Tunable genetic devices through simultaneous control of transcription and translation.

abstract：:Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other organs leading to smaller accumulated amounts in tumor tissu...

journal_title：Nature communications

authors： Chen F,Ma K,Madajewski B,Zhuang L,Zhang L,Rickert K,Marelli M,Yoo B,Turker MZ,Overholtzer M,Quinn TP,Gonen M,Zanzonico P,Tuesca A,Bowen MA,Norton L,Subramony JA,Wiesner U,Bradbury MS

更新日期：2018-10-08 00:00:00

abstract：:Pladienolide, herboxidiene and spliceostatin have been identified as splicing modulators that target SF3B1 in the SF3b subcomplex. Here we report that PHF5A, another component of this subcomplex, is also targeted by these compounds. Mutations in PHF5A-Y36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 confer resistance to ...

journal_title：Nature communications

authors： Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ

更新日期：2017-05-25 00:00:00

abstract：:Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear receptor RORγ, compared to estrogen receptor-positive breast cancer. G...

journal_title：Nature communications

authors： Cai D,Wang J,Gao B,Li J,Wu F,Zou JX,Xu J,Jiang Y,Zou H,Huang Z,Borowsky AD,Bold RJ,Lara PN,Li JJ,Chen X,Lam KS,To KF,Kung HJ,Fiehn O,Zhao R,Evans RM,Chen HW

更新日期：2019-10-11 00:00:00

abstract：:Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion of group A or B cells into O cells has been ...

journal_title：Nature communications

authors： Kim YH,Kim HO,Baek EJ,Kurita R,Cha HJ,Nakamura Y,Kim H

更新日期：2015-06-16 00:00:00

abstract：:Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To explore the mechanism by which Ca(2+) blocks intercellular communication during tissue injury, we determined the X-ray crystal structures of...

journal_title：Nature communications

authors： Bennett BC,Purdy MD,Baker KA,Acharya C,McIntire WE,Stevens RC,Zhang Q,Harris AL,Abagyan R,Yeager M

更新日期：2016-01-12 00:00:00

abstract：:Gramicidin A (gA) is the simplest known natural channel, and important progress in improving conduction activity has previously been obtained with modified natural gAs. However, simple artificial systems mimicking the gA functions are unknown. Here we show that gA can be mimicked using a simple synthetic triazole or '...

journal_title：Nature communications

authors： Barboiu M,Le Duc Y,Gilles A,Cazade PA,Michau M,Marie Legrand Y,van der Lee A,Coasne B,Parvizi P,Post J,Fyles T

更新日期：2014-06-26 00:00:00

abstract：:Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further stud...

journal_title：Nature communications

authors： Chen HY,Wu CT,Tang CC,Lin YN,Wang WJ,Tang TK

更新日期：2017-08-15 00:00:00

abstract：:In order to control and eradicate epidemic cholera, we need to understand how epidemics begin, how they spread, and how they decline and eventually end. This requires extensive sampling of epidemic disease over time, alongside the background of endemic disease that may exist concurrently with the epidemic. The unique ...

journal_title：Nature communications

authors： Dorman MJ,Domman D,Poklepovich T,Tolley C,Zolezzi G,Kane L,Viñas MR,Panagópulo M,Moroni M,Binsztein N,Caffer MI,Clare S,Dougan G,Salmond GPC,Parkhill J,Campos J,Thomson NR

更新日期：2020-10-01 00:00:00

abstract：:Exfoliated two-dimensional (2D) sheets can readily stack to form flexible, free-standing films with lamellar microstructure. The interlayer spaces in such lamellar films form a percolated network of molecularly sized, 2D nanochannels that could be used to regulate molecular transport. Here we report self-assembled cla...

journal_title：Nature communications

authors： Shao JJ,Raidongia K,Koltonow AR,Huang J

更新日期：2015-07-13 00:00:00

abstract：:Autophagosomes are double-membrane vesicles that sequester cytoplasmic material for lysosomal degradation. Their biogenesis is initiated by recruitment of Atg9-vesicles to the phagophore assembly site. This process depends on the regulated activation of the Atg1-kinase complex. However, the underlying molecular mechan...

journal_title：Nature communications

authors： Rao Y,Perna MG,Hofmann B,Beier V,Wollert T

更新日期：2016-01-12 00:00:00

abstract：:Low-damping magnetic materials have been widely used in microwave and spintronic applications because of their low energy loss and high sensitivity. While the Gilbert damping constant can reach 10-4 to 10-5 in some insulating ferromagnets, metallic ferromagnets generally have larger damping due to magnon scattering by...

