Origin and adaptation to high altitude of Tibetan semi-wild wheat.

abstract：:Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune sign...

journal_title：Nature communications

authors： Singhania A,Graham CM,Gabryšová L,Moreira-Teixeira L,Stavropoulos E,Pitt JM,Chakravarty P,Warnatsch A,Branchett WJ,Conejero L,Lin JW,Davidson S,Wilson MS,Bancroft G,Langhorne J,Frickel E,Sesay AK,Priestnall SL,Herbert

更新日期：2019-06-28 00:00:00

abstract：:Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functional electrical stimulation (FES) elicits significant, clinicall...

journal_title：Nature communications

authors： Biasiucci A,Leeb R,Iturrate I,Perdikis S,Al-Khodairy A,Corbet T,Schnider A,Schmidlin T,Zhang H,Bassolino M,Viceic D,Vuadens P,Guggisberg AG,Millán JDR

更新日期：2018-06-20 00:00:00

abstract：:The formation of the HIV-1 core is the final step in the viral maturation pathway, resulting in the formation of infectious virus. Most current models for HIV-1 core formation suggest that, upon proteolytic cleavage from the immature Gag, capsid (CA) dissociates into the viral interior before reforming into the core. ...

journal_title：Nature communications

authors： Frank GA,Narayan K,Bess JW Jr,Del Prete GQ,Wu X,Moran A,Hartnell LM,Earl LA,Lifson JD,Subramaniam S

更新日期：2015-01-08 00:00:00

abstract：:Researchers strive to produce nanoparticles with complexity in composition and structure. Although traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, scientists seek more complicated geometries for potential functionality. Here we report the simple solution construction of mul...

journal_title：Nature communications

authors： Zhu J,Zhang S,Zhang K,Wang X,Mays JW,Wooley KL,Pochan DJ

更新日期：2013-01-01 00:00:00

abstract：:Recently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like spectra. As current Raman scanners rely on a slow, point-by-point spectrum acquisition, there is an unmet need for faster imaging to cove...

journal_title：Nature communications

authors： Pal S,Ray A,Andreou C,Zhou Y,Rakshit T,Wlodarczyk M,Maeda M,Toledo-Crow R,Berisha N,Yang J,Hsu HT,Oseledchyk A,Mondal J,Zou S,Kircher MF

更新日期：2019-04-26 00:00:00

abstract：:Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility an...

journal_title：Nature communications

authors： Liu L,Leng L,Liu C,Lu C,Yuan Y,Wu L,Gong F,Zhang S,Wei X,Wang M,Zhao L,Hu L,Wang J,Yang H,Zhu S,Chen F,Lu G,Shang Z,Lin G

更新日期：2019-01-21 00:00:00

abstract：:When two periodic potentials compete in materials, one may adopt the other, which straightforwardly generates topological defects. Of particular interest are domain walls in charge-, dipole-, and spin-ordered systems, which govern macroscopic properties and important functionality. However, detailed atomic and electro...

journal_title：Nature communications

authors： Park JW,Cho GY,Lee J,Yeom HW

更新日期：2019-09-06 00:00:00

abstract：:Expression of the matricellular protein CCN1 (CYR61) is associated with inflammation and is required for successful wound repair. Here, we show that CCN1 binds bacterial pathogen-associated molecular patterns including peptidoglycans of Gram-positive bacteria and lipopolysaccharides of Gram-negative bacteria. CCN1 ops...

journal_title：Nature communications

authors： Jun JI,Lau LF

更新日期：2020-03-06 00:00:00

abstract：:The worldwide prevalence of infections caused by antibiotic-resistant Gram-negative bacteria poses a serious threat to public health due to the limited therapeutic alternatives. Cationic peptides represent a large family of antibiotics and have attracted interest due to their diverse chemical structures and potential ...

journal_title：Nature communications

authors： Li YX,Zhong Z,Zhang WP,Qian PY

更新日期：2018-08-16 00:00:00

abstract：:Topological defects in matter behave collectively to form highly non-trivial structures called topological textures that are characterised by conserved quantities such as the winding number. Here we show that an epitaxial ferroelectric square nanoplate of bismuth ferrite subjected to a large strain gradient (as much a...

journal_title：Nature communications

authors： Kim KE,Jeong S,Chu K,Lee JH,Kim GY,Xue F,Koo TY,Chen LQ,Choi SY,Ramesh R,Yang CH

更新日期：2018-01-26 00:00:00

abstract：:Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that evolves in parallel wi...

