Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

abstract：:Quantum states induced by single-atomic impurities are at the frontier of physics and material science. While such states have been reported in high-temperature superconductors and dilute magnetic semiconductors, they are unexplored in topological magnets which can feature spin-orbit tunability. Here we use spin-polar...

journal_title：Nature communications

authors： Yin JX,Shumiya N,Jiang Y,Zhou H,Macam G,Sura HOM,Zhang SS,Cheng ZJ,Guguchia Z,Li Y,Wang Q,Litskevich M,Belopolski I,Yang XP,Cochran TA,Chang G,Zhang Q,Huang ZQ,Chuang FC,Lin H,Lei H,Andersen BM,Wang Z,Jia S

更新日期：2020-09-04 00:00:00

abstract：:Deregulation of transcription factors (TFs) is an important driver of tumorigenesis, but non-invasive assays for assessing transcription factor activity are lacking. Here we develop and validate a minimally invasive method for assessing TF activity based on cell-free DNA sequencing and nucleosome footprint analysis. W...

journal_title：Nature communications

authors： Ulz P,Perakis S,Zhou Q,Moser T,Belic J,Lazzeri I,Wölfler A,Zebisch A,Gerger A,Pristauz G,Petru E,White B,Roberts CES,John JS,Schimek MG,Geigl JB,Bauernhofer T,Sill H,Bock C,Heitzer E,Speicher MR

更新日期：2019-10-11 00:00:00

abstract：:Van Allen radiation belts consist of relativistic electrons trapped by Earth's magnetic field. Trapped electrons often drift azimuthally around Earth and display a butterfly pitch angle distribution of a minimum at 90° further out than geostationary orbit. This is usually attributed to drift shell splitting resulting ...

journal_title：Nature communications

authors： Xiao F,Yang C,Su Z,Zhou Q,He Z,He Y,Baker DN,Spence HE,Funsten HO,Blake JB

更新日期：2015-10-05 00:00:00

abstract：:Optimal decision-making employs short-term rewards and abstract long-term information based on which of these is deemed relevant. Employing short- vs. long-term information is associated with different learning mechanisms, yet neural evidence showing that these two are dissociable is lacking. Here we demonstrate that ...

journal_title：Nature communications

authors： Fischer AG,Bourgeois-Gironde S,Ullsperger M

更新日期：2017-11-22 00:00:00

abstract：:Modern computation relies crucially on modular architectures, breaking a complex algorithm into self-contained subroutines. A client can then call upon a remote server to implement parts of the computation independently via an application programming interface (API). Present APIs relay only classical information. Here...

journal_title：Nature communications

authors： Zhang K,Thompson J,Zhang X,Shen Y,Lu Y,Zhang S,Ma J,Vedral V,Gu M,Kim K

更新日期：2019-10-16 00:00:00

abstract：:Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication. We analyse the cellular pathways in which human proviral genes are...

journal_title：Nature communications

authors： Karlas A,Berre S,Couderc T,Varjak M,Braun P,Meyer M,Gangneux N,Karo-Astover L,Weege F,Raftery M,Schönrich G,Klemm U,Wurzlbauer A,Bracher F,Merits A,Meyer TF,Lecuit M

更新日期：2016-05-12 00:00:00

abstract：:Recent studies of thermal transport in nanomaterials have demonstrated the breakdown of Fourier's law through observations of ballistic transport. Despite its unique features, another instance of the breakdown of Fourier's law, hydrodynamic phonon transport, has drawn less attention because it has been observed only a...

journal_title：Nature communications

authors： Lee S,Broido D,Esfarjani K,Chen G

更新日期：2015-02-18 00:00:00

abstract：:Various promising qubit concepts have been put forward recently based on engineered superconductor subgap states like Andreev bound states, Majorana zero modes or the Yu-Shiba-Rusinov (Shiba) states. The coupling of these subgap states via a superconductor strongly depends on their spatial extension and is an essentia...

journal_title：Nature communications

authors： Scherübl Z,Fülöp G,Moca CP,Gramich J,Baumgartner A,Makk P,Elalaily T,Schönenberger C,Nygård J,Zaránd G,Csonka S

更新日期：2020-04-14 00:00:00

abstract：:Charge transfer states play a crucial role in organic photovoltaics, mediating both photocurrent generation and recombination losses. In this work, we examine recombination losses as a function of the electron-hole spacing in fluorescent charge transfer states, including direct monitoring of both singlet and triplet c...

journal_title：Nature communications

authors： Chang W,Congreve DN,Hontz E,Bahlke ME,McMahon DP,Reineke S,Wu TC,Bulović V,Van Voorhis T,Baldo MA

