dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes.

abstract：:It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we show that pluripotent stem cell aggregates pre-differentiated into the early cardiac lineage and encapsulated in a biocompatib...

journal_title：Nature communications

authors： Zhao S,Xu Z,Wang H,Reese BE,Gushchina LV,Jiang M,Agarwal P,Xu J,Zhang M,Shen R,Liu Z,Weisleder N,He X

更新日期：2016-10-27 00:00:00

abstract：:Auxin is a key coordinative signal required for many aspects of plant development and its levels are controlled by auxin metabolism and intercellular auxin transport. Here we find that a member of PIN auxin transporter family, PIN8 is expressed in male gametophyte of Arabidopsis thaliana and has a crucial role in poll...

journal_title：Nature communications

authors： Ding Z,Wang B,Moreno I,Dupláková N,Simon S,Carraro N,Reemmer J,Pěnčík A,Chen X,Tejos R,Skůpa P,Pollmann S,Mravec J,Petrášek J,Zažímalová E,Honys D,Rolčík J,Murphy A,Orellana A,Geisler M,Friml J

更新日期：2012-07-03 00:00:00

abstract：:The demand for highly scalable, low-power devices for data storage and logic operations is strongly stimulating research into resistive switching as a novel concept for future non-volatile memory devices. To meet technological requirements, it is imperative to have a set of material design rules based on fundamental m...

journal_title：Nature communications

authors： Baeumer C,Schmitz C,Ramadan AH,Du H,Skaja K,Feyer V,Müller P,Arndt B,Jia CL,Mayer J,De Souza RA,Michael Schneider C,Waser R,Dittmann R

更新日期：2015-10-19 00:00:00

abstract：:Foldamers provide an attractive medium to test the mechanisms by which biological macromolecules fold into complex three-dimensional structures, and ultimately to design novel protein-like architectures with properties unprecedented in nature. Here, we describe a large cage-like structure formed from an amphiphilic ar...

journal_title：Nature communications

authors： Pavone V,Zhang SQ,Merlino A,Lombardi A,Wu Y,DeGrado WF

更新日期：2014-04-07 00:00:00

abstract：:The ability to modulate nanoparticle (NP) assemblies with atomic precision is still lacking, which hinders us from creating hierarchical NP organizations with desired properties. In this work, a hierarchical fibrous (1D to 3D) assembly of Au NPs (21-gold atom, Au21) is realized and further modulated with atomic precis...

journal_title：Nature communications

authors： Li Q,Russell JC,Luo TY,Roy X,Rosi NL,Zhu Y,Jin R

更新日期：2018-09-24 00:00:00

abstract：:As energy efficiency becomes a paramount issue in this day and age, reversible computing may serve as a critical step towards energy conservation in information technology. The inputs of reversible computing elements define the outputs and vice versa. Some reversible gates such as the Fredkin gate are also universal; ...

journal_title：Nature communications

authors： Cohen E,Dolev S,Rosenblit M

更新日期：2016-04-26 00:00:00

abstract：:Modern computation relies crucially on modular architectures, breaking a complex algorithm into self-contained subroutines. A client can then call upon a remote server to implement parts of the computation independently via an application programming interface (API). Present APIs relay only classical information. Here...

journal_title：Nature communications

authors： Zhang K,Thompson J,Zhang X,Shen Y,Lu Y,Zhang S,Ma J,Vedral V,Gu M,Kim K

更新日期：2019-10-16 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors. They can exist and act as dimers, but the requirement of dimers for agonist-induced signal initiation and structural dynamics remains largely unknown. Frizzled 6 (FZD6) is a member of Class F GPCRs, which bind WNT proteins to ...

journal_title：Nature communications

authors： Petersen J,Wright SC,Rodríguez D,Matricon P,Lahav N,Vromen A,Friedler A,Strömqvist J,Wennmalm S,Carlsson J,Schulte G

更新日期：2017-08-09 00:00:00

abstract：:Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of antibiotics and switching between them in ON/OFF manner. Using a multiplexe...

journal_title：Nature communications

authors： Yoshida M,Reyes SG,Tsuda S,Horinouchi T,Furusawa C,Cronin L

更新日期：2017-06-08 00:00:00

abstract：:Overcoming the restricted axonal regenerative ability that limits functional repair following a central nervous system injury remains a challenge. Here we report a regenerative paradigm that we call enriched conditioning, which combines environmental enrichment (EE) followed by a conditioning sciatic nerve axotomy tha...

journal_title：Nature communications

authors： De Virgiliis F,Hutson TH,Palmisano I,Amachree S,Miao J,Zhou L,Todorova R,Thompson R,Danzi MC,Lemmon VP,Bixby JL,Wittig I,Shah AM,Di Giovanni S

