Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription.

abstract：:Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility an...

journal_title：Nature communications

authors： Liu L,Leng L,Liu C,Lu C,Yuan Y,Wu L,Gong F,Zhang S,Wei X,Wang M,Zhao L,Hu L,Wang J,Yang H,Zhu S,Chen F,Lu G,Shang Z,Lin G

更新日期：2019-01-21 00:00:00

abstract：:Submarine channels are ubiquitous on the seafloor and their inception and evolution is a result of dynamic interaction between turbidity currents and the evolving seafloor. However, the morphodynamic links between channel inception and flow dynamics have not yet been monitored in experiments and only in one instance o...

journal_title：Nature communications

authors： de Leeuw J,Eggenhuisen JT,Cartigny MJ

更新日期：2016-03-21 00:00:00

abstract：:Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 cases, 2677 controls) and replication analysis of NTS bacteraemia in Keny...

journal_title：Nature communications

authors： Gilchrist JJ,Rautanen A,Fairfax BP,Mills TC,Naranbhai V,Trochet H,Pirinen M,Muthumbi E,Mwarumba S,Njuguna P,Mturi N,Msefula CL,Gondwe EN,MacLennan JM,Chapman SJ,Molyneux ME,Knight JC,Spencer CCA,Williams TN,MacLenna

更新日期：2018-03-09 00:00:00

abstract：:Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut mic...

journal_title：Nature communications

authors： Vojinovic D,Radjabzadeh D,Kurilshikov A,Amin N,Wijmenga C,Franke L,Ikram MA,Uitterlinden AG,Zhernakova A,Fu J,Kraaij R,van Duijn CM

更新日期：2019-12-20 00:00:00

abstract：:The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discoverin...

journal_title：Nature communications

authors： Ntalla I,Weng LC,Cartwright JH,Hall AW,Sveinbjornsson G,Tucker NR,Choi SH,Chaffin MD,Roselli C,Barnes MR,Mifsud B,Warren HR,Hayward C,Marten J,Cranley JJ,Concas MP,Gasparini P,Boutin T,Kolcic I,Polasek O,Rudan I,

更新日期：2020-05-21 00:00:00

abstract：:The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen of DUBs, we identif...

journal_title：Nature communications

authors： Qin J,Zhou Z,Chen W,Wang C,Zhang H,Ge G,Shao M,You D,Fan Z,Xia H,Liu R,Chen C

更新日期：2015-09-30 00:00:00

abstract：:DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 5'-flaps one nucleotide into duplex (ds) DNA. Yet, how FEN1 selects for but does not incise the ss 5'-flap was enigmatic. Here we combine...

journal_title：Nature communications

authors： Tsutakawa SE,Thompson MJ,Arvai AS,Neil AJ,Shaw SJ,Algasaier SI,Kim JC,Finger LD,Jardine E,Gotham VJB,Sarker AH,Her MZ,Rashid F,Hamdan SM,Mirkin SM,Grasby JA,Tainer JA

更新日期：2017-06-27 00:00:00

abstract：:Gramicidin A (gA) is the simplest known natural channel, and important progress in improving conduction activity has previously been obtained with modified natural gAs. However, simple artificial systems mimicking the gA functions are unknown. Here we show that gA can be mimicked using a simple synthetic triazole or '...

journal_title：Nature communications

authors： Barboiu M,Le Duc Y,Gilles A,Cazade PA,Michau M,Marie Legrand Y,van der Lee A,Coasne B,Parvizi P,Post J,Fyles T

更新日期：2014-06-26 00:00:00

abstract：:Optogenetics enables manipulation of biological processes with light at high spatio-temporal resolution to control the behavior of cells, networks, or even whole animals. In contrast to the performance of excitatory rhodopsins, the effectiveness of inhibitory optogenetic tools is still insufficient. Here we report a t...

journal_title：Nature communications

authors： Bernal Sierra YA,Rost BR,Pofahl M,Fernandes AM,Kopton RA,Moser S,Holtkamp D,Masala N,Beed P,Tukker JJ,Oldani S,Bönigk W,Kohl P,Baier H,Schneider-Warme F,Hegemann P,Beck H,Seifert R,Schmitz D

更新日期：2018-11-05 00:00:00

abstract：:Many photosynthetic organisms globally, including crops, forests and algae, must grow in environments where the availability of light energy fluctuates dramatically. How photosynthesis maintains high efficiency despite such fluctuations in its energy source remains poorly understood. Here we show that Arabidopsis thal...

