Abstract:
:Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10-8) or suggestively genome wide (p < 2.3 × 10-6). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Zillikens MC,Demissie S,Hsu YH,Yerges-Armstrong LM,Chou WC,Stolk L,Livshits G,Broer L,Johnson T,Koller DL,Kutalik Z,Luan J,Malkin I,Ried JS,Smith AV,Thorleifsson G,Vandenput L,Hua Zhao J,Zhang W,Aghdassi A,Åkessondoi
10.1038/s41467-017-00031-7subject
Has Abstractpub_date
2017-07-19 00:00:00pages
80issue
1issn
2041-1723pii
10.1038/s41467-017-00031-7journal_volume
8pub_type
杂志文章,meta分析abstract::The molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial intracellular adenosine and its key regulator adenosine kinase (ADK) play important roles in vascular inflammation. Pro-inflammatory stimuli lead to endothelial in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00986-7
更新日期:2017-10-16 00:00:00
abstract::Coalescence is an essential phenomenon that governs the equilibrium behaviour in a variety of systems from intercellular transport to planetary formation. In this report, we study coalescence pathways of circularly shaped two-dimensional colloidal membranes, which are one rod-length-thick liquid-like monolayers of ali...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4063
更新日期:2014-01-01 00:00:00
abstract::Domesticator-domesticate relationships are specialized mutualisms where one species provides multigenerational support to another in exchange for a resource or service, and through which both partners gain an advantage over individuals outside the relationship. While this ecological innovation has profoundly reshaped ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19958-5
更新日期:2020-12-07 00:00:00
abstract::India is located at a critical geographic crossroads for understanding the dispersal of Homo sapiens out of Africa and into Asia and Oceania. Here we report evidence for long-term human occupation, spanning the last ~80 thousand years, at the site of Dhaba in the Middle Son River Valley of Central India. An unchanging...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14668-4
更新日期:2020-02-25 00:00:00
abstract::Seismic tomography provides unique constraints on the morphology, the deformation, and (indirectly) the rheology of subducting slabs. We use teleseismic double-difference P-wave tomography to image with unprecedented clarity the structural complexity of the Izu-Bonin slab. We resolve a tear in the slab in the mantle t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09279-7
更新日期:2019-03-21 00:00:00
abstract::Light trapping across a wide band of frequencies is important for applications such as solar cells and photodetectors. Here, we demonstrate a new approach to light management by forming whispering-gallery resonant modes inside a spherical nanoshell structure. The geometry of the structure gives rise to a low quality-f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1664
更新日期:2012-02-07 00:00:00
abstract::Phase separation of specific biomolecules into liquid droplet-like condensates is a key mechanism to form membrane-less organelles, which spatio-temporally organize diverse biochemical processes in cells. To investigate the working principles of these biomolecular condensates as dynamic reaction centers, precise contr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19391-8
更新日期:2020-11-03 00:00:00
abstract::Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to contribute to speech discrimination and intelligibility deficits in people with normal audiological tests. Animals and humans with HHL have normal auditory thresholds but defective cochlear neurotransmission, that is, reduced suprathresh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14487
更新日期:2017-02-17 00:00:00
abstract::The central issues for understanding iron (Fe)-based superconductors are the symmetry and structure of the superconducting gap. So far the experimental data and theoretical models have been highly controversial. Some experiments favor two or more constant or nearly constant gaps, others indicate strong anisotropy and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1115
更新日期:2010-11-16 00:00:00
abstract::RNAs contain post-transcriptional modifications, which fulfill a variety of functions in translation, secondary structure stabilization and cellular stress survival. Here, 2-methylthiocytidine (ms2C) is identified in tRNA of E. coli and P. aeruginosa using NAIL-MS (nucleic acid isotope labeling coupled mass spectromet...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13565-9
更新日期:2019-12-06 00:00:00
abstract::Iridium N-heterocyclic carbene (NHC) complexes catalyse the para-hydrogen-induced hyperpolarization process, Signal Amplification by Reversible Exchange (SABRE). This process transfers the latent magnetism of para-hydrogen into a substrate, without changing its chemical identity, to dramatically improve its nuclear ma...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06766-1
更新日期:2018-10-12 00:00:00
abstract::Understanding human cooperation is of major interest across the natural and social sciences. But it is unclear to what extent cooperation is actually a general concept. Most research on cooperation has implicitly assumed that a person's behaviour in one cooperative context is related to their behaviour in other settin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5939
更新日期:2014-09-16 00:00:00
abstract::Clostridium difficile is the leading cause of nosocomial diarrhea and colitis in the industrialized world. Disruption of the protective gut microbiota by antibiotics enables colonization by multidrug-resistant C. difficile, which secrete up to three different protein toxins that are responsible for the gastrointestina...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07705-w
更新日期:2018-12-07 00:00:00
abstract::High-angle grain boundaries are always the preferential fatigue cracking sites, while the intrinsic fatigue cracking mechanism of coherent twin boundary remains elusive. Here we systematically investigate the fatigue cracking behaviours of copper bicrystals with a coherent twin boundary as their sole internal boundary...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4536
