Chemical synthesis of lactic acid from cellulose catalysed by lead(II) ions in water.

abstract：:The analysis of whole-genome sequencing studies is challenging due to the large number of noncoding rare variants, our limited understanding of their functional effects, and the lack of natural units for testing. Here we propose a scan statistic framework, WGScan, to simultaneously detect the existence, and estimate t...

journal_title：Nature communications

authors： He Z,Xu B,Buxbaum J,Ionita-Laza I

更新日期：2019-07-09 00:00:00

abstract：:The capability to detect traces of explosives sensitively, selectively and rapidly could be of great benefit for applications relating to civilian national security and military needs. Here, we show that, when chemically modified in a multiplexed mode, nanoelectrical devices arrays enable the supersensitive discrimina...

journal_title：Nature communications

authors： Lichtenstein A,Havivi E,Shacham R,Hahamy E,Leibovich R,Pevzner A,Krivitsky V,Davivi G,Presman I,Elnathan R,Engel Y,Flaxer E,Patolsky F

更新日期：2014-06-24 00:00:00

abstract：:Vortices play a crucial role in determining the properties of superconductors as well as their applications. Therefore, characterization and manipulation of vortices, especially at the single-vortex level, is of great importance. Among many techniques to study single vortices, scanning tunnelling microscopy (STM) stan...

journal_title：Nature communications

authors： Ge JY,Gladilin VN,Tempere J,Xue C,Devreese JT,Van de Vondel J,Zhou Y,Moshchalkov VV

更新日期：2016-12-09 00:00:00

abstract：:Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = 3,541) for genotype imputation by integrating t...

journal_title：Nature communications

authors： Akiyama M,Ishigaki K,Sakaue S,Momozawa Y,Horikoshi M,Hirata M,Matsuda K,Ikegawa S,Takahashi A,Kanai M,Suzuki S,Matsui D,Naito M,Yamaji T,Iwasaki M,Sawada N,Tanno K,Sasaki M,Hozawa A,Minegishi N,Wakai K,Tsugane S

更新日期：2019-09-27 00:00:00

abstract：:Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesize...

journal_title：Nature communications

authors： Yun CS,Motoyama T,Osada H

更新日期：2015-10-27 00:00:00

abstract：:MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of ubiquitination of MAVS and MITA at different phases of viral infection...

journal_title：Nature communications

authors： Zhang ZD,Xiong TC,Yao SQ,Wei MC,Chen M,Lin D,Zhong B

更新日期：2020-11-02 00:00:00

abstract：:Memory metamaterials are artificial media that sustain transformed electromagnetic properties without persistent external stimuli. Previous memory metamaterials were realized with phase-change materials, such as vanadium dioxide or chalcogenide glasses, which exhibit memory behaviour with respect to electrically/optic...

journal_title：Nature communications

authors： Kim WY,Kim HD,Kim TT,Park HS,Lee K,Choi HJ,Lee SH,Son J,Park N,Min B

更新日期：2016-01-27 00:00:00

abstract：:Blood vessels in the central nervous system (CNS) develop unique features, but the contribution of CNS neurons to regulating those features is not fully understood. We report that inhibiting spontaneous cholinergic activity or reducing starburst amacrine cell numbers prevents invasion of endothelial cells into the dee...

journal_title：Nature communications

authors： Weiner GA,Shah SH,Angelopoulos CM,Bartakova AB,Pulido RS,Murphy A,Nudleman E,Daneman R,Goldberg JL

更新日期：2019-06-06 00:00:00

abstract：:The ubiquitin proteasome system (UPS) has emerged as a drug target for diverse diseases characterized by altered proteostasis, but pharmacological agents that enhance UPS activity have been challenging to establish. Here we report the Deg-On system, a genetic inverter that translates proteasomal degradation of the tra...

journal_title：Nature communications

authors： Zhao W,Bonem M,McWhite C,Silberg JJ,Segatori L

更新日期：2014-04-08 00:00:00

abstract：:The spin of a single electron in a semiconductor quantum dot provides a well-controlled and long-lived qubit implementation. The electron charge in turn allows control of the position of individual electrons in a quantum dot array, and enables charge sensors to probe the charge configuration. Here we show that the Cou...

journal_title：Nature communications

authors： van Diepen CJ,Hsiao TK,Mukhopadhyay U,Reichl C,Wegscheider W,Vandersypen LMK

更新日期：2021-01-04 00:00:00

abstract：:In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additi...

