Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.

abstract：:FeV(O)(OH) species have long been proposed to play a key role in a wide range of biomimetic and enzymatic oxidations, including as intermediates in arene dihydroxylation catalyzed by Rieske oxygenases. However, the inability to accumulate these intermediates in solution has thus far prevented their spectroscopic and c...

journal_title：Nature communications

authors： Borrell M,Andris E,Navrátil R,Roithová J,Costas M

更新日期：2019-02-22 00:00:00

abstract：:Ensuring that protected areas (PAs) maintain the biodiversity within their boundaries is fundamental in achieving global conservation goals. Despite this objective, wildlife abundance changes in PAs are patchily documented and poorly understood. Here, we use linear mixed effect models to explore correlates of populati...

journal_title：Nature communications

authors： Barnes MD,Craigie ID,Harrison LB,Geldmann J,Collen B,Whitmee S,Balmford A,Burgess ND,Brooks T,Hockings M,Woodley S

更新日期：2016-09-01 00:00:00

abstract：:Tibetan wheat is grown under environmental constraints at high-altitude conditions, but its underlying adaptation mechanism remains unknown. Here, we present a draft genome sequence of a Tibetan semi-wild wheat (Triticum aestivum ssp. tibetanum Shao) accession Zang1817 and re-sequence 245 wheat accessions, including w...

journal_title：Nature communications

authors： Guo W,Xin M,Wang Z,Yao Y,Hu Z,Song W,Yu K,Chen Y,Wang X,Guan P,Appels R,Peng H,Ni Z,Sun Q

更新日期：2020-10-08 00:00:00

abstract：:Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are evolutionarily and biochemically distinct from cytoplasmic dyneins that transport cargo, and the mechanisms regulating their localizat...

journal_title：Nature communications

authors： Walton T,Wu H,Brown A

更新日期：2021-01-20 00:00:00

abstract：:Many regulatory and signaling proteins have multiple modification sites. In bacterial chemotaxis, each chemoreceptor has multiple methylation sites that are responsible for adaptation. However, whether the ordering of the multisite methylation process affects adaptation remains unclear. Furthermore, the benefit of hav...

journal_title：Nature communications

authors： Mello BA,Beserra AB,Tu Y

更新日期：2020-06-08 00:00:00

abstract：:How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep...

journal_title：Nature communications

authors： Seibt J,Richard CJ,Sigl-Glöckner J,Takahashi N,Kaplan DI,Doron G,de Limoges D,Bocklisch C,Larkum ME

更新日期：2017-09-25 00:00:00

abstract：:The rapid development of scientific CMOS (sCMOS) technology has greatly advanced optical microscopy for biomedical research with superior sensitivity, resolution, field-of-view, and frame rates. However, for sCMOS sensors, the parallel charge-voltage conversion and different responsivity at each pixel induces extra re...

journal_title：Nature communications

authors： Mandracchia B,Hua X,Guo C,Son J,Urner T,Jia S

更新日期：2020-01-03 00:00:00

abstract：:Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain, which must be folded in a process that entraps segments of an N-terminal passenger domain. This first stage of autotransporter folding determines whether subsequent translocation can deliver the N-terminal domain to its functional for...

journal_title：Nature communications

authors： Leyton DL,Johnson MD,Thapa R,Huysmans GH,Dunstan RA,Celik N,Shen HH,Loo D,Belousoff MJ,Purcell AW,Henderson IR,Beddoe T,Rossjohn J,Martin LL,Strugnell RA,Lithgow T

更新日期：2014-06-26 00:00:00

abstract：:Geometric phase, associated with holonomy transformation in quantum state space, is an important quantum-mechanical effect. Besides fundamental interest, this effect has practical applications, among which geometric quantum computation is a paradigm, where quantum logic operations are realized through geometric phase ...

journal_title：Nature communications

authors： Song C,Zheng SB,Zhang P,Xu K,Zhang L,Guo Q,Liu W,Xu D,Deng H,Huang K,Zheng D,Zhu X,Wang H

更新日期：2017-10-20 00:00:00

abstract：:A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying the harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous glucose storage in the form of glycogen, resistance to oxidative...

journal_title：Nature communications

authors： Gusarov I,Pani B,Gautier L,Smolentseva O,Eremina S,Shamovsky I,Katkova-Zhukotskaya O,Mironov A,Nudler E

更新日期：2017-06-19 00:00:00

abstract：:Mangrove forests hold some of the highest densities of carbon recorded in any ecosystem, but have experienced widespread deforestation through conversion to aquaculture and agriculture. Alongside deforestation, mangroves have shown simultaneous natural expansion in some parts of the world, and considerable investments...

