Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway.

abstract：:A non-syngas direct steam reforming route is investigated for the conversion of methanol to hydrogen and carbon dioxide over a CuZnGaO(x) catalyst at 150-200 °C. This route is in marked contrast with the conventional complex route involving steam reformation to syngas (CO/H2) at high temperature, followed by water gas...

journal_title：Nature communications

authors： Yu KM,Tong W,West A,Cheung K,Li T,Smith G,Guo Y,Tsang SC

更新日期：2012-01-01 00:00:00

abstract：:Imaging compound action potentials (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation of identified fascicles. Existing methods have low resolution, limited imaging depth, or are invasive. Fast neural electrical impedance tomography (EIT) allows fascicular CAP imaging...

journal_title：Nature communications

authors： Ravagli E,Mastitskaya S,Thompson N,Iacoviello F,Shearing PR,Perkins J,Gourine AV,Aristovich K,Holder D

更新日期：2020-12-07 00:00:00

abstract：:All motile organisms use spatially distributed chemical features of their surroundings to guide their behaviors, but the neural mechanisms underlying such behaviors in mammals have been difficult to study, largely due to the technical challenges of controlling chemical concentrations in space and time during behaviora...

journal_title：Nature communications

authors： Radvansky BA,Dombeck DA

更新日期：2018-02-26 00:00:00

abstract：:Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, e...

journal_title：Nature communications

authors： Zhang Y,Fu L,Qi X,Zhang Z,Xia Y,Jia J,Jiang J,Zhao Y,Wu G

更新日期：2013-01-01 00:00:00

abstract：:Liquids cooled towards the glass transition temperature transform into amorphous solids that have a wide range of applications. While the nature of this transformation is understood rigorously in the mean-field limit of infinite spatial dimensions, the problem remains wide open in physical dimensions. Nontrivial finit...

journal_title：Nature communications

authors： Berthier L,Charbonneau P,Ninarello A,Ozawa M,Yaida S

更新日期：2019-04-03 00:00:00

abstract：:HOXA9 and MEIS1 have essential oncogenic roles in mixed lineage leukaemia (MLL)-rearranged leukaemia. Here we show that they are direct targets of miRNA-196b, a microRNA (miRNA) located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukaemic cells. Forced expression of miR-196b significantly delays MLL-fu...

journal_title：Nature communications

authors： Li Z,Huang H,Chen P,He M,Li Y,Arnovitz S,Jiang X,He C,Hyjek E,Zhang J,Zhang Z,Elkahloun A,Cao D,Shen C,Wunderlich M,Wang Y,Neilly MB,Jin J,Wei M,Lu J,Valk PJM,Delwel R,Lowenberg B,Le Beau MM,Vardiman J,M

更新日期：2012-02-21 00:00:00

abstract：:In mammals, a subset of arginine tRNA isoacceptors are methylated in the anticodon loop by the METTL2 methyltransferase to form the 3-methylcytosine (m3C) modification. However, the mechanism by which METTL2 identifies specific tRNA arginine species for m3C formation as well as the biological role of m3C in mammals is...

journal_title：Nature communications

authors： Lentini JM,Alsaif HS,Faqeih E,Alkuraya FS,Fu D

更新日期：2020-05-19 00:00:00

abstract：:Assessing the physical connections and allosteric communications in multi-domain nuclear receptor (NR) polypeptides has remained challenging, with few crystal structures available to show their overall structural organizations. Here we report the quaternary architecture of multi-domain retinoic acid receptor β-retinoi...

journal_title：Nature communications

authors： Chandra V,Wu D,Li S,Potluri N,Kim Y,Rastinejad F

更新日期：2017-10-11 00:00:00

abstract：:An elusive goal in the field of driven quantum matter is the induction of long-range order. Here, we propose a mechanism based on light-induced evaporative cooling of holes in a correlated fermionic system. Since the entropy of a filled narrow band grows rapidly with hole doping, the isentropic transfer of holes from ...

journal_title：Nature communications

authors： Werner P,Eckstein M,Müller M,Refael G

更新日期：2019-12-05 00:00:00

abstract：:Recent years have witnessed thriving progress of flexible and portable electronics, with very high demand for cost-effective and tailor-made multifunctional devices. Here, we report on an ingenious origami hierarchical sensor array (OHSA) written with a conductive ink. Thanks to origami as a controllable hierarchical ...

journal_title：Nature communications

authors： Zhang M,Sun JJ,Khatib M,Lin ZY,Chen ZH,Saliba W,Gharra A,Horev YD,Kloper V,Milyutin Y,Huynh TP,Brandon S,Shi G,Haick H

