Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.

abstract：:Remarkable breakthroughs have established the functionality of graphene and carbon nanotube transistors as replacements to silicon in conventional computing structures, and numerous spintronic logic gates have been presented. However, an efficient cascaded logic structure that exploits electron spin has not yet been d...

journal_title：Nature communications

authors： Friedman JS,Girdhar A,Gelfand RM,Memik G,Mohseni H,Taflove A,Wessels BW,Leburton JP,Sahakian AV

更新日期：2017-06-05 00:00:00

abstract：:In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additi...

journal_title：Nature communications

authors： Piedrafita G,Kostiou V,Wabik A,Colom B,Fernandez-Antoran D,Herms A,Murai K,Hall BA,Jones PH

更新日期：2020-03-18 00:00:00

abstract：:Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of agricultural and medicinal importance, have now been discovered in plant genomes. However, little is known about how these complex traits are assembled and diversified. Here, we examine a large number of variants within and between spec...

journal_title：Nature communications

authors： Liu Z,Cheema J,Vigouroux M,Hill L,Reed J,Paajanen P,Yant L,Osbourn A

更新日期：2020-10-23 00:00:00

abstract：:Ions are ubiquitous biological regulators playing a key role for vital processes in animals and plants. The combined detection of ion concentration and real-time monitoring of small variations with respect to the resting conditions is a multiscale functionality providing important information on health states. This mu...

journal_title：Nature communications

authors： Romele P,Gkoupidenis P,Koutsouras DA,Lieberth K,Kovács-Vajna ZM,Blom PWM,Torricelli F

更新日期：2020-07-27 00:00:00

abstract：:Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to the invading protozoan Entamoeba histolytica. Classical monocytes as well as testosterone are identified to have important functions for the development of hepatic amebiasis in mice, but a link between testosterone and monocy...

journal_title：Nature communications

authors： Sellau J,Groneberg M,Fehling H,Thye T,Hoenow S,Marggraff C,Weskamm M,Hansen C,Stanelle-Bertram S,Kuehl S,Noll J,Wolf V,Metwally NG,Hagen SH,Dorn C,Wernecke J,Ittrich H,Tannich E,Jacobs T,Bruchhaus I,Altfeld M,Lo

更新日期：2020-07-10 00:00:00

abstract：:It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (SK) channels enable ...

journal_title：Nature communications

authors： Huang CG,Zhang ZD,Chacron MJ

更新日期：2016-04-18 00:00:00

abstract：:Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. Mechanistically, DILA1 inhibits the pho...

journal_title：Nature communications

authors： Shi Q,Li Y,Li S,Jin L,Lai H,Wu Y,Cai Z,Zhu M,Li Q,Li Y,Wang J,Liu Y,Wu Z,Song E,Liu Q

更新日期：2020-11-02 00:00:00

abstract：:Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by "translation bottlenecks": points in the translation cycle where antibiotics block ribosomal progression. To elucidate the underlying mechanisms of drug interactions bet...

journal_title：Nature communications

authors： Kavčič B,Tkačik G,Bollenbach T

更新日期：2020-08-11 00:00:00

abstract：:The spatial scaling of stability is key to understanding ecological sustainability across scales and the sensitivity of ecosystems to habitat destruction. Here we propose the invariability-area relationship (IAR) as a novel approach to investigate the spatial scaling of stability. The shape and slope of IAR are largel...

journal_title：Nature communications

authors： Wang S,Loreau M,Arnoldi JF,Fang J,Rahman KA,Tao S,de Mazancourt C

更新日期：2017-05-19 00:00:00

abstract：:Synthetic genetic circuits allow us to modify the behavior of living cells. However, changes in environmental conditions and unforeseen interactions with the host cell can cause deviations from a desired function, resulting in the need for time-consuming reassembly to fix these issues. Here, we use a regulatory motif ...

journal_title：Nature communications

authors： Bartoli V,Meaker GA,di Bernardo M,Gorochowski TE

更新日期：2020-04-29 00:00:00

abstract：:Highly regio- and enantioselective intermolecular hydroamination of alkenes is a challenging process potentially leading to valuable chiral amines. Hydroamination of alkenes via metal-catalyzed hydrogen atom transfer (HAT) with good regioselectivity and functional group tolerance has been reported, however, high enant...

journal_title：Nature communications

authors： Shen X,Chen X,Chen J,Sun Y,Cheng Z,Lu Z

更新日期：2020-02-07 00:00:00

abstract：:The hydrodesulfurization process is one of the cornerstones of the chemical industry, removing harmful sulfur from oil to produce clean hydrocarbons. The reaction is catalyzed by the edges of MoS2 nanoislands and is operated in hydrogen-oil mixtures at 5-160 bar and 260-380 °C. Until now, it has remained unclear how t...

