Abstract:
:Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also found in human breast cancer, represent a macrophage phenotype similar to that observed during the wound healing response. Importantly, the expression of a wound-like cytokine response within the tumour is clinically associated with poor prognosis in a variety of cancers. We show that co-expression of FAP and HO-1 in macrophages results from an innate early regenerative response driven by IL-6, which both directly regulates HO-1 expression and licenses FAP expression in a skin-like collagen-rich environment. We show that tumours can exploit this response to facilitate transendothelial migration and metastatic spread of the disease, which can be pharmacologically targeted using a clinically relevant HO-1 inhibitor.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JNdoi
10.1038/s41467-018-05346-7subject
Has Abstractpub_date
2018-07-27 00:00:00pages
2951issue
1issn
2041-1723pii
10.1038/s41467-018-05346-7journal_volume
9pub_type
杂志文章abstract::Extensive efforts have been expended in developing hybrid quantum systems to overcome the short coherence time of superconducting circuits by introducing the naturally long-lived spin degree of freedom. Among all the possible materials, single-crystal yttrium iron garnet has shown up recently as a promising candidate ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9914
更新日期:2015-11-16 00:00:00
abstract::Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and clonal evolution of papillary renal cell carcinoma (pRCC) and rarer kidney cancer subtypes, integrating whole...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16546-5
更新日期:2020-06-18 00:00:00
abstract::Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10192-2
更新日期:2019-05-27 00:00:00
abstract::It is widely believed that range resolution, the ability to distinguish between two closely situated targets, depends inversely on the bandwidth of the transmitted radar signal. Here we demonstrate a different type of ranging system, which possesses superior range resolution that is almost completely free of bandwidth...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09380-x
更新日期:2019-03-29 00:00:00
abstract::Microbiome-derived metabolites influence intestinal homeostasis and regulate graft-versus-host disease (GVHD), but the molecular mechanisms remain unknown. Here we show the metabolite sensor G-protein-coupled receptor 43 (GPR43) is important for attenuation of gastrointestinal GVHD in multiple clinically relevant muri...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06048-w
更新日期:2018-09-10 00:00:00
abstract::Electric gating can strongly modulate a wide variety of physical properties in semiconductors and insulators, such as significant changes of conductivity in silicon, appearance of superconductivity in SrTiO3, the paramagnet-ferromagnet transition in (In,Mn)As, and so on. The key to such modulation is charge accumulati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05611-9
更新日期:2018-08-07 00:00:00
abstract::The neurochemical changes underlying human emotions and social behaviour are largely unknown. Here we report on the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala. We show that hypocretin-1 levels are maximal during positive emoti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2461
更新日期:2013-01-01 00:00:00
abstract::The bacteria-derived clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are powerful tools for genome engineering. Recently, in addition to Cas protein engineering, the improvement of guide RNAs are also performed, contributing to broadening the research area of CRISPR-Cas9 systems. Here we ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01650-w
更新日期:2017-11-23 00:00:00
abstract::Metals and polymers are dissimilar materials in terms of their physicochemical properties, but complementary in terms of functionality. As a result, metal-organic structures can introduce a wealth of novel applications in small-scale robotics. However, current fabrication techniques are unable to process three-dimensi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19725-6
更新日期:2020-11-24 00:00:00
abstract::The diversity of life and its organization in networks of interacting species has been a long-standing theoretical puzzle for ecologists. Ever since May's provocative paper challenging whether 'large complex systems [are] stable' various hypotheses have been proposed to explain when stability should be the rule, not t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12457
更新日期:2016-08-24 00:00:00
abstract::The isolation of the two-dimensional semiconductor molybdenum disulphide introduced a new optically active material possessing a band gap that can be facilely tuned via elastic strain. As an atomically thin membrane with exceptional strength, monolayer molybdenum disulphide subjected to biaxial strain can embed wide b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8381
更新日期:2015-06-19 00:00:00
abstract::We have been alerted that in our recent Article the calculations used to transform the heritability from the observed scale to the liability scale did not take into account the individuals in category 2 of the baldness scale, who were removed in our original analysis. This led to an overestimation of the heritability ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04857-7
更新日期:2018-06-29 00:00:00
abstract::The original version of this Article contained an error in the last sentence of the first paragraph of the Introduction and incorrectly read 'A proper electron beam control is one of the main challenges towards the Graal of developing a compact alternative of X-ray free-electron lasers by coupling LWFA gigaelectron-vo...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04299-1
更新日期:2018-05-02 00:00:00
abstract::Glacier retreat is a worldwide phenomenon with important consequences for the hydrological cycle and downstream ecosystem structure and functioning. To determine the effects of glacier retreat on aquatic communities, we conducted a 4-year flow manipulation in a tropical glacier-fed stream. Compared with an adjacent re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12025
