The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.

abstract：:Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8(+) T-cell population that expresses the marker NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. NK1....

journal_title：Nature communications

authors： Ruiz AL,Soudja SM,Deceneux C,Lauvau G,Marie JC

更新日期：2014-10-06 00:00:00

abstract：:Precise frequency discrimination is a hallmark of auditory function in birds and mammals and is required for distinguishing similar sounding words, like 'bat,' 'cat' and 'hat.' In the cochlea, tuning and spectral separation result from longitudinal differences in basilar membrane stiffness and numerous individual grad...

journal_title：Nature communications

authors： Thiede BR,Mann ZF,Chang W,Ku YC,Son YK,Lovett M,Kelley MW,Corwin JT

更新日期：2014-05-20 00:00:00

abstract：:The primary productivity of the Southern Ocean ecosystem is limited by iron availability. Away from benthic and aeolian sources, iron reaches phytoplankton primarily when iron-rich subsurface waters enter the euphotic zone. Here, eddy-resolving physical/biogeochemical simulations of a seasonally-forced, open-Southern-...

journal_title：Nature communications

authors： Uchida T,Balwada D,P Abernathey R,A McKinley G,K Smith S,Lévy M

更新日期：2020-02-28 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Jiang L,Shen Y,Guo D,Yang D,Liu J,Fei X,Yang Y,Zhang B,Lin Z,Yang F,Wang X,Wang K,Wang J,Cai Z

更新日期：2020-07-16 00:00:00

abstract：:Potassium ion channels utilize a highly selective filter to rapidly transport K+ ions across cellular membranes. This selectivity filter is composed of four binding sites which display almost equal electron density in crystal structures with high potassium ion concentrations. This electron density can be interpreted t...

journal_title：Nature communications

authors： Langan PS,Vandavasi VG,Weiss KL,Afonine PV,El Omari K,Duman R,Wagner A,Coates L

更新日期：2018-10-31 00:00:00

abstract：:Understanding and reshaping cellular behaviors with synthetic gene networks requires the ability to sense and respond to changes in the intracellular environment. Intracellular proteins are involved in almost all cellular processes, and thus can provide important information about changes in cellular conditions such a...

journal_title：Nature communications

authors： Siciliano V,DiAndreth B,Monel B,Beal J,Huh J,Clayton KL,Wroblewska L,McKeon A,Walker BD,Weiss R

更新日期：2018-05-14 00:00:00

abstract：:A recent review concluded that earthworm presence increases CO₂ emissions by 33% but does not affect soil organic carbon stocks. However, the findings are controversial and raise new questions. Here we hypothesize that neither an increase in CO₂ emission nor in stabilized carbon would entirely reflect the earthworms' ...

journal_title：Nature communications

authors： Zhang W,Hendrix PF,Dame LE,Burke RA,Wu J,Neher DA,Li J,Shao Y,Fu S

更新日期：2013-01-01 00:00:00

abstract：:Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain st...

journal_title：Nature communications

authors： Bittner N,Jockwitz C,Mühleisen TW,Hoffstaedter F,Eickhoff SB,Moebus S,Bayen UJ,Cichon S,Zilles K,Amunts K,Caspers S

更新日期：2019-02-06 00:00:00

abstract：:Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time...

journal_title：Nature communications

authors： Galenkamp NS,Soskine M,Hermans J,Wloka C,Maglia G

更新日期：2018-10-05 00:00:00

abstract：:Prediction of Indian summer monsoon rainfall (ISMR) is at the heart of tropical climate prediction. Despite enormous progress having been made in predicting ISMR since 1886, the operational forecasts during recent decades (1989-2012) have little skill. Here we show, with both dynamical and physical-empirical models, t...

journal_title：Nature communications

authors： Wang B,Xiang B,Li J,Webster PJ,Rajeevan MN,Liu J,Ha KJ

更新日期：2015-05-18 00:00:00

abstract：:Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here we find that junctional adh...

journal_title：Nature communications

authors： Tuncay H,Brinkmann BF,Steinbacher T,Schürmann A,Gerke V,Iden S,Ebnet K

更新日期：2015-08-26 00:00:00

abstract：:HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man9-V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope...