journal_title：Nature communications

authors： Armbruster U,Carrillo LR,Venema K,Pavlovic L,Schmidtmann E,Kornfeld A,Jahns P,Berry JA,Kramer DM,Jonikas MC

更新日期：2014-11-13 00:00:00

abstract：:Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectric...

journal_title：Nature communications

authors： Zillikens MC,Demissie S,Hsu YH,Yerges-Armstrong LM,Chou WC,Stolk L,Livshits G,Broer L,Johnson T,Koller DL,Kutalik Z,Luan J,Malkin I,Ried JS,Smith AV,Thorleifsson G,Vandenput L,Hua Zhao J,Zhang W,Aghdassi A,Åkesson

更新日期：2017-07-19 00:00:00

abstract：:We constructed an intelligent cloud lab that integrates lab automation with cloud servers and artificial intelligence (AI) to detect chirality in perovskites. Driven by the materials acceleration operating system in cloud (MAOSIC) platform, on-demand experimental design by remote users was enabled in this cloud lab. B...

journal_title：Nature communications

authors： Li J,Li J,Liu R,Tu Y,Li Y,Cheng J,He T,Zhu X

更新日期：2020-04-27 00:00:00

abstract：:The Lyme disease agent, Borrelia burgdorferi, colonizes the gut of the tick Ixodes scapularis, which transmits the pathogen to vertebrate hosts including humans. Here we show that B. burgdorferi colonization increases the expression of several tick gut genes including pixr, encoding a secreted gut protein with a Reele...

journal_title：Nature communications

authors： Narasimhan S,Schuijt TJ,Abraham NM,Rajeevan N,Coumou J,Graham M,Robson A,Wu MJ,Daffre S,Hovius JW,Fikrig E

更新日期：2017-08-04 00:00:00

abstract：:Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical γ-secretase modulators affect the processing of APP by the γ-secretase complex and the production of the amyloid-beta peptide Aβ42, the accumulation of which is considered causative of Alzheimer's disease. Here we demonstrate tha...

journal_title：Nature communications

authors： Dimitrov M,Alattia JR,Lemmin T,Lehal R,Fligier A,Houacine J,Hussain I,Radtke F,Dal Peraro M,Beher D,Fraering PC

更新日期：2013-01-01 00:00:00

abstract：:The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read 'µm' rather than the correct 'nm.' This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Babakhanova G,Turiv T,Guo Y,Hendrikx M,Wei QH,Schenning APHJ,Broer DJ,Lavrentovich OD

更新日期：2018-03-14 00:00:00

abstract：:Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to support the development of potentially useful self-major histocompatibility complex class I (MHC-I)-restricted T cells. Optimal positive selection of CD8(+) T cells requires cortical thymic epithelial cells that express β5t-cont...

journal_title：Nature communications

authors： Sasaki K,Takada K,Ohte Y,Kondo H,Sorimachi H,Tanaka K,Takahama Y,Murata S

更新日期：2015-06-23 00:00:00

abstract：:Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes. During the process, binding of FAs to CD36 activates its downstream kinase LYN, which phosphorylates DH...

journal_title：Nature communications

authors： Hao JW,Wang J,Guo H,Zhao YY,Sun HH,Li YF,Lai XY,Zhao N,Wang X,Xie C,Hong L,Huang X,Wang HR,Li CB,Liang B,Chen S,Zhao TJ

更新日期：2020-09-21 00:00:00

abstract：:Liquid phase separation into two or more coexisting phases has emerged as a new paradigm for understanding subcellular organization, prebiotic life, and the origins of disease. The design principles underlying biomolecular phase separation have the potential to drive the development of novel liquid-based organelles an...

journal_title：Nature communications

authors： Fisher RS,Elbaum-Garfinkle S

更新日期：2020-09-15 00:00:00

abstract：:Soliton microcombs constitute chip-scale optical frequency combs, and have the potential to impact a myriad of applications from frequency synthesis and telecommunications to astronomy. The demonstration of soliton formation via self-injection locking of the pump laser to the microresonator has significantly relaxed t...

journal_title：Nature communications

authors： Voloshin AS,Kondratiev NM,Lihachev GV,Liu J,Lobanov VE,Dmitriev NY,Weng W,Kippenberg TJ,Bilenko IA

更新日期：2021-01-11 00:00:00

abstract：:Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state NMR. However, widespread applications of this methodology have been limited by challenges in obtaining confident resonance assignments. Here, we present Methyl...

