Ligand-promoted cobalt-catalyzed radical hydroamination of alkenes.

abstract：:The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effect...

journal_title：Nature communications

authors： Kim JH,Matsubara T,Lee J,Fenollar-Ferrer C,Han K,Kim D,Jia S,Chang CJ,Yang H,Nagano T,Krausz KW,Yim SH,Gonzalez FJ

更新日期：2021-01-12 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms14013. ...

journal_title：Nature communications

authors： Kang YJ,Balter B,Csizmadia E,Haas B,Sharma H,Bronson R,Yan CT

更新日期：2017-08-14 00:00:00

abstract：:In cancer metastasis, various environmental stressors attack the disseminating cells. The successful colonization of cancer cells in secondary sites therefore requires the ability of the cells to avoid the consequences of such exposure to the stressors. Here we show that orthotopic transplantation of a CD44 variant is...

journal_title：Nature communications

authors： Yae T,Tsuchihashi K,Ishimoto T,Motohara T,Yoshikawa M,Yoshida GJ,Wada T,Masuko T,Mogushi K,Tanaka H,Osawa T,Kanki Y,Minami T,Aburatani H,Ohmura M,Kubo A,Suematsu M,Takahashi K,Saya H,Nagano O

更新日期：2012-06-06 00:00:00

abstract：:In nature, electrical signalling occurs with ions and protons, rather than electrons. Artificial devices that can control and monitor ionic and protonic currents are thus an ideal means for interfacing with biological systems. Here we report the first demonstration of a biopolymer protonic field-effect transistor with...

journal_title：Nature communications

authors： Zhong C,Deng Y,Roudsari AF,Kapetanovic A,Anantram MP,Rolandi M

更新日期：2011-09-20 00:00:00

abstract：:The biological pump transports organic carbon produced by photosynthesis to the meso- and bathypelagic zones, the latter removing carbon from exchanging with the atmosphere over centennial time scales. Organisms living in both zones are supported by a passive flux of particles, and carbon transported to the deep-sea t...

journal_title：Nature communications

authors： Hernández-León S,Koppelmann R,Fraile-Nuez E,Bode A,Mompeán C,Irigoien X,Olivar MP,Echevarría F,Fernández de Puelles ML,González-Gordillo JI,Cózar A,Acuña JL,Agustí S,Duarte CM

更新日期：2020-11-27 00:00:00

abstract：:Mitochondria and peroxisomes proliferate by division. During division, a part of their membrane is pinched off by constriction of the ring-shaped mitochondrial division (MD) and peroxisome-dividing (POD) machinery. This constriction is mediated by a dynamin-like GTPase Dnm1 that requires a large amount of GTP as an en...

journal_title：Nature communications

authors： Imoto Y,Abe Y,Honsho M,Okumoto K,Ohnuma M,Kuroiwa H,Kuroiwa T,Fujiki Y

更新日期：2018-11-06 00:00:00

abstract：:Synthetic polymers are indispensable in many different applications, but there is a growing need for green processes and natural surfactants for emulsion polymerization. The use of solid particles to stabilize Pickering emulsions is a particularly attractive avenue, but oxygen sensitivity has remained a formidable cha...

journal_title：Nature communications

authors： Moreno A,Sipponen MH

更新日期：2020-11-05 00:00:00

abstract：:Xylanolytic enzymes from glycoside hydrolase family 43 (GH43) are involved in the breakdown of hemicellulose, the second most abundant carbohydrate in plants. Here, we kinetically and mechanistically describe the non-reducing-end xylose-releasing exo-oligoxylanase activity and report the crystal structure of a native ...

journal_title：Nature communications

authors： Morais MAB,Coines J,Domingues MN,Pirolla RAS,Tonoli CCC,Santos CR,Correa JBL,Gozzo FC,Rovira C,Murakami MT

更新日期：2021-01-14 00:00:00

abstract：:Socioeconomic challenges continue to mount for half a billion residents of central India because of a decline in the total rainfall and a concurrent rise in the magnitude and frequency of extreme rainfall events. Alongside a weakening monsoon circulation, the locally available moisture and the frequency of moisture-la...

journal_title：Nature communications

authors： Roxy MK,Ghosh S,Pathak A,Athulya R,Mujumdar M,Murtugudde R,Terray P,Rajeevan M

更新日期：2017-10-03 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this transformation occurs are still unclear. Here, hyperpolyploidization of ...

