Synthesis of chiral heterocycles by ligand-controlled regiodivergent and enantiospecific Suzuki Miyaura cross-coupling.

abstract：:Members of the Herpesviridae, including the medically important alphaherpesvirus varicella-zoster virus (VZV), induce fusion of the virion envelope with cell membranes during entry, and between cells to form polykaryocytes in infected tissues. The conserved glycoproteins, gB, gH and gL, are the core functional protein...

journal_title：Nature communications

authors： Oliver SL,Xing Y,Chen DH,Roh SH,Pintilie GD,Bushnell DA,Sommer MH,Yang E,Carfi A,Chiu W,Arvin AM

更新日期：2020-08-18 00:00:00

abstract：:Performance for skills such as a sequence of finger movements improves during sleep. This has widely been interpreted as evidence for a role of sleep in strengthening skill learning. Here we propose a different interpretation. We propose that practice and sleep form different aspects of skill. To show this, we train 8...

journal_title：Nature communications

authors： Song S,Cohen LG

更新日期：2014-03-19 00:00:00

abstract：:Adult-type granulosa cell tumors of the ovary (aGCTs) are rare gynecologic malignancies that exhibit a high frequency of somatic FOXL2 c.C402G (p.Cys134Trp) mutation. Treatment of relapsed aGCT remains a significant clinical challenge. Here we show, using whole-exome and cancer gene panel sequencing of 79 aGCTs from t...

journal_title：Nature communications

authors： Hillman RT,Celestino J,Terranova C,Beird HC,Gumbs C,Little L,Nguyen T,Thornton R,Tippen S,Zhang J,Lu KH,Gershenson DM,Rai K,Broaddus RR,Futreal PA

更新日期：2018-06-27 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is characterized by defects in both insulin sensitivity and glucose-stimulated insulin secretion (GSIS) and is often accompanied by obesity. In this study, we show that disruption of thioredoxin binding protein-2 (TBP-2, also called Txnip) in obese mice (ob/ob) dramatically improves hyp...

journal_title：Nature communications

authors： Yoshihara E,Fujimoto S,Inagaki N,Okawa K,Masaki S,Yodoi J,Masutani H

更新日期：2010-11-23 00:00:00

abstract：:Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Berry MH,Holt A,Levitz J,Broichhagen J,Gaub BM,Visel M,Stanley C,Aghi K,Kim YJ,Cao K,Kramer RH,Trauner D,Flannery J,Isacoff EY

更新日期：2018-03-13 00:00:00

abstract：:Cytidine base editors (CBEs) and adenine base editors (ABEs), composed of a cytidine deaminase or an evolved adenine deaminase fused to Cas9 nickase, enable the conversion of C·G to T·A or A·T to G·C base pair in organisms, respectively. Here, we show that BE3 and ABE7.10 systems can achieve a targeted mutation effici...

journal_title：Nature communications

authors： Liu Z,Chen M,Chen S,Deng J,Song Y,Lai L,Li Z

更新日期：2018-07-13 00:00:00

abstract：:The burial of terrestrial organic carbon (terrOC) in marine sediments contributes to the regulation of atmospheric CO2 on geological timescales and may mitigate positive feedback to present-day climate warming. However, the fate of terrOC in marine settings is debated, with uncertainties regarding its degradation duri...

journal_title：Nature communications

authors： Bröder L,Tesi T,Andersson A,Semiletov I,Gustafsson Ö

更新日期：2018-02-23 00:00:00

abstract：:Despite centuries of research, much about the barbarian migrations that took place between the fourth and sixth centuries in Europe remains hotly debated. To better understand this key era that marks the dawn of modern European societies, we obtained ancient genomic DNA from 63 samples from two cemeteries (from Hungar...

journal_title：Nature communications

authors： Amorim CEG,Vai S,Posth C,Modi A,Koncz I,Hakenbeck S,La Rocca MC,Mende B,Bobo D,Pohl W,Baricco LP,Bedini E,Francalacci P,Giostra C,Vida T,Winger D,von Freeden U,Ghirotto S,Lari M,Barbujani G,Krause J,Caramelli D

更新日期：2018-09-11 00:00:00

abstract：:6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusi...

journal_title：Nature communications

authors： Liu R,Li W,Tao B,Wang X,Yang Z,Zhang Y,Wang C,Liu R,Gao H,Liang J,Yang W

更新日期：2019-03-01 00:00:00

abstract：:Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal co...

