Rh D blood group conversion using transcription activator-like effector nucleases.

abstract：:Intentional doping is the core of semiconductor technologies to tune electrical and optical properties of semiconductors for electronic devices, however, it has shown to be a grand challenge for halide perovskites. Here, we show that some metal ions, such as silver, strontium, cerium ions, which exist in the precursor...

journal_title：Nature communications

authors： Lin Y,Shao Y,Dai J,Li T,Liu Y,Dai X,Xiao X,Deng Y,Gruverman A,Zeng XC,Huang J

更新日期：2021-01-04 00:00:00

abstract：:Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction of Piezo1 with the small molecule ago...

journal_title：Nature communications

authors： Lacroix JJ,Botello-Smith WM,Luo Y

更新日期：2018-05-23 00:00:00

abstract：:Inversions are one type of structural variants linked to phenotypic differences and adaptation in multiple organisms. However, there is still very little information about polymorphic inversions in the human genome due to the difficulty of their detection. Here, we develop a new high-throughput genotyping method based...

journal_title：Nature communications

authors： Giner-Delgado C,Villatoro S,Lerga-Jaso J,Gayà-Vidal M,Oliva M,Castellano D,Pantano L,Bitarello BD,Izquierdo D,Noguera I,Olalde I,Delprat A,Blancher A,Lalueza-Fox C,Esko T,O'Reilly PF,Andrés AM,Ferretti L,Puig M,Cáce

更新日期：2019-09-17 00:00:00

abstract：:Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role of GRP in sensory neurons, we generated a floxed Grp mouse line. We found that conditional knockout of Grp in sensory neurons ...

journal_title：Nature communications

authors： Barry DM,Liu XT,Liu B,Liu XY,Gao F,Zeng X,Liu J,Yang Q,Wilhelm S,Yin J,Tao A,Chen ZF

更新日期：2020-03-13 00:00:00

abstract：:Mantle plumes are thought to play a key role in transferring heat from the core-mantle boundary to the lithosphere, where it can significantly influence plate tectonics. On impinging on the lithosphere at spreading ridges or in intra-plate settings, mantle plumes may generate hotspots, large igneous provinces and henc...

journal_title：Nature communications

authors： Chang SJ,Ferreira AM,Faccenda M

更新日期：2016-02-29 00:00:00

abstract：:The Hippo pathway regulates the self-renewal and differentiation of various adult stem cells, but its role in cell fate determination and differentiation during liver development remains unclear. Here we report that the Hippo pathway controls liver cell lineage specification and proliferation separately from Notch sig...

journal_title：Nature communications

authors： Lee DH,Park JO,Kim TS,Kim SK,Kim TH,Kim MC,Park GS,Kim JH,Kuninaka S,Olson EN,Saya H,Kim SY,Lee H,Lim DS

更新日期：2016-06-30 00:00:00

abstract：:Transport of nanoscale energy in the form of excitons is at the core of photosynthesis and the operation of a wide range of nanostructured optoelectronic devices such as solar cells, light-emitting diodes and excitonic transistors. Of particular importance is the relationship between exciton transport and nanoscale di...

journal_title：Nature communications

authors： Akselrod GM,Deotare PB,Thompson NJ,Lee J,Tisdale WA,Baldo MA,Menon VM,Bulović V

更新日期：2014-04-16 00:00:00

abstract：:Defensins are cationic antimicrobial peptides expressed throughout the plant and animal kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is a crucial function of many defensins, however the precise mechanism remains unclear. Certain plant defensins form dimers that specifically ...

journal_title：Nature communications

authors： Järvå M,Lay FT,Phan TK,Humble C,Poon IKH,Bleackley MR,Anderson MA,Hulett MD,Kvansakul M

更新日期：2018-05-17 00:00:00

abstract：:The mammary gland experiences substantial remodeling and regeneration during development and reproductive life, facilitated by stem cells and progenitors that act in concert with physiological stimuli. While studies have focused on deciphering regenerative cells within the parenchymal epithelium, cell lineages in the ...

journal_title：Nature communications

authors： Joshi PA,Waterhouse PD,Kasaian K,Fang H,Gulyaeva O,Sul HS,Boutros PC,Khokha R

更新日期：2019-04-15 00:00:00

abstract：:A metal-organic hybrid perovskite (CH3NH3PbI3) with three-dimensional framework of metal-halide octahedra has been reported as a low-cost, solution-processable absorber for a thin-film solar cell with a power-conversion efficiency over 20%. Low-dimensional layered perovskites with metal halide slabs separated by the i...

