Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology.

abstract：:Untethered small actuators have various applications in multiple fields. However, existing small-scale actuators are very limited in their intractability with their surroundings, respond to only a single type of stimulus and are unable to achieve programmable structural changes under different stimuli. Here, we presen...

journal_title：Nature communications

authors： Dong Y,Wang J,Guo X,Yang S,Ozen MO,Chen P,Liu X,Du W,Xiao F,Demirci U,Liu BF

更新日期：2019-09-09 00:00:00

abstract：:Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a...

journal_title：Nature communications

authors： Dadaev T,Saunders EJ,Newcombe PJ,Anokian E,Leongamornlert DA,Brook MN,Cieza-Borrella C,Mijuskovic M,Wakerell S,Olama AAA,Schumacher FR,Berndt SI,Benlloch S,Ahmed M,Goh C,Sheng X,Zhang Z,Muir K,Govindasami K,Lophatan

更新日期：2018-06-11 00:00:00

abstract：:Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by incre...

journal_title：Nature communications

authors： Novo D,Heath N,Mitchell L,Caligiuri G,MacFarlane A,Reijmer D,Charlton L,Knight J,Calka M,McGhee E,Dornier E,Sumpton D,Mason S,Echard A,Klinkert K,Secklehner J,Kruiswijk F,Vousden K,Macpherson IR,Blyth K,Bailey P,

更新日期：2018-11-29 00:00:00

abstract：:Synapse formation is triggered through trans-synaptic interaction between pairs of pre- and postsynaptic adhesion molecules, the specificity of which depends on splice inserts known as 'splice-insert signaling codes'. Receptor protein tyrosine phosphatase δ (PTPδ) can bidirectionally induce pre- and postsynaptic diffe...

journal_title：Nature communications

authors： Yamagata A,Yoshida T,Sato Y,Goto-Ito S,Uemura T,Maeda A,Shiroshima T,Iwasawa-Okamoto S,Mori H,Mishina M,Fukai S

更新日期：2015-04-24 00:00:00

abstract：:DNA damage and secondary structures can stall the replication machinery. Cells possess numerous tolerance mechanisms to complete genome duplication in the presence of such impediments. In addition to translesion synthesis (TLS) polymerases, most eukaryotic cells contain a multifunctional replicative enzyme called prim...

journal_title：Nature communications

authors： Guilliam TA,Brissett NC,Ehlinger A,Keen BA,Kolesar P,Taylor EM,Bailey LJ,Lindsay HD,Chazin WJ,Doherty AJ

更新日期：2017-05-23 00:00:00

abstract：:Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic polymorphism impacts on the observed...

journal_title：Nature communications

authors： Bell CG,Gao F,Yuan W,Roos L,Acton RJ,Xia Y,Bell J,Ward K,Mangino M,Hysi PG,Wang J,Spector TD

更新日期：2018-01-02 00:00:00

abstract：:Electric gating can strongly modulate a wide variety of physical properties in semiconductors and insulators, such as significant changes of conductivity in silicon, appearance of superconductivity in SrTiO3, the paramagnet-ferromagnet transition in (In,Mn)As, and so on. The key to such modulation is charge accumulati...

journal_title：Nature communications

authors： Dushenko S,Hokazono M,Nakamura K,Ando Y,Shinjo T,Shiraishi M

更新日期：2018-08-07 00:00:00

abstract：:Improved measurement techniques are central to technological development and foundational scientific exploration. Quantum physics relies on detectors sensitive to non-classical features of systems, enabling precise tests of physical laws and quantum-enhanced technologies including precision measurement and secure comm...

journal_title：Nature communications

authors： Cooper M,Karpiński M,Smith BJ

更新日期：2014-07-14 00:00:00

abstract：:Application of force on biomolecules has been instrumental in understanding biofunctional behaviour from single molecules to complex collections of cells. Current approaches, for example, those based on atomic force microscopy or magnetic or optical tweezers, are powerful but limited in their applicability as integrat...

journal_title：Nature communications

authors： Webster A,Vollmer F,Sato Y

更新日期：2014-10-21 00:00:00

abstract：:As an in-plane charge current flows in a heavy metal film with spin-orbit coupling, it produces a torque on and thereby switches the magnetization in a neighbouring ferromagnetic metal film. Such spin-orbit torque (SOT)-induced switching has been studied extensively in recent years and has shown higher efficiency than...

