Probing biomechanical properties with a centrifugal force quartz crystal microbalance.

abstract：:Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear...

journal_title：Nature communications

authors： Peng Y,Liao Q,Tan W,Peng C,Hu Z,Chen Y,Li Z,Li J,Zhen B,Zhu W,Li X,Yao Y,Song Q,Liu C,Qi X,He F,Pei H

更新日期：2019-03-15 00:00:00

abstract：:Τhe morphology, physiology and immunology, of solid tumors exhibit spatial heterogeneity which complicates our understanding of cancer progression and therapy response. Understanding spatial heterogeneity necessitates high resolution in vivo imaging of anatomical and pathophysiological tumor information. We introduce ...

journal_title：Nature communications

authors： Peters L,Weidenfeld I,Klemm U,Loeschcke A,Weihmann R,Jaeger KE,Drepper T,Ntziachristos V,Stiel AC

更新日期：2019-03-13 00:00:00

abstract：:Previous research has focused on feeding circuits residing in the hindbrain and midbrain that govern homeostatic or hedonic control of food intake. However, the feeding circuits controlling emotional or cognitive aspects of food intake are largely unknown. Here we use chemical genetics and optogenetic techniques to di...

journal_title：Nature communications

authors： Sweeney P,Yang Y

更新日期：2015-12-15 00:00:00

abstract：:Single chip integrated spectrometers are critical to bring chemical and biological sensing, spectroscopy, and spectral imaging into robust, compact and cost-effective devices. Existing on-chip spectrometer approaches fail to realize both high resolution and broad band. Here we demonstrate a microring resonator-assiste...

journal_title：Nature communications

authors： Zheng SN,Zou J,Cai H,Song JF,Chin LK,Liu PY,Lin ZP,Kwong DL,Liu AQ

更新日期：2019-05-28 00:00:00

abstract：:At photonic Dirac points, electromagnetic waves are governed by the same equations as two-component massless relativistic fermions. However, photonic Dirac points are known to occur in pairs in "photonic graphene" and other similar photonic crystals, which necessitates special precautions to excite only one valley sta...

journal_title：Nature communications

authors： Liu GG,Zhou P,Yang Y,Xue H,Ren X,Lin X,Sun HX,Bi L,Chong Y,Zhang B

更新日期：2020-04-20 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity, learning and memory, and are implicated in various neuronal disorders. We synthesized a diffusible photochromic glutamate analogue, azobenzene-triazole-glutamate (ATG), which is specific for NMDARs and functions as a photoswitchable ag...

journal_title：Nature communications

authors： Laprell L,Repak E,Franckevicius V,Hartrampf F,Terhag J,Hollmann M,Sumser M,Rebola N,DiGregorio DA,Trauner D

更新日期：2015-08-27 00:00:00

abstract：:Much of the global annual mean temperature change over Quaternary glacial cycles can be attributed to slow ice sheet and greenhouse gas feedbacks, but analysis of the short-term response to orbital forcings has the potential to reveal key relationships in the climate system. In particular, obliquity and precession bot...

journal_title：Nature communications

authors： Erb MP,Jackson CS,Broccoli AJ,Lea DW,Valdes PJ,Crucifix M,DiNezio PN

更新日期：2018-04-10 00:00:00

abstract：:Temporal cloaks have aroused tremendous research interest in both optical physics and optical communications, unfolding a distinct approach to conceal temporal events from an interrogating optical field. The state-of-the-art temporal cloaks exhibit picosecond-scale and static cloaking window, owing to significantly li...

journal_title：Nature communications

authors： Zhou F,Yan S,Zhou H,Wang X,Qiu H,Dong J,Zhou L,Ding Y,Qiu CW,Zhang X

更新日期：2019-06-20 00:00:00

abstract：: ...

journal_title：Nature communications

authors： Tsai D,Sawyer D,Bradd A,Yuste R,Shepard KL

更新日期：2018-10-24 00:00:00

abstract：:Separation of C2H4 from C2H4/C2H2/C2H6 mixture with high working capacity is still a challenging task. Herein, we deliberately design a Th-metal-organic framework (MOF) for highly efficient separation of C2H4 from a binary C2H6/C2H4 and ternary C2H4/C2H2/C2H6 mixture. The synthesized MOF Azole-Th-1 shows a UiO-66-type...

