increases vulnerability to Alzheimer's disease-related dementias. Despite severe consequence...

journal_title：Nature communications

authors： Spreng RN,Dimas E,Mwilambwe-Tshilobo L,Dagher A,Koellinger P,Nave G,Ong A,Kernbach JM,Wiecki TV,Ge T,Li Y,Holmes AJ,Yeo BTT,Turner GR,Dunbar RIM,Bzdok D

更新日期：2020-12-15 00:00:00

abstract：:Application of force on biomolecules has been instrumental in understanding biofunctional behaviour from single molecules to complex collections of cells. Current approaches, for example, those based on atomic force microscopy or magnetic or optical tweezers, are powerful but limited in their applicability as integrat...

journal_title：Nature communications

authors： Webster A,Vollmer F,Sato Y

更新日期：2014-10-21 00:00:00

abstract：:Everyone experiences common events differently. This leads to personal memories that presumably provide neural signatures of individual identity when events are reimagined. We present initial evidence that these signatures can be read from brain activity. To do this, we progress beyond previous work that has deployed ...

journal_title：Nature communications

authors： Anderson AJ,McDermott K,Rooks B,Heffner KL,Dodell-Feder D,Lin FV

更新日期：2020-11-20 00:00:00

abstract：:MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of ubiquitination of MAVS and MITA at different phases of viral infection...

journal_title：Nature communications

authors： Zhang ZD,Xiong TC,Yao SQ,Wei MC,Chen M,Lin D,Zhong B

更新日期：2020-11-02 00:00:00