Pink-beam serial crystallography.

abstract：:Intercellular signaling is indispensable for single cells to form complex biological structures, such as biofilms, tissues and organs. The genetic tools available for engineering intercellular signaling, however, are quite limited. Here we exploit the chemical diversity of biological small molecules to de novo design ...

journal_title：Nature communications

authors： Du P,Zhao H,Zhang H,Wang R,Huang J,Tian Y,Luo X,Luo X,Wang M,Xiang Y,Qian L,Chen Y,Tao Y,Lou C

更新日期：2020-08-24 00:00:00

abstract：:Synthetic genetic circuits allow us to modify the behavior of living cells. However, changes in environmental conditions and unforeseen interactions with the host cell can cause deviations from a desired function, resulting in the need for time-consuming reassembly to fix these issues. Here, we use a regulatory motif ...

journal_title：Nature communications

authors： Bartoli V,Meaker GA,di Bernardo M,Gorochowski TE

更新日期：2020-04-29 00:00:00

abstract：:The ventral striatum has long been proposed as an integrator of biologically significant associative information to drive actions. Although inputs from the amygdala and hippocampus have been much studied, the role of prominent inputs from orbitofrontal cortex (OFC) are less well understood. Here, we recorded single-un...

journal_title：Nature communications

authors： Cooch NK,Stalnaker TA,Wied HM,Bali-Chaudhary S,McDannald MA,Liu TL,Schoenbaum G

更新日期：2015-05-21 00:00:00

abstract：:Competing interactions in the so-called spin-ice compounds stabilize a frustrated ground state with finite zero-point entropy and, interestingly, emergent magnetic monopole excitations. The properties of these monopoles are at the focus of recent research with particular emphasis on their quantum dynamics. It is predi...

journal_title：Nature communications

authors： Grams CP,Valldor M,Garst M,Hemberger J

更新日期：2014-09-04 00:00:00

abstract：:Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection against clinically important pathogens are unknown. Here we show th...

journal_title：Nature communications

authors： Wang H,D'Souza C,Lim XY,Kostenko L,Pediongco TJ,Eckle SBG,Meehan BS,Shi M,Wang N,Li S,Liu L,Mak JYW,Fairlie DP,Iwakura Y,Gunnersen JM,Stent AW,Godfrey DI,Rossjohn J,Westall GP,Kjer-Nielsen L,Strugnell RA,McClusk

更新日期：2018-08-22 00:00:00

abstract：:Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a po...

journal_title：Nature communications

authors： Sant'Anna R,Gallego P,Robinson LZ,Pereira-Henriques A,Ferreira N,Pinheiro F,Esperante S,Pallares I,Huertas O,Almeida MR,Reixach N,Insa R,Velazquez-Campoy A,Reverter D,Reig N,Ventura S

更新日期：2016-02-23 00:00:00

abstract：:Affiliation 4 incorrectly read 'University of the Basque Country (Ikerbasque), University of the Basque Country and Donostia International Physics Center, San Sebastian 20018, Spain.'Also, the affiliations of Ignacio Arganda-Carreras with 'IKERBASQUE, Basque Foundation for Science, Bilbao, 48013, Spain' and 'Donostia ...

journal_title：Nature communications

authors： Abdeladim L,Matho KS,Clavreul S,Mahou P,Sintes JM,Solinas X,Arganda-Carreras I,Turney SG,Lichtman JW,Chessel A,Bemelmans AP,Loulier K,Supatto W,Livet J,Beaurepaire E

更新日期：2019-05-09 00:00:00

abstract：:Human-machine interfaces have benefited from the advent of wireless sensor networks and the internet of things, but rely on wearable/attachable electronics exhibiting stretchability, biocompatibility, and transmittance. Limited by weight and volume, wearable devices should be energy efficient and even self-powered. He...

journal_title：Nature communications

authors： Lee Y,Cha SH,Kim YW,Choi D,Sun JY

更新日期：2018-05-04 00:00:00

abstract：:It is generally assumed that cells interrogate the mechanical properties of their environment by pushing and pulling on the extracellular matrix (ECM). For instance, acto-myosin-dependent contraction forces exerted at focal adhesions (FAs) allow the cell to actively probe substrate elasticity. Here, we report that a s...

journal_title：Nature communications

authors： Baschieri F,Dayot S,Elkhatib N,Ly N,Capmany A,Schauer K,Betz T,Vignjevic DM,Poincloux R,Montagnac G