journal_title：Nature communications

authors： Xu Z,Xiong X,Xiong J,Krishna R,Li L,Fan Y,Luo F,Chen B

更新日期：2020-06-22 00:00:00

abstract：:Stress granules (SG) are translationally silent sites of RNA triage induced by environmental stresses including viral infection. Here we show that HIV-1 Gag blocks SG assembly irrespective of eIF2α phosphorylation and even when SG assembly is forced by overexpression of Ras-GAP SH3 domain-binding protein (G3BP1) or TI...

journal_title：Nature communications

authors： Valiente-Echeverría F,Melnychuk L,Vyboh K,Ajamian L,Gallouzi IE,Bernard N,Mouland AJ

更新日期：2014-09-17 00:00:00

abstract：:Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop ...

journal_title：Nature communications

authors： Boudewijns R,Thibaut HJ,Kaptein SJF,Li R,Vergote V,Seldeslachts L,Van Weyenbergh J,De Keyzer C,Bervoets L,Sharma S,Liesenborghs L,Ma J,Jansen S,Van Looveren D,Vercruysse T,Wang X,Jochmans D,Martens E,Roose K,De Vlie

更新日期：2020-11-17 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are maintained in a hypoxic niche to limit oxidative stress. Although iron elicits oxidative stress, the importance of iron homeostasis in HSCs has been unknown. Here we show that iron regulation by the F-box protein FBXL5 is required for HSC self-renewal. Conditional deletion of Fbxl5 ...

journal_title：Nature communications

authors： Muto Y,Nishiyama M,Nita A,Moroishi T,Nakayama KI

更新日期：2017-07-17 00:00:00

abstract：:DNA-based nanopores are synthetic biomolecular membrane pores, whose geometry and chemical functionality can be tuned using the tools of DNA nanotechnology, making them promising molecular devices for applications in single-molecule biosensing and synthetic biology. Here we introduce a large DNA membrane channel with ...

journal_title：Nature communications

authors： Krishnan S,Ziegler D,Arnaut V,Martin TG,Kapsner K,Henneberg K,Bausch AR,Dietz H,Simmel FC

更新日期：2016-09-23 00:00:00

abstract：:Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state NMR. However, widespread applications of this methodology have been limited by challenges in obtaining confident resonance assignments. Here, we present Methyl...

journal_title：Nature communications

authors： Nerli S,De Paula VS,McShan AC,Sgourakis NG

更新日期：2021-01-29 00:00:00

abstract：:Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C, Tbx5), has recently been demonstrated, suggesting a novel therapeutic strategy for cardiac repair. However, current approaches are inefficient. Here we demonstr...

journal_title：Nature communications

authors： Zhao Y,Londono P,Cao Y,Sharpe EJ,Proenza C,O'Rourke R,Jones KL,Jeong MY,Walker LA,Buttrick PM,McKinsey TA,Song K

更新日期：2015-09-10 00:00:00

abstract：:Transition metal-catalyzed C-H activation and radical reactions are two versatile strategies to construct diverse organic skeletons. Here we show the construction of a class of flavylium fluorophores via the merge of radical chemistry and C-H activation starting from (hetero)aryl ketones and alkynes. This protocol is ...

journal_title：Nature communications

authors： Yin J,Zhang Y,Li J,Zhu L,Lan Y,You J

更新日期：2019-12-11 00:00:00

abstract：:DNA damage and secondary structures can stall the replication machinery. Cells possess numerous tolerance mechanisms to complete genome duplication in the presence of such impediments. In addition to translesion synthesis (TLS) polymerases, most eukaryotic cells contain a multifunctional replicative enzyme called prim...

journal_title：Nature communications

authors： Guilliam TA,Brissett NC,Ehlinger A,Keen BA,Kolesar P,Taylor EM,Bailey LJ,Lindsay HD,Chazin WJ,Doherty AJ

更新日期：2017-05-23 00:00:00

abstract：:Hollow-core fibre (HCF) is a powerful technology platform offering breakthrough performance improvements in sensing, communications, higher-power pulse delivery and other applications. Free from the usual constraints on what materials can guide light, it promises qualitatively new and ideal operating regimes: precisio...

journal_title：Nature communications

authors： Fini JM,Nicholson JW,Mangan B,Meng L,Windeler RS,Monberg EM,DeSantolo A,DiMarcello FV,Mukasa K

更新日期：2014-10-28 00:00:00

abstract：:Serial X-ray crystallography allows macromolecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for serial synchrotron crystallography experiments has been limited to millisecond timescales with monochromatic beams. The polychromatic, "...

journal_title：Nature communications

authors： Meents A,Wiedorn MO,Srajer V,Henning R,Sarrou I,Bergtholdt J,Barthelmess M,Reinke PYA,Dierksmeyer D,Tolstikova A,Schaible S,Messerschmidt M,Ogata CM,Kissick DJ,Taft MH,Manstein DJ,Lieske J,Oberthuer D,Fischetti RF,C

