Understanding water's anomalies with locally favoured structures.

abstract：:Cryptochrome (Cry) 1 and Cry2 are regarded as critical components for circadian rhythm generation in mammals. Nevertheless, cultured suprachiasmatic nucleus (SCN) of neonatal Cry double deficient (Cry1(-/-)/Cry2(-/-)) mice exhibit circadian rhythms that damp out in several cycles. Here, by combining bioluminescence im...

journal_title：Nature communications

authors： Ono D,Honma S,Honma K

更新日期：2013-01-01 00:00:00

abstract：:Reliable quantum information processing in the face of errors is a major fundamental and technological challenge. Quantum error correction protects quantum states by encoding a logical quantum bit (qubit) in multiple physical qubits. To be compatible with universal fault-tolerant computations, it is essential that sta...

journal_title：Nature communications

authors： Cramer J,Kalb N,Rol MA,Hensen B,Blok MS,Markham M,Twitchen DJ,Hanson R,Taminiau TH

更新日期：2016-05-05 00:00:00

abstract：:Polycyclic aromatic hydrocarbons as well as other organic molecules appear among the most abundant observed species in interstellar space and are key molecules to understanding the prebiotic roots of life. However, their existence and abundance in space remain a puzzle. Here we present a new top-down route to form pol...

journal_title：Nature communications

authors： Merino P,Švec M,Martinez JI,Jelinek P,Lacovig P,Dalmiglio M,Lizzit S,Soukiassian P,Cernicharo J,Martin-Gago JA

更新日期：2014-01-01 00:00:00

abstract：:Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. He...

journal_title：Nature communications

authors： Pan Y,Ren Z,Gao S,Shen J,Wang L,Xu Z,Yu Y,Bachina P,Zhang H,Fan X,Laganowsky A,Yan N,Zhou M

更新日期：2020-11-10 00:00:00

abstract：:Targeted insertion of transgenes at pre-determined plant genomic safe harbors provides a desirable alternative to insertions at random sites achieved through conventional methods. Most existing cases of targeted gene insertion in plants have either relied on the presence of a selectable marker gene in the insertion ca...

journal_title：Nature communications

authors： Dong OX,Yu S,Jain R,Zhang N,Duong PQ,Butler C,Li Y,Lipzen A,Martin JA,Barry KW,Schmutz J,Tian L,Ronald PC

更新日期：2020-03-04 00:00:00

abstract：:Erythropoietin (Epo) supports both primitive erythropoiesis in the yolk sac and definitive erythropoiesis in the fetal liver and bone marrow. Although definitive erythropoiesis requires kidney- and liver-secreted Epo, it is unclear which cells produce Epo for primitive erythropoiesis. Here we find neural Epo-producing...

journal_title：Nature communications

authors： Suzuki N,Hirano I,Pan X,Minegishi N,Yamamoto M

更新日期：2013-01-01 00:00:00

abstract：:Controlling the properties of quantum dots at the atomic scale, such as dangling bonds, is a general motivation as they allow studying various nanoscale processes including atomic switches, charge storage, or low binding energy state interactions. Adjusting the coupling of individual silicon dangling bonds to form a 2...

journal_title：Nature communications

authors： Yengui M,Duverger E,Sonnet P,Riedel D

更新日期：2017-12-20 00:00:00

abstract：:Development of effective antimicrobial agents continues to be a great challenge, particularly due to the increasing resistance of superbugs and frequent hospital breakouts. There is an urgent need for more potent and safer antibiotics with novel scaffolds. As historically many commercial drugs were derived from natura...

journal_title：Nature communications

authors： Lin Z,Xu X,Zhao S,Yang X,Guo J,Zhang Q,Jing C,Chen S,He Y

更新日期：2018-09-04 00:00:00

abstract：:Knowledge of the RNA three-dimensional structure, either in isolation or as part of RNP complexes, is fundamental to understand the mechanism of numerous cellular processes. Because of its flexibility, RNA represents a challenge for crystallization, while the large size of cellular complexes brings solution-state NMR ...

journal_title：Nature communications

authors： Marchanka A,Simon B,Althoff-Ospelt G,Carlomagno T

更新日期：2015-05-11 00:00:00

abstract：:Bioluminescent organisms are likely to have an evolutionary drive towards high radiance. As such, bio-optimized materials derived from them hold great promise for photonic applications. Here, we show that biologically produced fluorescent proteins retain their high brightness even at the maximum density in solid state...

