Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography.

abstract：:It has been speculated that the partial pressure of carbon dioxide (pCO2) in shelf waters may lag the rise in atmospheric CO2. Here, we show that this is the case across many shelf regions, implying a tendency for enhanced shelf uptake of atmospheric CO2. This result is based on analysis of long-term trends in the air...

journal_title：Nature communications

authors： Laruelle GG,Cai WJ,Hu X,Gruber N,Mackenzie FT,Regnier P

更新日期：2018-01-31 00:00:00

abstract：:Highly specific Cas9 nucleases derived from SpCas9 are valuable tools for genome editing, but their wide applications are hampered by a lack of knowledge governing guide RNA (gRNA) activity. Here, we perform a genome-scale screen to measure gRNA activity for two highly specific SpCas9 variants (eSpCas9(1.1) and SpCas9...

journal_title：Nature communications

authors： Wang D,Zhang C,Wang B,Li B,Wang Q,Liu D,Wang H,Zhou Y,Shi L,Lan F,Wang Y

更新日期：2019-09-19 00:00:00

abstract：:The original version of this Article contained an error in Figure 4. In panel a, the colour code for hot and cold clusters was inadvertently inverted. In the correct version of panel a, the hot clusters are blue and the cold clusters are yellow. This error has now been corrected in both the PDF and HTML versions of th...

journal_title：Nature communications

authors： Chakravarthy A,Furness A,Joshi K,Ghorani E,Ford K,Ward MJ,King EV,Lechner M,Marafioti T,Quezada SA,Thomas GJ,Feber A,Fenton TR

更新日期：2018-11-02 00:00:00

abstract：:Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression-methylation quantitative trait loci (emQTL) analysis between DNA methylation and gene expression. On a w...

journal_title：Nature communications

authors： Fleischer T,Tekpli X,Mathelier A,Wang S,Nebdal D,Dhakal HP,Sahlberg KK,Schlichting E,Oslo Breast Cancer Research Consortium (OSBREAC).,Børresen-Dale AL,Borgen E,Naume B,Eskeland R,Frigessi A,Tost J,Hurtado A,Kristensen VN

更新日期：2017-11-09 00:00:00

abstract：:The Satb1 genome organizer regulates multiple cellular and developmental processes. It is not yet clear how Satb1 selects different sets of targets throughout the genome. Here we have used live-cell single molecule imaging and deep sequencing to assess determinants of Satb1 binding-site selectivity. We have found that...

journal_title：Nature communications

authors： Ghosh RP,Shi Q,Yang L,Reddick MP,Nikitina T,Zhurkin VB,Fordyce P,Stasevich TJ,Chang HY,Greenleaf WJ,Liphardt JT

更新日期：2019-07-19 00:00:00

abstract：:Dislocation defects together with their associated strain fields and segregated impurities are of considerable significance in many areas of materials science. However, their atomic-scale structures have remained extremely challenging to resolve, limiting our understanding of these ubiquitous defects. Here, by develop...

journal_title：Nature communications

authors： Wang Z,Saito M,McKenna KP,Ikuhara Y

更新日期：2014-01-01 00:00:00

abstract：:Metastasis is the main cause of cancer-related death and thus understanding the molecular and cellular mechanisms underlying this process is critical. Here, our data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tumour metastasis. U...

journal_title：Nature communications

authors： Batista S,Maniati E,Reynolds LE,Tavora B,Lees DM,Fernandez I,Elia G,Casanovas O,Lo Celso C,Hagemann T,Hodivala-Dilke K

更新日期：2014-10-01 00:00:00

abstract：:The complete human genome sequence is used as a reference for next-generation sequencing analyses. However, some ethnic ancestries are under-represented in the reference genome (e.g., GRCh37) due to its bias toward European and African ancestries. Here, we perform de novo assembly of three Japanese male genomes using ...

journal_title：Nature communications

authors： Takayama J,Tadaka S,Yano K,Katsuoka F,Gocho C,Funayama T,Makino S,Okamura Y,Kikuchi A,Sugimoto S,Kawashima J,Otsuki A,Sakurai-Yageta M,Yasuda J,Kure S,Kinoshita K,Yamamoto M,Tamiya G

更新日期：2021-01-11 00:00:00

abstract：:Conducting polymers can be easily obtained by electrochemical oxidation of aromatic monomers on an electrode surface as a film state. To prepare conducting polymer fibres by electropolymerization, templates such as porous membranes are necessary in the conventional methods. Here we report the electropolymerization of ...