journal_title：Nature communications

authors： Lee AJ,Brangham JT,Cheng Y,White SP,Ruane WT,Esser BD,McComb DW,Hammel PC,Yang F

更新日期：2017-08-10 00:00:00

abstract：:Nonbiaryl N-C atropisomer is an important structural scaffold, which is present in natural products, medicines and chiral ligands. However the direct enantioselective C-H amination to access optically pure N-C atropisomer is still difficult and rare. Here we report a π-π interaction and dual H-bond concerted control s...

journal_title：Nature communications

authors： Bai HY,Tan FX,Liu TQ,Zhu GD,Tian JM,Ding TM,Chen ZM,Zhang SY

更新日期：2019-07-11 00:00:00

abstract：:The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be reversed have favoured development of epigenetic drugs. In this study, we design and synthesize potent novel, selective and reversible chemical probes that simultaneously inhibit the G9a and DNMTs methyltransferase activity....

journal_title：Nature communications

authors： San José-Enériz E,Agirre X,Rabal O,Vilas-Zornoza A,Sanchez-Arias JA,Miranda E,Ugarte A,Roa S,Paiva B,Estella-Hermoso de Mendoza A,Alvarez RM,Casares N,Segura V,Martín-Subero JI,Ogi FX,Soule P,Santiveri CM,Campos-Olivas

更新日期：2017-05-26 00:00:00

abstract：:Dimensionality reduction is often used to visualize complex expression profiling data. Here, we use the Uniform Manifold Approximation and Projection (UMAP) method on published transcript profiles of 1484 single gene deletions of Saccharomyces cerevisiae. Proximity in low-dimensional UMAP space identifies groups of ge...

journal_title：Nature communications

authors： Dorrity MW,Saunders LM,Queitsch C,Fields S,Trapnell C

更新日期：2020-03-24 00:00:00

abstract：:Heterostructured material systems devoid of ferroic components are presumed not to display ordering associated with ferroelectricity. In heterostructures composed of transition metal oxides, however, the disruption introduced by an interface can affect the balance of the competing interactions among electronic spins, ...

journal_title：Nature communications

authors： Rogdakis K,Seo JW,Viskadourakis Z,Wang Y,Qune LF,Choi E,Burton JD,Tsymbal EY,Lee J,Panagopoulos C

更新日期：2012-01-01 00:00:00

abstract：:SIRT1, the founding member of the mammalian family of seven NAD(+)-dependent sirtuins, is composed of 747 amino acids forming a catalytic domain and extended N- and C-terminal regions. We report the design and characterization of an engineered human SIRT1 construct (mini-hSIRT1) containing the minimal structural eleme...

journal_title：Nature communications

authors： Dai H,Case AW,Riera TV,Considine T,Lee JE,Hamuro Y,Zhao H,Jiang Y,Sweitzer SM,Pietrak B,Schwartz B,Blum CA,Disch JS,Caldwell R,Szczepankiewicz B,Oalmann C,Yee Ng P,White BH,Casaubon R,Narayan R,Koppetsch K,Bourb

更新日期：2015-07-02 00:00:00

abstract：:Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understandin...

journal_title：Nature communications

authors： Zhu Z,Zhang S,Liu H,Shen H,Lin X,Yang F,Zhou YJ,Jin G,Ye M,Zou H,Zhao ZK

更新日期：2012-01-01 00:00:00

abstract：:Bacterial infections and antibiotic resistance, particularly by Gram-negative pathogens, have become a global healthcare crisis. We report the design of a class of cationic antimicrobial polymers that cluster local facial amphiphilicity from repeating units to enhance interactions with bacterial membranes without requ...

journal_title：Nature communications

authors： Rahman MA,Bam M,Luat E,Jui MS,Ganewatta MS,Shokfai T,Nagarkatti M,Decho AW,Tang C

更新日期：2018-12-07 00:00:00

abstract：:How spatial and temporal information are integrated to determine the direction of cell migration remains poorly understood. Here, by precise microfluidics emulation of dynamic chemoattractant waves, we demonstrate that, in Dictyostelium, directional movement as well as activation of small guanosine triphosphatase Ras ...

journal_title：Nature communications

authors： Nakajima A,Ishihara S,Imoto D,Sawai S

更新日期：2014-11-06 00:00:00

abstract：:Generating a comprehensive map of molecular interactions in living cells is difficult and great efforts are undertaken to infer molecular interactions from large-scale perturbation experiments. Here, we develop the analytical and numerical tools to quantify the fundamental limits for inferring transcriptional networks...