journal_title：Nature communications

authors： Nerli S,De Paula VS,McShan AC,Sgourakis NG

更新日期：2021-01-29 00:00:00

abstract：:Zeolite catalysis is determined by a combination of pore architecture and Brønsted acidity. As Brønsted acid sites are formed by the substitution of AlO4 for SiO4 tetrahedra, it is of utmost importance to have information on the number as well as the location and neighbouring sites of framework aluminium. Unfortunatel...

journal_title：Nature communications

authors： Perea DE,Arslan I,Liu J,Ristanović Z,Kovarik L,Arey BW,Lercher JA,Bare SR,Weckhuysen BM

更新日期：2015-07-02 00:00:00

abstract：:Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease patients. Here, to ...

journal_title：Nature communications

authors： Matic S,Jiang M,Nicholls TJ,Uhler JP,Dirksen-Schwanenland C,Polosa PL,Simard ML,Li X,Atanassov I,Rackham O,Filipovska A,Stewart JB,Falkenberg M,Larsson NG,Milenkovic D

更新日期：2018-03-23 00:00:00

abstract：:Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act redundantly to drive apoptotic cell death. From an unbiased genome-wide CR...

journal_title：Nature communications

authors： Chin HS,Li MX,Tan IKL,Ninnis RL,Reljic B,Scicluna K,Dagley LF,Sandow JJ,Kelly GL,Samson AL,Chappaz S,Khaw SL,Chang C,Morokoff A,Brinkmann K,Webb A,Hockings C,Hall CM,Kueh AJ,Ryan MT,Kluck RM,Bouillet P,Herold

更新日期：2018-11-26 00:00:00

abstract：:Malaria reduces host fitness and survival by pathogen-mediated damage and inflammation. Disease tolerance mechanisms counter these negative effects without decreasing pathogen load. Here, we demonstrate that in four different mouse models of malaria, adrenal hormones confer disease tolerance and protect against early ...

journal_title：Nature communications

authors： Vandermosten L,Pham TT,Knoops S,De Geest C,Lays N,Van der Molen K,Kenyon CJ,Verma M,Chapman KE,Schuit F,De Bosscher K,Opdenakker G,Van den Steen PE

更新日期：2018-10-30 00:00:00

abstract：:The ability to suppress unwanted emotional memories is crucial for human mental health. Through consolidation over time, emotional memories often become resistant to change. However, how consolidation impacts the effectiveness of emotional memory suppression is still unknown. Using event-related fMRI while concurrentl...

journal_title：Nature communications

authors： Liu Y,Lin W,Liu C,Luo Y,Wu J,Bayley PJ,Qin S

更新日期：2016-11-29 00:00:00

abstract：:The vertebrate mineralized skeleton is known to have first emerged as an exoskeleton that extensively covered the fossil jawless fish. The evolutionary origin of this exoskeleton has long been attributed to the emergence of the neural crest, but experimental evaluation for this is still poor. Here we determine the emb...

journal_title：Nature communications

authors： Shimada A,Kawanishi T,Kaneko T,Yoshihara H,Yano T,Inohaya K,Kinoshita M,Kamei Y,Tamura K,Takeda H

更新日期：2013-01-01 00:00:00

abstract：:Non-linear interactions in coherent gases are not only at the origin of bright and dark solitons and superfluids; they also give rise to phenomena such as multistability, which hold great promise for the development of advanced photonic and spintronic devices. In particular, spinor multistability in strongly coupled s...

journal_title：Nature communications

authors： Cerna R,Léger Y,Paraïso TK,Wouters M,Morier-Genoud F,Portella-Oberli MT,Deveaud B

更新日期：2013-01-01 00:00:00

abstract：:Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immun...

journal_title：Nature communications

authors： Liu WL,Zou MZ,Liu T,Zeng JY,Li X,Yu WY,Li CX,Ye JJ,Song W,Feng J,Zhang XZ

更新日期：2019-07-19 00:00:00

abstract：:The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional ima...

journal_title：Nature communications

authors： Mariotti L,Losi G,Lia A,Melone M,Chiavegato A,Gómez-Gonzalo M,Sessolo M,Bovetti S,Forli A,Zonta M,Requie LM,Marcon I,Pugliese A,Viollet C,Bettler B,Fellin T,Conti F,Carmignoto G

更新日期：2018-01-08 00:00:00

abstract：:Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. Mechanistically, DILA1 inhibits the pho...

journal_title：Nature communications

authors： Shi Q,Li Y,Li S,Jin L,Lai H,Wu Y,Cai Z,Zhu M,Li Q,Li Y,Wang J,Liu Y,Wu Z,Song E,Liu Q

更新日期：2020-11-02 00:00:00