journal_title：Nature communications

authors： Piedrafita G,Kostiou V,Wabik A,Colom B,Fernandez-Antoran D,Herms A,Murai K,Hall BA,Jones PH

更新日期：2020-03-18 00:00:00

abstract：:Acetic acid is an important bulk chemical that is currently produced via methanol carbonylation using fossil based CO. Synthesis of acetic acid from the renewable and cheap CO2 is of great importance, but state of the art routes encounter difficulties, especially in reaction selectivity and activity. Here we report a ...

journal_title：Nature communications

authors： Qian Q,Zhang J,Cui M,Han B

更新日期：2016-05-11 00:00:00

abstract：:5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes for CRC patients. Here, we demonstrate that p53 promotes WNT3 transcription, leading to activation of the WNT/...

journal_title：Nature communications

authors： Cho YH,Ro EJ,Yoon JS,Mizutani T,Kang DW,Park JC,Il Kim T,Clevers H,Choi KY

更新日期：2020-10-21 00:00:00

abstract：:Persistent exposure to man-made endocrine disrupting chemicals during fetal endocrine development may lead to disruption of metabolic homeostasis contributing to childhood obesity. Limited cellular platforms exist to test endocrine disrupting chemical-induced developmental abnormalities in human endocrine tissues. Her...

journal_title：Nature communications

authors： Rajamani U,Gross AR,Ocampo C,Andres AM,Gottlieb RA,Sareen D

更新日期：2017-08-09 00:00:00

abstract：:Ni/Fe oxyhydroxides are the best performing Earth-abundant electrocatalysts for water oxidation. However, the origin of their remarkable performance is not well understood. Herein, we employ spectroelectrochemical techniques to analyse the kinetics of water oxidation on a series of Ni/Fe oxyhydroxide films: FeOOH, FeO...

journal_title：Nature communications

authors： Francàs L,Corby S,Selim S,Lee D,Mesa CA,Godin R,Pastor E,Stephens IEL,Choi KS,Durrant JR

更新日期：2019-11-15 00:00:00

abstract：:Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with and is a direct sub...

journal_title：Nature communications

authors： Song L,Liu Z,Hu HH,Yang Y,Li TY,Lin ZZ,Ye J,Chen J,Huang X,Liu DT,Zhou J,Shi Y,Zhao H,Xie C,Chen L,Song E,Lin SY,Lin SC

更新日期：2020-11-17 00:00:00

abstract：:It is generally assumed that cells interrogate the mechanical properties of their environment by pushing and pulling on the extracellular matrix (ECM). For instance, acto-myosin-dependent contraction forces exerted at focal adhesions (FAs) allow the cell to actively probe substrate elasticity. Here, we report that a s...

journal_title：Nature communications

authors： Baschieri F,Dayot S,Elkhatib N,Ly N,Capmany A,Schauer K,Betz T,Vignjevic DM,Poincloux R,Montagnac G

更新日期：2018-09-20 00:00:00

abstract：:Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative traits-plasma total cholesterol, low-density lipoprotein cholesterol (L...

journal_title：Nature communications

authors： Natarajan P,Peloso GM,Zekavat SM,Montasser M,Ganna A,Chaffin M,Khera AV,Zhou W,Bloom JM,Engreitz JM,Ernst J,O'Connell JR,Ruotsalainen SE,Alver M,Manichaikul A,Johnson WC,Perry JA,Poterba T,Seed C,Surakka IL,Esko T

更新日期：2018-08-23 00:00:00

abstract：:Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme mu...

journal_title：Nature communications

authors： Chapple CE,Robisson B,Spinelli L,Guien C,Becker E,Brun C

更新日期：2015-06-09 00:00:00

abstract：:Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR) involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a ligand-binding domain (LBD). Functionally relevant inter-domain interactions between the DBD and LBD have been observed in several other NRs, but f...

journal_title：Nature communications

authors： Huang W,Peng Y,Kiselar J,Zhao X,Albaqami A,Mendez D,Chen Y,Chakravarthy S,Gupta S,Ralston C,Kao HY,Chance MR,Yang S

更新日期：2018-08-30 00:00:00

abstract：:The rate of interictal high frequency oscillations (HFOs) is a promising biomarker of the seizure onset zone, though little is known about its consistency over hours to days. Here we test whether the highest HFO-rate channels are consistent across different 10-min segments of EEG during sleep. An automated HFO detecto...

journal_title：Nature communications

authors： Gliske SV,Irwin ZT,Chestek C,Hegeman GL,Brinkmann B,Sagher O,Garton HJL,Worrell GA,Stacey WC