更新日期：2020-12-21 00:00:00

abstract：:The Unc-51 like autophagy activating kinase 1 (ULK1) complex plays a central role in the initiation stage of autophagy. However, the function of ULK1 in the late stage of autophagy is unknown. Here, we report that ULK1, a central kinase of the ULK1 complex involved in autophagy initiation, promotes autophagosome-lysos...

journal_title：Nature communications

authors： Wang C,Wang H,Zhang D,Luo W,Liu R,Xu D,Diao L,Liao L,Liu Z

更新日期：2018-08-28 00:00:00

abstract：:Ions are ubiquitous biological regulators playing a key role for vital processes in animals and plants. The combined detection of ion concentration and real-time monitoring of small variations with respect to the resting conditions is a multiscale functionality providing important information on health states. This mu...

journal_title：Nature communications

authors： Romele P,Gkoupidenis P,Koutsouras DA,Lieberth K,Kovács-Vajna ZM,Blom PWM,Torricelli F

更新日期：2020-07-27 00:00:00

abstract：:Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. We track daily ch...

journal_title：Nature communications

authors： Asokan MM,Williamson RS,Hancock KE,Polley DB

更新日期：2018-06-25 00:00:00

abstract：:Temperature measurement is critical for many technological applications and scientific experiments, and different types of thermometers have been developed to detect temperature at macroscopic length scales. However, quantitative measurement of the temperature of nanostructures remains a challenge. Here, we show a new...

journal_title：Nature communications

authors： Guo H,Khan MI,Cheng C,Fan W,Dames C,Wu J,Minor AM

更新日期：2014-10-13 00:00:00

abstract：:The direct transformation of cellulose, which is the main component of lignocellulosic biomass, into building-block chemicals is the key to establishing biomass-based sustainable chemical processes. Only limited successes have been achieved for such transformations under mild conditions. Here we report the simple and ...

journal_title：Nature communications

authors： Wang Y,Deng W,Wang B,Zhang Q,Wan X,Tang Z,Wang Y,Zhu C,Cao Z,Wang G,Wan H

更新日期：2013-01-01 00:00:00

abstract：:The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....

journal_title：Nature communications

authors： Kiss L,Zeng J,Dickson CF,Mallery DL,Yang JC,McLaughlin SH,Boland A,Neuhaus D,James LC

更新日期：2019-10-03 00:00:00

abstract：:Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously blocking TNF-α growth-promoting activities. SMCs also regulate several immunomodulatory properties within immune cells. We report that SMCs synergize with innat...

journal_title：Nature communications

authors： Beug ST,Beauregard CE,Healy C,Sanda T,St-Jean M,Chabot J,Walker DE,Mohan A,Earl N,Lun X,Senger DL,Robbins SM,Staeheli P,Forsyth PA,Alain T,LaCasse EC,Korneluk RG

更新日期：2017-02-15 00:00:00

abstract：:Single-nucleotide substitutions are a defining characteristic of cancer genomes. Many single-nucleotide substitutions in cancer genomes arise because of errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and can...

journal_title：Nature communications

authors： Liu L,De S,Michor F

更新日期：2013-01-01 00:00:00

abstract：:Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a replication-coupled manner; however, additional proteolytic mechanisms...

journal_title：Nature communications

authors： Kojima Y,Machida Y,Palani S,Caulfield TR,Radisky ES,Kaufmann SH,Machida YJ

更新日期：2020-03-12 00:00:00

abstract：:Trade-offs play an important role in evolution. Without trade-offs, evolution would maximize fitness of all traits leading to a "master of all traits". The shape of trade-offs has been shown to determine evolutionary trajectories and is often assumed to be static and independent of the actual evolutionary process. Her...

journal_title：Nature communications

authors： Huang W,Traulsen A,Werner B,Hiltunen T,Becks L

更新日期：2017-12-12 00:00:00

abstract：:Gamma-ray 'glows' are long duration (seconds to tens of minutes) X-ray and gamma-ray emission coming from thunderclouds. Measurements suggest the presence of relativistic runaway electron avalanches (RREA), the same process underlying terrestrial gamma-ray flashes. Here we demonstrate that glows are relatively a commo...

journal_title：Nature communications

authors： Kelley NA,Smith DM,Dwyer JR,Splitt M,Lazarus S,Martinez-McKinney F,Hazelton B,Grefenstette B,Lowell A,Rassoul HK