journal_title：Nature communications

authors： Koizumi Y,Shida N,Ohira M,Nishiyama H,Tomita I,Inagi S

更新日期：2016-01-25 00:00:00

abstract：:Accurate estimates of the BOLD hemodynamic response function (HRF) are crucial for the interpretation and analysis of event-related functional MRI data. To date, however, there have been no comprehensive measurements of the HRF in white matter (WM) despite increasing evidence that BOLD signals in WM change after a sti...

journal_title：Nature communications

authors： Li M,Newton AT,Anderson AW,Ding Z,Gore JC

更新日期：2019-03-08 00:00:00

abstract：:Though the concept of Berry force was proposed thirty years ago, little is known about the practical consequences of this force as far as chemical dynamics are concerned. Here, we report that when molecular dynamics pass near a conical intersection, a massive Berry force can appear as a result of even a small amount o...

journal_title：Nature communications

authors： Wu Y,Subotnik JE

更新日期：2021-01-29 00:00:00

abstract：:Rabi oscillations describe the process whereby electromagnetic radiation interacts coherently with spin states in a non-equilibrium interaction. To date, Rabi oscillations have not been studied in one of the most common spin ensembles in nature: spins in ferromagnets. Here, using a combination of femtosecond laser pul...

journal_title：Nature communications

authors： Capua A,Rettner C,Yang SH,Phung T,Parkin SSP

更新日期：2017-06-28 00:00:00

abstract：:It is unclear why atmospheric oxygen remained trapped at low levels for more than 1.5 billion years following the Paleoproterozoic Great Oxidation Event. Here, we use models for erosion, weathering and biogeochemical cycling to show that this can be explained by the tectonic recycling of previously accumulated sedimen...

journal_title：Nature communications

authors： Daines SJ,Mills BJ,Lenton TM

更新日期：2017-02-02 00:00:00

abstract：:Loss of seed dispersal is a key agronomical trait targeted by ancient human selection and has been regarded as a milestone of crop domestication. In this study, in the legume crop soybean Glycine max (L.) Merr. which provides vegetable oils and proteins for humans, we show that the key cellular feature of the shatteri...

journal_title：Nature communications

authors： Dong Y,Yang X,Liu J,Wang BH,Liu BL,Wang YZ

更新日期：2014-01-01 00:00:00

abstract：:Water is a complex liquid that displays a surprising array of unusual properties, the most famous being the density maximum at about 4 °C. The origin of these anomalies is still a matter of debate, and so far a quantitative description of water's phase behaviour starting from the molecular arrangements is still missin...

journal_title：Nature communications

authors： Russo J,Tanaka H

更新日期：2014-04-02 00:00:00

abstract：:Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin increases myogenic d...

journal_title：Nature communications

authors： Reza MM,Subramaniyam N,Sim CM,Ge X,Sathiakumar D,McFarlane C,Sharma M,Kambadur R

更新日期：2017-10-24 00:00:00

abstract：:A challenge for neuroscience is to understand the conscious and unconscious processes underlying construction of willed actions. We investigated the neural substrate of human motor awareness during awake brain surgery. In a first experiment, awake patients performed a voluntary hand motor task and verbally monitored t...

journal_title：Nature communications

authors： Fornia L,Puglisi G,Leonetti A,Bello L,Berti A,Cerri G,Garbarini F

更新日期：2020-02-04 00:00:00

abstract：:Oriented assemblies of functional nanoparticles, with the aid of external physical and chemical driving forces, have been prepared on two-dimensional solid substrates. It is challengeable, however, to achieve three-dimensional assembly directly in solution, owing to thermal fluctuations and free diffusion. Here we des...

journal_title：Nature communications

authors： Kim K,Han HS,Choi I,Lee C,Hong S,Suh SH,Lee LP,Kang T

更新日期：2013-01-01 00:00:00

abstract：:Ferromagnetism is usually deemed incompatible with superconductivity. Consequently, the coexistence of superconductivity and ferromagnetism is usually observed only in elegantly designed multi-ingredient structures in which the two competing electronic states originate from separate structural components. Here we repo...

journal_title：Nature communications

authors： Zhu X,Guo Y,Cheng H,Dai J,An X,Zhao J,Tian K,Wei S,Cheng Zeng X,Wu C,Xie Y

更新日期：2016-04-04 00:00:00

abstract：:The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins. Here, we decipher the consequences of m5C deposition into the abundant non-c...

journal_title：Nature communications

authors： Sajini AA,Choudhury NR,Wagner RE,Bornelöv S,Selmi T,Spanos C,Dietmann S,Rappsilber J,Michlewski G,Frye M

更新日期：2019-06-11 00:00:00

abstract：:Substantial efforts have been made to understand the interactions between immune checkpoint receptors and their ligands targeted in immunotherapies against cancer. To carefully characterize the complete network of interactions involved and the binding affinities between their extracellular domains, an improved kinetic...