journal_title：Nature communications

authors： Ni C,Hedley G,Payne J,Svrcek V,McDonald C,Jagadamma LK,Edwards P,Martin R,Jain G,Carolan D,Mariotti D,Maguire P,Samuel I,Irvine J

更新日期：2017-08-01 00:00:00

abstract：:There are concerns that pneumococcal conjugate vaccines (PCVs) in sub-Saharan Africa sub-optimally interrupt Streptococcus pneumoniae vaccine-serotype (VT) carriage and transmission. Here we assess PCV carriage using rolling, prospective nasopharyngeal carriage surveys between 2015 and 2018, 3.6-7.1 years after Malawi...

journal_title：Nature communications

authors： Swarthout TD,Fronterre C,Lourenço J,Obolski U,Gori A,Bar-Zeev N,Everett D,Kamng'ona AW,Mwalukomo TS,Mataya AA,Mwansambo C,Banda M,Gupta S,Diggle P,French N,Heyderman RS

更新日期：2020-05-06 00:00:00

abstract：:Many physical phenomena can be understood by single-particle physics; that is, treating particles as non-interacting entities. When this fails, many-body interactions lead to spontaneous symmetry breaking and phenomena such as fundamental particles' mass generation, superconductivity and magnetism. Competition between...

journal_title：Nature communications

authors： Lee Y,Tran D,Myhro K,Velasco J,Gillgren N,Lau CN,Barlas Y,Poumirol JM,Smirnov D,Guinea F

更新日期：2014-12-12 00:00:00

abstract：:Single-atom catalysts have recently been applied in many applications such as CO oxidation. Experimental in situ investigations into this reaction, however, are limited. Hereby, we present a suite of operando/in situ spectroscopic experiments for structurally well-defined atomically dispersed Rh on phosphotungstic aci...

journal_title：Nature communications

authors： Hülsey MJ,Zhang B,Ma Z,Asakura H,Do DA,Chen W,Tanaka T,Zhang P,Wu Z,Yan N

更新日期：2019-03-22 00:00:00

abstract：:Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we show that methylglyoxa...

journal_title：Nature communications

authors： Rodrigues DC,Harvey EM,Suraj R,Erickson SL,Mohammad L,Ren M,Liu H,He G,Kaplan DR,Ellis J,Yang G

更新日期：2020-04-24 00:00:00

abstract：:Nonreciprocal microwave devices are ubiquitous in radar and radio communication and indispensable in the readout chains of superconducting quantum circuits. Since they commonly rely on ferrite materials requiring large magnetic fields that make them bulky and lossy, there has been significant interest in magnetic-fiel...

journal_title：Nature communications

authors： Bernier NR,Tóth LD,Koottandavida A,Ioannou MA,Malz D,Nunnenkamp A,Feofanov AK,Kippenberg TJ

更新日期：2017-09-19 00:00:00

abstract：:Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of BRCA1 promoter hypermethylation in 237 triple-negative breast cancers (TNBCs) from a population-based study using rep...

journal_title：Nature communications

authors： Glodzik D,Bosch A,Hartman J,Aine M,Vallon-Christersson J,Reuterswärd C,Karlsson A,Mitra S,Niméus E,Holm K,Häkkinen J,Hegardt C,Saal LH,Larsson C,Malmberg M,Rydén L,Ehinger A,Loman N,Kvist A,Ehrencrona H,Nik-Zainal

更新日期：2020-07-27 00:00:00

abstract：:Even as the study of plant genomics rapidly develops through the use of high-throughput sequencing techniques, traditional plant phenotyping lags far behind. Here we develop a high-throughput rice phenotyping facility (HRPF) to monitor 13 traditional agronomic traits and 2 newly defined traits during the rice growth p...

journal_title：Nature communications

authors： Yang W,Guo Z,Huang C,Duan L,Chen G,Jiang N,Fang W,Feng H,Xie W,Lian X,Wang G,Luo Q,Zhang Q,Liu Q,Xiong L

更新日期：2014-10-08 00:00:00

abstract：:Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple cell types and organisms. Here,...

journal_title：Nature communications

authors： Ron G,Globerson Y,Moran D,Kaplan T

更新日期：2017-12-21 00:00:00

abstract：:Lysocin E, a 37-membered natural depsipeptide, induces rapid bacteriolysis in methicillin-resistant Staphylococcus aureus via a unique menaquinone-dependent mechanism, presenting a promising therapeutic lead. Despite the great medical importance, exploring the potential utility of its derivatives as new platform struc...

