当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake.

Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake.

Abstract：

:The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water intake currently remain unclear. We previously reported that thirst-driving neurons (water neurons) in the subfornical organ (SFO) are cholecystokinin (CCK)-dependently suppressed by GABAergic interneurons under Na-depleted conditions. We herein show that CCK-producing excitatory neurons in the SFO stimulate the activity of GABAergic interneurons via CCK-B receptors. Fluorescence-microscopic Ca2+ imaging demonstrates two distinct subpopulations in CCK-positive neurons in the SFO, which are persistently activated under hyponatremic conditions or transiently activated in response to water drinking, respectively. Optical and chemogenetic silencings of the respective types of CCK-positive neurons both significantly increase water intake under water-repleted conditions. The present study thus reveals CCK-mediated neural mechanisms in the central nervous system for the control of water-intake behaviors.

journal_name

Nat Commun

journal_title

Nature communications

authors

Matsuda T,Hiyama TY,Kobayashi K,Kobayashi K,Noda M

doi

10.1038/s41467-020-19191-0

subject

Has Abstract

pub_date

2020-11-10 00:00:00

pages

5692

issue

1

issn

2041-1723

pii

10.1038/s41467-020-19191-0

journal_volume

11

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Poly(4-styrenesulfonate)-induced sulfur vacancy self-healing strategy for monolayer MoS2 homojunction photodiode.

    abstract：:We establish a powerful poly(4-styrenesulfonate) (PSS)-treated strategy for sulfur vacancy healing in monolayer MoS2 to precisely and steadily tune its electronic state. The self-healing mechanism, in which the sulfur vacancies are healed spontaneously by the sulfur adatom clusters on the MoS2 surface through a PSS-in...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15881

    authors： Zhang X,Liao Q,Liu S,Kang Z,Zhang Z,Du J,Li F,Zhang S,Xiao J,Liu B,Ou Y,Liu X,Gu L,Zhang Y

    更新日期：2017-06-22 00:00:00

  • Emergence of chirality and structural complexity in single crystals at the molecular and morphological levels.

    abstract：:Naturally occurring single crystals having a multidomain morphology are a counterintuitive phenonomon: the macroscopic appearance is expected to follow the symmetry of the unit cell. Growing such crystals in the lab is a great challenge, especially from organic molecules. We achieve here uniform metallo-organic crysta...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13925-5

    authors： di Gregorio MC,Shimon LJW,Brumfeld V,Houben L,Lahav M,van der Boom ME

    更新日期：2020-01-20 00:00:00

  • A global strategy to mitigate the environmental impact of China's ruminant consumption boom.

    abstract：:Rising demand for ruminant meat and dairy products in developing countries is expected to double anthropogenic greenhouse gas and ammonia emissions from livestock by 2050. Mitigation strategies are urgently needed to meet demand while minimizing environmental impacts. Here, we develop scenarios for mitigating emission...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06381-0

    authors： Du Y,Ge Y,Ren Y,Fan X,Pan K,Lin L,Wu X,Min Y,Meyerson LA,Heino M,Chang SX,Liu X,Mao F,Yang G,Peng C,Qu Z,Chang J,Didham RK

    更新日期：2018-10-08 00:00:00

  • Intellectual synthesis in mentorship determines success in academic careers.

    abstract：:As academic careers become more competitive, junior scientists need to understand the value that mentorship brings to their success in academia. Previous research has found that, unsurprisingly, successful mentors tend to train successful students. But what characteristics of this relationship predict success, and how...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07034-y

    authors： Liénard JF,Achakulvisut T,Acuna DE,David SV

    更新日期：2018-11-27 00:00:00

  • Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics.

    abstract：:Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthogonal non-canonical amino acid tagging and high-resolution mass spectr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18718-9

    authors： Kato A,Adachi S,Kawano S,Takeshima K,Watanabe M,Kitazume S,Sato R,Kusano H,Koyanagi N,Maruzuru Y,Arii J,Hatta T,Natsume T,Kawaguchi Y

    更新日期：2020-09-29 00:00:00

  • Dereplication of microbial metabolites through database search of mass spectra.

