Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps.

abstract：:Insects that use ephemeral resources must rapidly digest nutrients and simultaneously protect them from competitors. Here we use burying beetles (Nicrophorus vespilloides), which feed their offspring on vertebrate carrion, to investigate the digestive and defensive basis of carrion utilization. We characterize gene ex...

journal_title：Nature communications

authors： Vogel H,Shukla SP,Engl T,Weiss B,Fischer R,Steiger S,Heckel DG,Kaltenpoth M,Vilcinskas A

更新日期：2017-05-09 00:00:00

abstract：:Mass extinction events are short-lived and characterized by catastrophic biosphere collapse and subsequent reorganization. Their abrupt nature necessitates a similarly short-lived trigger, and large igneous province magmatism is often implicated. However, large igneous provinces are long-lived compared to mass extinct...

journal_title：Nature communications

authors： Burgess SD,Muirhead JD,Bowring SA

更新日期：2017-07-31 00:00:00

abstract：:HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcinogen...

journal_title：Nature communications

authors： Zhu B,Xiao Y,Yeager M,Clifford G,Wentzensen N,Cullen M,Boland JF,Bass S,Steinberg MK,Raine-Bennett T,Lee D,Burk RD,Pinheiro M,Song L,Dean M,Nelson CW,Burdett L,Yu K,Roberson D,Lorey T,Franceschi S,Castle PE,Wa

更新日期：2020-02-14 00:00:00

abstract：:MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of ubiquitination of MAVS and MITA at different phases of viral infection...

journal_title：Nature communications

authors： Zhang ZD,Xiong TC,Yao SQ,Wei MC,Chen M,Lin D,Zhong B

更新日期：2020-11-02 00:00:00

abstract：:It is unclear whether the establishment of apical-basal cell polarity during the generation of epithelial lumens requires molecules acting at the plasma membrane/actin interface. Here, we show that the I-BAR-containing IRSp53 protein controls lumen formation and the positioning of the polarity determinants aPKC and po...

journal_title：Nature communications

authors： Bisi S,Marchesi S,Rizvi A,Carra D,Beznoussenko GV,Ferrara I,Deflorian G,Mironov A,Bertalot G,Pisati F,Oldani A,Cattaneo A,Saberamoli G,Pece S,Viale G,Bachi A,Tripodo C,Scita G,Disanza A

更新日期：2020-07-14 00:00:00

abstract：:Metal particles supported on oxide surfaces are used as catalysts for a wide variety of processes in the chemical and energy conversion industries. For catalytic applications, metal particles are generally formed on an oxide support by physical or chemical deposition, or less commonly by exsolution from it. Although f...

journal_title：Nature communications

authors： Neagu D,Oh TS,Miller DN,Ménard H,Bukhari SM,Gamble SR,Gorte RJ,Vohs JM,Irvine JTS

更新日期：2015-09-11 00:00:00

abstract：:It has been observed that concentrated solutions of short DNA oligomers develop liquid crystal ordering as the result of a hierarchically structured supramolecular self-assembly. In mixtures of oligomers with various degree of complementarity, liquid crystal microdomains are formed via the selective aggregation of tho...

journal_title：Nature communications

authors： Fraccia TP,Smith GP,Zanchetta G,Paraboschi E,Yi Y,Walba DM,Dieci G,Clark NA,Bellini T

更新日期：2015-03-10 00:00:00

abstract：:Cortical neurons are often functionally heterogeneous even for molecularly defined subtypes. In sensory cortices, physiological responses to natural stimuli can be sparse and vary widely even for neighboring neurons. It is thus difficult to parse out circuits that encode specific stimuli for further experimentation. H...

journal_title：Nature communications

authors： Tasaka GI,Guenthner CJ,Shalev A,Gilday O,Luo L,Mizrahi A

更新日期：2018-02-28 00:00:00

abstract：:Materials genomics represents a research mode for materials development, for which reliable methods for efficient materials construction are essential. Here we present a methodology for high-throughput construction of covalent organic frameworks (COFs) based on materials genomics strategy, in which a gene partition me...

journal_title：Nature communications

authors： Lan Y,Han X,Tong M,Huang H,Yang Q,Liu D,Zhao X,Zhong C

更新日期：2018-12-10 00:00:00

abstract：:Development of promising battery systems is being intensified to fulfil the needs of long-driving-ranged electric vehicles. The successful candidates for new generation batteries should have higher energy densities than those of currently used batteries and reasonable rechargeability. Here we report that aqueous lithi...

journal_title：Nature communications

authors： Zhao Y,Wang L,Byon HR

更新日期：2013-01-01 00:00:00

abstract：:Non-line-of-sight (NLOS) imaging recovers objects using diffusely reflected indirect light using transient illumination devices in combination with a computational inverse method. While capture systems capable of collecting light from the entire NLOS relay surface can be much more light efficient than single pixel poi...