更新日期:2016-06-24 00:00:00
abstract::Quintulene, a non-graphitic cycloarene with fivefold symmetry, has remained synthetically elusive due to its high molecular strain originating from its curved structure. Here we report the construction of extended quintulene, which was unambiguously characterized by mass and NMR spectroscopy. The extended quintulene r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17691-7
更新日期:2020-08-07 00:00:00
abstract::HIV infection causes bone loss. We previously reported that immunosuppression-mediated B-cell production of receptor activator of NF-κB ligand (RANKL) coupled with decline in osteoprotegerin correlate with decreased bone mineral density (BMD) in untreated HIV infection. Paradoxically, antiretroviral therapy (ART) wors...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9282
更新日期:2015-09-22 00:00:00
abstract::In social species, the phenotype and fitness of an individual depend in part on the genotype of its social partners. However, how these indirect genetic effects affect genotype fitness in competitive situations is poorly understood in animal societies. We therefore studied phenotypic plasticity and fitness of two clon...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4363
更新日期:2014-01-01 00:00:00
abstract::Domain walls can be driven by current at very high speeds in nanowires formed from ultra-thin, perpendicularly magnetized cobalt layers and cobalt/nickel multilayers deposited on platinum underlayers due to a chiral spin torque. An important feature of this torque is a magnetic chiral exchange field that each domain w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4910
更新日期:2014-05-23 00:00:00
abstract::The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05220-6
更新日期:2018-07-24 00:00:00
abstract::Although environmental selection and spatial separation have been shown to shape the distribution and abundance of marine microorganisms, the effects of advection (physical transport) have not been directly tested. Here we examine 25 samples covering all major water masses of the Southern Ocean to determine the effect...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3457
更新日期:2013-01-01 00:00:00
abstract::Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway. Activation of this pathway involves Shh-induced ciliary accumulation of Smoothened (SMO), which ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14177
更新日期:2017-01-30 00:00:00
abstract::Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re-programming cognate antigen-experienced CD4+ T-cells into disease-suppressing T-regulatory type 1 (TR1) cells. Here, we show that single pMHCII...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09893-5
更新日期:2019-05-14 00:00:00
abstract::Iron chelators have been widely used to remove excess toxic iron from patients with secondary iron overload. However, small molecule-based iron chelators can cause adverse side effects such as infection, gastrointestinal bleeding, kidney failure, and liver fibrosis. Here we report renal clearable nanochelators for iro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13143-z
更新日期:2019-11-13 00:00:00
abstract::Human metapneumovirus (hMPV) is a frequent cause of bronchiolitis in young children. Its F glycoprotein mediates virus-cell membrane fusion and is the primary target of neutralizing antibodies. The inability to produce recombinant hMPV F glycoprotein in the metastable pre-fusion conformation has hindered structural an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01708-9
更新日期:2017-11-16 00:00:00
abstract::Solitary, persistent wave packets called solitons hold potential to transfer information and energy across a wide range of spatial and temporal scales in physical, chemical, and biological systems. Mechanical solitons characteristically emerge either as a single wave packet or uncorrelated propagating topological enti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13546-y
更新日期:2019-12-06 00:00:00
abstract::Precise rare-cell technologies require the blood to be processed immediately or be stabilized with fixatives. Such restrictions limit the translation of circulating tumor cell (CTC)-based liquid biopsy assays that provide accurate molecular data in guiding clinical decisions. Here we describe a method to preserve whol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01705-y
更新日期:2017-11-23 00:00:00
abstract::Autophagy cargo recognition and clearance are essential for intracellular protein quality control. SQSTM1/p62 sequesters intracellular aberrant proteins and mediates cargo delivery for their selective autophagic degradation. The formation of p62 non-membrane-bound liquid compartments is critical for its function as a ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11671-2
更新日期:2019-08-21 00:00:00
abstract::Manganese based layered oxides have received increasing attention as cathode materials for sodium ion batteries due to their high theoretical capacities and good sodium ion conductivities. However, the Jahn-Teller distortion arising from the manganese (III) centers destabilizes the host structure and deteriorates the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07646-4
更新日期:2019-01-07 00:00:00
abstract::Clustering of arc volcanoes in subduction zones indicates along-arc variation in the physical condition of the underlying mantle where majority of arc magmas are generated. The sub-arc mantle is brought in from the back-arc largely by slab-driven mantle wedge flow. Dynamic processes in the back-arc, such as small-scal...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15753
更新日期:2017-06-29 00:00:00
abstract::Graphite dual-ion batteries represent a potential battery concept for large-scale stationary storage of electricity, especially when constructed free of lithium and other chemical elements with limited natural reserves. Owing to their non-rocking-chair operation mechanism, however, the practical deployment of graphite...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06923-6
更新日期:2018-10-26 00:00:00