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Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage.

Abstract：

:Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. We track daily changes in sound processing using chronic widefield calcium imaging of L5 axon terminals on the dorsal cap of the IC in awake, adult mice. Sound level growth functions at the level of the auditory nerve and corticocollicular axon terminals are both strongly depressed hours after noise-induced damage of cochlear afferent synapses. Corticocollicular response gain rebounded above baseline levels by the following day and remained elevated for several weeks despite a persistent reduction in auditory nerve input. Sustained potentiation of excitatory ACtx projection neurons that innervate multiple limbic and subcortical auditory centers may underlie hyperexcitability and aberrant functional coupling of distributed brain networks in tinnitus and hyperacusis.

journal_name

Nat Commun

journal_title

Nature communications

authors

Asokan MM,Williamson RS,Hancock KE,Polley DB

doi

10.1038/s41467-018-04852-y

subject

Has Abstract

pub_date

2018-06-25 00:00:00

pages

2468

issue

1

issn

2041-1723

pii

10.1038/s41467-018-04852-y

journal_volume

9

pub_type

杂志文章

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