journal_title：Nature communications

authors： Gather MC,Yun SH

更新日期：2014-12-08 00:00:00

abstract：:It is well known that both recipient cells and donor nuclei demonstrate a mitotic advantage as observed in the traditional reprogramming with somatic cell nuclear transfer (SCNT). However, it is not known whether a specific mitotic factor plays a critical role in reprogramming. Here we identify an isoform of human bro...

journal_title：Nature communications

authors： Shao Z,Zhang R,Khodadadi-Jamayran A,Chen B,Crowley MR,Festok MA,Crossman DK,Townes TM,Hu K

更新日期：2016-03-07 00:00:00

abstract：:The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the tumour suppressing mechanisms of CYLD remain poorly understood. Here we show that loss of CYLD catalytic activity causes impaired DNA damage-induced p53 stabilization and activation in epitheli...

journal_title：Nature communications

authors： Fernández-Majada V,Welz PS,Ermolaeva MA,Schell M,Adam A,Dietlein F,Komander D,Büttner R,Thomas RK,Schumacher B,Pasparakis M

更新日期：2016-08-26 00:00:00

abstract：:Angiogenesis is essential for tissue development, wound healing and tissue perfusion, with its dysregulation linked to tumorigenesis, rheumatoid arthritis and heart disease. Here we show that pro-angiogenic stimuli couple to NADPH oxidase-dependent generation of oxidants that catalyse an activating intermolecular-disu...

journal_title：Nature communications

authors： Burgoyne JR,Rudyk O,Cho HJ,Prysyazhna O,Hathaway N,Weeks A,Evans R,Ng T,Schröder K,Brandes RP,Shah AM,Eaton P

更新日期：2015-08-10 00:00:00

abstract：:The original version of this article contained an error in the spelling of Juan Pedro Martinez-Barbera, which was incorrectly given as Juan Pedro Martinez Barbera. This error has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Bowling S,Di Gregorio A,Sancho M,Pozzi S,Aarts M,Signore M,Schneider MD,Martinez-Barbera JP,Gil J,Rodríguez TA

更新日期：2018-08-02 00:00:00

abstract：:Transition metal-catalyzed enantioselective Sonogashira-type oxidative C(sp3)-C(sp) coupling of unactivated C(sp3)-H bonds with terminal alkynes has remained a prominent challenge. The difficulties mainly stem from the regiocontrol in unactivated C(sp3)-H bond functionalization and the inhibition of readily occurring ...

journal_title：Nature communications

authors： Zhang ZH,Dong XY,Du XY,Gu QS,Li ZL,Liu XY

更新日期：2019-12-12 00:00:00

abstract：:In many dynamical systems and complex networks time delays appear naturally in feedback loops or coupling connections of individual elements. Moreover, in a whole class of systems, these delay times can depend on the state of the system. Nevertheless, so far the understanding of the impact of such state-dependent dela...

journal_title：Nature communications

authors： Martínez-Llinàs J,Porte X,Soriano MC,Colet P,Fischer I

更新日期：2015-06-17 00:00:00

abstract：:Recent years have witnessed the growing interest in the remote functionalization of alkenes for it offers a strategy to activate the challenging C-H bonds distant from the initiation point via alkene isomerization/functionalization. However, the catalytic enantioselective isomerization/functionalization with one singl...

journal_title：Nature communications

authors： Chen X,Cheng Z,Guo J,Lu Z

更新日期：2018-09-26 00:00:00

abstract：:Sinc-shaped Nyquist pulses possess a rectangular spectrum, enabling data to be encoded in a minimum spectral bandwidth and satisfying by essence the Nyquist criterion of zero inter-symbol interference (ISI). This property makes them very attractive for communication systems since data transmission rates can be maximiz...

journal_title：Nature communications

authors： Soto MA,Alem M,Amin Shoaie M,Vedadi A,Brès CS,Thévenaz L,Schneider T

更新日期：2013-01-01 00:00:00

abstract：:Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further stud...

journal_title：Nature communications

authors： Chen HY,Wu CT,Tang CC,Lin YN,Wang WJ,Tang TK

更新日期：2017-08-15 00:00:00

abstract：:MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with hi...

journal_title：Nature communications

authors： Meng L,Liu C,Lü J,Zhao Q,Deng S,Wang G,Qiao J,Zhang C,Zhen L,Lu Y,Li W,Zhang Y,Pestell RG,Fan H,Chen YH,Liu Z,Yu Z

更新日期：2017-01-03 00:00:00

abstract：:A key challenge in the field of molecular spintronics, and for the design of single-molecule magnet-based devices in particular, is the understanding and control of the molecular coupling at the electrode interfaces. It was demonstrated for the field of molecular electronics that the characterization of the molecule-m...

