Abstract:
:A human cell contains hundreds to thousands of mitochondrial DNA (mtDNA) packaged into nucleoids. Currently, the segregation and allocation of nucleoids are thought to be passively determined by mitochondrial fusion and division. Here we provide evidence, using live-cell super-resolution imaging, that nucleoids can be actively transported via KIF5B-driven mitochondrial dynamic tubulation (MDT) activities that predominantly occur at the ER-mitochondria contact sites (EMCS). We further demonstrate that a mitochondrial inner membrane protein complex MICOS links nucleoids to Miro1, a KIF5B receptor on mitochondria, at the EMCS. We show that such active transportation is a mechanism essential for the proper distribution of nucleoids in the peripheral zone of the cell. Together, our work identifies an active transportation mechanism of nucleoids, with EMCS serving as a key platform for the interplay of nucleoids, MICOS, Miro1, and KIF5B to coordinate nucleoids segregation and transportation.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Qin J,Guo Y,Xue B,Shi P,Chen Y,Su QP,Hao H,Zhao S,Wu C,Yu L,Li D,Sun Ydoi
10.1038/s41467-020-18202-4subject
Has Abstractpub_date
2020-09-08 00:00:00pages
4471issue
1issn
2041-1723pii
10.1038/s41467-020-18202-4journal_volume
11pub_type
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