更新日期：2015-03-12 00:00:00

abstract：:Post-transcriptional RNA modifications play a critical role in the pathogenesis of human mitochondrial disorders, but the mechanisms by which specific modifications affect mitochondrial protein synthesis remain poorly understood. Here we used a quantitative RNA sequencing approach to investigate, at nucleotide resolut...

journal_title：Nature communications

authors： Richter U,Evans ME,Clark WC,Marttinen P,Shoubridge EA,Suomalainen A,Wredenberg A,Wedell A,Pan T,Battersby BJ

更新日期：2018-09-27 00:00:00

abstract：:Percolation in complex networks is a process that mimics network degradation and a tool that reveals peculiarities of the network structure. During the course of percolation, the emergent properties of networks undergo non-trivial transformations, which include a phase transition in the connectivity, and in some speci...

journal_title：Nature communications

authors： Kryven I

更新日期：2019-01-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Rees-Garbutt J,Chalkley O,Landon S,Purcell O,Marucci L,Grierson C

更新日期：2020-05-06 00:00:00

abstract：:Much of the world's Li deposits occurs as basinal brines in magmatic orogens, particularly in continental volcanic arcs. However, the exact origin of Li enrichment in arc magmatic systems is not clear. Here, we show that, globally, primitive arc magmas have Li contents and Li/Y ratios similar to mid-ocean ridge basalt...

journal_title：Nature communications

authors： Chen C,Lee CA,Tang M,Biddle K,Sun W

更新日期：2020-10-20 00:00:00

abstract：:Remarkable breakthroughs have established the functionality of graphene and carbon nanotube transistors as replacements to silicon in conventional computing structures, and numerous spintronic logic gates have been presented. However, an efficient cascaded logic structure that exploits electron spin has not yet been d...

journal_title：Nature communications

authors： Friedman JS,Girdhar A,Gelfand RM,Memik G,Mohseni H,Taflove A,Wessels BW,Leburton JP,Sahakian AV

更新日期：2017-06-05 00:00:00

abstract：:2,3-Dihydrobenzofurans and indolines are common substructures in medicines and natural products. Herein, we describe a method that enables direct access to these core structures from non-conjugated alkenyl amides and ortho-iodoanilines/phenols. Under palladium(II) catalysis this [3 + 2] heteroannulation proceeds in an...

journal_title：Nature communications

authors： Ni HQ,Kevlishvili I,Bedekar PG,Barber JS,Yang S,Tran-Dubé M,Romine AM,Lu HX,McAlpine IJ,Liu P,Engle KM

更新日期：2020-12-22 00:00:00

abstract：:The NLRP3 inflammasome is the most characterized inflammasome activated by cellular infection or stress, which is responsible for the maturation of proinflammatory cytokines IL-1β and IL-18. The precise molecular mechanism for negative regulation of NLRP3 inflammasome activation needs to be further defined. Here we id...

journal_title：Nature communications

authors： Jin J,Yu Q,Han C,Hu X,Xu S,Wang Q,Wang J,Li N,Cao X

更新日期：2013-01-01 00:00:00

abstract：:Environmental challenges to plants typically entail retardation of vegetative growth and delay or cessation of flowering. Here we report a link between the flowering time regulator, GIGANTEA (GI), and adaptation to salt stress that is mechanistically based on GI degradation under saline conditions, thus retarding flow...

journal_title：Nature communications

authors： Kim WY,Ali Z,Park HJ,Park SJ,Cha JY,Perez-Hormaeche J,Quintero FJ,Shin G,Kim MR,Qiang Z,Ning L,Park HC,Lee SY,Bressan RA,Pardo JM,Bohnert HJ,Yun DJ

更新日期：2013-01-01 00:00:00

abstract：:Capturing and controlling plasmons at buried interfaces with nanometre and femtosecond resolution has yet to be achieved and is critical for next generation plasmonic devices. Here we use light to excite plasmonic interference patterns at a buried metal-dielectric interface in a nanostructured thin film. Plasmons are ...

journal_title：Nature communications

authors： Lummen TTA,Lamb RJ,Berruto G,LaGrange T,Dal Negro L,García de Abajo FJ,McGrouther D,Barwick B,Carbone F

更新日期：2016-10-11 00:00:00

abstract：:Innate immune signaling through the NLRP3 inflammasome is activated by multiple diabetes-related stressors, but whether targeting the inflammasome is beneficial for diabetes is still unclear. Nucleoside reverse-transcriptase inhibitors (NRTI), drugs approved to treat HIV-1 and hepatitis B infections, also block inflam...