    abstract：:Natural products have traditionally been rich sources for drug discovery. In order to clear the road toward the discovery of unknown natural products, biologists need dereplication strategies that identify known ones. Here we report DEREPLICATOR+, an algorithm that improves on the previous approaches for identifying p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06082-8

    authors： Mohimani H,Gurevich A,Shlemov A,Mikheenko A,Korobeynikov A,Cao L,Shcherbin E,Nothias LF,Dorrestein PC,Pevzner PA

    更新日期：2018-10-02 00:00:00

  • Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein.

    abstract：:Haploinsufficiency of the SLC2A1 gene and paucity of its translated product, the glucose transporter-1 (Glut1) protein, disrupt brain function and cause the neurodevelopmental disorder, Glut1 deficiency syndrome (Glut1 DS). There is little to suggest how reduced Glut1 causes cognitive dysfunction and no optimal treatm...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14152

    authors： Tang M,Gao G,Rueda CB,Yu H,Thibodeaux DN,Awano T,Engelstad KM,Sanchez-Quintero MJ,Yang H,Li F,Li H,Su Q,Shetler KE,Jones L,Seo R,McConathy J,Hillman EM,Noebels JL,De Vivo DC,Monani UR

    更新日期：2017-01-20 00:00:00

  • Biogeography and habitat modelling of high-alpine bacteria.

    abstract：:Soil microorganisms dominate terrestrial biogeochemical cycles; however, we know very little about their spatial distribution and how changes in the distributions of specific groups of microbes translate into landscape and global patterns of biogeochemical processes. In this paper, we use a nested sampling scheme at s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1055

    authors： King AJ,Freeman KR,McCormick KF,Lynch RC,Lozupone C,Knight R,Schmidt SK

    更新日期：2010-08-10 00:00:00

  • Ice sheets as a significant source of highly reactive nanoparticulate iron to the oceans.

    abstract：:The Greenland and Antarctic Ice Sheets cover ~ 10% of global land surface, but are rarely considered as active components of the global iron cycle. The ocean waters around both ice sheets harbour highly productive coastal ecosystems, many of which are iron limited. Measurements of iron concentrations in subglacial run...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4929

    authors： Hawkings JR,Wadham JL,Tranter M,Raiswell R,Benning LG,Statham PJ,Tedstone A,Nienow P,Lee K,Telling J

    更新日期：2014-05-21 00:00:00

  • MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.

    abstract：:The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activation of muscle-spec...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12397

    authors： Moretti I,Ciciliot S,Dyar KA,Abraham R,Murgia M,Agatea L,Akimoto T,Bicciato S,Forcato M,Pierre P,Uhlenhaut NH,Rigby PW,Carvajal JJ,Blaauw B,Calabria E,Schiaffino S

    更新日期：2016-08-03 00:00:00

  • Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription.

    abstract：:The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2.0-Å resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14076

    authors： Qi S,Li Z,Schulze-Gahmen U,Stjepanovic G,Zhou Q,Hurley JH

    更新日期：2017-01-30 00:00:00

  • Publisher Correction: Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-13138-w

    authors： Weinert LA,Chaudhuri RR,Wang J,Peters SE,Corander J,Jombart T,Baig A,Howell KJ,Vehkala M,Välimäki N,Harris D,Chieu TTB,Van Vinh Chau N,Campbell J,Schultsz C,Parkhill J,Bentley SD,Langford PR,Rycroft AN,Wren BW,Far

    更新日期：2019-11-22 00:00:00

  • Precise radiometric age establishes Yarrabubba, Western Australia, as Earth's oldest recognised meteorite impact structure.

    abstract：:The ~70 km-diameter Yarrabubba impact structure in Western Australia is regarded as among Earth's oldest, but has hitherto lacked precise age constraints. Here we present U-Pb ages for impact-driven shock-recrystallised accessory minerals. Shock-recrystallised monazite yields a precise impact age of 2229 ± 5 Ma, coeva...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13985-7

    authors： Erickson TM,Kirkland CL,Timms NE,Cavosie AJ,Davison TM

    更新日期：2020-01-21 00:00:00

  • Sleep-dependent memory consolidation in infants protects new episodic memories from existing semantic memories.

    abstract：:Any experienced event may be encoded and retained in detail as part of our episodic memory, and may also refer and contribute to our generalized knowledge stored in semantic memory. The beginnings of this declarative memory formation are only poorly understood. Even less is known about the interrelation between episod...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14850-8

    authors： Friedrich M,Mölle M,Friederici AD,Born J

    更新日期：2020-03-10 00:00:00

  • Pink-beam serial crystallography.