journal_title：Nature communications

authors： Liu X,Bauer S,Velten A

更新日期：2020-04-02 00:00:00

abstract：:Supercooled liquids exhibit spatial heterogeneity in the dynamics of their fluctuating atomic arrangements. The length and time scales of the heterogeneous dynamics are central to the glass transition and influence nucleation and growth of crystals from the liquid. Here, we report direct experimental visualization of ...

journal_title：Nature communications

authors： Zhang P,Maldonis JJ,Liu Z,Schroers J,Voyles PM

更新日期：2018-03-19 00:00:00

abstract：:Defect-free monolayers of graphene and hexagonal boron nitride are surprisingly permeable to thermal protons, despite being completely impenetrable to all gases. It remains untested whether small ions can permeate through the two-dimensional crystals. Here we show that mechanically exfoliated graphene and hexagonal bo...

journal_title：Nature communications

authors： Mogg L,Zhang S,Hao GP,Gopinadhan K,Barry D,Liu BL,Cheng HM,Geim AK,Lozada-Hidalgo M

更新日期：2019-09-18 00:00:00

abstract：:HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man9-V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope...

journal_title：Nature communications

authors： Fera D,Lee MS,Wiehe K,Meyerhoff RR,Piai A,Bonsignori M,Aussedat B,Walkowicz WE,Ton T,Zhou JO,Danishefsky S,Haynes BF,Harrison SC

更新日期：2018-03-16 00:00:00

abstract：:In-plane anisotropic ground states are ubiquitous in correlated solids such as pnictides, cuprates and manganites. They can arise from doping Mott insulators and compete with phases such as superconductivity; however, their origins are debated. Strong coupling between lattice, charge, orbital and spin degrees of freed...

journal_title：Nature communications

authors： Miller TA,Chhajlany RW,Tagliacozzo L,Green B,Kovalev S,Prabhakaran D,Lewenstein M,Gensch M,Wall S

更新日期：2015-09-18 00:00:00

abstract：:Insects have presented human society with some of its greatest development challenges by spreading diseases, consuming crops and damaging infrastructure. Despite the massive human and financial toll of invasive insects, cost estimates of their impacts remain sporadic, spatially incomplete and of questionable quality. ...

journal_title：Nature communications

authors： Bradshaw CJ,Leroy B,Bellard C,Roiz D,Albert C,Fournier A,Barbet-Massin M,Salles JM,Simard F,Courchamp F

更新日期：2016-10-04 00:00:00

abstract：:Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one inflammasome constituent, but little is known about its cellular handling. Here we show a mechanism for NALP7 protein stabil...

journal_title：Nature communications

authors： Bednash JS,Weathington N,Londino J,Rojas M,Gulick DL,Fort R,Han S,McKelvey AC,Chen BB,Mallampalli RK

更新日期：2017-05-11 00:00:00

abstract：:A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach for increasing the opportunities to rationally access natural product with novel structures and biological activities through total biosynthesis and combinatorial biosynthesis. Here, we demonstrate the adva...

journal_title：Nature communications

authors： Tsukada K,Shinki S,Kaneko A,Murakami K,Irie K,Murai M,Miyoshi H,Dan S,Kawaji K,Hayashi H,Kodama EN,Hori A,Salim E,Kuraishi T,Hirata N,Kanda Y,Asai T

更新日期：2020-04-14 00:00:00

abstract：:The early diversification of animals (∼ 630 Ma), and their development into both motile and macroscopic forms (∼ 575-565 Ma), has been linked to stepwise increases in the oxygenation of Earth's surface environment. However, establishing such a linkage between oxygen and evolution for the later Cambrian 'explosion' (54...

journal_title：Nature communications

authors： Chen X,Ling HF,Vance D,Shields-Zhou GA,Zhu M,Poulton SW,Och LM,Jiang SY,Li D,Cremonese L,Archer C

更新日期：2015-05-18 00:00:00

abstract：:The mega-diversity of herbivorous insects is attributed to their co-evolutionary associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether host-plant shifts have impacted both genomic adaptation and species diversification over geological times. We show that the antagonist...

journal_title：Nature communications

authors： Allio R,Nabholz B,Wanke S,Chomicki G,Pérez-Escobar OA,Cotton AM,Clamens AL,Kergoat GJ,Sperling FAH,Condamine FL

更新日期：2021-01-13 00:00:00

abstract：:Biocatalytic cyclization is highly desirable for efficient synthesis of biologically derived chemical substances, such as the commodity chemicals ε-caprolactam and δ-valerolactam. To identify biocatalysts in lactam biosynthesis, we develop a caprolactam-detecting genetic enzyme screening system (CL-GESS). The Alcalige...

journal_title：Nature communications

authors： Yeom SJ,Kim M,Kwon KK,Fu Y,Rha E,Park SH,Lee H,Kim H,Lee DH,Kim DM,Lee SG