journal_title：Nature communications

authors： Schwöbel J,Fu Y,Brede J,Dilullo A,Hoffmann G,Klyatskaya S,Ruben M,Wiesendanger R

更新日期：2012-07-17 00:00:00

abstract：:Systems allowing label-free molecular detection are expected to have enormous impact on biochemical sciences. Research focuses on materials and technologies based on exploiting localized surface plasmon resonances in metallic nanostructures. The reason for this focused attention is their suitability for single-molecul...

journal_title：Nature communications

authors： Maccaferri N,Gregorczyk KE,de Oliveira TV,Kataja M,van Dijken S,Pirzadeh Z,Dmitriev A,Åkerman J,Knez M,Vavassori P

更新日期：2015-02-02 00:00:00

abstract：:Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. ...

journal_title：Nature communications

authors： Garcia-Gomez A,Li T,de la Calle-Fabregat C,Rodríguez-Ubreva J,Ciudad L,Català-Moll F,Godoy-Tena G,Martín-Sánchez M,San-Segundo L,Muntión S,Morales X,Ortiz-de-Solórzano C,Oyarzabal J,San José-Enériz E,Esteller M,Agirre X,P

更新日期：2021-01-18 00:00:00

abstract：:Quantum fluctuations give rise to van der Waals and Casimir forces that dominate the interaction between electrically neutral objects at sub-micron separations. Under the trend of miniaturization, such quantum electrodynamical effects are expected to play an important role in micro- and nano-mechanical devices. Nevert...

journal_title：Nature communications

authors： Zou J,Marcet Z,Rodriguez AW,Reid MT,McCauley AP,Kravchenko II,Lu T,Bao Y,Johnson SG,Chan HB

更新日期：2013-01-01 00:00:00

abstract：:Dense ceramic materials can form in nature under mild temperatures in water. By contrast, man-made ceramics often require sintering temperatures in excess of 1,400 °C for densification. Chemical strategies inspired by biomineralization processes have been demonstrated but remain limited to the fabrication of thin film...

journal_title：Nature communications

authors： Bouville F,Studart AR

更新日期：2017-03-06 00:00:00

abstract：:Social dilemmas force players to balance between personal and collective gain. In many dilemmas, such as elected governments negotiating climate-change mitigation measures, the decisions are made not by individual players but by their representatives. However, the behaviour of representatives in social dilemmas has no...

journal_title：Nature communications

authors： Milinski M,Hilbe C,Semmann D,Sommerfeld R,Marotzke J

更新日期：2016-03-07 00:00:00

abstract：:It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct ske...

journal_title：Nature communications

authors： Li M,Wu H,Luo Z,Xia Y,Guan J,Wang T,Gu Y,Chen L,Zhang K,Ma J,Liu Y,Zhong Z,Nie J,Zhou S,Mu Z,Wang X,Qu J,Jing L,Wang H,Huang S,Yi N,Wang Z,Xi D,Wang J,Yin G,Wang L,Li N,Jiang Z,Lang Q,Xiao H,Ji

更新日期：2012-05-22 00:00:00

abstract：:Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly been observed. In this study, to elucidate mechanisms of adaptive resistance, we analyse the tumour immune mic...

journal_title：Nature communications

authors： Koyama S,Akbay EA,Li YY,Herter-Sprie GS,Buczkowski KA,Richards WG,Gandhi L,Redig AJ,Rodig SJ,Asahina H,Jones RE,Kulkarni MM,Kuraguchi M,Palakurthi S,Fecci PE,Johnson BE,Janne PA,Engelman JA,Gangadharan SP,Costa DB,

更新日期：2016-02-17 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the intricate alveolar network of the lung is progressively replaced by fibrotic scars. Myofibroblasts are the effector cells that excessively deposit extracellular matrix proteins thus compromising lung structure and function. Emerging literature suggest...

journal_title：Nature communications

authors： Kheirollahi V,Wasnick RM,Biasin V,Vazquez-Armendariz AI,Chu X,Moiseenko A,Weiss A,Wilhelm J,Zhang JS,Kwapiszewska G,Herold S,Schermuly RT,Mari B,Li X,Seeger W,Günther A,Bellusci S,El Agha E

更新日期：2019-07-05 00:00:00

abstract：:Coelacanths are known for their evolutionary conservatism, and the body plan seen in Latimeria can be traced to late Middle Devonian Diplocercides, Holopterygius and presumably Euporosteus. However, the group's early history is unclear because of an incomplete fossil record. Until now, the only Early Devonian coelacan...

journal_title：Nature communications

authors： Zhu M,Yu X,Lu J,Qiao T,Zhao W,Jia L

更新日期：2012-04-10 00:00:00