Stability and complexity in model meta-ecosystems.

abstract：:The superconducting state is formed by the condensation of Cooper pairs and protected by the superconducting gap. The pairing interaction between the two electrons of a Cooper pair determines the gap function. Thus, it is pivotal to detect the gap structure for understanding the mechanism of superconductivity. In cupr...

journal_title：Nature communications

authors： Gu Q,Wan S,Tang Q,Du Z,Yang H,Wang QH,Zhong R,Wen J,Gu GD,Wen HH

更新日期：2019-04-08 00:00:00

abstract：:Due to the non-flammable nature of water-based electrolytes, aqueous lithium-ion batteries are resistant to catching fire. However, they are not immune to the risk of explosion, since the sealing structure adopted by current batteries limits the dissipation of heat and pressure within the cells. Here, we report a safe...

journal_title：Nature communications

authors： Chen L,Cao L,Ji X,Hou S,Li Q,Chen J,Yang C,Eidson N,Wang C

更新日期：2020-05-26 00:00:00

abstract：:Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize 'eat me' signals presented on the surface of apoptotic cells, this subsequently induces cytoskeletal rearrangement of phagocytes for the engulfment through Rac1 activation. However, the intracellular sign...

journal_title：Nature communications

authors： Nakaya M,Tajima M,Kosako H,Nakaya T,Hashimoto A,Watari K,Nishihara H,Ohba M,Komiya S,Tani N,Nishida M,Taniguchi H,Sato Y,Matsumoto M,Tsuda M,Kuroda M,Inoue K,Kurose H

更新日期：2013-01-01 00:00:00

abstract：:A skullcap found in the Salkhit Valley in northeast Mongolia is, to our knowledge, the only Pleistocene hominin fossil found in the country. It was initially described as an individual with possible archaic affinities, but its ancestry has been debated since the discovery. Here, we determine the age of the Salkhit sku...

journal_title：Nature communications

authors： Devièse T,Massilani D,Yi S,Comeskey D,Nagel S,Nickel B,Ribechini E,Lee J,Tseveendorj D,Gunchinsuren B,Meyer M,Pääbo S,Higham T

更新日期：2019-01-30 00:00:00

abstract：:Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here we find that junctional adh...

journal_title：Nature communications

authors： Tuncay H,Brinkmann BF,Steinbacher T,Schürmann A,Gerke V,Iden S,Ebnet K

更新日期：2015-08-26 00:00:00

abstract：:Post-translational protein modification by tyrosine sulfation has an important role in extracellular protein-protein interactions. The protein tyrosine sulfation reaction is catalysed by the Golgi enzyme called the tyrosylprotein sulfotransferase. To date, no crystal structure is available for tyrosylprotein sulfotran...

journal_title：Nature communications

authors： Teramoto T,Fujikawa Y,Kawaguchi Y,Kurogi K,Soejima M,Adachi R,Nakanishi Y,Mishiro-Sato E,Liu MC,Sakakibara Y,Suiko M,Kimura M,Kakuta Y

更新日期：2013-01-01 00:00:00

abstract：:Development of effective antimicrobial agents continues to be a great challenge, particularly due to the increasing resistance of superbugs and frequent hospital breakouts. There is an urgent need for more potent and safer antibiotics with novel scaffolds. As historically many commercial drugs were derived from natura...

journal_title：Nature communications

authors： Lin Z,Xu X,Zhao S,Yang X,Guo J,Zhang Q,Jing C,Chen S,He Y

更新日期：2018-09-04 00:00:00

abstract：:Strategies to harness photosynthesis from living organisms to generate electrical power have long been considered, yet efficiency remains low. Here, we aimed to reroute photosynthetic electron flow in photosynthetic organisms without compromising their phototrophic properties. We show that 2,6-dimethyl-p-benzoquinone ...

journal_title：Nature communications

authors： Fu HY,Picot D,Choquet Y,Longatte G,Sayegh A,Delacotte J,Guille-Collignon M,Lemaître F,Rappaport F,Wollman FA

更新日期：2017-05-03 00:00:00

abstract：:Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specif...

journal_title：Nature communications

authors： Freedman BS,Brooks CR,Lam AQ,Fu H,Morizane R,Agrawal V,Saad AF,Li MK,Hughes MR,Werff RV,Peters DT,Lu J,Baccei A,Siedlecki AM,Valerius MT,Musunuru K,McNagny KM,Steinman TI,Zhou J,Lerou PH,Bonventre JV

更新日期：2015-10-23 00:00:00

abstract：:Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineered programmable cytidine deaminases and test if we could introduce site-specific...