journal_title：Nature communications

authors： Richards DR,Thompson BS,Wijedasa L

更新日期：2020-08-26 00:00:00

abstract：:Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. The NAc receives glutamatergic inputs from the medial prefrontal cortex ...

journal_title：Nature communications

authors： Bagot RC,Parise EM,Peña CJ,Zhang HX,Maze I,Chaudhury D,Persaud B,Cachope R,Bolaños-Guzmán CA,Cheer JF,Deisseroth K,Han MH,Nestler EJ

更新日期：2015-05-08 00:00:00

abstract：:Polycyclic aromatic hydrocarbons as well as other organic molecules appear among the most abundant observed species in interstellar space and are key molecules to understanding the prebiotic roots of life. However, their existence and abundance in space remain a puzzle. Here we present a new top-down route to form pol...

journal_title：Nature communications

authors： Merino P,Švec M,Martinez JI,Jelinek P,Lacovig P,Dalmiglio M,Lizzit S,Soukiassian P,Cernicharo J,Martin-Gago JA

更新日期：2014-01-01 00:00:00

abstract：:Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble org...

journal_title：Nature communications

authors： Antaris AL,Chen H,Diao S,Ma Z,Zhang Z,Zhu S,Wang J,Lozano AX,Fan Q,Chew L,Zhu M,Cheng K,Hong X,Dai H,Cheng Z

更新日期：2017-05-19 00:00:00

abstract：:Non-aromatic nitrogen- and oxygen-containing heterocycles such as piperidines and pyrans are prevalent components of natural products and pharmaceutical drugs. Although it has been a workhorse as a synthetic method for assembling unsaturated sp(2)-hybridized substrates, transition metal-catalysed cross-coupling chemis...

journal_title：Nature communications

authors： Ding J,Rybak T,Hall DG

更新日期：2014-11-18 00:00:00

abstract：:Silicon dioxide is one of the most abundant natural compounds. Polymorphs of SiO₂ and their phase transitions have long been a focus of great interest and intense theoretical and experimental pursuits. Here, compressing single-crystal coesite SiO₂ under hydrostatic pressures of 26-53 GPa at room temperature, we discov...

journal_title：Nature communications

authors： Hu QY,Shu JF,Cadien A,Meng Y,Yang WG,Sheng HW,Mao HK

更新日期：2015-03-20 00:00:00

abstract：:The original version of this Article contained errors in the units of concentration of three reagents listed in the Methods. These errors have all been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Stepanauskas R,Fergusson EA,Brown J,Poulton NJ,Tupper B,Labonté JM,Becraft ED,Brown JM,Pachiadaki MG,Povilaitis T,Thompson BP,Mascena CJ,Bellows WK,Lubys A

更新日期：2017-12-12 00:00:00

abstract：:Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP is essential for l...

journal_title：Nature communications

authors： Johnson AE,Orr BO,Fetter RD,Moughamian AJ,Primeaux LA,Geier EG,Yokoyama JS,Miller BL,Davis GW

更新日期：2021-01-21 00:00:00

abstract：:5-Methylfurfural (MF) is a very useful chemical. Selective hydrogenation of biomass platform molecule 5-(hydroxymethyl)furfural (HMF) to MF using H2 as the reducing agent is very attractive, but challenging because hydrogenation of C=O bond in HMF is more favourable than C-OH both kinetically and thermodynamically, an...

journal_title：Nature communications

authors： Li S,Dong M,Yang J,Cheng X,Shen X,Liu S,Wang ZQ,Gong XQ,Liu H,Han B

更新日期：2021-01-26 00:00:00

abstract：:Epitaxy is widely employed to create highly oriented crystalline films. A less appreciated, but nonetheless powerful means of creating such films is via topotactic transformation, in which a chemical reaction transforms a single crystal of one phase into a single crystal of a different phase, which inherits its orient...

journal_title：Nature communications

authors： Mairoser T,Mundy JA,Melville A,Hodash D,Cueva P,Held R,Glavic A,Schubert J,Muller DA,Schlom DG,Schmehl A

更新日期：2015-07-16 00:00:00

abstract：:Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epig...

journal_title：Nature communications

authors： Perone Y,Farrugia AJ,Rodríguez-Meira A,Győrffy B,Ion C,Uggetti A,Chronopoulos A,Marrazzo P,Faronato M,Shousha S,Davies C,Steel JH,Patel N,Del Rio Hernandez A,Coombes C,Pruneri G,Lim A,Calvo F,Magnani L

