Abstract:
:Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epigenetic reprogramming in aromatase inhibitors (AI)-resistant cells, leading to Keratin-80 (KRT80) upregulation. KRT80 expression is driven by de novo enhancer activation by sterol regulatory element-binding protein 1 (SREBP1). KRT80 upregulation directly promotes cytoskeletal rearrangements at the leading edge, increased focal adhesion and cellular stiffening, collectively promoting cancer cell invasion. Shearwave elasticity imaging performed on prospectively recruited patients confirms KRT80 levels correlate with stiffer tumors. Immunohistochemistry showed increased KRT80-positive cells at relapse and, using several clinical endpoints, KRT80 expression associates with poor survival. Collectively, our data uncover an unpredicted and potentially targetable direct link between epigenetic and cytoskeletal reprogramming promoting cell invasion in response to chronic AI treatment.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Perone Y,Farrugia AJ,Rodríguez-Meira A,Győrffy B,Ion C,Uggetti A,Chronopoulos A,Marrazzo P,Faronato M,Shousha S,Davies C,Steel JH,Patel N,Del Rio Hernandez A,Coombes C,Pruneri G,Lim A,Calvo F,Magnani Ldoi
10.1038/s41467-019-09676-ysubject
Has Abstractpub_date
2019-05-09 00:00:00pages
2115issue
1issn
2041-1723pii
10.1038/s41467-019-09676-yjournal_volume
10pub_type
杂志文章abstract::With its light weight, low cost and high efficiency even at low operation frequency, the triboelectric nanogenerator is considered a potential solution for self-powered sensor networks and large-scale renewable blue energy. As an energy harvester, its output power density and efficiency are dictated by the triboelectr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00131-4
更新日期:2017-07-20 00:00:00
abstract::TFIIS-like transcript cleavage factors enhance the processivity and fidelity of archaeal and eukaryotic RNA polymerases. Sulfolobus solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evolved into a potent RNA polymerase inhibitor. TFS4 destabilises the TBP-TFB-RNAP pre-initiation com...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02081-3
更新日期:2017-12-04 00:00:00
abstract::Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the choles...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07959-4
更新日期:2019-01-09 00:00:00
abstract::Biodiversity loss can alter ecosystem functioning; however, it remains unclear how it alters decomposition-a critical component of biogeochemical cycles in the biosphere. Here, we provide a global-scale meta-analysis to quantify how changes in the diversity of organic matter derived from plants (i.e. litter) affect ra...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-020-18296-w
更新日期:2020-09-11 00:00:00
abstract::Acetylene hydrochlorination is an important coal-based technology for the industrial production of vinyl chloride, however it is plagued by the toxicity of the mercury chloride catalyst. Therefore extensive efforts have been made to explore alternative catalysts with various metals. Here we report that a nanocomposite...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4688
更新日期:2014-04-22 00:00:00
abstract::Topologically nontrivial materials host protected edge states associated with the bulk band inversion through the bulk-edge correspondence. Manipulating such edge states is highly desired for developing new functions and devices practically using their dissipation-less nature and spin-momentum locking. Here we introdu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16290-w
更新日期:2020-05-18 00:00:00
abstract::The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, in the original HTML version of this...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-08107-8
更新日期:2019-01-10 00:00:00
abstract::Microbial community structure can be analyzed by quantifying cell numbers or by quantifying biomass for individual populations. Methods for quantifying cell numbers are already available (e.g., fluorescence in situ hybridization, 16-S rRNA gene amplicon sequencing), yet high-throughput methods for assessing community ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01544-x
更新日期:2017-11-16 00:00:00
abstract::In magnetic materials, the Pauli exclusion principle typically drives anti-alignment between electron spins on neighbouring species resulting in antiferromagnetic behaviour. Ferromagnetism exhibiting spontaneous spin alignment is a fairly rare behaviour, but once materialized is often associated with itinerant electro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7677
更新日期:2015-03-25 00:00:00
abstract::Non-linear interactions in coherent gases are not only at the origin of bright and dark solitons and superfluids; they also give rise to phenomena such as multistability, which hold great promise for the development of advanced photonic and spintronic devices. In particular, spinor multistability in strongly coupled s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3008
更新日期:2013-01-01 00:00:00
abstract::Many ecological responses to climate change have been documented. However, due to indirect effects, some responses can be complex and difficult to predict. For example, our understanding of effects on consumers involving responses on several trophic levels is limited. Here, combining the knowledge of trophic interacti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6992
更新日期:2015-01-14 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-14316-x
更新日期:2020-01-14 00:00:00
abstract::Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides. Erastin, the ferroptosis activator, binds to voltage-dependent anion channels VDAC2 and VDCA3, but treatment with erastin can result in the degradation of the channels. Here, the author...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14324-x
更新日期:2020-01-23 00:00:00