    abstract：:Serial X-ray crystallography allows macromolecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for serial synchrotron crystallography experiments has been limited to millisecond timescales with monochromatic beams. The polychromatic, "...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01417-3

    authors： Meents A,Wiedorn MO,Srajer V,Henning R,Sarrou I,Bergtholdt J,Barthelmess M,Reinke PYA,Dierksmeyer D,Tolstikova A,Schaible S,Messerschmidt M,Ogata CM,Kissick DJ,Taft MH,Manstein DJ,Lieske J,Oberthuer D,Fischetti RF,C

    更新日期：2017-11-03 00:00:00

  • Compounding impact of severe weather events fuels marine heatwave in the coastal ocean.

    abstract：:Exposure to extreme events is a major concern in coastal regions where growing human populations and stressed natural ecosystems are at significant risk to such phenomena. However, the complex sequence of processes that transform an event from notable to extreme can be challenging to identify and hence, limit forecast...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18339-2

    authors： Dzwonkowski B,Coogan J,Fournier S,Lockridge G,Park K,Lee T

    更新日期：2020-09-22 00:00:00

  • Stable magnetostructural coupling with tunable magnetoresponsive effects in hexagonal ferromagnets.

    abstract：:The magnetostructural coupling between the structural and the magnetic transition has a crucial role in magnetoresponsive effects in a martensitic-transition system. A combination of various magnetoresponsive effects based on this coupling may facilitate the multifunctional applications of a host material. Here we dem...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1868

    authors： Liu E,Wang W,Feng L,Zhu W,Li G,Chen J,Zhang H,Wu G,Jiang C,Xu H,de Boer F

    更新日期：2012-05-29 00:00:00

  • Orbitofrontal lesions eliminate signalling of biological significance in cue-responsive ventral striatal neurons.

    abstract：:The ventral striatum has long been proposed as an integrator of biologically significant associative information to drive actions. Although inputs from the amygdala and hippocampus have been much studied, the role of prominent inputs from orbitofrontal cortex (OFC) are less well understood. Here, we recorded single-un...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8195

    authors： Cooch NK,Stalnaker TA,Wied HM,Bali-Chaudhary S,McDannald MA,Liu TL,Schoenbaum G

    更新日期：2015-05-21 00:00:00

  • Atomically engineering activation sites onto metallic 1T-MoS2 catalysts for enhanced electrochemical hydrogen evolution.

    abstract：:Engineering catalytic sites at the atomic level provides an opportunity to understand the catalyst's active sites, which is vital to the development of improved catalysts. Here we show a reliable and tunable polyoxometalate template-based synthetic strategy to atomically engineer metal doping sites onto metallic 1T-Mo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08877-9

    authors： Huang Y,Sun Y,Zheng X,Aoki T,Pattengale B,Huang J,He X,Bian W,Younan S,Williams N,Hu J,Ge J,Pu N,Yan X,Pan X,Zhang L,Wei Y,Gu J

    更新日期：2019-02-28 00:00:00

  • Author Correction: Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent.

    abstract：:The originally published version of this Article contained errors in Figure 4. In panel b, the square and diamond labels associated with the uppermost survival curve were incorrectly displayed as 'n' and 'u', respectively. These errors have now been corrected in both the PDF and HTML versions of the Article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-017-02205-9

    authors： Wang P,Li X,Wang J,Gao D,Li Y,Li H,Chu Y,Zhang Z,Liu H,Jiang G,Cheng Z,Wang S,Dong J,Feng B,Chard LS,Lemoine NR,Wang Y

    更新日期：2018-01-10 00:00:00

  • Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells.

    abstract：:Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and negative regulators are indispensable for homeostasis. For this reason, generating human anterior pituitary tissue that retains regulatory hormonal control in vitro is an important step for the development of cell transplantat...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10351

    authors： Ozone C,Suga H,Eiraku M,Kadoshima T,Yonemura S,Takata N,Oiso Y,Tsuji T,Sasai Y

    更新日期：2016-01-14 00:00:00

  • Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials.