journal_title：Nature communications

authors： Li P,Liu T,Chang H,Kalitsov A,Zhang W,Csaba G,Li W,Richardson D,DeMann A,Rimal G,Dey H,Jiang JS,Porod W,Field SB,Tang J,Marconi MC,Hoffmann A,Mryasov O,Wu M

更新日期：2016-09-01 00:00:00

abstract：:The accuracy of state-of-the-art atomic clocks is derived from the insensitivity of narrow optical atomic resonances to environmental perturbations. Two such resonances in singly ionized lutetium have been identified with potentially lower sensitivities compared to other clock candidates. Here we report measurement of...

journal_title：Nature communications

authors： Arnold KJ,Kaewuam R,Roy A,Tan TR,Barrett MD

更新日期：2018-04-25 00:00:00

abstract：:Doping is a primary tool for the modification of the properties of materials. Occlusion of guest molecules in crystals generally reduces their symmetry by the creation of polar domains, which engender polarization and pyroelectricity in the doped crystals. Here we describe a molecular-level determination of the struct...

journal_title：Nature communications

authors： Meirzadeh E,Azuri I,Qi Y,Ehre D,Rappe AM,Lahav M,Kronik L,Lubomirsky I

更新日期：2016-11-08 00:00:00

abstract：:Quantum Griffiths singularity was theoretically proposed to interpret the phenomenon of divergent dynamical exponent in quantum phase transitions. It has been discovered experimentally in three-dimensional (3D) magnetic metal systems and two-dimensional (2D) superconductors. But, whether this state exists in lower dim...

journal_title：Nature communications

authors： Zhang E,Zhi J,Zou YC,Ye Z,Ai L,Shi J,Huang C,Liu S,Lin Z,Zheng X,Kang N,Xu H,Wang W,He L,Zou J,Liu J,Mao Z,Xiu F

更新日期：2018-11-07 00:00:00

abstract：:In the original version of this Article, equation three contained a sign error whereby the term RT was added when it should have been subtracted. This has now been corrected in the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Jung C,Bandilla P,von Reutern M,Schnepf M,Rieder S,Unnerstall U,Gaul U

更新日期：2019-02-05 00:00:00

abstract：:The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism and obesity in mammals. However, studies investigating the impact of the diet on the establishment of the gut microbiome early in life are generally lacking, and most notably so in primate models. Here we report that a high-fat mat...

journal_title：Nature communications

authors： Ma J,Prince AL,Bader D,Hu M,Ganu R,Baquero K,Blundell P,Alan Harris R,Frias AE,Grove KL,Aagaard KM

更新日期：2014-05-20 00:00:00

abstract：:A prerequisite to myelination of peripheral axons by Schwann cells (SCs) is SC differentiation, and recent evidence indicates that reprogramming from a glycolytic to oxidative metabolism occurs during cellular differentiation. Whether this reprogramming is essential for SC differentiation, and the genes that regulate ...

journal_title：Nature communications

authors： Pooya S,Liu X,Kumar VB,Anderson J,Imai F,Zhang W,Ciraolo G,Ratner N,Setchell KD,Yoshida Y,Jankowski MP,Dasgupta B

更新日期：2014-09-26 00:00:00

abstract：:In the original version of this Article, extraneous text not belonging to the Article was accidentally appended to the results section. This error has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Zhu Y,Orre LM,Johansson HJ,Huss M,Boekel J,Vesterlund M,Fernandez-Woodbridge A,Branca RMM,Lehtiö J

更新日期：2018-05-08 00:00:00

abstract：:Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase acting on RNA (ADAR or ADAR1) as an essential gene for the survival of a subset of cancer cell lines. ADAR1-de...

journal_title：Nature communications

authors： Gannon HS,Zou T,Kiessling MK,Gao GF,Cai D,Choi PS,Ivan AP,Buchumenski I,Berger AC,Goldstein JT,Cherniack AD,Vazquez F,Tsherniak A,Levanon EY,Hahn WC,Meyerson M

更新日期：2018-12-21 00:00:00

abstract：:Cellobiohydrolase 1 from Trichoderma reesei (TrCel7A) processively hydrolyses cellulose into cellobiose. Although enzymatic techniques have been established as promising tools in biofuel production, a clear understanding of the motor's mechanistic action has yet to be revealed. Here, we develop an optical tweezers-bas...

journal_title：Nature communications

authors： Brady SK,Sreelatha S,Feng Y,Chundawat SP,Lang MJ

更新日期：2015-12-10 00:00:00

abstract：:Understanding the behaviour of thermally excited many-particle systems, composed of a single particle type having a well-defined shape and size, is important in condensed matter, notably protein crystallization. Here we observe and explain the origin of local chiral symmetry breaking in a surprisingly simple system of...