更新日期：2018-11-29 00:00:00

abstract：:Bird song has historically been considered an almost exclusively male trait, an observation fundamental to the formulation of Darwin's theory of sexual selection. Like other male ornaments, song is used by male songbirds to attract females and compete with rivals. Thus, bird song has become a textbook example of the p...

journal_title：Nature communications

authors： Odom KJ,Hall ML,Riebel K,Omland KE,Langmore NE

更新日期：2014-03-04 00:00:00

abstract：:Solid-state quantum acoustodynamic (QAD) systems provide a compact platform for quantum information storage and processing by coupling acoustic phonon sources with superconducting or spin qubits. The multi-mode composite high-overtone bulk acoustic wave resonator (HBAR) is a popular phonon source well suited for QAD. ...

journal_title：Nature communications

authors： Gokhale VJ,Downey BP,Katzer DS,Nepal N,Lang AC,Stroud RM,Meyer DJ

更新日期：2020-05-08 00:00:00

abstract：:Scenarios that limit global warming to below 2 °C by 2100 assume significant land-use change to support large-scale carbon dioxide (CO2) removal from the atmosphere by afforestation/reforestation, avoided deforestation, and Biomass Energy with Carbon Capture and Storage (BECCS). The more ambitious mitigation scenarios...

journal_title：Nature communications

authors： Harper AB,Powell T,Cox PM,House J,Huntingford C,Lenton TM,Sitch S,Burke E,Chadburn SE,Collins WJ,Comyn-Platt E,Daioglou V,Doelman JC,Hayman G,Robertson E,van Vuuren D,Wiltshire A,Webber CP,Bastos A,Boysen L,Ciais

更新日期：2018-08-07 00:00:00

abstract：:CD8+ T cells provide a critical defence from pathogens at mucosal epithelia including the female reproductive tract (FRT). Mucosal immunisation is considered essential to initiate this response, however this is difficult to reconcile with evidence that antigen delivered to skin can recruit protective CD8+ T cells to m...

journal_title：Nature communications

authors： Zaric M,Becker PD,Hervouet C,Kalcheva P,Doszpoly A,Blattman N,A O' Neill L,Yus BI,Cocita C,Kwon SY,Baker AH,Lord GM,Klavinskis LS

更新日期：2019-05-17 00:00:00

abstract：:Clock genes are expressed throughout the body, although how they oscillate in unrestrained animals is not known. Here, we show an in vivo imaging technique that enables long-term simultaneous imaging of multiple tissues. We use dual-focal 3D tracking and signal-intensity calibration to follow gene expression in a targ...

journal_title：Nature communications

authors： Hamada T,Sutherland K,Ishikawa M,Miyamoto N,Honma S,Shirato H,Honma K

更新日期：2016-06-10 00:00:00

abstract：:Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including invariant natural killer T (iNKT) and γδ-T cells, but their contributio...

journal_title：Nature communications

authors： Venken K,Jacques P,Mortier C,Labadia ME,Decruy T,Coudenys J,Hoyt K,Wayne AL,Hughes R,Turner M,Van Gassen S,Martens L,Smith D,Harcken C,Wahle J,Wang CT,Verheugen E,Schryvers N,Varkas G,Cypers H,Wittoek R,Piette Y

更新日期：2019-01-02 00:00:00

abstract：:In contrast to processive molecular motors, skeletal myosins form a large motor ensemble for contraction of muscles against high loads. Despite numerous information on the molecular properties of skeletal myosin, its ensemble effects on collective force generation have not been rigorously clarified. Here we show 4 nm ...

journal_title：Nature communications

authors： Kaya M,Tani Y,Washio T,Hisada T,Higuchi H

更新日期：2017-07-06 00:00:00

abstract：:The emerging monolayer transition metal dichalcogenides have provided an unprecedented material platform for miniaturized opto-electronic devices with integrated functionalities. Although excitonic light-matter interactions associated with their direct bandgaps have received tremendous research efforts, wavefront engi...

journal_title：Nature communications

authors： Qin F,Liu B,Zhu L,Lei J,Fang W,Hu D,Zhu Y,Ma W,Wang B,Shi T,Cao Y,Guan BO,Qiu CW,Lu Y,Li X

更新日期：2021-01-04 00:00:00

abstract：:Most chemical vapor deposition methods for transition metal dichalcogenides use an extremely small amount of precursor to render large single-crystal flakes, which usually causes low coverage of the materials on the substrate. In this study, a self-capping vapor-liquid-solid reaction is proposed to fabricate large-gra...

journal_title：Nature communications

authors： Chang MC,Ho PH,Tseng MF,Lin FY,Hou CH,Lin IK,Wang H,Huang PP,Chiang CH,Yang YC,Wang IT,Du HY,Wen CY,Shyue JJ,Chen CW,Chen KH,Chiu PW,Chen LC

更新日期：2020-07-23 00:00:00