更新日期：2017-11-03 00:00:00

abstract：:The Paris Agreement set a goal to keep global warming well below 2 °C and pursue efforts to limit it to 1.5 °C. Understanding how 0.5 °C less warming reduces impacts and risks is key for climate policies. Here, we show that both areal and population exposures to dangerous extreme precipitation events (e.g., once in 10...

journal_title：Nature communications

authors： Zhang W,Zhou T,Zou L,Zhang L,Chen X

更新日期：2018-08-08 00:00:00

abstract：:Antiretroviral therapy (ART) suppresses viral replication in people living with HIV. Yet, infected cells persist for decades on ART and viremia returns if ART is stopped. Persistence has been attributed to viral replication in an ART sanctuary and long-lived and/or proliferating latently infected cells. Using ecologic...

journal_title：Nature communications

authors： Reeves DB,Duke ER,Wagner TA,Palmer SE,Spivak AM,Schiffer JT

更新日期：2018-11-16 00:00:00

abstract：:The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cel...

journal_title：Nature communications

authors： Zhang Y,Jiao Y,Liu Z,Zhu YX

更新日期：2015-01-29 00:00:00

abstract：:Amino-terminal acetylation is among the most ubiquitous of protein modifications in eukaryotes. Although loss of N-terminal acetylation is associated with many abnormalities, the molecular basis of these effects is known for only a few cases, where acetylation of single factors has been linked to binding avidity or me...

journal_title：Nature communications

authors： Holmes WM,Mannakee BK,Gutenkunst RN,Serio TR

更新日期：2014-07-15 00:00:00

abstract：:In the original version of this Article, the four structural depictions of orbital distributions were inadvertently omitted from Figure 5. This has now been corrected in both the HTML and PDF versions of the Article. ...

journal_title：Nature communications

authors： Zhao J,Peng Q,Wang Z,Xu W,Xiao H,Wu Q,Sun HL,Ma F,Zhao J,Sun CJ,Zhao J,Li J

更新日期：2019-06-21 00:00:00

abstract：:The ter region of the bacterial chromosome, where replication terminates, is the last to be segregated before cell division in Escherichia coli. Delayed segregation is controlled by the MatP protein, which binds to specific sites (matS) within ter, and interacts with other proteins such as ZapB. Here, we investigate t...

journal_title：Nature communications

authors： Crozat E,Tardin C,Salhi M,Rousseau P,Lablaine A,Bertoni T,Holcman D,Sclavi B,Cicuta P,Cornet F

更新日期：2020-07-30 00:00:00

abstract：:Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the choles...

journal_title：Nature communications

authors： Mahoney CE,Pirman D,Chubukov V,Sleger T,Hayes S,Fan ZP,Allen EL,Chen Y,Huang L,Liu M,Zhang Y,McDonald G,Narayanaswamy R,Choe S,Chen Y,Gross S,Cianchetta G,Padyana AK,Murray S,Liu W,Marks KM,Murtie J,Dorsch M,

更新日期：2019-01-09 00:00:00

abstract：:Colloidal quantum dots have emerged as a material platform for low-cost high-performance optoelectronics. At the heart of optoelectronic devices lies the formation of a junction, which requires the intimate contact of n-type and p-type semiconductors. Doping in bulk semiconductors has been largely deployed for many de...

journal_title：Nature communications

authors： Stavrinadis A,Rath AK,de Arquer FP,Diedenhofen SL,Magén C,Martinez L,So D,Konstantatos G

更新日期：2013-01-01 00:00:00

abstract：:The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy req...

journal_title：Nature communications

authors： Rothe S,Andreyev AN,Antalic S,Borschevsky A,Capponi L,Cocolios TE,De Witte H,Eliav E,Fedorov DV,Fedosseev VN,Fink DA,Fritzsche S,Ghys L,Huyse M,Imai N,Kaldor U,Kudryavtsev Y,Köster U,Lane JF,Lassen J,Liberati V,

更新日期：2013-01-01 00:00:00

abstract：:The central issue in the physics of cuprate superconductivity is the mutual relationship among superconductivity, pseudogap and broken-spatial-symmetry states. A magnetic field B suppresses superconductivity, providing an opportunity to investigate the competition among these states. Although various B-induced electro...

journal_title：Nature communications

authors： Machida T,Kohsaka Y,Matsuoka K,Iwaya K,Hanaguri T,Tamegai T

更新日期：2016-05-27 00:00:00