journal_title：Nature communications

authors： Ambati J,Magagnoli J,Leung H,Wang SB,Andrews CA,Fu D,Pandey A,Sahu S,Narendran S,Hirahara S,Fukuda S,Sun J,Pandya L,Ambati M,Pereira F,Varshney A,Cummings T,Hardin JW,Edun B,Bennett CL,Ambati K,Fowler BJ,Kerur

更新日期：2020-09-23 00:00:00

abstract：:N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibility for subtype-specific targeting by pharmacological means for treatme...

journal_title：Nature communications

authors： Wang JX,Irvine MW,Burnell ES,Sapkota K,Thatcher RJ,Li M,Simorowski N,Volianskis A,Collingridge GL,Monaghan DT,Jane DE,Furukawa H

更新日期：2020-01-22 00:00:00

abstract：:Whole-genome sequencing using sequencing technologies such as Illumina enables the accurate detection of small-scale variants but provides limited information about haplotypes and variants in repetitive regions of the human genome. Single-molecule sequencing (SMS) technologies such as Pacific Biosciences and Oxford Na...

journal_title：Nature communications

authors： Edge P,Bansal V

更新日期：2019-10-11 00:00:00

abstract：:Brain-inspired parallel computing, which is typically performed using a hardware neural-network platform consisting of numerous artificial synapses, is a promising technology for effectively handling large amounts of informational data. However, the reported nonlinear and asymmetric conductance-update characteristics ...

journal_title：Nature communications

authors： Seo S,Kang BS,Lee JJ,Ryu HJ,Kim S,Kim H,Oh S,Shim J,Heo K,Oh S,Park JH

更新日期：2020-08-07 00:00:00

abstract：:Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to electroactive substrates for voltage control of their myriad functional properties. Here we demonstrate g...

journal_title：Nature communications

authors： Pesquera D,Khestanova E,Ghidini M,Zhang S,Rooney AP,Maccherozzi F,Riego P,Farokhipoor S,Kim J,Moya X,Vickers ME,Stelmashenko NA,Haigh SJ,Dhesi SS,Mathur ND

更新日期：2020-06-24 00:00:00

abstract：:Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently ...

journal_title：Nature communications

authors： Pouget C,Peterkin T,Simões FC,Lee Y,Traver D,Patient R

更新日期：2014-11-27 00:00:00

abstract：:Vertebrates exhibit specific requirements for replicative H3 and non-replicative H3.3 variants during development. To disentangle whether this involves distinct modes of deposition or unique functions once incorporated into chromatin, we combined studies in Xenopus early development with chromatin assays. Here we inve...

journal_title：Nature communications

authors： Sitbon D,Boyarchuk E,Dingli F,Loew D,Almouzni G

更新日期：2020-03-09 00:00:00

abstract：:The mitochondrial respiratory chain is essential for oxidative phosphorylation and comprises multiple complexes, including cytochrome c oxidase, assembled in macromolecular supercomplexes. Little is known about factors that contribute to supercomplex organization. Here we identify COX7RP as a factor that promotes supe...

journal_title：Nature communications

authors： Ikeda K,Shiba S,Horie-Inoue K,Shimokata K,Inoue S

更新日期：2013-01-01 00:00:00

abstract：:We lack an understanding of how the full range of genetic variants that occur in individuals can interact. To address this shortcoming, here we combine diverse mutations between genes in a model regulatory network, the galactose (GAL) switch of budding yeast. The effects of thousands of pairs of mutations fall into a ...

journal_title：Nature communications

authors： New AM,Lehner B

更新日期：2019-08-14 00:00:00

abstract：:Dense ceramic materials can form in nature under mild temperatures in water. By contrast, man-made ceramics often require sintering temperatures in excess of 1,400 °C for densification. Chemical strategies inspired by biomineralization processes have been demonstrated but remain limited to the fabrication of thin film...

journal_title：Nature communications

authors： Bouville F,Studart AR

更新日期：2017-03-06 00:00:00

abstract：:A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. Here we train a machine learning model using functional, mutational an...

journal_title：Nature communications

authors： Wells A,Heckerman D,Torkamani A,Yin L,Sebat J,Ren B,Telenti A,di Iulio J

更新日期：2019-11-20 00:00:00

abstract：:Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate perisomatic inhibition is thought to underlie the aetiology of neurological dysfunction in seizures, autism spectrum disorders and schizophrenia. Here we show that in...

journal_title：Nature communications

authors： Baohan A,Ikrar T,Tring E,Xu X,Trachtenberg JT

更新日期：2016-09-09 00:00:00