更新日期：2019-03-08 00:00:00

abstract：:To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, there...

journal_title：Nature communications

authors： Chen M,Chen X,Schafer NP,Clementi C,Komives EA,Ferreiro DU,Wolynes PG

更新日期：2020-11-23 00:00:00

abstract：:Surface and subsurface are commonly considered as separate entities because of the difference in the bonding environment and are often investigated separately due to the experimental challenges in differentiating the surface and subsurface effects. Using in-situ atomic-scale transmission electron microscopy to resolve...

journal_title：Nature communications

authors： Sun X,Zhu W,Wu D,Li C,Wang J,Zhu Y,Chen X,Boscoboinik JA,Sharma R,Zhou G

更新日期：2020-01-16 00:00:00

abstract：:The original version of this Article omitted the following from the Acknowledgements:"Satish Patil thanks Department of Science and Technology, New Delhi, India for a Swarnajayanti fellowship."This has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Roy P,Jha A,Yasarapudi VB,Ram T,Puttaraju B,Patil S,Dasgupta J

更新日期：2018-01-03 00:00:00

abstract：:Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by in...

journal_title：Nature communications

authors： Su BH,Tseng YL,Shieh GS,Chen YC,Shiang YC,Wu P,Li KJ,Yen TH,Shiau AL,Wu CL

更新日期：2013-01-01 00:00:00

abstract：:Mappings of classical computation onto statistical mechanics models have led to remarkable successes in addressing some complex computational problems. However, such mappings display thermodynamic phase transitions that may prevent reaching solution even for easy problems known to be solvable in polynomial time. Here ...

journal_title：Nature communications

authors： Chamon C,Mucciolo ER,Ruckenstein AE,Yang ZC

更新日期：2017-05-12 00:00:00

abstract：:In photosystem II, light-induced water oxidation occurs at the Mn4CaO5 cluster. Here we demonstrate proton releases, dioxygen formation, and substrate water incorporation in response to Mn4CaO5 oxidation in the protein environment, using a quantum mechanical/molecular mechanical approach and molecular dynamics simulat...

journal_title：Nature communications

authors： Kawashima K,Takaoka T,Kimura H,Saito K,Ishikita H

更新日期：2018-03-28 00:00:00

abstract：:Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in Escherichia coli. We show that sign epistasis arises from the benefit of tuning phenoty...

journal_title：Nature communications

authors： Nghe P,Kogenaru M,Tans SJ

更新日期：2018-04-13 00:00:00

abstract：:Ever since its discovery around a decade ago, all-optical magnetization switching (AOS) using femtosecond laser pulses has shown potential for future data storage and logic devices. In particular, single pulse helicity independent AOS in certain ferrimagnetic alloys and multilayers is highly efficient and ultrafast. H...

journal_title：Nature communications

authors： van Hees YLW,van de Meugheuvel P,Koopmans B,Lavrijsen R

更新日期：2020-07-31 00:00:00

abstract：:Bacteriophage Q protein engages σ-dependent paused RNA polymerase (RNAP) by binding to a DNA site embedded in late gene promoter and renders RNAP resistant to termination signals. Here, we report a single-particle cryo-electron microscopy (cryo-EM) structure of an intact Q-engaged arrested complex. The structure revea...

journal_title：Nature communications

authors： Shi J,Gao X,Tian T,Yu Z,Gao B,Wen A,You L,Chang S,Zhang X,Zhang Y,Feng Y

更新日期：2019-07-02 00:00:00

abstract：:The dynamics of an order parameter's amplitude and phase determines the collective behaviour of novel states emerging in complex materials. Time- and momentum-resolved pump-probe spectroscopy, by virtue of measuring material properties at atomic and electronic time scales out of equilibrium, can decouple entangled deg...

journal_title：Nature communications

authors： Lee WS,Chuang YD,Moore RG,Zhu Y,Patthey L,Trigo M,Lu DH,Kirchmann PS,Krupin O,Yi M,Langner M,Huse N,Robinson JS,Chen Y,Zhou SY,Coslovich G,Huber B,Reis DA,Kaindl RA,Schoenlein RW,Doering D,Denes P,Schlotter WF

更新日期：2012-05-15 00:00:00

abstract：:Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein aggregates from PD...

journal_title：Nature communications

authors： Strohäker T,Jung BC,Liou SH,Fernandez CO,Riedel D,Becker S,Halliday GM,Bennati M,Kim WS,Lee SJ,Zweckstetter M

