Abstract：
:Many regulatory and signaling proteins have multiple modification sites. In bacterial chemotaxis, each chemoreceptor has multiple methylation sites that are responsible for adaptation. However, whether the ordering of the multisite methylation process affects adaptation remains unclear. Furthermore, the benefit of having multiple modification sites is also unclear. Here, we show that sequentially ordered methylation/demethylation is critical for perfect adaptation; adaptation accuracy decreases as randomness in the multisite methylation process increases. A tradeoff between adaptation accuracy and response gain is discovered. We find that this accuracy-gain tradeoff is lifted significantly by having more methylation sites, but only when the multisite modification process is sequential. Our study suggests that having multiple modification sites and a sequential modification process constitute a general strategy to achieve both accurate adaptation and high response gain simultaneously. Our theory agrees with existing data and predictions are made to help identify the molecular mechanism underlying ordered covalent modifications.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Mello BA,Beserra AB,Tu Ydoi
10.1038/s41467-020-16644-4subject
Has Abstractpub_date
2020-06-08 00:00:00pages
2875issue
1issn
2041-1723pii
10.1038/s41467-020-16644-4journal_volume
11pub_type
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