Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.

abstract：:Transcription initiation involves the coordinated activities of large multimeric complexes, but little is known about their biogenesis. Here we report several principles underlying the assembly and topological organization of the highly conserved SAGA and NuA4 co-activator complexes, which share the Tra1 subunit. We s...

journal_title：Nature communications

authors： Elías-Villalobos A,Toullec D,Faux C,Séveno M,Helmlinger D

更新日期：2019-11-20 00:00:00

abstract：:Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering gut microbiota like oral intake of probiotics or berberine (BBR), a bacteriostatic agent, merit metabolic homoeostasis. We hence conducted a randomized, double-blind, placebo-controlled trial with newly diagnosed T2D patie...

journal_title：Nature communications

authors： Zhang Y,Gu Y,Ren H,Wang S,Zhong H,Zhao X,Ma J,Gu X,Xue Y,Huang S,Yang J,Chen L,Chen G,Qu S,Liang J,Qin L,Huang Q,Peng Y,Li Q,Wang X,Kong P,Hou G,Gao M,Shi Z,Li X,Qiu Y,Zou Y,Yang H,Wang J,Xu G,

更新日期：2020-10-06 00:00:00

abstract：:5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whether 5S rRNA autonomy is critical for ribosome function and cell survi...

journal_title：Nature communications

authors： Huang S,Aleksashin NA,Loveland AB,Klepacki D,Reier K,Kefi A,Szal T,Remme J,Jaeger L,Vázquez-Laslop N,Korostelev AA,Mankin AS

更新日期：2020-06-09 00:00:00

abstract：:Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is essential for development, wound healing and disease. Membrane-localized vascular endothelial growth factor receptor-1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis. ...

journal_title：Nature communications

authors： Boucher JM,Clark RP,Chong DC,Citrin KM,Wylie LA,Bautch VL

更新日期：2017-06-07 00:00:00

abstract：:Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associa...

journal_title：Nature communications

authors： Uyoga S,Macharia AW,Ndila CM,Nyutu G,Shebe M,Awuondo KO,Mturi N,Peshu N,Tsofa B,Scott JAG,Maitland K,Williams TN

更新日期：2019-02-20 00:00:00

abstract：:Supported atomic clusters with uniform metal sites and definite low-nuclearity are intermediate states between single-atom catalysts (SACs) and nanoparticles in size. Benefiting from the presence of metal-metal bonds, supported atomic clusters can trigger synergistic effects among every metal atom, which contributes t...

journal_title：Nature communications

authors： Rong H,Ji S,Zhang J,Wang D,Li Y

更新日期：2020-11-18 00:00:00

abstract：:There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant in CDKN2A associate...

journal_title：Nature communications

authors： Xu H,Zhang H,Yang W,Yadav R,Morrison AC,Qian M,Devidas M,Liu Y,Perez-Andreu V,Zhao X,Gastier-Foster JM,Lupo PJ,Neale G,Raetz E,Larsen E,Bowman WP,Carroll WL,Winick N,Williams R,Hansen T,Holm JC,Mardis E,Fulton

更新日期：2015-06-24 00:00:00

abstract：:Lanthanide compounds show much higher energy barriers to magnetic relaxation than 3d-block compounds, and this has led to speculation that they could be used in molecular spintronic devices. Prototype molecular spin valves and molecular transistors have been reported, with remarkable experiments showing the influence ...

journal_title：Nature communications

authors： Moreno Pineda E,Chilton NF,Marx R,Dörfel M,Sells DO,Neugebauer P,Jiang SD,Collison D,van Slageren J,McInnes EJ,Winpenny RE

更新日期：2014-10-13 00:00:00

abstract：:The striking diversity of bird beak shapes is an outcome of natural selection, yet the relative importance of the limitations imposed by the process of beak development on generating such variation is unclear. Untangling these factors requires mapping developmental mechanisms over a phylogeny far exceeding model syste...

journal_title：Nature communications

authors： Fritz JA,Brancale J,Tokita M,Burns KJ,Hawkins MB,Abzhanov A,Brenner MP

更新日期：2014-04-16 00:00:00

abstract：:The generation of temporal cavity solitons in microresonators results in coherent low-noise optical frequency combs that are critical for applications in spectroscopy, astronomy, navigation or telecommunications. Breather solitons also form an important part of many different classes of nonlinear wave systems, manifes...

