Abstract:
:Amino-terminal acetylation is among the most ubiquitous of protein modifications in eukaryotes. Although loss of N-terminal acetylation is associated with many abnormalities, the molecular basis of these effects is known for only a few cases, where acetylation of single factors has been linked to binding avidity or metabolic stability. In contrast, the impact of N-terminal acetylation for the majority of the proteome, and its combinatorial contributions to phenotypes, are unknown. Here, by studying the yeast prion [PSI(+)], an amyloid of the Sup35 protein, we show that loss of N-terminal acetylation promotes general protein misfolding, a redeployment of chaperones to these substrates, and a corresponding stress response. These proteostasis changes, combined with the decreased stability of unacetylated Sup35 amyloid, reduce the size of prion aggregates and reverse their phenotypic consequences. Thus, loss of N-terminal acetylation, and its previously unanticipated role in protein biogenesis, globally resculpts the proteome to create a unique phenotype.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Holmes WM,Mannakee BK,Gutenkunst RN,Serio TRdoi
10.1038/ncomms5383subject
Has Abstractpub_date
2014-07-15 00:00:00pages
4383issn
2041-1723pii
ncomms5383journal_volume
5pub_type
杂志文章abstract::Postsynaptic density (PSD) proteins have been implicated in the pathophysiology of neurodevelopmental and psychiatric disorders. Here, we present detailed clinical and genetic data for 20 patients with likely gene-disrupting mutations in TANC2-whose protein product interacts with multiple PSD proteins. Pediatric patie...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12435-8
更新日期:2019-10-15 00:00:00
abstract::Enlarged vestibular aqueduct (EVA) is one of the most commonly identified inner ear malformations in hearing loss patients including Pendred syndrome. While biallelic mutations of the SLC26A4 gene, encoding pendrin, causes non-syndromic hearing loss with EVA or Pendred syndrome, a considerable number of patients appea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15198-9
更新日期:2020-03-12 00:00:00
abstract::Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03621-1
更新日期:2018-05-08 00:00:00
abstract::The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived infl...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2877
更新日期:2013-01-01 00:00:00
abstract::Solitary, persistent wave packets called solitons hold potential to transfer information and energy across a wide range of spatial and temporal scales in physical, chemical, and biological systems. Mechanical solitons characteristically emerge either as a single wave packet or uncorrelated propagating topological enti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13546-y
更新日期:2019-12-06 00:00:00
abstract::Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine vesicle relocalisat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19840-4
更新日期:2020-11-25 00:00:00
abstract::The main advantage of organic transistors with dual gates/bases is that the threshold voltages can be set as a function of the applied second gate/base bias, which is crucial for the application in logic gates and integrated circuits. However, incorporating a dual gate/base structure into an ultra-short channel vertic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18576-5
更新日期:2020-09-18 00:00:00
abstract::Past studies of the end-Permian extinction (EPE), the largest biotic crisis of the Phanerozoic, have not resolved the timing of events in southern high-latitudes. Here we use palynology coupled with high-precision CA-ID-TIMS dating of euhedral zircons from continental sequences of the Sydney Basin, Australia, to show ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07934-z
更新日期:2019-01-23 00:00:00
abstract::Graphene and hexagonal boron nitride are typical conductor and insulator, respectively, while their hybrids hexagonal boron carbonitride are promising as a semiconductor. Here we demonstrate a direct chemical conversion reaction, which systematically converts the hexagonal carbon lattice of graphene to boron nitride, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4193
更新日期:2014-01-01 00:00:00
abstract::Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one inflammasome constituent, but little is known about its cellular handling. Here we show a mechanism for NALP7 protein stabil...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15203
更新日期:2017-05-11 00:00:00
abstract::Aerobic methane oxidation is catalyzed by particulate methane monooxygenase (pMMO), a copper-dependent, membrane metalloenzyme composed of subunits PmoA, PmoB, and PmoC. Characterization of the copper active site has been limited by challenges in spectroscopic analysis stemming from the presence of multiple copper bin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10590-6
更新日期:2019-06-17 00:00:00
abstract::Our ability to uncover complex network structure and dynamics from data is fundamental to understanding and controlling collective dynamics in complex systems. Despite recent progress in this area, reconstructing networks with stochastic dynamical processes from limited time series remains to be an outstanding problem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5323
更新日期:2014-07-11 00:00:00
abstract::Malaria reduces host fitness and survival by pathogen-mediated damage and inflammation. Disease tolerance mechanisms counter these negative effects without decreasing pathogen load. Here, we demonstrate that in four different mouse models of malaria, adrenal hormones confer disease tolerance and protect against early ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06986-5
更新日期:2018-10-30 00:00:00
abstract::The interaction of lipids and proteins plays an important role in plasma membrane bioactivity, and much can be learned from their diffusion characteristics. Here we present the combination of super-resolution STED microscopy with scanning fluorescence correlation spectroscopy (scanning STED-FCS, sSTED-FCS) to characte...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6412