    abstract：:Antibiotic resistance poses rapidly increasing global problems in combatting multidrug-resistant (MDR) infectious diseases like MDR tuberculosis, prompting for novel approaches including host-directed therapies (HDT). Intracellular pathogens like Salmonellae and Mycobacterium tuberculosis (Mtb) exploit host pathways t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02777-6

    authors： Korbee CJ,Heemskerk MT,Kocev D,van Strijen E,Rabiee O,Franken KLMC,Wilson L,Savage NDL,Džeroski S,Haks MC,Ottenhoff THM

    更新日期：2018-01-24 00:00:00

  • Overpumping leads to California groundwater arsenic threat.

    abstract：:Water resources are being challenged to meet domestic, agricultural, and industrial needs. To complement finite surface water supplies that are being stressed by changes in precipitation and increased demand, groundwater is increasingly being used. Sustaining groundwater use requires considering both water quantity an...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04475-3

    authors： Smith R,Knight R,Fendorf S

    更新日期：2018-06-05 00:00:00

  • Towards nanoprinting with metals on graphene.

    abstract：:Graphene and carbon nanotubes are envisaged as suitable materials for the fabrication of the new generation of nanoelectronics. The controlled patterning of such nanostructures with metal nanoparticles is conditioned by the transfer between a recipient and the surface to pattern. Electromigration under the impact of a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9071

    authors： Melinte G,Moldovan S,Hirlimann C,Liu X,Bégin-Colin S,Bégin D,Banhart F,Pham-Huu C,Ersen O

    更新日期：2015-08-28 00:00:00

  • Structure of the mouse TRPC4 ion channel.

    abstract：:Members of the transient receptor potential (TRP) ion channels conduct cations into cells. They mediate functions ranging from neuronally mediated hot and cold sensation to intracellular organellar and primary ciliary signaling. Here we report a cryo-electron microscopy (cryo-EM) structure of TRPC4 in its unliganded (...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05247-9

    authors： Duan J,Li J,Zeng B,Chen GL,Peng X,Zhang Y,Wang J,Clapham DE,Li Z,Zhang J

    更新日期：2018-08-06 00:00:00

  • Mesopelagic fishes dominate otolith record of past two millennia in the Santa Barbara Basin.

    abstract：:The mesopelagic (200-1000 m) separates the productive upper ocean from the deep ocean, yet little is known of its long-term dynamics despite recent research that suggests fishes of this zone likely dominate global fish biomass and contribute to the downward flux of carbon. Here we show that mesopelagic fishes dominate...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12600-z

    authors： Jones WA,Checkley DM Jr

    更新日期：2019-10-08 00:00:00

  • DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation.

    abstract：:DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17531-8

    authors： Adam S,Anteneh H,Hornisch M,Wagner V,Lu J,Radde NE,Bashtrykov P,Song J,Jeltsch A

    更新日期：2020-07-24 00:00:00

  • Human large-scale cooperation as a product of competition between cultural groups.

    abstract：:A fundamental puzzle of human evolution is how we evolved to cooperate with genetically unrelated strangers in transient interactions. Group-level selection on culturally differentiated populations is one proposed explanation. We evaluate a central untested prediction of Cultural Group Selection theory, by assessing w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14416-8

    authors： Handley C,Mathew S

    更新日期：2020-02-04 00:00:00

  • Rapid visualization of grain boundaries in monolayer MoS2 by multiphoton microscopy.

    abstract：:Grain boundaries have a major effect on the physical properties of two-dimensional layered materials. Therefore, it is important to develop simple, fast and sensitive characterization methods to visualize grain boundaries. Conventional Raman and photoluminescence methods have been used for detecting grain boundaries; ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15714

    authors： Karvonen L,Säynätjoki A,Huttunen MJ,Autere A,Amirsolaimani B,Li S,Norwood RA,Peyghambarian N,Lipsanen H,Eda G,Kieu K,Sun Z

    更新日期：2017-06-05 00:00:00

  • Dispersion relation of the collective excitations in a resonantly driven polariton fluid.

    abstract：:Exciton-polaritons in semiconductor microcavities constitute the archetypal realization of a quantum fluid of light. Under coherent optical drive, remarkable effects such as superfluidity, dark solitons or the nucleation of vortices have been observed, and can be all understood as specific manifestations of the conden...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11886-3

    authors： Stepanov P,Amelio I,Rousset JG,Bloch J,Lemaître A,Amo A,Minguzzi A,Carusotto I,Richard M

    更新日期：2019-08-27 00:00:00