journal_title：Nature communications

authors： Shen S,Faouzi S,Bastide A,Martineau S,Malka-Mahieu H,Fu Y,Sun X,Mateus C,Routier E,Roy S,Desaubry L,André F,Eggermont A,David A,Scoazec JY,Vagner S,Robert C

更新日期：2019-12-16 00:00:00

abstract：:The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiquitous or osteoclas...

journal_title：Nature communications

authors： Keller J,Catala-Lehnen P,Huebner AK,Jeschke A,Heckt T,Lueth A,Krause M,Koehne T,Albers J,Schulze J,Schilling S,Haberland M,Denninger H,Neven M,Hermans-Borgmeyer I,Streichert T,Breer S,Barvencik F,Levkau B,Rathkolb B

更新日期：2014-10-21 00:00:00

abstract：:Despite the growing evidence for the regulated spindle orientation in mammals, a systematic approach for identifying the responsible genes in mammalian cells has not been established. Here we perform a kinase-targeting RNAi screen in HeLa cells and identify ABL1 as a novel regulator of spindle orientation. Knockdown o...

journal_title：Nature communications

authors： Matsumura S,Hamasaki M,Yamamoto T,Ebisuya M,Sato M,Nishida E,Toyoshima F

更新日期：2012-01-17 00:00:00

abstract：:The development of transistors with high gain is essential for applications ranging from switching elements and drivers to transducers for chemical and biological sensing. Organic transistors have become well-established based on their distinct advantages, including ease of fabrication, synthetic freedom for chemical ...

journal_title：Nature communications

authors： Khodagholy D,Rivnay J,Sessolo M,Gurfinkel M,Leleux P,Jimison LH,Stavrinidou E,Herve T,Sanaur S,Owens RM,Malliaras GG

更新日期：2013-01-01 00:00:00

abstract：:The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology p...

journal_title：Nature communications

authors： Ellenrieder L,Opaliński Ł,Becker L,Krüger V,Mirus O,Straub SP,Ebell K,Flinner N,Stiller SB,Guiard B,Meisinger C,Wiedemann N,Schleiff E,Wagner R,Pfanner N,Becker T

更新日期：2016-10-10 00:00:00

abstract：:In response to intracellular signals in Gram--negative bacteria, translational riboswitches--commonly embedded in messenger RNAs (mRNAs)-regulate gene expression through inhibition of translation initiation. It is generally thought that this regulation originates from occlusion of the Shine-Dalgarno (SD) sequence upon...

journal_title：Nature communications

authors： Rinaldi AJ,Lund PE,Blanco MR,Walter NG

更新日期：2016-01-19 00:00:00

abstract：:Thermal conductivity of two-dimensional (2D) materials is of interest for energy storage, nanoelectronics and optoelectronics. Here, we report that the thermal conductivity of molybdenum disulfide can be modified by electrochemical intercalation. We observe distinct behaviour for thin films with vertically aligned bas...

journal_title：Nature communications

authors： Zhu G,Liu J,Zheng Q,Zhang R,Li D,Banerjee D,Cahill DG

更新日期：2016-10-21 00:00:00

abstract：:Defects can greatly influence the properties of oxide materials; however, facile defect engineering of oxides at room temperature remains challenging. The generation of defects in oxides is difficult to control by conventional chemical reduction methods that usually require high temperatures and are time consuming. He...

journal_title：Nature communications

authors： Ou G,Xu Y,Wen B,Lin R,Ge B,Tang Y,Liang Y,Yang C,Huang K,Zu D,Yu R,Chen W,Li J,Wu H,Liu LM,Li Y

更新日期：2018-04-03 00:00:00

abstract：:The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs). We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant componen...

journal_title：Nature communications

authors： Hernandez-Fernaud JR,Ruengeler E,Casazza A,Neilson LJ,Pulleine E,Santi A,Ismail S,Lilla S,Dhayade S,MacPherson IR,McNeish I,Ennis D,Ali H,Kugeratski FG,Al Khamici H,van den Biggelaar M,van den Berghe PV,Cloix C,McDona

更新日期：2017-02-15 00:00:00

abstract：:Black phosphorus, a fast emerging two-dimensional material, has been configured as field effect transistors, showing a hole-transport-dominated ambipolar characteristic. Here we report an effective modulation on ambipolar characteristics of few-layer black phosphorus transistors through in situ surface functionalizati...

journal_title：Nature communications

authors： Xiang D,Han C,Wu J,Zhong S,Liu Y,Lin J,Zhang XA,Ping Hu W,Özyilmaz B,Neto AH,Wee AT,Chen W