journal_title：Nature communications

authors： Lin H,Huang YS,Fustin JM,Doi M,Chen H,Lai HH,Lin SH,Lee YL,King PC,Hou HS,Chen HW,Young PY,Chao HW

更新日期：2021-01-28 00:00:00

abstract：:Magnetic reconnection (MR) is a fundamental plasma process associated with conversion of the magnetic field energy into kinetic plasma energy, which is invoked to explain many non-thermal signatures in astrophysical events. Here we demonstrate that ultrafast relativistic MR in a magnetically dominated regime can be tr...

journal_title：Nature communications

authors： Yi L,Shen B,Pukhov A,Fülöp T

更新日期：2018-04-23 00:00:00

abstract：:Inactivation is an intrinsic property of several voltage-dependent ion channels, closing the conduction pathway during membrane depolarization and dynamically regulating neuronal activity. BK K(+) channels undergo N-type inactivation via their β2 subunit, but the physiological significance is not clear. Here, we repor...

journal_title：Nature communications

authors： Whitt JP,Montgomery JR,Meredith AL

更新日期：2016-03-04 00:00:00

abstract：:The c-Jun/AP-1 transcription factor controls key cellular behaviours, including proliferation and apoptosis, in response to JNK and Ras/MAPK signalling. While the JNK pathway has been well characterized, the mechanism of activation by Ras was elusive. Here we identify the uncharacterized ubiquitin ligase Trim7 as a cr...

journal_title：Nature communications

authors： Chakraborty A,Diefenbacher ME,Mylona A,Kassel O,Behrens A

更新日期：2015-04-08 00:00:00

abstract：:The ability to modulate light at high speeds is of paramount importance for telecommunications, information processing and medical imaging technologies. This has stimulated intense efforts to master optoelectronic switching at visible and near-infrared frequencies, although coping with current computer speeds in integ...

journal_title：Nature communications

authors： Manjavacas A,García de Abajo FJ

更新日期：2014-03-27 00:00:00

abstract：:Tyrosine sulfation, a well-characterized post-translation modification in eukaryotes, has not previously been reported in prokaryotes. Here, we demonstrate that the RaxST protein from the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae, is a tyrosine sulfotransferase. We used a newly developed sulfotransferase ...

journal_title：Nature communications

authors： Han SW,Lee SW,Bahar O,Schwessinger B,Robinson MR,Shaw JB,Madsen JA,Brodbelt JS,Ronald PC

更新日期：2012-01-01 00:00:00

abstract：:Non-line-of-sight (NLOS) imaging recovers objects using diffusely reflected indirect light using transient illumination devices in combination with a computational inverse method. While capture systems capable of collecting light from the entire NLOS relay surface can be much more light efficient than single pixel poi...

journal_title：Nature communications

authors： Liu X,Bauer S,Velten A

更新日期：2020-04-02 00:00:00

abstract：:Thin films of several microns in thickness are ubiquitously used in packaging, electronics, and acoustic sensors. Here we demonstrate that natural wood can be directly converted into an ultrathin film with a record-small thickness of less than 10 μm through partial delignification followed by densification. Benefiting...

journal_title：Nature communications

authors： Gan W,Chen C,Kim HT,Lin Z,Dai J,Dong Z,Zhou Z,Ping W,He S,Xiao S,Yu M,Hu L

更新日期：2019-11-08 00:00:00

abstract：:Many heritable mutualisms, in which beneficial symbionts are transmitted vertically between host generations, originate as antagonisms with parasite dispersal constrained by the host. Only after the parasite gains control over its transmission is the symbiosis expected to transition from antagonism to mutualism. Here,...

journal_title：Nature communications

authors： Mondo SJ,Lastovetsky OA,Gaspar ML,Schwardt NH,Barber CC,Riley R,Sun H,Grigoriev IV,Pawlowska TE

更新日期：2017-11-29 00:00:00

abstract：:Bystander activation of memory T cells occurs in the absence of cognate antigen during infections that elicit strong systemic inflammatory responses, which subsequently affect host immune responses. Here we report that memory T cell bystander activation is not limited to induction by systemic inflammation. We initiall...

journal_title：Nature communications

authors： Maurice NJ,McElrath MJ,Andersen-Nissen E,Frahm N,Prlic M

更新日期：2019-11-01 00:00:00

abstract：:The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that violate the weak equivalence principle. Here we report on a successful ...