journal_title：Nature communications

authors： Fera D,Lee MS,Wiehe K,Meyerhoff RR,Piai A,Bonsignori M,Aussedat B,Walkowicz WE,Ton T,Zhou JO,Danishefsky S,Haynes BF,Harrison SC

更新日期：2018-03-16 00:00:00

abstract：:The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....

journal_title：Nature communications

authors： Kiss L,Zeng J,Dickson CF,Mallery DL,Yang JC,McLaughlin SH,Boland A,Neuhaus D,James LC

更新日期：2019-10-03 00:00:00

abstract：:Addressing the intrinsic charge transport limitation of metal oxides has been of significance for pursuing viable PEC water splitting photoelectrodes. Growing a photoelectrode with conductive nanoobjects embedded in the matrix is promising for enhanced charge transport but remains a challenge technically. We herein sh...

journal_title：Nature communications

authors： Jian J,Xu Y,Yang X,Liu W,Fu M,Yu H,Xu F,Feng F,Jia L,Friedrich D,van de Krol R,Wang H

更新日期：2019-06-13 00:00:00

abstract：:Recent outbreaks of Zika, chikungunya and dengue highlight the importance of better understanding the spread of disease-carrying mosquitoes across multiple spatio-temporal scales. Traditional surveillance tools are limited by jurisdictional boundaries and cost constraints. Here we show how a scalable citizen science s...

journal_title：Nature communications

authors： Palmer JRB,Oltra A,Collantes F,Delgado JA,Lucientes J,Delacour S,Bengoa M,Eritja R,Bartumeus F

更新日期：2017-10-24 00:00:00

abstract：:Nitrogen acquisition is a major challenge for herbivorous animals, and the repeated origins of herbivory across the ants have raised expectations that nutritional symbionts have shaped their diversification. Direct evidence for N provisioning by internally housed symbionts is rare in animals; among the ants, it has be...

journal_title：Nature communications

authors： Hu Y,Sanders JG,Łukasik P,D'Amelio CL,Millar JS,Vann DR,Lan Y,Newton JA,Schotanus M,Kronauer DJC,Pierce NE,Moreau CS,Wertz JT,Engel P,Russell JA

更新日期：2018-03-06 00:00:00

abstract：:Although substantial progress has been made in cancer biology and treatment, clinical outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor microenvironment (TME) is a potential target. Here, by single-cell RNA sequencing on 8 BC tumor samples and 3 para tumor samples, we identify 19 differ...

journal_title：Nature communications

authors： Chen Z,Zhou L,Liu L,Hou Y,Xiong M,Yang Y,Hu J,Chen K

更新日期：2020-10-08 00:00:00

abstract：:Deep subsurface formations (for example, high-temperature oil reservoirs) are candidate sites for carbon capture and storage technology. However, very little is known about how the subsurface microbial community would respond to an increase in CO2 pressure resulting from carbon capture and storage. Here we construct m...

journal_title：Nature communications

authors： Mayumi D,Dolfing J,Sakata S,Maeda H,Miyagawa Y,Ikarashi M,Tamaki H,Takeuchi M,Nakatsu CH,Kamagata Y

更新日期：2013-01-01 00:00:00

abstract：:The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water intake currently remain unclear. We previously reported that thirst-driving neurons (water neurons) in...

journal_title：Nature communications

authors： Matsuda T,Hiyama TY,Kobayashi K,Kobayashi K,Noda M

更新日期：2020-11-10 00:00:00

abstract：:The fate of the enormous amount of reactive nitrogen released to the environment by human activities in India is unknown. Here we show occurrence of seasonal stratification and generally low concentrations of dissolved inorganic combined nitrogen, and high molecular nitrogen (N2) to argon ratio, thus suggesting season...

journal_title：Nature communications

authors： Naqvi SWA,Lam P,Narvenkar G,Sarkar A,Naik H,Pratihary A,Shenoy DM,Gauns M,Kurian S,Damare S,Duret M,Lavik G,Kuypers MMM

更新日期：2018-03-28 00:00:00

abstract：:Epigenomic data sets provide critical information about the dynamic role of chromatin states in gene regulation, but a key question of how chromatin state segmentations vary under different conditions across the genome has remained unaddressed. Here we present ChromDiff, a group-wise chromatin state comparison method ...