更新日期：2018-09-20 00:00:00

abstract：:Diagnosis of disease outside of sophisticated laboratories urgently requires low-cost, user-friendly devices. Disposable, instrument-free testing devices are used for home and physician office testing, but are limited in applicability to a small class of highly abundant analytes. Direct, unambiguous visual read-out is...

journal_title：Nature communications

authors： Besant JD,Das J,Burgess IB,Liu W,Sargent EH,Kelley SO

更新日期：2015-04-22 00:00:00

abstract：:Liquid-liquid phase separation is increasingly recognized as a process involved in cellular organization. Thus far, a detailed structural characterization of this intrinsically heterogeneous process has been challenging. Here we combine solid- and solution-state NMR spectroscopy to obtain atomic-level insights into th...

journal_title：Nature communications

authors： Damman R,Schütz S,Luo Y,Weingarth M,Sprangers R,Baldus M

更新日期：2019-10-04 00:00:00

abstract：:Various quantum applications can be reduced to estimating expectation values, which are inevitably deviated by operational and environmental errors. Although errors can be tackled by quantum error correction, the overheads are far from being affordable for near-term technologies. To alleviate the detrimental effects o...

journal_title：Nature communications

authors： Zhang S,Lu Y,Zhang K,Chen W,Li Y,Zhang JN,Kim K

更新日期：2020-01-30 00:00:00

abstract：:Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, e...

journal_title：Nature communications

authors： Zhang Y,Fu L,Qi X,Zhang Z,Xia Y,Jia J,Jiang J,Zhao Y,Wu G

更新日期：2013-01-01 00:00:00

abstract：:High-speed light emitters integrated on silicon chips can enable novel architectures for silicon-based optoelectronics, such as on-chip optical interconnects, and silicon photonics. However, conventional light sources based on compound semiconductors face major challenges for their integration with a silicon-based pla...

journal_title：Nature communications

authors： Miyoshi Y,Fukazawa Y,Amasaka Y,Reckmann R,Yokoi T,Ishida K,Kawahara K,Ago H,Maki H

更新日期：2018-03-29 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Lee CH,Kang TH,Godon O,Watanabe M,Delidakis G,Gillis CM,Sterlin D,Hardy D,Cogné M,Macdonald LE,Murphy AJ,Tu N,Lee J,McDaniel JR,Makowski E,Tessier PM,Meyer AS,Bruhns P,Georgiou G

更新日期：2019-11-26 00:00:00

abstract：:Epistasis emerges when the effects of an amino acid depend on the identities of interacting residues. This phenomenon shapes fitness landscapes, which have the power to reveal evolutionary paths and inform evolution of desired functions. However, there is a need for easily implemented, high-throughput methods to captu...

journal_title：Nature communications

authors： Yoo JI,Daugherty PS,O'Malley MA

更新日期：2020-02-04 00:00:00

abstract：:Diet is commonly assumed to affect the evolution of species, but few studies have directly tested its effect at macroevolutionary scales. Here we use Bayesian models of trait-dependent diversification and a comprehensive dietary database of all birds worldwide to assess speciation and extinction dynamics of avian diet...

journal_title：Nature communications

authors： Burin G,Kissling WD,Guimarães PR Jr,Şekercioğlu ÇH,Quental TB

更新日期：2016-04-07 00:00:00

abstract：:In bulk superfluid 3He at zero magnetic field, two phases emerge with the B-phase stable everywhere except at high pressures and temperatures, where the A-phase is favoured. Aerogels with nanostructure smaller than the superfluid coherence length are the only means to introduce disorder into the superfluid. Here we us...

journal_title：Nature communications

authors： Zhelev N,Reichl M,Abhilash TS,Smith EN,Nguyen KX,Mueller EJ,Parpia JM

更新日期：2016-09-27 00:00:00

abstract：:Amazonian Dark Earths (ADEs) are unusually fertile soils characterised by elevated concentrations of microscopic charcoal particles, which confer their distinctive colouration. Frequent occurrences of pre-Columbian artefacts at ADE sites led to their ubiquitous classification as Anthrosols (soils of anthropic origin)....

journal_title：Nature communications

authors： Silva LCR,Corrêa RS,Wright JL,Bomfim B,Hendricks L,Gavin DG,Muniz AW,Martins GC,Motta ACV,Barbosa JZ,Melo VF,Young SD,Broadley MR,Santos RV

更新日期：2021-01-04 00:00:00

abstract：:Amongst the rare-earth perovskite nickelates, LaNiO3 (LNO) is an exception. While the former have insulating and antiferromagnetic ground states, LNO remains metallic and non-magnetic down to the lowest temperatures. It is believed that LNO is a strange metal, on the verge of an antiferromagnetic instability. Our work...