更新日期：2018-06-01 00:00:00

abstract：:Past studies of the end-Permian extinction (EPE), the largest biotic crisis of the Phanerozoic, have not resolved the timing of events in southern high-latitudes. Here we use palynology coupled with high-precision CA-ID-TIMS dating of euhedral zircons from continental sequences of the Sydney Basin, Australia, to show ...

journal_title：Nature communications

authors： Fielding CR,Frank TD,McLoughlin S,Vajda V,Mays C,Tevyaw AP,Winguth A,Winguth C,Nicoll RS,Bocking M,Crowley JL

更新日期：2019-01-23 00:00:00

abstract：:Device performance and in particular device stability for blue perovskite light-emitting diodes (PeLEDs) remain considerable challenges for the whole community. In this manuscript, we conceive an approach by tuning the 'A-site' cation composition of perovskites to develop blue-emitters. We herein report a Rubidium-Ces...

journal_title：Nature communications

authors： Jiang Y,Qin C,Cui M,He T,Liu K,Huang Y,Luo M,Zhang L,Xu H,Li S,Wei J,Liu Z,Wang H,Kim GH,Yuan M,Chen J

更新日期：2019-04-23 00:00:00

abstract：:Paternal epigenetic inheritance is gaining attention for its growing medical relevance. However, the form in which paternal epigenetic information is transmitted to offspring and how it influences offspring development remain poorly understood. Here we show that in C. elegans, sperm-inherited chromatin states transmit...

journal_title：Nature communications

authors： Kaneshiro KR,Rechtsteiner A,Strome S

更新日期：2019-03-20 00:00:00

abstract：:Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...

journal_title：Nature communications

authors： Lin WY,Fordham SE,Sunter N,Elstob C,Rahman T,Willmore E,Shepherd C,Strathdee G,Mainou-Fowler T,Piddock R,Mearns H,Barrow T,Houlston RS,Marr H,Wallis J,Summerfield G,Marshall S,Pettitt A,Pepper C,Fegan C,Forconi F

更新日期：2021-01-28 00:00:00

abstract：:LPMO (lytic polysaccharide monooxygenase) represents a unique paradigm of cellulosic biomass degradation by an oxidative mechanism. Understanding the role of LPMO in deconstructing crystalline cellulose is fundamental to the enzyme's biological function and will help to specify the use of LPMO in biorefinery applicati...

journal_title：Nature communications

authors： Eibinger M,Sattelkow J,Ganner T,Plank H,Nidetzky B

更新日期：2017-10-12 00:00:00

abstract：:Gene-targeted animal models that are generated by injecting Cas9 and sgRNAs into zygotes are often accompanied by undesired double-strand break (DSB)-induced byproducts and random biallelic targeting due to uncontrollable Cas9 targeting activity. Here, we establish a parental allele-specific gene-targeting (Past-CRISP...

journal_title：Nature communications

authors： Li Y,Weng Y,Bai D,Jia Y,Liu Y,Zhang Y,Kou X,Zhao Y,Ruan J,Chen J,Yin J,Wang H,Teng X,Wang Z,Liu W,Gao S

更新日期：2020-09-14 00:00:00

abstract：:Loss of appetite or anorexia associated with inflammation impairs quality of life and increases morbidity in many diseases. However, the exact neural mechanism that mediates inflammation-associated anorexia is still poorly understood. Here we identified a population of neurons, marked by the expression of protein kina...

journal_title：Nature communications

authors： Wang Y,Kim J,Schmit MB,Cho TS,Fang C,Cai H

更新日期：2019-06-24 00:00:00

abstract：:The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs). We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant componen...

journal_title：Nature communications

authors： Hernandez-Fernaud JR,Ruengeler E,Casazza A,Neilson LJ,Pulleine E,Santi A,Ismail S,Lilla S,Dhayade S,MacPherson IR,McNeish I,Ennis D,Ali H,Kugeratski FG,Al Khamici H,van den Biggelaar M,van den Berghe PV,Cloix C,McDona

更新日期：2017-02-15 00:00:00

abstract：:Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from each other. We report that, upon developmental maturation, in mice 3...

journal_title：Nature communications

authors： Jean P,Anttonen T,Michanski S,de Diego AMG,Steyer AM,Neef A,Oestreicher D,Kroll J,Nardis C,Pangršič T,Möbius W,Ashmore J,Wichmann C,Moser T

更新日期：2020-06-25 00:00:00