更新日期：2019-12-04 00:00:00

abstract：:Enhancement of optical emission on plasmonic nanostructures is intrinsically limited by the distance between the emitter and nanostructure surface, owing to a tightly-confined and exponentially-decaying electromagnetic field. This fundamental limitation prevents efficient application of plasmonic fluorescence enhancem...

journal_title：Nature communications

authors： Kumar S,Park H,Cho H,Siddique RH,Narasimhan V,Yang D,Choo H

更新日期：2020-06-10 00:00:00

abstract：:Gut microbiota composition influences the clinical benefit of immune checkpoints in patients with advanced cancer but mechanisms underlying this relationship remain unclear. Molecular mechanism whereby gut microbiota influences immune responses is mainly assigned to gut microbial metabolites. Short-chain fatty acids (...

journal_title：Nature communications

authors： Coutzac C,Jouniaux JM,Paci A,Schmidt J,Mallardo D,Seck A,Asvatourian V,Cassard L,Saulnier P,Lacroix L,Woerther PL,Vozy A,Naigeon M,Nebot-Bral L,Desbois M,Simeone E,Mateus C,Boselli L,Grivel J,Soularue E,Lepage P,

更新日期：2020-05-01 00:00:00

abstract：:Recently, stretchable electronics combined with wireless technology have been crucial for realizing efficient human-machine interaction. Here, we demonstrate highly stretchable transparent wireless electronics composed of Ag nanofibers coils and functional electronic components for power transfer and information commu...

journal_title：Nature communications

authors： Zhang Y,Huo Z,Wang X,Han X,Wu W,Wan B,Wang H,Zhai J,Tao J,Pan C,Wang ZL

更新日期：2020-11-06 00:00:00

abstract：:Inspired by biological neural systems, neuromorphic devices may open up new computing paradigms to explore cognition, learning and limits of parallel computation. Here we report the demonstration of a synaptic transistor with SmNiO₃, a correlated electron system with insulator-metal transition temperature at 130°C in ...

journal_title：Nature communications

authors： Shi J,Ha SD,Zhou Y,Schoofs F,Ramanathan S

更新日期：2013-01-01 00:00:00

abstract：:Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced levels of BRCA1, but not of other DNA repair factors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mi...

journal_title：Nature communications

authors： Suberbielle E,Djukic B,Evans M,Kim DH,Taneja P,Wang X,Finucane M,Knox J,Ho K,Devidze N,Masliah E,Mucke L

更新日期：2015-11-30 00:00:00

abstract：:Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of matter. To fully harness this potential, we must accurately know the X-ray properties: intensity, spectrum and te...

journal_title：Nature communications

authors： Sanchez-Gonzalez A,Micaelli P,Olivier C,Barillot TR,Ilchen M,Lutman AA,Marinelli A,Maxwell T,Achner A,Agåker M,Berrah N,Bostedt C,Bozek JD,Buck J,Bucksbaum PH,Montero SC,Cooper B,Cryan JP,Dong M,Feifel R,Frasinski

更新日期：2017-06-05 00:00:00

abstract：:Nonsyndromic cleft lip with or without a cleft palate (NSCL/P) is among the most common human congenital birth defects and imposes a substantial physical and financial burden on affected individuals. Here, we conduct a case-control-based GWAS followed by two rounds of replication; we include six independent cohorts fr...

journal_title：Nature communications

authors： Sun Y,Huang Y,Yin A,Pan Y,Wang Y,Wang C,Du Y,Wang M,Lan F,Hu Z,Wang G,Jiang M,Ma J,Zhang X,Ma H,Ma J,Zhang W,Huang Q,Zhou Z,Ma L,Li Y,Jiang H,Xie L,Jiang Y,Shi B,Cheng J,Shen H,Wang L,Yang Y

更新日期：2015-03-16 00:00:00

abstract：:Transmission through disordered samples can be controlled by illuminating a sample with waveforms corresponding to the eigenchannels of the transmission matrix (TM). But can the TM be exploited to selectively excite quasi-normal modes and so control the spatial profile and dwell time inside the medium? We show in micr...

journal_title：Nature communications

authors： Davy M,Genack AZ

更新日期：2018-11-09 00:00:00

abstract：:Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they are remodelled upon developmental transitions remain poorly understood. Here, we report the existence of two types of enhancer units within SEs typified by distin...

journal_title：Nature communications

authors： Bell E,Curry EW,Megchelenbrink W,Jouneau L,Brochard V,Tomaz RA,Mau KHT,Atlasi Y,de Souza RA,Marks H,Stunnenberg HG,Jouneau A,Azuara V

更新日期：2020-02-28 00:00:00