journal_title：Nature communications

authors： Shi Z,Miao C,Schoepf UJ,Savage RH,Dargis DM,Pan C,Chai X,Li XL,Xia S,Zhang X,Gu Y,Zhang Y,Hu B,Xu W,Zhou C,Luo S,Wang H,Mao L,Liang K,Wen L,Zhou L,Yu Y,Lu GM,Zhang LJ

更新日期：2020-11-30 00:00:00

abstract：:Coherence in light-matter interaction is a necessary ingredient if light is used to control the quantum state of a material system. Coherent effects are firmly associated with isolated systems kept at low temperature. The exceedingly fast dephasing in condensed matter environments, in particular at elevated temperatur...

journal_title：Nature communications

authors： Kolarczik M,Owschimikow N,Korn J,Lingnau B,Kaptan Y,Bimberg D,Schöll E,Lüdge K,Woggon U

更新日期：2013-01-01 00:00:00

abstract：:Tibetan wheat is grown under environmental constraints at high-altitude conditions, but its underlying adaptation mechanism remains unknown. Here, we present a draft genome sequence of a Tibetan semi-wild wheat (Triticum aestivum ssp. tibetanum Shao) accession Zang1817 and re-sequence 245 wheat accessions, including w...

journal_title：Nature communications

authors： Guo W,Xin M,Wang Z,Yao Y,Hu Z,Song W,Yu K,Chen Y,Wang X,Guan P,Appels R,Peng H,Ni Z,Sun Q

更新日期：2020-10-08 00:00:00

abstract：:Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates sys...

journal_title：Nature communications

authors： Uno K,Yamada T,Ishigaki Y,Imai J,Hasegawa Y,Sawada S,Kaneko K,Ono H,Asano T,Oka Y,Katagiri H

更新日期：2015-08-13 00:00:00

abstract：:Though miR-205 function has been largely characterized, the nature of its host gene, MIR205HG, is still completely unknown. Here, we show that only lowly expressed alternatively spliced MIR205HG transcripts act as de facto pri-miRNAs, through a process that involves Drosha to prevent unfavorable splicing and directly ...

journal_title：Nature communications

authors： Profumo V,Forte B,Percio S,Rotundo F,Doldi V,Ferrari E,Fenderico N,Dugo M,Romagnoli D,Benelli M,Valdagni R,Dolfini D,Zaffaroni N,Gandellini P

更新日期：2019-01-18 00:00:00

abstract：:Increased vascular permeability contributes to many diseases, including acute respiratory distress syndrome, cancer and inflammation. Most past work on vascular barrier function has focused on soluble regulators, such as tumour-necrosis factor-α. Here we show that lung vascular permeability is controlled mechanically ...

journal_title：Nature communications

authors： Mammoto A,Mammoto T,Kanapathipillai M,Wing Yung C,Jiang E,Jiang A,Lofgren K,Gee EP,Ingber DE

更新日期：2013-01-01 00:00:00

abstract：:Zig-zag nanographenes are promising candidates for the applications in organic electronics due to the electronic properties induced by their periphery. However, the synthetic access to these compounds remains virtually unexplored. There is a lack in efficient and mild strategies origins in the reduced stability, incre...

journal_title：Nature communications

authors： Lungerich D,Papaianina O,Feofanov M,Liu J,Devarajulu M,Troyanov SI,Maier S,Amsharov K

更新日期：2018-11-12 00:00:00

abstract：:Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is di...

journal_title：Nature communications

authors： Ebo JS,Saunders JC,Devine PWA,Gordon AM,Warwick AS,Schiffrin B,Chin SE,England E,Button JD,Lloyd C,Bond NJ,Ashcroft AE,Radford SE,Lowe DC,Brockwell DJ

更新日期：2020-04-14 00:00:00

abstract：:The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology p...

journal_title：Nature communications

authors： Ellenrieder L,Opaliński Ł,Becker L,Krüger V,Mirus O,Straub SP,Ebell K,Flinner N,Stiller SB,Guiard B,Meisinger C,Wiedemann N,Schleiff E,Wagner R,Pfanner N,Becker T

更新日期：2016-10-10 00:00:00

abstract：:Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated the role of vimentin, a type III intermediate filament, in this process using three well-characterized murine models of ALI known to require N...