更新日期：2015-03-12 00:00:00

abstract：:Inferring neural mechanisms from functional magnetic resonance imaging (fMRI) is challenging because the fMRI signal integrates over millions of neurons. One approach is to compare computational models that map neural activity to fMRI responses, to see which best predicts fMRI data. We use this approach to compare fou...

journal_title：Nature communications

authors： Alink A,Abdulrahman H,Henson RN

更新日期：2018-09-21 00:00:00

abstract：:Problematic microfossils dominate the palaeontological record between the Great Oxidation Event 2.4 billion years ago (Ga) and the last Palaeoproterozoic iron formations, deposited 500-600 million years later. These fossils are often associated with iron-rich sedimentary rocks, but their affinities, metabolism, and, h...

journal_title：Nature communications

authors： Lepot K,Addad A,Knoll AH,Wang J,Troadec D,Béché A,Javaux EJ

更新日期：2017-03-23 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms14013. ...

journal_title：Nature communications

authors： Kang YJ,Balter B,Csizmadia E,Haas B,Sharma H,Bronson R,Yan CT

更新日期：2017-08-14 00:00:00

abstract：:Reversible acetylation of α-tubulin is an evolutionarily conserved modification in microtubule networks. Despite its prevalence, the physiological function and regulation of microtubule acetylation remain poorly understood. Here we report that macrophages challenged by bacterial lipopolysaccharides (LPS) undergo exten...

journal_title：Nature communications

authors： Wang B,Rao YH,Inoue M,Hao R,Lai CH,Chen D,McDonald SL,Choi MC,Wang Q,Shinohara ML,Yao TP

更新日期：2014-03-17 00:00:00

abstract：:Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate. Here we determine a super-resolved multiplex of 16 centriole-distal-end components. Surprisingly, rather th...

journal_title：Nature communications

authors： Yang TT,Chong WM,Wang WJ,Mazo G,Tanos B,Chen Z,Tran TMN,Chen YD,Weng RR,Huang CE,Jane WN,Tsou MB,Liao JC

更新日期：2018-05-22 00:00:00

abstract：:We previously reported a disease segregating causal germline mutation in a melanoma family and recurrent somatic mutations in metastasized tumours from unrelated patients in the core promoter region of the telomerase reverse transcriptase (TERT) gene. Here we show that the TERT promoter mutations, besides causing an i...

journal_title：Nature communications

authors： Heidenreich B,Nagore E,Rachakonda PS,Garcia-Casado Z,Requena C,Traves V,Becker J,Soufir N,Hemminki K,Kumar R

更新日期：2014-02-26 00:00:00

abstract：:The cell adhesion molecule Neuroligin2 (NL2) is localized selectively at GABAergic synapses, where it interacts with the scaffolding protein gephyrin in the post-synaptic density. However, the role of this interaction for formation and plasticity of GABAergic synapses is unclear. Here, we demonstrate that endogenous N...

journal_title：Nature communications

authors： Antonelli R,Pizzarelli R,Pedroni A,Fritschy JM,Del Sal G,Cherubini E,Zacchi P

更新日期：2014-10-09 00:00:00

abstract：:Nuclear factor-κB (NFκB) and peroxisome proliferator activated receptor-γ (PPARγ) are both transcription factors that perform distinct but overlapping roles in cellular regulation. Here we report that PPARγ acts as an E3 ubiquitin ligase, physically interacting with p65 to induce its ubiquitination and degradation. Th...

journal_title：Nature communications

authors： Hou Y,Moreau F,Chadee K

更新日期：2012-01-01 00:00:00

abstract：:Generally, a homogeneous catalyst exhibits good activity and defined active sites but it is difficult to recycle. Meanwhile, a heterogeneous catalyst can easily be reused but its active site is difficult to reveal. It is interesting to bridge the gap between homogeneous and heterogeneous catalysis via controllable con...

journal_title：Nature communications

authors： Zhang Y,Pang S,Wei Z,Jiao H,Dai X,Wang H,Shi F

更新日期：2018-04-13 00:00:00

abstract：:Ionic liquids (ILs) are emerging as superior solvents for numerous industrial applications, including the pretreatment of biomass for the microbial production of biofuels. However, some of the most effective ILs used to solubilize cellulose inhibit microbial growth, decreasing efficiency in the overall process. Here w...

journal_title：Nature communications

authors： Ruegg TL,Kim EM,Simmons BA,Keasling JD,Singer SW,Lee TS,Thelen MP

更新日期：2014-03-26 00:00:00