journal_title：Nature communications

authors： Liu C,Humbert VFC,Bretz-Sullivan TM,Wang G,Hong D,Wrobel F,Zhang J,Hoffman JD,Pearson JE,Jiang JS,Chang C,Suslov A,Mason N,Norman MR,Bhattacharya A

更新日期：2020-03-16 00:00:00

abstract：:Urban residential buildings make large contributions to energy consumption. Energy consumption per square meter is most widely used to measure energy efficiency in urban residential buildings. This study aims to explore whether it is an appropriate indicator. An extended STIRPAT model was used based on the survey data...

journal_title：Nature communications

authors： Gao J,Zhong X,Cai W,Ren H,Huo T,Wang X,Mi Z

更新日期：2019-10-30 00:00:00

abstract：:A recent review concluded that earthworm presence increases CO₂ emissions by 33% but does not affect soil organic carbon stocks. However, the findings are controversial and raise new questions. Here we hypothesize that neither an increase in CO₂ emission nor in stabilized carbon would entirely reflect the earthworms' ...

journal_title：Nature communications

authors： Zhang W,Hendrix PF,Dame LE,Burke RA,Wu J,Neher DA,Li J,Shao Y,Fu S

更新日期：2013-01-01 00:00:00

abstract：:Circulating tumor cells (CTCs) have become an established biomarker for prognosis in patients with various carcinomas. However, current ex vivo CTC isolation technologies rely on small blood volumes from a single venipuncture limiting the number of captured CTCs. This produces statistical variability and inaccurate re...

journal_title：Nature communications

authors： Kim TH,Wang Y,Oliver CR,Thamm DH,Cooling L,Paoletti C,Smith KJ,Nagrath S,Hayes DF

更新日期：2019-04-01 00:00:00

abstract：:The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how...

journal_title：Nature communications

authors： Liu M,Lu Y,Yang B,Chen Y,Radda JSD,Hu M,Katz SG,Wang S

更新日期：2020-06-09 00:00:00

abstract：:The mobility of drops on surfaces is important in many biological and industrial processes, but the phenomena governing their adhesion, which is dictated by the morphology of the three-phase contact line, remain unclear. Here we describe a technique for measuring the dynamic behaviour of the three-phase contact line a...

journal_title：Nature communications

authors： Paxson AT,Varanasi KK

更新日期：2013-01-01 00:00:00

abstract：:CRISPR-Cas immunity is at the forefront of antivirus defense in bacteria and archaea and specifically targets viruses carrying protospacers matching the spacers catalogued in the CRISPR arrays. Here, we perform deep sequencing of the CRISPRome-all spacers contained in a microbiome-associated with hyperthermophilic arc...

journal_title：Nature communications

authors： Medvedeva S,Liu Y,Koonin EV,Severinov K,Prangishvili D,Krupovic M

更新日期：2019-11-15 00:00:00

abstract：:The alloy-design strategy of combining multiple elements in near-equimolar ratios has shown great potential for producing exceptional engineering materials, often known as 'high-entropy alloys'. Understanding the elemental distribution, and, thus, the evolution of the configurational entropy during solidification, is ...

journal_title：Nature communications

authors： Santodonato LJ,Zhang Y,Feygenson M,Parish CM,Gao MC,Weber RJ,Neuefeind JC,Tang Z,Liaw PK

更新日期：2015-01-20 00:00:00

abstract：:The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show that basal myosin II oscill...

journal_title：Nature communications

authors： Qin X,Hannezo E,Mangeat T,Liu C,Majumder P,Liu J,Choesmel-Cadamuro V,McDonald JA,Liu Y,Yi B,Wang X

更新日期：2018-03-23 00:00:00

abstract：:5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whether 5S rRNA autonomy is critical for ribosome function and cell survi...

journal_title：Nature communications

authors： Huang S,Aleksashin NA,Loveland AB,Klepacki D,Reier K,Kefi A,Szal T,Remme J,Jaeger L,Vázquez-Laslop N,Korostelev AA,Mankin AS

更新日期：2020-06-09 00:00:00

abstract：:Epitaxy is widely employed to create highly oriented crystalline films. A less appreciated, but nonetheless powerful means of creating such films is via topotactic transformation, in which a chemical reaction transforms a single crystal of one phase into a single crystal of a different phase, which inherits its orient...

journal_title：Nature communications

authors： Mairoser T,Mundy JA,Melville A,Hodash D,Cueva P,Held R,Glavic A,Schubert J,Muller DA,Schlom DG,Schmehl A

更新日期：2015-07-16 00:00:00