更新日期:2014-11-20 00:00:00
abstract::The rice blast fungus Magnaporthe oryzae is a model for studying fungal-plant interactions. Although it produces two types of spores (microconidia and macroconidia), previous infection studies have exclusively dealt with macroconidia. Germination of microconidia has not been reported, and their role in plant infection...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5518
更新日期:2014-08-01 00:00:00
abstract::The nitrogen-vacancy (NV) centre in diamond is a promising candidate for a solid-state qubit. However, its charge state is known to be unstable, discharging from the qubit state NV(-) into the neutral state NV(0) under various circumstances. Here we demonstrate that the charge state can be controlled by an electrolyti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1729
更新日期:2012-03-06 00:00:00
abstract::Multilayer hexagonal boron nitride (h-BN) is highly desirable as a dielectric substrate for the fabrication of two-dimensional (2D) electronic and optoelectronic devices. However, the controllable synthesis of multilayer h-BN in large areas is still limited in terms of crystallinity, thickness and stacking order. Here...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14596-3
更新日期:2020-02-12 00:00:00
abstract::As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process is confirmed by successful trifluoromethoxylation, 18O...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13359-z
更新日期:2019-11-25 00:00:00
abstract::We are constantly interacting with our environment whilst we encode memories. However, how actions influence memory formation remains poorly understood. Goal-directed movement engages the locus coeruleus (LC), the main source of noradrenaline in the brain. Noradrenaline is also known to enhance episodic encoding, sugg...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11358-8
更新日期:2019-08-06 00:00:00
abstract::Self-assembly of electroactive molecules is a promising route to new types of functional semiconductors. Here we report a capsule-shaped molecule that assembles itself into a cellular semiconducting material. The interior space of the capsule with a volume of ~415 Å3 is a nanoenvironment that can accommodate a guest. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04246-0
更新日期:2018-05-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-15994-3
更新日期:2020-05-06 00:00:00
abstract::Gold recovery using environmentally benign chemistry is imperative from an environmental perspective. Here we report the spontaneous assembly of a one-dimensional supramolecular complex with an extended {[K(OH₂)₆][AuBr₄](α-cyclodextrin)₂}n chain superstructure formed during the rapid co-precipitation of α-cyclodextrin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2891
更新日期:2013-01-01 00:00:00
abstract::Fullerene peapods, which are carbon nanotubes encapsulating fullerene molecules, can offer enhanced functionality with respect to empty nanotubes. Their prospective applications include, for example, data storage devices, single-electron transistors and spin-qubit arrays for quantum computing. However, the present inc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1034
更新日期:2010-07-13 00:00:00
abstract::Biomechanical energy harvesting textiles based on nanogenerators that convert mechanical energy into electricity have broad application prospects in next-generation wearable electronic devices. However, the difficult-to-weave structure, limited flexibility and stretchability, small device size and poor weatherability ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08846-2
更新日期:2019-02-20 00:00:00
abstract::Combinatorial polyvalent contacts of histone-binding domains or readers commonly mediate localization and activities of chromatin-associated proteins. A pair of readers, the PHD fingers of the protein CHD4, has been shown to bivalently recognize histone H3 tails. Here we describe a mechanism by which these linked but ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01598-x
更新日期:2017-11-14 00:00:00
abstract::Nitrogen fixation by cyanobacteria supplies critical bioavailable nitrogen to marine ecosystems worldwide; however, field and lab data have demonstrated it to be limited by iron, phosphorus and/or CO2. To address unknown future interactions among these factors, we grew the nitrogen-fixing cyanobacterium Trichodesmium ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12081
更新日期:2016-06-27 00:00:00
abstract::Disordered mechanical systems, when strongly deformed, have complex configuration spaces with multiple stable states and pathways connecting them. The topology of such pathways determines which states are smoothly accessible from any part of configuration space. Controlling this topology would allow us to limit access...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06720-1
更新日期:2018-10-16 00:00:00
abstract::Transition metal oxides with a perovskite crystal structure exhibit a variety of physical properties associated with the lattice. Among these materials, strontium ruthenate (SrRuO3) displays unusually strong coupling of charge, spin and lattice degrees of freedom that can give rise to the photostriction, that is, chan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15108
更新日期:2017-04-24 00:00:00
abstract::One of the most dramatic events in river environments is the natural diversion, or avulsion, of a channel across its floodplain. Though rarely witnessed, avulsions can cause massive floods, and over geologic time they create most of the fluvial stratigraphic record. Avulsions exhibit behavior ranging from reoccupying ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15859-9
更新日期:2020-04-30 00:00:00
abstract::The Johnson-Kendall-Roberts theory is the basis of modern contact mechanics. It describes how two deformable objects adhere together, driven by adhesion energy and opposed by elasticity. Here we characterize the indentation of glass particles into soft, silicone substrates using confocal microscopy. We show that, wher...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3728
更新日期:2013-01-01 00:00:00