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Meta-analysis of gut microbiome studies identifies disease-specific and shared responses.

Abstract：

:Hundreds of clinical studies have demonstrated associations between the human microbiome and disease, yet fundamental questions remain on how we can generalize this knowledge. Results from individual studies can be inconsistent, and comparing published data is further complicated by a lack of standard processing and analysis methods. Here we introduce the MicrobiomeHD database, which includes 28 published case-control gut microbiome studies spanning ten diseases. We perform a cross-disease meta-analysis of these studies using standardized methods. We find consistent patterns characterizing disease-associated microbiome changes. Some diseases are associated with over 50 genera, while most show only 10-15 genus-level changes. Some diseases are marked by the presence of potentially pathogenic microbes, whereas others are characterized by a depletion of health-associated bacteria. Furthermore, we show that about half of genera associated with individual studies are bacteria that respond to more than one disease. Thus, many associations found in case-control studies are likely not disease-specific but rather part of a non-specific, shared response to health and disease.

journal_name

Nat Commun

journal_title

Nature communications

authors

Duvallet C,Gibbons SM,Gurry T,Irizarry RA,Alm EJ

doi

10.1038/s41467-017-01973-8

subject

Has Abstract

pub_date

2017-12-05 00:00:00

pages

1784

issue

1

issn

2041-1723

pii

10.1038/s41467-017-01973-8

journal_volume

8

pub_type

杂志文章,meta分析

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