journal_title：Nature communications

authors： Lee JR,Bechstein DJ,Ooi CC,Patel A,Gaster RS,Ng E,Gonzalez LC,Wang SX

更新日期：2016-07-22 00:00:00

abstract：:Understanding the formation chemistry of metal halide perovskites is key to optimizing processing conditions and realizing enhanced optoelectronic properties. Here, we reveal the structure of the crystalline precursor in the formation of methylammonium lead iodide (MAPbI3) from the single-step deposition of lead chlor...

journal_title：Nature communications

authors： Stone KH,Gold-Parker A,Pool VL,Unger EL,Bowring AR,McGehee MD,Toney MF,Tassone CJ

更新日期：2018-08-27 00:00:00

abstract：:The primary motor cortex has an important role in the precise execution of learned motor responses. During motor learning, synaptic efficacy between sensory and primary motor cortical neurons is enhanced, possibly involving long-term potentiation and N-methyl-D-aspartate (NMDA)-specific glutamate receptor function. To...

journal_title：Nature communications

authors： Hasan MT,Hernández-González S,Dogbevia G,Treviño M,Bertocchi I,Gruart A,Delgado-García JM

更新日期：2013-01-01 00:00:00

abstract：:Mycobacterium tuberculosis (MTB) infects 30% of all humans and kills someone every 20-30 s. Here we report genome-wide binding for ~80% of all predicted MTB transcription factors (TFs), and assayed global expression following induction of each TF. The MTB DNA-binding network consists of ~16,000 binding events from 154...

journal_title：Nature communications

authors： Minch KJ,Rustad TR,Peterson EJ,Winkler J,Reiss DJ,Ma S,Hickey M,Brabant W,Morrison B,Turkarslan S,Mawhinney C,Galagan JE,Price ND,Baliga NS,Sherman DR

更新日期：2015-01-12 00:00:00

abstract：:Zika virus is a mosquito-borne flavivirus closely related to dengue virus that can cause severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults. Specific treatments and vaccines for Zika virus are not currently available. Here, we isolate and characterize four monoclonal ant...

journal_title：Nature communications

authors： Bailey MJ,Duehr J,Dulin H,Broecker F,Brown JA,Arumemi FO,Bermúdez González MC,Leyva-Grado VH,Evans MJ,Simon V,Lim JK,Krammer F,Hai R,Palese P,Tan GS

更新日期：2018-11-01 00:00:00

abstract：:Shifting between goal-directed and habitual actions allows for efficient and flexible decision making. Here we demonstrate a novel, within-subject instrumental lever-pressing paradigm, in which mice shift between goal-directed and habitual actions. We identify a role for orbitofrontal cortex (OFC) in actions following...

journal_title：Nature communications

authors： Gremel CM,Costa RM

更新日期：2013-01-01 00:00:00

abstract：:Models of visual attention postulate the existence of a saliency map whose function is to guide attention and gaze to the most conspicuous regions in a visual scene. Although cortical representations of saliency have been reported, there is mounting evidence for a subcortical saliency mechanism, which pre-dates the ev...

journal_title：Nature communications

authors： White BJ,Berg DJ,Kan JY,Marino RA,Itti L,Munoz DP

更新日期：2017-01-24 00:00:00

abstract：:Chirality and liquid crystals are both widely expressed in nature and biology. Helical assembly of mesophasic molecules and colloids may produce intriguing chiral liquid crystals. To date, chiral liquid crystals of 2D colloids have not been explored. As a typical 2D colloid, graphene is now receiving unprecedented att...

journal_title：Nature communications

authors： Xu Z,Gao C

更新日期：2011-12-06 00:00:00

abstract：:Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing ne...

journal_title：Nature communications

authors： Dhandapani R,Arokiaraj CM,Taberner FJ,Pacifico P,Raja S,Nocchi L,Portulano C,Franciosa F,Maffei M,Hussain AF,de Castro Reis F,Reymond L,Perlas E,Garcovich S,Barth S,Johnsson K,Lechner SG,Heppenstall PA

更新日期：2018-04-24 00:00:00

abstract：:Accumulation of nucleotide building blocks prior to and during S phase facilitates DNA duplication. Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) synchronizes ribose-5-phosphate levels and DNA synthesis during the cell cycle. In late G1 and S phases, transketolase-like 1 (TKTL1) is overexpresse...

journal_title：Nature communications

authors： Li Y,Yao CF,Xu FJ,Qu YY,Li JT,Lin Y,Cao ZL,Lin PC,Xu W,Zhao SM,Zhao JY

更新日期：2019-06-07 00:00:00