更新日期:2014-03-26 00:00:00
abstract::Gene deletion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic pregnancy. Here we report the key autophagy regulators modulated by diabetes in the murine developing neuroepithelium. Diabetes predominantly leads to exencephaly, induces neuroepithelial cell apoptosis and sup...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15182
更新日期:2017-05-05 00:00:00
abstract::Dynamics of molecules in the solid state holds promise for connecting molecular behaviors with properties of bulk materials. Solid-state dynamics of [60]fullerene (C60) is controlled by intimate intermolecular contacts and results in restricted motions of a ratchet phase at low temperatures. Manipulation of the solid-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04325-2
更新日期:2018-05-15 00:00:00
abstract::Much of the global annual mean temperature change over Quaternary glacial cycles can be attributed to slow ice sheet and greenhouse gas feedbacks, but analysis of the short-term response to orbital forcings has the potential to reveal key relationships in the climate system. In particular, obliquity and precession bot...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03800-0
更新日期:2018-04-10 00:00:00
abstract::Variation in the geographic spread of fossil localities strongly biases inferences about the evolution of biodiversity, due to the ubiquitous scaling of species richness with area. This obscures answers to key questions, such as how tetrapods attained their tremendous extant diversity. Here, we address this problem by...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15381
更新日期:2017-05-22 00:00:00
abstract::Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5880
更新日期:2014-09-10 00:00:00
abstract::Analyzing scattered wave to recognize object is of fundamental significance in wave physics. Recently-emerged deep learning technique achieved great success in interpreting wave field such as in ultrasound non-destructive testing and disease diagnosis, but conventionally need time-consuming computer postprocessing or ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19693-x
更新日期:2020-12-09 00:00:00
abstract::Quantum states induced by single-atomic impurities are at the frontier of physics and material science. While such states have been reported in high-temperature superconductors and dilute magnetic semiconductors, they are unexplored in topological magnets which can feature spin-orbit tunability. Here we use spin-polar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18111-6
更新日期:2020-09-04 00:00:00
abstract::It is unclear whether the establishment of apical-basal cell polarity during the generation of epithelial lumens requires molecules acting at the plasma membrane/actin interface. Here, we show that the I-BAR-containing IRSp53 protein controls lumen formation and the positioning of the polarity determinants aPKC and po...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17091-x
更新日期:2020-07-14 00:00:00
abstract::The direct transformation of cellulose, which is the main component of lignocellulosic biomass, into building-block chemicals is the key to establishing biomass-based sustainable chemical processes. Only limited successes have been achieved for such transformations under mild conditions. Here we report the simple and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3141
更新日期:2013-01-01 00:00:00
abstract::The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11276-9
更新日期:2019-08-20 00:00:00
abstract::The space charge layer (SCL) is generally considered one of the origins of the sluggish interfacial lithium-ion transport in all-solid-state lithium-ion batteries (ASSLIBs). However, in-situ visualization of the SCL effect on the interfacial lithium-ion transport in sulfide-based ASSLIBs is still a great challenge. He...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19726-5
更新日期:2020-11-18 00:00:00
abstract::Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of diseases includes serious or fatal neurological presentations such as Leigh syndrome and there are very limited evidence-based treatment options available. Here...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12317
更新日期:2016-08-09 00:00:00
abstract::Prolonged cell survival occurs through the expression of specific protein isoforms generated by alternate splicing of mRNA precursors in cancer cells. How alternate splicing regulates tumor development and resistance to targeted therapies in cancer remain poorly understood. Here we show that RNF113A, whose loss-of-fun...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15003-7
更新日期:2020-03-09 00:00:00
abstract::Hundreds of clinical studies have demonstrated associations between the human microbiome and disease, yet fundamental questions remain on how we can generalize this knowledge. Results from individual studies can be inconsistent, and comparing published data is further complicated by a lack of standard processing and a...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-017-01973-8
更新日期:2017-12-05 00:00:00
abstract::Pattern-triggered immunity and effector-triggered immunity are two primary forms of innate immunity in land plants. The molecular components and connecting nodes of pattern-triggered immunity and effector-triggered immunity are not fully understood. Here, we report that the Arabidopsis calcium-dependent protein kinase...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20007-4
更新日期:2020-12-04 00:00:00
abstract::The Gibbs energy, G, determines the equilibrium conditions of chemical reactions and materials stability. Despite this fundamental and ubiquitous role, G has been tabulated for only a small fraction of known inorganic compounds, impeding a comprehensive perspective on the effects of temperature and composition on mate...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06682-4
更新日期:2018-10-09 00:00:00