更新日期：2019-05-09 00:00:00

abstract：:Micro-optics are widely used in numerous applications, such as beam shaping, collimation, focusing and imaging. We use femtosecond 3D printing to manufacture free-form micro-optical elements. Our method gives sub-micrometre accuracy so that direct manufacturing even on single-mode fibres is possible. We demonstrate th...

journal_title：Nature communications

authors： Gissibl T,Thiele S,Herkommer A,Giessen H

更新日期：2016-06-24 00:00:00

abstract：:In LaAlO(3)/SrTiO(3) heterointerfaces, charge carriers migrate from the LaAlO(3) to the interface in an electronic reconstruction. Magnetism has been observed in LaAlO(3)/SrTiO(3), but its relationship to the interface conductivity is unknown. Here we show that reconstruction is necessary, but not sufficient, for the ...

journal_title：Nature communications

authors： Kalisky B,Bert JA,Klopfer BB,Bell C,Sato HK,Hosoda M,Hikita Y,Hwang HY,Moler KA

更新日期：2012-06-26 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alternative strategies ...

journal_title：Nature communications

authors： Krarup A,Truan D,Furmanova-Hollenstein P,Bogaert L,Bouchier P,Bisschop IJM,Widjojoatmodjo MN,Zahn R,Schuitemaker H,McLellan JS,Langedijk JPM

更新日期：2015-09-03 00:00:00

abstract：:Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of BRCA1 promoter hypermethylation in 237 triple-negative breast cancers (TNBCs) from a population-based study using rep...

journal_title：Nature communications

authors： Glodzik D,Bosch A,Hartman J,Aine M,Vallon-Christersson J,Reuterswärd C,Karlsson A,Mitra S,Niméus E,Holm K,Häkkinen J,Hegardt C,Saal LH,Larsson C,Malmberg M,Rydén L,Ehinger A,Loman N,Kvist A,Ehrencrona H,Nik-Zainal

更新日期：2020-07-27 00:00:00

abstract：:The Mid-Cayman spreading centre is an ultraslow-spreading ridge in the Caribbean Sea. Its extreme depth and geographic isolation from other mid-ocean ridges offer insights into the effects of pressure on hydrothermal venting, and the biogeography of vent fauna. Here we report the discovery of two hydrothermal vent fie...

journal_title：Nature communications

authors： Connelly DP,Copley JT,Murton BJ,Stansfield K,Tyler PA,German CR,Van Dover CL,Amon D,Furlong M,Grindlay N,Hayman N,Hühnerbach V,Judge M,Le Bas T,McPhail S,Meier A,Nakamura K,Nye V,Pebody M,Pedersen RB,Plouviez S,

更新日期：2012-01-10 00:00:00

abstract：:Architectural proteins have an important role in shaping the genome and act as global regulators of gene expression. How these proteins jointly modulate genome plasticity is largely unknown. In archaea, one of the most abundant proteins, Alba, is considered to have a key role in organizing the genome. Here we characte...

journal_title：Nature communications

authors： Laurens N,Driessen RP,Heller I,Vorselen D,Noom MC,Hol FJ,White MF,Dame RT,Wuite GJ

更新日期：2012-01-01 00:00:00

abstract：:Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N2O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether NO can be used by micr...

journal_title：Nature communications

authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

更新日期：2019-03-20 00:00:00

abstract：:Radiotherapy is not currently informed by the genetic composition of an individual patient's tumour. To identify genetic features regulating survival after DNA damage, here we conduct large-scale profiling of cellular survival after exposure to radiation in a diverse collection of 533 genetically annotated human tumou...

journal_title：Nature communications

authors： Yard BD,Adams DJ,Chie EK,Tamayo P,Battaglia JS,Gopal P,Rogacki K,Pearson BE,Phillips J,Raymond DP,Pennell NA,Almeida F,Cheah JH,Clemons PA,Shamji A,Peacock CD,Schreiber SL,Hammerman PS,Abazeed ME

更新日期：2016-04-25 00:00:00

abstract：:Phospholipase C is a key enzyme in phosphoinositide turnover. Although its functions have been extensively studied at the cellular level, many questions remain concerning its functions at the organ and individual animal levels. Here we demonstrate that mice lacking phospholipase Cδ1 develop granulocytosis associated w...

journal_title：Nature communications

authors： Kanemaru K,Nakamura Y,Sato K,Kojima R,Takahashi S,Yamaguchi M,Ichinohe M,Kiyonari H,Shioi G,Kabashima K,Nakahigashi K,Asagiri M,Jamora C,Yamaguchi H,Fukami K

更新日期：2012-07-17 00:00:00