journal_title：Nature communications

authors： Aghion S,Ahlén O,Amsler C,Ariga A,Ariga T,Belov AS,Berggren K,Bonomi G,Bräunig P,Bremer J,Brusa RS,Cabaret L,Canali C,Caravita R,Castelli F,Cerchiari G,Cialdi S,Comparat D,Consolati G,Derking H,Di Domizio S,Di N

更新日期：2014-07-28 00:00:00

abstract：:Accumulation of mutant p53 proteins is frequently found in a wide range of cancers. While conventional antibodies fail to target intracellular proteins, proteosomal degradation results in the presentation of p53-derived peptides on the tumour cell surface by class I molecules of the major histocompatibility complex (M...

journal_title：Nature communications

authors： Low L,Goh A,Koh J,Lim S,Wang CI

更新日期：2019-11-26 00:00:00

abstract：:Disordered proteins, such as those central to Alzheimer's and Parkinson's, are particularly intractable for structure-targeted therapeutic design. Here we demonstrate the capacity of a synthetic foldamer to capture structure in a disease relevant peptide. Oligoquinoline amides have a defined fold with a solvent-exclud...

journal_title：Nature communications

authors： Kumar S,Birol M,Schlamadinger DE,Wojcik SP,Rhoades E,Miranker AD

更新日期：2016-04-25 00:00:00

abstract：:Antibodies conjugated to bioactive compounds allow targeted delivery of therapeutics to cell types of choice based on that antibody's specificity. Here we develop a new type of conjugate that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR), fused via their C-termini. We address act...

journal_title：Nature communications

authors： Cheloha RW,Fischer FA,Woodham AW,Daley E,Suminski N,Gardella TJ,Ploegh HL

更新日期：2020-04-29 00:00:00

abstract：:Natural killer (NK) cells are reported to have immunological memory, with CD49a+ liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, are generated in the l...

journal_title：Nature communications

authors： Wang X,Peng H,Cong J,Wang X,Lian Z,Wei H,Sun R,Tian Z

更新日期：2018-11-19 00:00:00

abstract：:A metal-organic hybrid perovskite (CH3NH3PbI3) with three-dimensional framework of metal-halide octahedra has been reported as a low-cost, solution-processable absorber for a thin-film solar cell with a power-conversion efficiency over 20%. Low-dimensional layered perovskites with metal halide slabs separated by the i...

journal_title：Nature communications

authors： Ni C,Hedley G,Payne J,Svrcek V,McDonald C,Jagadamma LK,Edwards P,Martin R,Jain G,Carolan D,Mariotti D,Maguire P,Samuel I,Irvine J

更新日期：2017-08-01 00:00:00

abstract：:The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitativ...

journal_title：Nature communications

authors： Pérez-Medina C,Abdel-Atti D,Tang J,Zhao Y,Fayad ZA,Lewis JS,Mulder WJM,Reiner T

更新日期：2016-06-20 00:00:00

abstract：:We have determined the cryo-electron microscopic (cryo-EM) structures of two archaeal type IV pili (T4P), from Pyrobaculum arsenaticum and Saccharolobus solfataricus, at 3.8 Å and 3.4 Å resolution, respectively. This triples the number of high resolution archaeal T4P structures, and allows us to pinpoint the evolution...

journal_title：Nature communications

authors： Wang F,Baquero DP,Su Z,Beltran LC,Prangishvili D,Krupovic M,Egelman EH

更新日期：2020-07-09 00:00:00

abstract：:Many biological processes involve large-scale changes in membrane shape. Computer simulations of these processes are challenging since they occur across a wide range of spatiotemporal scales that cannot be investigated in full by any single current simulation technique. A potential solution is to combine different lev...

journal_title：Nature communications

authors： Pezeshkian W,König M,Wassenaar TA,Marrink SJ

更新日期：2020-05-08 00:00:00

abstract：:Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is ...

journal_title：Nature communications

authors： Lin SH,Cheng YR,Banks RW,Min MY,Bewick GS,Chen CC

更新日期：2016-05-10 00:00:00

abstract：:Urban residential buildings make large contributions to energy consumption. Energy consumption per square meter is most widely used to measure energy efficiency in urban residential buildings. This study aims to explore whether it is an appropriate indicator. An extended STIRPAT model was used based on the survey data...

journal_title：Nature communications

authors： Gao J,Zhong X,Cai W,Ren H,Huo T,Wang X,Mi Z

更新日期：2019-10-30 00:00:00