journal_title：Nature communications

authors： Zhao K,Bruinsma R,Mason TG

更新日期：2012-05-01 00:00:00

abstract：:Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, e...

journal_title：Nature communications

authors： Zhang Y,Fu L,Qi X,Zhang Z,Xia Y,Jia J,Jiang J,Zhao Y,Wu G

更新日期：2013-01-01 00:00:00

abstract：:Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is tightly controlled in vivo and aberrations in this process are associated with several human diseas...

journal_title：Nature communications

authors： Liu Y,Gupta GD,Barnabas DD,Agircan FG,Mehmood S,Wu D,Coyaud E,Johnson CM,McLaughlin SH,Andreeva A,Freund SMV,Robinson CV,Cheung SWT,Raught B,Pelletier L,van Breugel M

更新日期：2018-04-30 00:00:00

abstract：:Materials with a negative Poisson's ratio, also known as auxetic materials, exhibit unusual and counterintuitive mechanical behaviour-becoming fatter in cross-section when stretched. Such behaviour is mostly attributed to some special re-entrant or hinged geometric structures regardless of the chemical composition and...

journal_title：Nature communications

authors： Yu L,Yan Q,Ruzsinszky A

更新日期：2017-05-25 00:00:00

abstract：:The original version of this article contained an error in the spelling of Juan Pedro Martinez-Barbera, which was incorrectly given as Juan Pedro Martinez Barbera. This error has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Bowling S,Di Gregorio A,Sancho M,Pozzi S,Aarts M,Signore M,Schneider MD,Martinez-Barbera JP,Gil J,Rodríguez TA

更新日期：2018-08-02 00:00:00

abstract：:Performance for skills such as a sequence of finger movements improves during sleep. This has widely been interpreted as evidence for a role of sleep in strengthening skill learning. Here we propose a different interpretation. We propose that practice and sleep form different aspects of skill. To show this, we train 8...

journal_title：Nature communications

authors： Song S,Cohen LG

更新日期：2014-03-19 00:00:00

abstract：:Random numbers are commonly used in many different fields, ranging from simulations in fundamental science to security applications. In some critical cases, as Bell's tests and cryptography, the random numbers are required to be both private and to be provided at an ultra-fast rate. However, practical generators are u...

journal_title：Nature communications

authors： Avesani M,Marangon DG,Vallone G,Villoresi P

更新日期：2018-12-18 00:00:00

abstract：:Samarium hexaboride is a classic three-dimensional mixed valence system with a high-temperature metallic phase that evolves into a paramagnetic charge insulator below 40 K. A number of recent experiments have suggested the possibility that the low-temperature insulating bulk hosts electrically neutral gapless fermioni...

journal_title：Nature communications

authors： Chowdhury D,Sodemann I,Senthil T

更新日期：2018-05-02 00:00:00

abstract：:Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication. We analyse the cellular pathways in which human proviral genes are...

journal_title：Nature communications

authors： Karlas A,Berre S,Couderc T,Varjak M,Braun P,Meyer M,Gangneux N,Karo-Astover L,Weege F,Raftery M,Schönrich G,Klemm U,Wurzlbauer A,Bracher F,Merits A,Meyer TF,Lecuit M

更新日期：2016-05-12 00:00:00

abstract：:Flexible organic memory devices are one of the integral components for future flexible organic electronics. However, high-density all-organic memory cell arrays on malleable substrates without cross-talk have not been demonstrated because of difficulties in their fabrication and relatively poor performances to date. H...

journal_title：Nature communications

authors： Ji Y,Zeigler DF,Lee DS,Choi H,Jen AK,Ko HC,Kim TW

更新日期：2013-01-01 00:00:00

abstract：:Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies, but the generalizability of such findings remains unknown. Here we genotype 1,267 individuals from a Greek population isolate on the Illumina HumanExome Beadchip, in search ...

journal_title：Nature communications

authors： Tachmazidou I,Dedoussis G,Southam L,Farmaki AE,Ritchie GR,Xifara DK,Matchan A,Hatzikotoulas K,Rayner NW,Chen Y,Pollin TI,O'Connell JR,Yerges-Armstrong LM,Kiagiadaki C,Panoutsopoulou K,Schwartzentruber J,Moutsianas L,UK1

更新日期：2013-01-01 00:00:00