journal_title：Nature communications

authors： dos Santos G,Rogel MR,Baker MA,Troken JR,Urich D,Morales-Nebreda L,Sennello JA,Kutuzov MA,Sitikov A,Davis JM,Lam AP,Cheresh P,Kamp D,Shumaker DK,Budinger GR,Ridge KM

更新日期：2015-03-12 00:00:00

abstract：:Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze t...

journal_title：Nature communications

authors： Chai PC,Cruchet S,Wigger L,Benton R

更新日期：2019-02-07 00:00:00

abstract：:Liquid-liquid phase separation is increasingly recognized as a process involved in cellular organization. Thus far, a detailed structural characterization of this intrinsically heterogeneous process has been challenging. Here we combine solid- and solution-state NMR spectroscopy to obtain atomic-level insights into th...

journal_title：Nature communications

authors： Damman R,Schütz S,Luo Y,Weingarth M,Sprangers R,Baldus M

更新日期：2019-10-04 00:00:00

abstract：:Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also fou...

journal_title：Nature communications

authors： Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JN

更新日期：2018-07-27 00:00:00

abstract：:The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E ...

journal_title：Nature communications

authors： Kawamura A,Münzel M,Kojima T,Yapp C,Bhushan B,Goto Y,Tumber A,Katoh T,King ON,Passioura T,Walport LJ,Hatch SB,Madden S,Müller S,Brennan PE,Chowdhury R,Hopkinson RJ,Suga H,Schofield CJ

更新日期：2017-04-06 00:00:00

abstract：:A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. Here we train a machine learning model using functional, mutational an...

journal_title：Nature communications

authors： Wells A,Heckerman D,Torkamani A,Yin L,Sebat J,Ren B,Telenti A,di Iulio J

更新日期：2019-11-20 00:00:00

abstract：:Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimPol displays a poten...

journal_title：Nature communications

authors： Picher ÁJ,Budeus B,Wafzig O,Krüger C,García-Gómez S,Martínez-Jiménez MI,Díaz-Talavera A,Weber D,Blanco L,Schneider A

更新日期：2016-11-29 00:00:00

abstract：:Geometric phase, associated with holonomy transformation in quantum state space, is an important quantum-mechanical effect. Besides fundamental interest, this effect has practical applications, among which geometric quantum computation is a paradigm, where quantum logic operations are realized through geometric phase ...

journal_title：Nature communications

authors： Song C,Zheng SB,Zhang P,Xu K,Zhang L,Guo Q,Liu W,Xu D,Deng H,Huang K,Zheng D,Zhu X,Wang H

更新日期：2017-10-20 00:00:00

abstract：:Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms contributing to chronic inflammation and increased morbidity and mortality during antiretroviral-treated HIV disease. Sexual practice has recently been uncovered as a major source of microbiota variation, potentially confounding prior...

journal_title：Nature communications

authors： Vujkovic-Cvijin I,Sortino O,Verheij E,Sklar J,Wit FW,Kootstra NA,Sellers B,Brenchley JM,Ananworanich J,Loeff MSV,Belkaid Y,Reiss P,Sereti I

更新日期：2020-05-15 00:00:00

abstract：:Sepsis is a life-threatening condition triggered by a dysregulated host response to microbial infection resulting in vascular dysfunction, organ failure and death. Here we provide a semi-quantitative atlas of the murine vascular cell-surface proteome at the organ level, and how it changes during sepsis. Using in vivo ...

journal_title：Nature communications

authors： Toledo AG,Golden G,Campos AR,Cuello H,Sorrentino J,Lewis N,Varki N,Nizet V,Smith JW,Esko JD

更新日期：2019-10-11 00:00:00

abstract：:The current study uses big data to study prosocial behavior by analyzing donations made on the GoFundMe platform. In a dataset of more than $44 million in online donations, we find that 21% were made while opting to be anonymous to the public, with survey results indicating that 11% of these anonymous donations (2.3% ...

journal_title：Nature communications

authors： Sisco MR,Weber EU

更新日期：2019-09-03 00:00:00

abstract：:Extensive efforts have been expended in developing hybrid quantum systems to overcome the short coherence time of superconducting circuits by introducing the naturally long-lived spin degree of freedom. Among all the possible materials, single-crystal yttrium iron garnet has shown up recently as a promising candidate ...

journal_title：Nature communications

authors： Zhang X,Zou CL,Zhu N,Marquardt F,Jiang L,Tang HX

更新日期：2015-11-16 00:00:00