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Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis.

Abstract：

:Erythropoietin (Epo) supports both primitive erythropoiesis in the yolk sac and definitive erythropoiesis in the fetal liver and bone marrow. Although definitive erythropoiesis requires kidney- and liver-secreted Epo, it is unclear which cells produce Epo for primitive erythropoiesis. Here we find neural Epo-producing (NEP) cells in mid-gestational stage embryos using mouse lines that express green fluorescent protein (GFP) under the Epo gene regulation. In these mice, GFP is expressed exclusively in a subpopulation of neural and neural crest cells at embryonic day 9.0 when Epo-deficient embryos exhibit abnormalities in primitive erythropoiesis. The GFP-positive NEP cells express Epo mRNA and the ex vivo culture of embryonic day 8.5 neural tubes results in the secretion of Epo, which is able to induce the proliferation and differentiation of yolk sac-derived erythroid cells. These results thus suggest that NEP cells secrete Epo and might support the development of primitive erythropoiesis.

journal_name

Nat Commun

journal_title

Nature communications

authors

Suzuki N,Hirano I,Pan X,Minegishi N,Yamamoto M

doi

10.1038/ncomms3902

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

2902

issn

2041-1723

pii

ncomms3902

journal_volume

4

pub_type

杂志文章

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