Redesigning the QA binding site of Photosystem II allows reduction of exogenous quinones.

abstract：:How spatial and temporal information are integrated to determine the direction of cell migration remains poorly understood. Here, by precise microfluidics emulation of dynamic chemoattractant waves, we demonstrate that, in Dictyostelium, directional movement as well as activation of small guanosine triphosphatase Ras ...

journal_title：Nature communications

authors： Nakajima A,Ishihara S,Imoto D,Sawai S

更新日期：2014-11-06 00:00:00

abstract：:The turnover of messenger RNAs (mRNAs) is a key regulatory step of gene expression in eukaryotic cells. Due to the complexity of the mammalian degradation machinery, the contribution of decay factors to the directionality of mRNA decay is poorly understood. Here we characterize a molecular tool to interrogate mRNA tur...

journal_title：Nature communications

authors： Boehm V,Gerbracht JV,Marx MC,Gehring NH

更新日期：2016-12-05 00:00:00

abstract：:The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in dependent rats. In the present study we describe that the CeA neuronal ensemble that is activated by withdrawal from chronic alcohol exposure c...

journal_title：Nature communications

authors： de Guglielmo G,Kallupi M,Pomrenze MB,Crawford E,Simpson S,Schweitzer P,Koob GF,Messing RO,George O

更新日期：2019-03-18 00:00:00

abstract：:Myoblast fusion is an indispensable step for skeletal muscle development, postnatal growth, and regeneration. Myeloid differentiation primary response gene 88 (MyD88) is an adaptor protein that mediates Toll-like receptors and interleukin-1 receptor signaling. Here we report a cell-autonomous role of MyD88 in the regu...

journal_title：Nature communications

authors： Hindi SM,Shin J,Gallot YS,Straughn AR,Simionescu-Bankston A,Hindi L,Xiong G,Friedland RP,Kumar A

更新日期：2017-11-20 00:00:00

abstract：:Habituation and dishabituation modulate the neural resources and behavioral significance allocated to incoming stimuli across the sensory systems. We characterize these processes in the mouse olfactory bulb (OB) and uncover a role for OB acetylcholine (ACh) in physiological and behavioral olfactory dishabituation. We ...

journal_title：Nature communications

authors： Ogg MC,Ross JM,Bendahmane M,Fletcher ML

更新日期：2018-05-14 00:00:00

abstract：:Graphene and hexagonal boron nitride are typical conductor and insulator, respectively, while their hybrids hexagonal boron carbonitride are promising as a semiconductor. Here we demonstrate a direct chemical conversion reaction, which systematically converts the hexagonal carbon lattice of graphene to boron nitride, ...

journal_title：Nature communications

authors： Gong Y,Shi G,Zhang Z,Zhou W,Jung J,Gao W,Ma L,Yang Y,Yang S,You G,Vajtai R,Xu Q,MacDonald AH,Yakobson BI,Lou J,Liu Z,Ajayan PM

更新日期：2014-01-01 00:00:00

abstract：:Networks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that artificial networks of protein nanofibrils can induce controlled deformation and division of al...

journal_title：Nature communications

authors： Song Y,Michaels TCT,Ma Q,Liu Z,Yuan H,Takayama S,Knowles TPJ,Shum HC

更新日期：2018-05-29 00:00:00

abstract：:Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical description, reminiscent of Onsager's trajectory ...

journal_title：Nature communications

authors： Astumian RD

更新日期：2019-08-23 00:00:00

abstract：:The circular photogalvanic effect (CPGE) is the part of a photocurrent that switches depending on the sense of circular polarization of the incident light. It has been consistently observed in systems without inversion symmetry and depends on non-universal material details. Here we find that in a class of Weyl semimet...

journal_title：Nature communications

authors： de Juan F,Grushin AG,Morimoto T,Moore JE

更新日期：2017-07-06 00:00:00

abstract：:A key question of theoretical ecology is which properties of ecosystems favour their stability and help maintaining biodiversity. This question recently reconsidered mutualistic systems, generating intense controversy about the role of mutualistic interactions and their network architecture. Here we show analytically ...

journal_title：Nature communications

authors： Pascual-García A,Bastolla U

更新日期：2017-02-24 00:00:00

abstract：:Terephthalic acid (TPA) is an important industrial chemical currently produced by energy intensive and potentially hazardous p-xylene (pX) oxidation process. Here we report the development of metabolically engineered Escherichia coli system for biological transformation of pX into TPA. The engineered E. coli strain ha...