journal_title：Nature communications

authors： Yang L,Briggs AW,Chew WL,Mali P,Guell M,Aach J,Goodman DB,Cox D,Kan Y,Lesha E,Soundararajan V,Zhang F,Church G

更新日期：2016-11-02 00:00:00

abstract：:Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored. Here we use gene expression profiles to infer CNAs in 3,108 samples from 45 mouse models, provid...

journal_title：Nature communications

authors： Ben-David U,Ha G,Khadka P,Jin X,Wong B,Franke L,Golub TR

更新日期：2016-07-04 00:00:00

abstract：:In 1816, the coldest summer of the past two centuries was observed over northeastern North America and western Europe. This so-called Year Without a Summer (YWAS) has been widely attributed to the 1815 eruption of Indonesia's Mt. Tambora and was concurrent with agricultural failures and famines worldwide. To understan...

journal_title：Nature communications

authors： Fasullo JT,Tomas R,Stevenson S,Otto-Bliesner B,Brady E,Wahl E

更新日期：2017-10-31 00:00:00

abstract：:A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. Here we train a machine learning model using functional, mutational an...

journal_title：Nature communications

authors： Wells A,Heckerman D,Torkamani A,Yin L,Sebat J,Ren B,Telenti A,di Iulio J

更新日期：2019-11-20 00:00:00

abstract：:According to quantum theory, measurements generate random outcomes, in stark contrast with classical mechanics. This raises the question of whether there could exist an extension of the theory that removes this indeterminism, as suspected by Einstein, Podolsky and Rosen. Although this has been shown to be impossible, ...

journal_title：Nature communications

authors： Colbeck R,Renner R

更新日期：2011-08-02 00:00:00

abstract：:Organic semiconductors enable the fabrication of a range of lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to the need for a support substrate. Here, we use a simple fabrication process to make membrane-based, s...

journal_title：Nature communications

authors： Karl M,Glackin JME,Schubert M,Kronenberg NM,Turnbull GA,Samuel IDW,Gather MC

更新日期：2018-05-01 00:00:00

abstract：:Stimuli-responsive behaviors of flexible metal-organic frameworks (MOFs) make these materials promising in a wide variety of applications such as gas separation, drug delivery, and molecular sensing. Considerable efforts have been made over the last decade to understand the structural changes of flexible MOFs in respo...

journal_title：Nature communications

authors： Zhao P,Fang H,Mukhopadhyay S,Li A,Rudić S,McPherson IJ,Tang CC,Fairen-Jimenez D,Tsang SCE,Redfern SAT

更新日期：2019-03-01 00:00:00

abstract：:Epitaxy is widely employed to create highly oriented crystalline films. A less appreciated, but nonetheless powerful means of creating such films is via topotactic transformation, in which a chemical reaction transforms a single crystal of one phase into a single crystal of a different phase, which inherits its orient...

journal_title：Nature communications

authors： Mairoser T,Mundy JA,Melville A,Hodash D,Cueva P,Held R,Glavic A,Schubert J,Muller DA,Schlom DG,Schmehl A

更新日期：2015-07-16 00:00:00

abstract：:In most applications of nanoporous materials the pore structure is as important as the chemical composition as a determinant of performance. For example, one can alter performance in applications like carbon capture or methane storage by orders of magnitude by only modifying the pore structure. For these applications ...

journal_title：Nature communications

authors： Lee Y,Barthel SD,Dłotko P,Moosavi SM,Hess K,Smit B

更新日期：2017-05-23 00:00:00

abstract：:Electrocatalysts for oxygen reduction are a critical component that may dramatically enhance the performance of fuel cells and metal-air batteries, which may provide the power for future electric vehicles. Here we report a novel bio-inspired composite electrocatalyst, iron phthalocyanine with an axial ligand anchored ...

journal_title：Nature communications

authors： Cao R,Thapa R,Kim H,Xu X,Gyu Kim M,Li Q,Park N,Liu M,Cho J

更新日期：2013-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adaptations including a non-canonical glutamine (Gln) metabolic pathway and...

journal_title：Nature communications

authors： Biancur DE,Paulo JA,Małachowska B,Quiles Del Rey M,Sousa CM,Wang X,Sohn ASW,Chu GC,Gygi SP,Harper JW,Fendler W,Mancias JD,Kimmelman AC

更新日期：2017-07-03 00:00:00

abstract：:The HIRA histone chaperone complex deposits the histone variant H3.3 onto chromatin in a DNA synthesis-independent manner. It comprises three identified subunits, HIRA, UBN1 and CABIN1, however the functional oligomerization state of the complex has not been investigated. Here we use biochemical and crystallographic a...