journal_title：Nature communications

authors： Mom RV,Louwen JN,Frenken JWM,Groot IMN

更新日期：2019-06-11 00:00:00

abstract：:Aging is characterized by a chronic, low-grade inflammation, which is a major risk factor for cardiovascular diseases. It remains poorly understood whether pro-inflammatory factors released from non-cardiac tissues contribute to the non-autonomous regulation of age-related cardiac dysfunction. Here, we report that age...

journal_title：Nature communications

authors： Huang K,Miao T,Chang K,Kim J,Kang P,Jiang Q,Simmonds AJ,Di Cara F,Bai H

更新日期：2020-06-10 00:00:00

abstract：:Machines that simultaneously process and store multistate data at one and the same location can provide a new class of fast, powerful and efficient general-purpose computers. We demonstrate the central element of an all-optical calculator, a photonic abacus, which provides multistate compute-and-store operation by int...

journal_title：Nature communications

authors： Feldmann J,Stegmaier M,Gruhler N,Ríos C,Bhaskaran H,Wright CD,Pernice WHP

更新日期：2017-11-02 00:00:00

abstract：:The Barbier reaction, a widely utilized reaction for carbon-carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an...

journal_title：Nature communications

authors： Sun XL,Liu DM,Tian D,Zhang XY,Wu W,Wan WM

更新日期：2017-10-31 00:00:00

abstract：:Hydroarylation is an environmentally attractive strategy which incorporates all of the atoms contained in the substrates into the desired products. Almost all the hydroarylations of norbornene reported to date involve an exo-selective reaction. Here we show the endo-selective hydroarylation of norbornene in the Rh(I)-...

journal_title：Nature communications

authors： Shibata K,Natsui S,Tobisu M,Fukumoto Y,Chatani N

更新日期：2017-11-13 00:00:00

abstract：:The nitrogen-vacancy (NV) centre in diamond is emerging as a promising platform for solid-state quantum information processing and nanoscale metrology. Of interest in these applications is the manipulation of the NV charge, which can be attained by optical excitation. Here, we use two-colour optical microscopy to inve...

journal_title：Nature communications

authors： Jayakumar H,Henshaw J,Dhomkar S,Pagliero D,Laraoui A,Manson NB,Albu R,Doherty MW,Meriles CA

更新日期：2016-08-30 00:00:00

abstract：:Chromatin remodeling is of crucial importance during brain development. Pathogenic alterations of several chromatin remodeling ATPases have been implicated in neurodevelopmental disorders. We describe an index case with a de novo missense mutation in CHD3, identified during whole genome sequencing of a cohort of child...

journal_title：Nature communications

authors： Snijders Blok L,Rousseau J,Twist J,Ehresmann S,Takaku M,Venselaar H,Rodan LH,Nowak CB,Douglas J,Swoboda KJ,Steeves MA,Sahai I,Stumpel CTRM,Stegmann APA,Wheeler P,Willing M,Fiala E,Kochhar A,Gibson WT,Cohen ASA,Agb

更新日期：2018-11-05 00:00:00

abstract：:Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and obs...

journal_title：Nature communications

authors： Fernandez-Cuesta L,Peifer M,Lu X,Sun R,Ozretić L,Seidal D,Zander T,Leenders F,George J,Müller C,Dahmen I,Pinther B,Bosco G,Konrad K,Altmüller J,Nürnberg P,Achter V,Lang U,Schneider PM,Bogus M,Soltermann A,Brustu

更新日期：2014-03-27 00:00:00

abstract：:Electric eels (Electrophorus electricus) are legendary for their ability to incapacitate fish, humans, and horses with hundreds of volts of electricity. The function of this output as a weapon has been obvious for centuries but its potential role for electroreception has been overlooked. Here it is shown that electric...

journal_title：Nature communications

authors： Catania KC

更新日期：2015-10-20 00:00:00

abstract：:Fear conditioning is a form of associative learning that is known to involve different brain areas, notably the amygdala, the prefrontal cortex and the periaqueductal grey (PAG). Here, we describe the functional role of pathways that link the cerebellum with the fear network. We found that the cerebellar fastigial nuc...

journal_title：Nature communications

authors： Frontera JL,Baba Aissa H,Sala RW,Mailhes-Hamon C,Georgescu IA,Léna C,Popa D