journal_title：Nature communications

authors： Itoh H,Tokumoto K,Kaji T,Paudel A,Panthee S,Hamamoto H,Sekimizu K,Inoue M

更新日期：2019-07-05 00:00:00

abstract：:Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule u...

journal_title：Nature communications

authors： Perunicic VS,Hill CD,Hall LT,Hollenberg LC

更新日期：2016-10-11 00:00:00

abstract：:Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We ...

journal_title：Nature communications

authors： Barbeira AN,Dickinson SP,Bonazzola R,Zheng J,Wheeler HE,Torres JM,Torstenson ES,Shah KP,Garcia T,Edwards TL,Stahl EA,Huckins LM,GTEx Consortium.,Nicolae DL,Cox NJ,Im HK

更新日期：2018-05-08 00:00:00

abstract：:Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...

journal_title：Nature communications

authors： Yao Z,Aboualizadeh F,Kroll J,Akula I,Snider J,Lyakisheva A,Tang P,Kotlyar M,Jurisica I,Boxem M,Stagljar I

更新日期：2020-05-15 00:00:00

abstract：:Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments. Here, we use single-molecule imaging in live cells to directly study the beh...

journal_title：Nature communications

authors： Jain S,Shukla S,Yang C,Zhang M,Fatma Z,Lingamaneni M,Abesteh S,Lane ST,Xiong X,Wang Y,Schroeder CM,Selvin PR,Zhao H

更新日期：2021-01-27 00:00:00

abstract：:Intestinal intraepithelial T cells contribute to the regulation of inflammatory responses in the intestine; however, the molecular basis for their development and maintenance is unknown. The aryl hydrocarbon receptor complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and senses environmental fact...

journal_title：Nature communications

authors： Nakajima K,Maekawa Y,Kataoka K,Ishifune C,Nishida J,Arimochi H,Kitamura A,Yoshimoto T,Tomita S,Nagahiro S,Yasutomo K

更新日期：2013-01-01 00:00:00

abstract：:Photoluminescence phenomena normally obey Stokes' law of luminescence according to which the emitted photon energy is typically lower than its excitation counterparts. Here we show that carbon nanotubes break this rule under one-photon excitation conditions. We found that the carbon nanotubes exhibit efficient near-in...

journal_title：Nature communications

authors： Akizuki N,Aota S,Mouri S,Matsuda K,Miyauchi Y

更新日期：2015-11-16 00:00:00

abstract：:Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%...

journal_title：Nature communications

authors： Garcia-Basteiro AL,Moncunill G,Tortajada M,Vidal M,Guinovart C,Jiménez A,Santano R,Sanz S,Méndez S,Llupià A,Aguilar R,Alonso S,Barrios D,Carolis C,Cisteró P,Chóliz E,Cruz A,Fochs S,Jairoce C,Hecht J,Lamoglia M,M

更新日期：2020-07-08 00:00:00

abstract：:The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...

journal_title：Nature communications

authors： Marissal T,Bonifazi P,Picardo MA,Nardou R,Petit LF,Baude A,Fishell GJ,Ben-Ari Y,Cossart R

更新日期：2012-01-01 00:00:00

abstract：:China has enacted a series of policies since 2015 to substitute electricity for in-home combustion for rural residential heating. The Electric Heating Policy (EHP) has contributed to significant improvements in air quality, benefiting hundreds of millions of people. This shift, however, has resulted in a sharp increas...

journal_title：Nature communications

authors： Wang J,Zhong H,Yang Z,Wang M,Kammen DM,Liu Z,Ma Z,Xia Q,Kang C

更新日期：2020-11-27 00:00:00

abstract：:HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man9-V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope...

journal_title：Nature communications

authors： Fera D,Lee MS,Wiehe K,Meyerhoff RR,Piai A,Bonsignori M,Aussedat B,Walkowicz WE,Ton T,Zhou JO,Danishefsky S,Haynes BF,Harrison SC

更新日期：2018-03-16 00:00:00

abstract：:Graphene is an ideal medium for long-distance spin communication in future spintronic technologies. So far, the prospect is limited by the smaller sizes of exfoliated graphene flakes and lower spin transport properties of large-area chemical vapour-deposited (CVD) graphene. Here we demonstrate a high spintronic perfor...

journal_title：Nature communications

authors： Kamalakar MV,Groenveld C,Dankert A,Dash SP

更新日期：2015-04-10 00:00:00