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Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

Abstract：

:Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune signatures are dominated by either IFN-γ and IFN-inducible, IL-17-induced neutrophil- or allergy-associated gene expression. Type I IFN and IFN-γ-inducible, but not IL-17- or allergy-associated signatures, are preserved in the blood. While IL-17-associated genes identified in lung are detected in blood, the allergy signature is only detectable in blood CD4+ effector cells. Type I IFN-inducible genes are abrogated in the absence of IFN-γ signaling and decrease in the absence of IFNAR signaling, both independently contributing to the regulation of granulocyte responses and pathology during Toxoplasma gondii infection. Our framework provides an ideal tool for comparative analyses of transcriptional signatures contributing to protection or pathogenesis in disease.

journal_name

Nat Commun

journal_title

Nature communications

authors

Singhania A,Graham CM,Gabryšová L,Moreira-Teixeira L,Stavropoulos E,Pitt JM,Chakravarty P,Warnatsch A,Branchett WJ,Conejero L,Lin JW,Davidson S,Wilson MS,Bancroft G,Langhorne J,Frickel E,Sesay AK,Priestnall SL,Herbert

doi

10.1038/s41467-019-10601-6

subject

Has Abstract

pub_date

2019-06-28 00:00:00

pages

2887

issue

1

issn

2041-1723

pii

10.1038/s41467-019-10601-6

journal_volume

10

pub_type

杂志文章

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