更新日期：2020-10-15 00:00:00

abstract：:Obesity is a pandemic disease associated with many metabolic alterations and involves several organs and systems. The endocannabinoid system (ECS) appears to be a key regulator of energy homeostasis and metabolism. Here we show that specific deletion of the ECS synthesizing enzyme, NAPE-PLD, in adipocytes induces obes...

journal_title：Nature communications

authors： Geurts L,Everard A,Van Hul M,Essaghir A,Duparc T,Matamoros S,Plovier H,Castel J,Denis RG,Bergiers M,Druart C,Alhouayek M,Delzenne NM,Muccioli GG,Demoulin JB,Luquet S,Cani PD

更新日期：2015-03-11 00:00:00

abstract：:Quantum metrology bears a great promise in enhancing measurement precision, but is unlikely to become practical in the near future. Its concepts can nevertheless inspire classical or hybrid methods of immediate value. Here we demonstrate NOON-like photonic states of m quanta of angular momentum up to m=100, in a setup...

journal_title：Nature communications

authors： D'Ambrosio V,Spagnolo N,Del Re L,Slussarenko S,Li Y,Kwek LC,Marrucci L,Walborn SP,Aolita L,Sciarrino F

更新日期：2013-01-01 00:00:00

abstract：:The friction between two adjacent tectonic plates under shear loading may dictate seismic activities. To advance the understanding of mechanisms underlying fault strength, we investigate the frictional characteristics of calcite in an aqueous environment. By conducting single-asperity friction experiments using an ato...

journal_title：Nature communications

authors： Diao Y,Espinosa-Marzal RM

更新日期：2018-06-13 00:00:00

abstract：:Potassium ion channels utilize a highly selective filter to rapidly transport K+ ions across cellular membranes. This selectivity filter is composed of four binding sites which display almost equal electron density in crystal structures with high potassium ion concentrations. This electron density can be interpreted t...

journal_title：Nature communications

authors： Langan PS,Vandavasi VG,Weiss KL,Afonine PV,El Omari K,Duman R,Wagner A,Coates L

更新日期：2018-10-31 00:00:00

abstract：:Amongst the many spectacular properties of hybrid lead halide perovskites, their defect tolerance is regarded as the key enabler for a spectrum of high-performance optoelectronic devices that propel perovskites to prominence. However, the plateauing efficiency enhancement of perovskite devices calls into question the ...

journal_title：Nature communications

authors： Righetto M,Lim SS,Giovanni D,Lim JWM,Zhang Q,Ramesh S,Tay YKE,Sum TC

更新日期：2020-06-01 00:00:00

abstract：:Malaria reduces host fitness and survival by pathogen-mediated damage and inflammation. Disease tolerance mechanisms counter these negative effects without decreasing pathogen load. Here, we demonstrate that in four different mouse models of malaria, adrenal hormones confer disease tolerance and protect against early ...

journal_title：Nature communications

authors： Vandermosten L,Pham TT,Knoops S,De Geest C,Lays N,Van der Molen K,Kenyon CJ,Verma M,Chapman KE,Schuit F,De Bosscher K,Opdenakker G,Van den Steen PE

更新日期：2018-10-30 00:00:00

abstract：:Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate cancer. Here we report that metabolomic profiling of longitudinal plasmas from a prospective cohort of 491 active surveillance (AS) participants indicates prominent elevations in plasma sphingolipids in AS progressors that, together wi...

journal_title：Nature communications

authors： Vykoukal J,Fahrmann JF,Gregg JR,Tang Z,Basourakos S,Irajizad E,Park S,Yang G,Creighton CJ,Fleury A,Mayo J,Paulucci-Holthauzen A,Dennison JB,Murage E,Peterson CB,Davis JW,Kim J,Hanash S,Thompson TC

更新日期：2020-08-27 00:00:00

abstract：:Although multiphoton-pumped lasing from a solution of chromophores is important in the emerging fields of nonlinear optofluidics and bio-photonics, conventionally used organic dyes are often rendered unsuitable because of relatively small multiphoton absorption cross-sections and low photostability. Here, we demonstra...

journal_title：Nature communications

authors： Li M,Zhi M,Zhu H,Wu WY,Xu QH,Jhon MH,Chan Y

更新日期：2015-09-30 00:00:00

abstract：:Because maintenance of non-scalable cellular components--membranes and chromosomes--requires an increasing fraction of energy as cell size decreases, miniaturization comes at a considerable energetic cost for a phytoplanktonic cell. Consequently, if eukaryotes can use their superior energetic resources to acquire nutr...

journal_title：Nature communications

authors： Zubkov MV

更新日期：2014-04-29 00:00:00