Abstract：
:Inferring neural mechanisms from functional magnetic resonance imaging (fMRI) is challenging because the fMRI signal integrates over millions of neurons. One approach is to compare computational models that map neural activity to fMRI responses, to see which best predicts fMRI data. We use this approach to compare four possible neural mechanisms of fMRI adaptation to repeated stimuli (scaling, sharpening, repulsive shifting and attractive shifting), acting across three domains (global, local and remote). Six features of fMRI repetition effects are identified, both univariate and multivariate, from two independent fMRI experiments. After searching over parameter values, only the local scaling model can simultaneously fit all data features from both experiments. Thus fMRI stimulus repetition effects are best captured by down-scaling neuronal tuning curves in proportion to the difference between the stimulus and neuronal preference. These results emphasise the importance of formal modelling for bridging neuronal and fMRI levels of investigation.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Alink A,Abdulrahman H,Henson RNdoi
10.1038/s41467-018-05957-0subject
Has Abstractpub_date
2018-09-21 00:00:00pages
3854issue
1issn
2041-1723pii
10.1038/s41467-018-05957-0journal_volume
9pub_type
杂志文章abstract：:The scientific significance of excited-state aromaticity concerns with the elucidation of processes and properties in the excited states. Here, we focus on TMTQ, an oligomer composed of a central 1,6-methano[10]annulene and 5-dicyanomethyl-thiophene peripheries (acceptor-donor-acceptor system), and investigate a two-e...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12986-w
更新日期：2019-11-01 00:00:00
abstract：:Sensory perception modulates health and aging across taxa. Understanding the nature of relevant cues and the mechanisms underlying their action may lead to novel interventions that improve the length and quality of life. We found that in the vinegar fly, Drosophila melanogaster, exposure to dead conspecifics in the en...
journal_title：Nature communications
pub_type： 杂志文章
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abstract：:Selective thermal emission in a useful range of energies from a material operating at high temperatures is required for effective solar thermophotovoltaic energy conversion. Three-dimensional metallic photonic crystals can exhibit spectral emissivity that is modified compared with the emissivity of unstructured metals...
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pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
abstract：:Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitu...
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pub_type： 杂志文章,评审
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更新日期：2019-05-29 00:00:00
abstract：:Glycans from microbial pathogens are well known pathogen-associated molecular patterns that are recognized by the host immunity; however, little is known about whether and how mammalian self-glycans activate the host immune response, especially in the context of autoimmune disease. Using biochemical fractionation and ...
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pub_type： 杂志文章
doi：10.1038/s41467-019-10319-5
更新日期：2019-05-30 00:00:00
abstract：:Semiconductor nanowires offer the opportunity to incorporate novel structures and functionality into electronic and optoelectronic devices. A clear understanding of the nanowire growth mechanism is essential for well-controlled growth of structures with desired properties, but the understanding is currently limited by...
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更新日期：2018-09-12 00:00:00
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abstract：:In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from National Institute of General Medical Sciences, National Institutes of Health grant R01GM124072. ...
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更新日期：2018-05-01 00:00:00
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更新日期：2020-12-18 00:00:00
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更新日期：2020-11-20 00:00:00
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更新日期：2019-07-23 00:00:00
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更新日期：2016-12-02 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,已发布勘误
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pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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更新日期：2018-11-28 00:00:00
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更新日期：2019-03-01 00:00:00
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更新日期：2014-06-24 00:00:00
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更新日期：2020-09-18 00:00:00
abstract：:Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative Claisen-like condensation reaction. KSs must recognize multiple ch...
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更新日期：2018-08-09 00:00:00
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更新日期：2016-06-03 00:00:00