abstract::Mitochondria and peroxisomes proliferate by division. During division, a part of their membrane is pinched off by constriction of the ring-shaped mitochondrial division (MD) and peroxisome-dividing (POD) machinery. This constriction is mediated by a dynamin-like GTPase Dnm1 that requires a large amount of GTP as an en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07009-z
更新日期:2018-11-06 00:00:00
abstract::LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09711-y
更新日期:2019-05-20 00:00:00
abstract::Many glasses exhibit fractional power law (FPL) between the mean atomic volume va and the first diffraction peak position q1, i.e. [Formula: see text] with d ≃ 2.5 deviating from the space dimension D = 3, under compression or composition change. What structural change causes such FPL and whether the FPL and d are uni...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15583-4
更新日期:2020-04-24 00:00:00
abstract::The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR st...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6383
更新日期:2014-11-21 00:00:00
abstract::China has enacted a series of policies since 2015 to substitute electricity for in-home combustion for rural residential heating. The Electric Heating Policy (EHP) has contributed to significant improvements in air quality, benefiting hundreds of millions of people. This shift, however, has resulted in a sharp increas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19854-y
更新日期:2020-11-27 00:00:00
abstract::Foldamers provide an attractive medium to test the mechanisms by which biological macromolecules fold into complex three-dimensional structures, and ultimately to design novel protein-like architectures with properties unprecedented in nature. Here, we describe a large cage-like structure formed from an amphiphilic ar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4581
更新日期:2014-04-07 00:00:00
abstract::A superconducting state is characterized by the gap in the electronic density of states, which vanishes at the superconducting transition temperature T(c). It was discovered that in high-temperature superconductors, a noticeable depression in the density of states, the pseudogap, still remains even at temperatures abo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1140
更新日期:2010-01-01 00:00:00
abstract::Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological and behavioural influences. However, cerebral contributions beyond nociception are not yet well characterized, leading to a predominant focus on nociception when studying pain and developing interventions. Here we use...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14211
更新日期:2017-02-14 00:00:00
abstract::Non-aromatic nitrogen- and oxygen-containing heterocycles such as piperidines and pyrans are prevalent components of natural products and pharmaceutical drugs. Although it has been a workhorse as a synthetic method for assembling unsaturated sp(2)-hybridized substrates, transition metal-catalysed cross-coupling chemis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6474
更新日期:2014-11-18 00:00:00
abstract::The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7003
更新日期:2015-01-29 00:00:00
abstract::For societies with writing systems, hereditary leadership is documented as one of the hallmarks of early political complexity and governance. In contrast, it is unknown whether hereditary succession played a role in the early formation of prehistoric complex societies that lacked writing. Here we use an archaeogenomic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14115
更新日期:2017-02-21 00:00:00
abstract::During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting mechanical tension. In this context, it is unclear how mechanica...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07448-8
更新日期:2018-11-27 00:00:00
abstract::Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs, including the most commonly prescribed antifungal, fluconazole. Here, we use a combinatorial screening approach to identify a bis-benzodioxolylindolinone (azoffluxin) that synergizes with fluconazole against C. auris. Azoffluxin e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20183-3
更新日期:2020-12-22 00:00:00
abstract::Tunnel junctions, an established platform for high resolution spectroscopy of superconductors, require defect-free insulating barriers; however, oxides, the most common barrier, can only grow on a limited selection of materials. We show that van der Waals tunnel barriers, fabricated by exfoliation and transfer of laye...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03000-w
更新日期:2018-02-09 00:00:00
abstract::Thanks to the nature of strong programmability, field-programmable gate arrays (FPGAs) have been playing a significant role in signal processing and control. With the explosive growth in digital data, big data analytics becomes an important emerging field, in which FPGAs are a major player. However, the computational ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14249-0
更新日期:2020-01-21 00:00:00
abstract::Polyps of the cnidarian Hydra maintain their adult anatomy through two developmental organizers, the head organizer located apically and the foot organizer basally. The head organizer is made of two antagonistic cross-reacting components, an activator, driving apical differentiation and an inhibitor, preventing ectopi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08242-2
更新日期:2019-01-18 00:00:00
abstract::The cycling of carbon between Earth's surface and interior governs the long-term habitability of the planet. But how carbon migrates in the deep Earth is not well understood. In particular, the potential role of hydrocarbon fluids in the deep carbon cycle has long been controversial. Here we show that immiscible isobu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15798
更新日期:2017-06-12 00:00:00