journal_title：Nature communications

authors： Yu M,Jang JK,Okawachi Y,Griffith AG,Luke K,Miller SA,Ji X,Lipson M,Gaeta AL

更新日期：2017-02-24 00:00:00

abstract：:Even as the study of plant genomics rapidly develops through the use of high-throughput sequencing techniques, traditional plant phenotyping lags far behind. Here we develop a high-throughput rice phenotyping facility (HRPF) to monitor 13 traditional agronomic traits and 2 newly defined traits during the rice growth p...

journal_title：Nature communications

authors： Yang W,Guo Z,Huang C,Duan L,Chen G,Jiang N,Fang W,Feng H,Xie W,Lian X,Wang G,Luo Q,Zhang Q,Liu Q,Xiong L

更新日期：2014-10-08 00:00:00

abstract：:Ubiquitin-specific protease 14 (USP14) is one of the major proteasome-associated deubiquitinating enzymes critical for proteome homeostasis. However, substrates of USP14 remain largely unknown, hindering the understanding of its functional roles. Here we conduct a comprehensive proteome, ubiquitinome and interactome a...

journal_title：Nature communications

authors： Liu B,Jiang S,Li M,Xiong X,Zhu M,Li D,Zhao L,Qian L,Zhai L,Li J,Lu H,Sun S,Lin J,Lu Y,Li X,Tan M

更新日期：2018-11-13 00:00:00

abstract：:Symmetric or asymmetric positioning of intracellular structures including the nucleus and mitotic spindle steers various biological processes such as cell migration, division, and embryogenesis. In typical animal cells, both a sparse actomyosin meshwork in the cytoplasm and a dense actomyosin cortex underneath the cel...

journal_title：Nature communications

authors： Sakamoto R,Tanabe M,Hiraiwa T,Suzuki K,Ishiwata S,Maeda YT,Miyazaki M

更新日期：2020-06-15 00:00:00

abstract：:The original version of this Article contained an error in Fig. 2f, in which the phospholipid was incorrectly labelled 'PE' rather than the correct 'PC'. This has now been corrected in the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Zhang W,Zhang D,Chen Q,Wu J,Ouyang Z,Xia Y

更新日期：2019-02-19 00:00:00

abstract：:Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has emerged as an important player in inflammatory disorders besides its well...

journal_title：Nature communications

authors： Sheppard S,Guedes J,Mroz A,Zavitsanou AM,Kudo H,Rothery SM,Angelopoulos P,Goldin R,Guerra N

更新日期：2017-01-27 00:00:00

abstract：:Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterise the DNA methylomes of zebrafish PGCs at four devel...

journal_title：Nature communications

authors： Skvortsova K,Tarbashevich K,Stehling M,Lister R,Irimia M,Raz E,Bogdanovic O

更新日期：2019-07-11 00:00:00

abstract：:Patterns in biomass production are determined by resource input (productivity) and trophic transfer efficiency. At fixed resource input, variation in consumer biomass production has been related to food quality, metabolic type and diversity among species. In contrast, intraspecific variation in individual body size be...

journal_title：Nature communications

authors： Reichstein B,Persson L,De Roos AM

更新日期：2015-03-04 00:00:00

abstract：:Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous spreading. Although stromal lymphatic vessels (LVs) serve as initial metastatic routes, roles of organ-residing LVs are underinvestigated. Here we show that lymphatic endothelial cells (LECs), a component of LVs within pre-metastatic...

journal_title：Nature communications

authors： Lee E,Fertig EJ,Jin K,Sukumar S,Pandey NB,Popel AS

更新日期：2014-09-02 00:00:00

abstract：:Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is ...

journal_title：Nature communications

authors： Lin SH,Cheng YR,Banks RW,Min MY,Bewick GS,Chen CC

更新日期：2016-05-10 00:00:00

abstract：:During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting mechanical tension. In this context, it is unclear how mechanica...

journal_title：Nature communications

authors： Kale GR,Yang X,Philippe JM,Mani M,Lenne PF,Lecuit T

更新日期：2018-11-27 00:00:00

abstract：:The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. Here, we demonstrate that the fibroblast growth factor-21 gene (Fgf21) is subject to peroxisome proliferator-activated receptor (PPAR) α-dependent DNA de...