journal_title：Nature communications

authors： Yen A,Kellis M

更新日期：2015-08-18 00:00:00

abstract：:Dense ceramic materials can form in nature under mild temperatures in water. By contrast, man-made ceramics often require sintering temperatures in excess of 1,400 °C for densification. Chemical strategies inspired by biomineralization processes have been demonstrated but remain limited to the fabrication of thin film...

journal_title：Nature communications

authors： Bouville F,Studart AR

更新日期：2017-03-06 00:00:00

abstract：:The experimental investigation of quantum devices incorporating mechanical resonators has opened up new frontiers in the study of quantum mechanics at a macroscopic level. It has recently been shown that surface acoustic waves (SAWs) can be piezoelectrically coupled to superconducting qubits, and confined in high-qual...

journal_title：Nature communications

authors： Manenti R,Kockum AF,Patterson A,Behrle T,Rahamim J,Tancredi G,Nori F,Leek PJ

更新日期：2017-10-17 00:00:00

abstract：:A subset of transcription factors classified as neural crest 'specifiers' are also core epithelial-mesenchymal transition regulatory factors, both in the neural crest and in tumour progression. The bHLH factor Twist is among the least well studied of these factors. Here we demonstrate that Twist is required for crania...

journal_title：Nature communications

authors： Lander R,Nasr T,Ochoa SD,Nordin K,Prasad MS,Labonne C

更新日期：2013-01-01 00:00:00

abstract：:During morphogenesis, remodelling of cell shape requires the expansion or contraction of plasma membrane domains. Here we identify a mechanism underlying the restructuring of the apical surface during epithelial morphogenesis in Drosophila. We show that the retraction of villous protrusions and subsequent apical plasm...

journal_title：Nature communications

authors： Fabrowski P,Necakov AS,Mumbauer S,Loeser E,Reversi A,Streichan S,Briggs JA,De Renzis S

更新日期：2013-01-01 00:00:00

abstract：:The field of optical metrology with its high precision position, rotation and wavefront sensors represents the basis for lithography and high resolution microscopy. However, the on-chip integration-a task highly relevant for future nanotechnological devices-necessitates the reduction of the spatial footprint of sensin...

journal_title：Nature communications

authors： Bag A,Neugebauer M,Mick U,Christiansen S,Schulz SA,Banzer P

更新日期：2020-06-09 00:00:00

abstract：:The large interest in chiral magnetic structures for realization of nanoscale magnetic storage or logic devices has necessitated methods which can quantify magnetic interactions at the atomic scale. To overcome the limitations of the typically used current-based sensing of atomic-scale exchange interactions, a force-b...

journal_title：Nature communications

authors： Hauptmann N,Haldar S,Hung TC,Jolie W,Gutzeit M,Wegner D,Heinze S,Khajetoorians AA

更新日期：2020-03-05 00:00:00

abstract：:The synergistic interaction among different components in complex catalysts is one of the crucial factors in determining catalytic performance. Here we report the interactions among the three components in controlling the catalytic performance of Cu-ZnO-ZrO2 (CZZ) catalyst for CO2 hydrogenation to methanol. The in sit...

journal_title：Nature communications

authors： Wang Y,Kattel S,Gao W,Li K,Liu P,Chen JG,Wang H

更新日期：2019-03-11 00:00:00

abstract：:The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy req...

journal_title：Nature communications

authors： Rothe S,Andreyev AN,Antalic S,Borschevsky A,Capponi L,Cocolios TE,De Witte H,Eliav E,Fedorov DV,Fedosseev VN,Fink DA,Fritzsche S,Ghys L,Huyse M,Imai N,Kaldor U,Kudryavtsev Y,Köster U,Lane JF,Lassen J,Liberati V,

更新日期：2013-01-01 00:00:00

abstract：:Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of the complementary C-strand by DNA polymerase α is also required to maintain telomere length. Polymerase α cannot perform this role without the ssDNA binding complex CST (CTC1-STN1-TEN1...

journal_title：Nature communications

authors： Feng X,Hsu SJ,Bhattacharjee A,Wang Y,Diao J,Price CM

更新日期：2018-07-19 00:00:00