journal_title：Nature communications

authors： Blum CF,Heramvand N,Khonsari AS,Kollmann M

更新日期：2018-01-09 00:00:00

abstract：:AMP-activated protein kinase (AMPK) plays a key role in controlling energy metabolism in response to physiological and nutritional status. Although AMPK activation has been proposed as a promising molecular target for treating obesity and its related comorbidities, the use of pharmacological AMPK activators has been m...

journal_title：Nature communications

authors： Lee MS,Han HJ,Han SY,Kim IY,Chae S,Lee CS,Kim SE,Yoon SG,Park JW,Kim JH,Shin S,Jeong M,Ko A,Lee HY,Oh KJ,Lee YH,Bae KH,Koo SH,Kim JW,Seong JK,Hwang D,Song J

更新日期：2018-08-24 00:00:00

abstract：:Quantum metrology bears a great promise in enhancing measurement precision, but is unlikely to become practical in the near future. Its concepts can nevertheless inspire classical or hybrid methods of immediate value. Here we demonstrate NOON-like photonic states of m quanta of angular momentum up to m=100, in a setup...

journal_title：Nature communications

authors： D'Ambrosio V,Spagnolo N,Del Re L,Slussarenko S,Li Y,Kwek LC,Marrucci L,Walborn SP,Aolita L,Sciarrino F

更新日期：2013-01-01 00:00:00

abstract：:Human Bestrophin1 (hBest1) is a Ca2+-activated Cl- channel in retinal pigment epithelium (RPE) essential for retina physiology, and its mutation results in retinal degenerative diseases that have no available treatments. Here, we discover that hBest1's channel activity in human RPE is significantly enhanced by adenosi...

journal_title：Nature communications

authors： Zhang Y,Kittredge A,Ward N,Ji C,Chen S,Yang T

更新日期：2018-08-07 00:00:00

abstract：:MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell p...

journal_title：Nature communications

authors： Alivernini S,Kurowska-Stolarska M,Tolusso B,Benvenuto R,Elmesmari A,Canestri S,Petricca L,Mangoni A,Fedele AL,Di Mario C,Gigante MR,Gremese E,McInnes IB,Ferraccioli G

更新日期：2016-09-27 00:00:00

abstract：:Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitu...

journal_title：Nature communications

authors： Hamant O,Inoue D,Bouchez D,Dumais J,Mjolsness E

更新日期：2019-05-29 00:00:00

abstract：:Biological cellular structures have inspired many scientific disciplines to design synthetic structures that can mimic their functions. Here, we closely emulate biological cellular structures in a rationally designed synthetic multicellular hybrid ion pump, composed of hydrogen-bonded [EMIM+][TFSI-] ion pairs on the s...

journal_title：Nature communications

authors： Amoli V,Kim JS,Jee E,Chung YS,Kim SY,Koo J,Choi H,Kim Y,Kim DH

更新日期：2019-09-05 00:00:00

abstract：:The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism and obesity in mammals. However, studies investigating the impact of the diet on the establishment of the gut microbiome early in life are generally lacking, and most notably so in primate models. Here we report that a high-fat mat...

journal_title：Nature communications

authors： Ma J,Prince AL,Bader D,Hu M,Ganu R,Baquero K,Blundell P,Alan Harris R,Frias AE,Grove KL,Aagaard KM

更新日期：2014-05-20 00:00:00

abstract：:Using asymmetric catalysis to simultaneously form carbon-carbon bonds and generate single isomer products is strategically important. Suzuki-Miyaura cross-coupling is widely used in the academic and industrial sectors to synthesize drugs, agrochemicals and biologically active and advanced materials. However, widely ap...

journal_title：Nature communications

authors： Schäfer P,Palacin T,Sidera M,Fletcher SP

更新日期：2017-06-13 00:00:00

abstract：:Enhancers are DNA sequences that enable complex temporal and tissue-specific regulation of genes in higher eukaryotes. Although it is not entirely clear how enhancer-promoter interactions can increase gene expression, this proximity has been observed in multiple systems at multiple loci and is thought to be essential ...

journal_title：Nature communications

authors： Crump NT,Ballabio E,Godfrey L,Thorne R,Repapi E,Kerry J,Tapia M,Hua P,Lagerholm C,Filippakopoulos P,Davies JOJ,Milne TA

更新日期：2021-01-11 00:00:00

abstract：:Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...

journal_title：Nature communications

authors： Sweeney JG,Liang J,Antonopoulos A,Giovannone N,Kang S,Mondala TS,Head SR,King SL,Tani Y,Brackett D,Dell A,Murphy GF,Haslam SM,Widlund HR,Dimitroff CJ

更新日期：2018-08-22 00:00:00