journal_title：Nature communications

authors： Luo ZW,Lee SY

更新日期：2017-05-31 00:00:00

abstract：:The survival of viruses partly relies on their ability to self-assemble inside host cells. Although coarse-grained simulations have identified different pathways leading to assembled virions from their components, experimental evidence is severely lacking. Here, we use time-resolved small-angle X-ray scattering to unc...

journal_title：Nature communications

authors： Chevreuil M,Law-Hine D,Chen J,Bressanelli S,Combet S,Constantin D,Degrouard J,Möller J,Zeghal M,Tresset G

更新日期：2018-08-06 00:00:00

abstract：:Adult stem cells commonly give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate decisions within the progenitor pool. Here we use quantitative analysis of Wnt, Hh, and Notch signalling reporters and the cell fate mark...

journal_title：Nature communications

authors： Dai W,Peterson A,Kenney T,Burrous H,Montell DJ

更新日期：2017-11-01 00:00:00

abstract：:Targeting the vasculature remains a promising approach for treating solid tumours; however, the mechanisms of tumour neovascularization are diverse and complex. Here we uncover a new subpopulation of melanoma cells that express the vascular cell adhesion molecule PECAM1, but not VEGFR-2, and participate in a PECAM1-de...

journal_title：Nature communications

authors： Dunleavey JM,Xiao L,Thompson J,Kim MM,Shields JM,Shelton SE,Irvin DM,Brings VE,Ollila DW,Brekken RA,Dayton PA,Melero-Martin JM,Dudley AC

更新日期：2014-10-22 00:00:00

abstract：:The microbial communities living in the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify...

journal_title：Nature communications

authors： Lahti L,Salojärvi J,Salonen A,Scheffer M,de Vos WM

更新日期：2014-07-08 00:00:00

abstract：:Rotational invariance strongly constrains the viscosity tensor of classical fluids. When this symmetry is broken in anisotropic materials a wide array of novel phenomena become possible. We explore electron fluid behaviors arising from the most general viscosity tensors in two and three dimensions, constrained only th...

journal_title：Nature communications

authors： Varnavides G,Jermyn AS,Anikeeva P,Felser C,Narang P

更新日期：2020-09-18 00:00:00

abstract：:Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 cases, 2677 controls) and replication analysis of NTS bacteraemia in Keny...

journal_title：Nature communications

authors： Gilchrist JJ,Rautanen A,Fairfax BP,Mills TC,Naranbhai V,Trochet H,Pirinen M,Muthumbi E,Mwarumba S,Njuguna P,Mturi N,Msefula CL,Gondwe EN,MacLennan JM,Chapman SJ,Molyneux ME,Knight JC,Spencer CCA,Williams TN,MacLenna

更新日期：2018-03-09 00:00:00

abstract：:Biodegradable polyesters with various tacticities have been synthesized by means of stereoselective ring-opening polymerization of racemic lactide and β-lactones but with limited side-chain groups. However, stereoselective synthesis of functional polyesters remains challenging from O-carboxyanhydrides that have abunda...

journal_title：Nature communications

authors： Feng Q,Yang L,Zhong Y,Guo D,Liu G,Xie L,Huang W,Tong R

更新日期：2018-04-19 00:00:00

abstract：:Modular and orthogonal genetic logic gates are essential for building robust biologically based digital devices to customize cell signalling in synthetic biology. Here we constructed an orthogonal AND gate in Escherichia coli using a novel hetero-regulation module from Pseudomonas syringae. The device comprises two co...

journal_title：Nature communications

authors： Wang B,Kitney RI,Joly N,Buck M

更新日期：2011-10-18 00:00:00

abstract：:Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glyco...

journal_title：Nature communications

authors： Wang Y,Quinsaat JEQ,Ono T,Maeki M,Tokeshi M,Isono T,Tajima K,Satoh T,Sato SI,Miura Y,Yamamoto T

更新日期：2020-11-30 00:00:00

abstract：:Omniphobic membranes are attractive for membrane distillation (MD) because of their superior wetting resistance. However, a design framework for MD membrane remains incomplete, due to the complexity of omniphobic membrane fabrication and the lack of fundamental relationship between wetting resistance and water vapor p...