更新日期：2015-08-12 00:00:00

abstract：:The Schrödinger equation is a fundamental equation to describe the wave function of a quantum-mechanical system. The similar forms between the Schrödinger equation and the paraxial wave equation allow a paradigm shift from the quantum mechanics to classical fields, opening up a plethora of interesting phenomena includ...

journal_title：Nature communications

authors： Shen YX,Peng YG,Cai F,Huang K,Zhao DG,Qiu CW,Zheng H,Zhu XF

更新日期：2019-07-30 00:00:00

abstract：:Deep subsurface formations (for example, high-temperature oil reservoirs) are candidate sites for carbon capture and storage technology. However, very little is known about how the subsurface microbial community would respond to an increase in CO2 pressure resulting from carbon capture and storage. Here we construct m...

journal_title：Nature communications

authors： Mayumi D,Dolfing J,Sakata S,Maeda H,Miyagawa Y,Ikarashi M,Tamaki H,Takeuchi M,Nakatsu CH,Kamagata Y

更新日期：2013-01-01 00:00:00

abstract：:Protein homeostasis (proteostasis) is a potential mechanism that contributes to cancer cell survival and drug resistance. Constitutively active androgen receptor (AR) variants confer anti-androgen resistance in advanced prostate cancer. However, the role of proteostasis involved in next generation anti-androgen resist...

journal_title：Nature communications

authors： Liu C,Lou W,Yang JC,Liu L,Armstrong CM,Lombard AP,Zhao R,Noel ODV,Tepper CG,Chen HW,Dall'Era M,Evans CP,Gao AC

更新日期：2018-11-16 00:00:00

abstract：:The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug resistance in clinical samples, and improvements in global surveillance. Here we show how de Bruijn graph representation of bacterial diversity can be used to identify species and resistance profiles of clinical isolates. W...

journal_title：Nature communications

authors： Bradley P,Gordon NC,Walker TM,Dunn L,Heys S,Huang B,Earle S,Pankhurst LJ,Anson L,de Cesare M,Piazza P,Votintseva AA,Golubchik T,Wilson DJ,Wyllie DH,Diel R,Niemann S,Feuerriegel S,Kohl TA,Ismail N,Omar SV,Smith E

更新日期：2015-12-21 00:00:00

abstract：:Novel methods for information processing are highly desired in our information-driven society. Inspired by the brain's ability to process information, the recently introduced paradigm known as 'reservoir computing' shows that complex networks can efficiently perform computation. Here we introduce a novel architecture ...

journal_title：Nature communications

authors： Appeltant L,Soriano MC,Van der Sande G,Danckaert J,Massar S,Dambre J,Schrauwen B,Mirasso CR,Fischer I

更新日期：2011-09-13 00:00:00

abstract：:Embedding tunable quantum emitters in a photonic bandgap structure enables control of dissipative and dispersive interactions between emitters and their photonic bath. Operation in the transmission band, outside the gap, allows for studying waveguide quantum electrodynamics in the slow-light regime. Alternatively, tun...

journal_title：Nature communications

authors： Mirhosseini M,Kim E,Ferreira VS,Kalaee M,Sipahigil A,Keller AJ,Painter O

更新日期：2018-09-12 00:00:00

abstract：:Wild boar (Sus scrofa) drastically colonized mainland Eurasia and North Africa, most likely from East Asia during the Plio-Pleistocene (2-1Mya). In recent studies, based on genome-wide information, it was hypothesized that wild boar did not replace the species it encountered, but instead exchanged genetic materials wi...

journal_title：Nature communications

authors： Liu L,Bosse M,Megens HJ,Frantz LAF,Lee YL,Irving-Pease EK,Narayan G,Groenen MAM,Madsen O

更新日期：2019-04-30 00:00:00

abstract：:Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased osteoclastic miR-214-...

journal_title：Nature communications

authors： Li D,Liu J,Guo B,Liang C,Dang L,Lu C,He X,Cheung HY,Xu L,Lu C,He B,Liu B,Shaikh AB,Li F,Wang L,Yang Z,Au DW,Peng S,Zhang Z,Zhang BT,Pan X,Qian A,Shang P,Xiao L,Jiang B,Wong CK,Xu J,Bian Z,Liang Z,

更新日期：2016-03-07 00:00:00

abstract：:While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generations ago, providing p...

journal_title：Nature communications

authors： Pierron D,Heiske M,Razafindrazaka H,Pereda-Loth V,Sanchez J,Alva O,Arachiche A,Boland A,Olaso R,Deleuze JF,Ricaut FX,Rakotoarisoa JA,Radimilahy C,Stoneking M,Letellier T

更新日期：2018-03-02 00:00:00