journal_title：Nature communications

authors： Ray-Gallet D,Ricketts MD,Sato Y,Gupta K,Boyarchuk E,Senda T,Marmorstein R,Almouzni G

更新日期：2018-08-06 00:00:00

abstract：:Exciton-polaritons in semiconductor microcavities constitute the archetypal realization of a quantum fluid of light. Under coherent optical drive, remarkable effects such as superfluidity, dark solitons or the nucleation of vortices have been observed, and can be all understood as specific manifestations of the conden...

journal_title：Nature communications

authors： Stepanov P,Amelio I,Rousset JG,Bloch J,Lemaître A,Amo A,Minguzzi A,Carusotto I,Richard M

更新日期：2019-08-27 00:00:00

abstract：:Habituation and dishabituation modulate the neural resources and behavioral significance allocated to incoming stimuli across the sensory systems. We characterize these processes in the mouse olfactory bulb (OB) and uncover a role for OB acetylcholine (ACh) in physiological and behavioral olfactory dishabituation. We ...

journal_title：Nature communications

authors： Ogg MC,Ross JM,Bendahmane M,Fletcher ML

更新日期：2018-05-14 00:00:00

abstract：:Bacterial CRISPR-Cas systems comprise diverse effector endonucleases with different targeting ranges, specificities and enzymatic properties, but many of them are inactive in mammalian cells and are thus precluded from genome-editing applications. Here we show that the type II-B FnCas9 from Francisella novicida posses...

journal_title：Nature communications

authors： Chen F,Ding X,Feng Y,Seebeck T,Jiang Y,Davis GD

更新日期：2017-04-07 00:00:00

abstract：:The study of the high pressure phase diagram of hydrogen has continued with renewed effort for about one century as it remains a fundamental challenge for experimental and theoretical techniques. Here we employ an efficient molecular dynamics based on the quantum Monte Carlo method, which can describe accurately the e...

journal_title：Nature communications

authors： Mazzola G,Yunoki S,Sorella S

更新日期：2014-03-19 00:00:00

abstract：:Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produced by novel rapid-acting antidepressants such as ketamine are mediated by mPFC activity. The mPFC contains multiple types of pyramidal cells, but it is unclear whether a particular subtype mediates th...

journal_title：Nature communications

authors： Hare BD,Shinohara R,Liu RJ,Pothula S,DiLeone RJ,Duman RS

更新日期：2019-01-15 00:00:00

abstract：:Characterizing complex viral transcriptomes by conventional RNA sequencing approaches is complicated by high gene density, overlapping reading frames, and complex splicing patterns. Direct RNA sequencing (direct RNA-seq) using nanopore arrays offers an exciting alternative whereby individual polyadenylated RNAs are se...

journal_title：Nature communications

authors： Depledge DP,Srinivas KP,Sadaoka T,Bready D,Mori Y,Placantonakis DG,Mohr I,Wilson AC

更新日期：2019-02-14 00:00:00

abstract：:The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cel...

journal_title：Nature communications

authors： Zhang Y,Jiao Y,Liu Z,Zhu YX

更新日期：2015-01-29 00:00:00

abstract：:The evolution of the seawater oxygen isotopic composition (δ18O) through geological time remains controversial. Yet, the past δ18Oseawater is key to assess past seawater temperatures, providing insights into past climate change and life evolution. Here we provide a new and unprecedentedly precise δ18O value of -1.33 ±...

journal_title：Nature communications

authors： Hodel F,Macouin M,Trindade RIF,Triantafyllou A,Ganne J,Chavagnac V,Berger J,Rospabé M,Destrigneville C,Carlut J,Ennih N,Agrinier P

更新日期：2018-04-13 00:00:00

abstract：:Deregulation of mitochondrial network in terminally differentiated cells contributes to a broad spectrum of disorders. Methylmalonic acidemia (MMA) is one of the most common inherited metabolic disorders, due to deficiency of the mitochondrial methylmalonyl-coenzyme A mutase (MMUT). How MMUT deficiency triggers cell d...

journal_title：Nature communications

authors： Luciani A,Schumann A,Berquez M,Chen Z,Nieri D,Failli M,Debaix H,Festa BP,Tokonami N,Raimondi A,Cremonesi A,Carrella D,Forny P,Kölker S,Diomedi Camassei F,Diaz F,Moraes CT,Di Bernardo D,Baumgartner MR,Devuyst O

更新日期：2020-02-20 00:00:00