journal_title：Nature communications

authors： Wang W,Du X,Vahabi H,Zhao S,Yin Y,Kota AK,Tong T

更新日期：2019-07-19 00:00:00

abstract：:The effects of high-fat diet (HFD) and postprandial endotoxemia on the development of type 2 diabetes are not fully understood. Here we show that the serine protease prostasin (PRSS8) regulates hepatic insulin sensitivity by modulating Toll-like receptor 4 (TLR4)-mediated signalling. HFD triggers the suppression of PR...

journal_title：Nature communications

authors： Uchimura K,Hayata M,Mizumoto T,Miyasato Y,Kakizoe Y,Morinaga J,Onoue T,Yamazoe R,Ueda M,Adachi M,Miyoshi T,Shiraishi N,Ogawa W,Fukuda K,Kondo T,Matsumura T,Araki E,Tomita K,Kitamura K

更新日期：2014-03-11 00:00:00

abstract：:The study of the high pressure phase diagram of hydrogen has continued with renewed effort for about one century as it remains a fundamental challenge for experimental and theoretical techniques. Here we employ an efficient molecular dynamics based on the quantum Monte Carlo method, which can describe accurately the e...

journal_title：Nature communications

authors： Mazzola G,Yunoki S,Sorella S

更新日期：2014-03-19 00:00:00

abstract：:Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) and is a...

journal_title：Nature communications

authors： Mouhieddine TH,Sperling AS,Redd R,Park J,Leventhal M,Gibson CJ,Manier S,Nassar AH,Capelletti M,Huynh D,Bustoros M,Sklavenitis-Pistofidis R,Tahri S,Hornburg K,Dumke H,Itani MM,Boehner CJ,Liu CJ,AlDubayan SH,Reardon B

更新日期：2020-06-12 00:00:00

abstract：:Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing ne...

journal_title：Nature communications

authors： Dhandapani R,Arokiaraj CM,Taberner FJ,Pacifico P,Raja S,Nocchi L,Portulano C,Franciosa F,Maffei M,Hussain AF,de Castro Reis F,Reymond L,Perlas E,Garcovich S,Barth S,Johnsson K,Lechner SG,Heppenstall PA

更新日期：2018-04-24 00:00:00

abstract：:Developing earth-abundant, active and stable electrocatalysts which operate in the same electrolyte for water splitting, including oxygen evolution reaction and hydrogen evolution reaction, is important for many renewable energy conversion processes. Here we demonstrate the improvement of catalytic activity when trans...

journal_title：Nature communications

authors： Wang H,Lee HW,Deng Y,Lu Z,Hsu PC,Liu Y,Lin D,Cui Y

更新日期：2015-06-23 00:00:00

abstract：:To expand the toolbox of imaging in living cells, we have engineered a single-chain variable fragment binding the linear HA epitope with high affinity and specificity in vivo. The resulting probe, called the HA frankenbody, can light up in multiple colors HA-tagged nuclear, cytoplasmic, membrane, and mitochondrial pro...

journal_title：Nature communications

authors： Zhao N,Kamijo K,Fox PD,Oda H,Morisaki T,Sato Y,Kimura H,Stasevich TJ

更新日期：2019-07-03 00:00:00

abstract：:Decision making in dynamic environments requires discounting old evidence that may no longer inform the current state of the world. Previous work found that humans discount old evidence in a dynamic environment, but do not discount at the optimal rate. Here we investigated whether rats can optimally discount evidence ...

journal_title：Nature communications

authors： Piet AT,El Hady A,Brody CD

更新日期：2018-10-15 00:00:00

abstract：:Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP...

journal_title：Nature communications

authors： Kang H,Yang B,Zhang K,Pan Q,Yuan W,Li G,Bian L

更新日期：2019-04-12 00:00:00

abstract：:The integration of β-barrel proteins into the bacterial outer membrane (OM) is catalysed by the β-barrel assembly machinery (BAM). The central BAM subunit (BamA) itself contains a β-barrel domain that is essential for OM protein biogenesis, but its mechanism of action is unknown. To elucidate its function, here we dev...

journal_title：Nature communications

authors： Doyle MT,Bernstein HD

更新日期：2019-07-26 00:00:00