journal_title：Nature communications

authors： Yuan X,Tsujimoto K,Hashimoto K,Kawahori K,Hanzawa N,Hamaguchi M,Seki T,Nawa M,Ehara T,Kitamura Y,Hatada I,Konishi M,Itoh N,Nakagawa Y,Shimano H,Takai-Igarashi T,Kamei Y,Ogawa Y

更新日期：2018-02-12 00:00:00

abstract：:Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham...

journal_title：Nature communications

authors： Chu AY,Tin A,Schlosser P,Ko YA,Qiu C,Yao C,Joehanes R,Grams ME,Liang L,Gluck CA,Liu C,Coresh J,Hwang SJ,Levy D,Boerwinkle E,Pankow JS,Yang Q,Fornage M,Fox CS,Susztak K,Köttgen A

更新日期：2017-11-03 00:00:00

abstract：:Liquids cooled towards the glass transition temperature transform into amorphous solids that have a wide range of applications. While the nature of this transformation is understood rigorously in the mean-field limit of infinite spatial dimensions, the problem remains wide open in physical dimensions. Nontrivial finit...

journal_title：Nature communications

authors： Berthier L,Charbonneau P,Ninarello A,Ozawa M,Yaida S

更新日期：2019-04-03 00:00:00

abstract：:Recent years have witnessed the growing interest in the remote functionalization of alkenes for it offers a strategy to activate the challenging C-H bonds distant from the initiation point via alkene isomerization/functionalization. However, the catalytic enantioselective isomerization/functionalization with one singl...

journal_title：Nature communications

authors： Chen X,Cheng Z,Guo J,Lu Z

更新日期：2018-09-26 00:00:00

abstract：:It has been observed that concentrated solutions of short DNA oligomers develop liquid crystal ordering as the result of a hierarchically structured supramolecular self-assembly. In mixtures of oligomers with various degree of complementarity, liquid crystal microdomains are formed via the selective aggregation of tho...

journal_title：Nature communications

authors： Fraccia TP,Smith GP,Zanchetta G,Paraboschi E,Yi Y,Walba DM,Dieci G,Clark NA,Bellini T

更新日期：2015-03-10 00:00:00

abstract：:Explaining trait differences between individuals is a core and challenging aim of life sciences. Here, we introduce a powerful framework for complete decomposition of trait variation into its underlying genetic causes in diploid model organisms. We sequence and systematically pair the recombinant gametes of two interc...

journal_title：Nature communications

authors： Hallin J,Märtens K,Young AI,Zackrisson M,Salinas F,Parts L,Warringer J,Liti G

更新日期：2016-11-02 00:00:00

abstract：:Currently, there is no comprehensive framework to evaluate the evolutionary forces acting on genomic regions associated with human complex traits and contextualize the relationship between evolution and molecular function. Here, we develop an approach to test for signatures of diverse evolutionary forces on trait-asso...

journal_title：Nature communications

authors： LaBella AL,Abraham A,Pichkar Y,Fong SL,Zhang G,Muglia LJ,Abbot P,Rokas A,Capra JA

更新日期：2020-07-24 00:00:00

abstract：:CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodology that allows en...

journal_title：Nature communications

authors： Wei T,Cheng Q,Min YL,Olson EN,Siegwart DJ

更新日期：2020-06-26 00:00:00

abstract：:Although soluble inhibitors are frequently used to block cell binding to the extracellular matrix (ECM), mechanical stretching of a protein fibre alone can physically destroy a cell-binding site. Here, we show using binding assays and steered molecular dynamics that mechanical tension along fibronectin (Fn) fibres cau...

journal_title：Nature communications

authors： Chabria M,Hertig S,Smith ML,Vogel V

更新日期：2010-01-01 00:00:00

abstract：:The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move significantly beyond the current state-of-the-art description of sleep, and in particular to characteri...

journal_title：Nature communications

authors： Stevner ABA,Vidaurre D,Cabral J,Rapuano K,Nielsen SFV,Tagliazucchi E,Laufs H,Vuust P,Deco G,Woolrich MW,Van Someren E,Kringelbach ML

更新日期：2019-03-04 00:00:00