Genome-wide association study identifies multiple susceptibility loci for glioma.

abstract：:Solar-driven photocatalysis has attracted significant attention in water splitting, CO2 reduction and organic synthesis. The syntheses of valuable azo- and azoxyaromatic dyes via selective photoreduction of nitroaromatic compounds have been realised using supported plasmonic metal nanoparticles at elevated temperature...

journal_title：Nature communications

authors： Dai Y,Li C,Shen Y,Lim T,Xu J,Li Y,Niemantsverdriet H,Besenbacher F,Lock N,Su R

更新日期：2018-01-04 00:00:00

abstract：:The fossil record of crocodylians and their relatives (pseudosuchians) reveals a rich evolutionary history, prompting questions about causes of long-term decline to their present-day low biodiversity. We analyse climatic drivers of subsampled pseudosuchian biodiversity over their 250 million year history, using a comp...

journal_title：Nature communications

authors： Mannion PD,Benson RBJ,Carrano MT,Tennant JP,Judd J,Butler RJ

更新日期：2015-09-24 00:00:00

abstract：:The accurate measurement of microscopic force fields is crucial in many branches of science and technology, from biophotonics and mechanobiology to microscopy and optomechanics. These forces are often probed by analysing their influence on the motion of Brownian particles. Here we introduce a powerful algorithm for mi...

journal_title：Nature communications

authors： Pérez García L,Donlucas Pérez J,Volpe G,V Arzola A,Volpe G

更新日期：2018-12-04 00:00:00

abstract：:The photon-like behavior of electrons in graphene causes unusual confinement properties that depend strongly on the geometry and strength of the surrounding potential. We report bottom-up synthesis of atomically-precise one-dimensional (1D) arrays of point charges on graphene that allow exploration of a new type of su...

journal_title：Nature communications

authors： Lu J,Tsai HZ,Tatan AN,Wickenburg S,Omrani AA,Wong D,Riss A,Piatti E,Watanabe K,Taniguchi T,Zettl A,Pereira VM,Crommie MF

更新日期：2019-01-29 00:00:00

abstract：:Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer's disease (AD). Here, we present the three-dimensional structure of an Aβ oligomer formed in a membrane mimicking environment, namely an Aβ(1-42) tetramer, which comprises a six stranded β-s...

journal_title：Nature communications

authors： Ciudad S,Puig E,Botzanowski T,Meigooni M,Arango AS,Do J,Mayzel M,Bayoumi M,Chaignepain S,Maglia G,Cianferani S,Orekhov V,Tajkhorshid E,Bardiaux B,Carulla N

更新日期：2020-06-15 00:00:00

abstract：:The quantum noise of the vacuum limits the achievable sensitivity of quantum sensors. In non-classical measurement schemes the noise can be reduced to overcome this limitation. However, schemes based on squeezed or Schrödinger cat states require alignment of the relative phase between the measured interaction and the ...

journal_title：Nature communications

authors： Wolf F,Shi C,Heip JC,Gessner M,Pezzè L,Smerzi A,Schulte M,Hammerer K,Schmidt PO

更新日期：2019-07-02 00:00:00

abstract：:Two-component signal transduction systems consist of pairs of histidine kinases and response regulators, which mediate adaptive responses to environmental cues. Most activated response regulators regulate transcription by binding tightly to promoter DNA via a phosphorylation-triggered inactive-to-active transition. Th...

journal_title：Nature communications

authors： Narayanan A,Kumar S,Evrard AN,Paul LN,Yernool DA

更新日期：2014-01-01 00:00:00

abstract：:Recent studies suggest that attention samples space rhythmically through oscillatory interactions in the frontoparietal network. How these attentional fluctuations coincide with spatial exploration/displacement and exploitation/selection by a dynamic attentional spotlight under top-down control is unclear. Here, we sh...

journal_title：Nature communications

authors： Gaillard C,Ben Hadj Hassen S,Di Bello F,Bihan-Poudec Y,VanRullen R,Ben Hamed S

更新日期：2020-02-17 00:00:00

abstract：:Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion of π-electrons, but its experimental verification is demanding. Here, we report on the observ...

journal_title：Nature communications

authors： Li J,Sanz S,Corso M,Choi DJ,Peña D,Frederiksen T,Pascual JI

更新日期：2019-01-14 00:00:00

abstract：:The divalent carbene carbon centre in cyclic (alkyl)(amino)carbenes (CAACs) is known to exhibit transition-metal-like insertion into E-H σ-bonds (E = H, N, Si, B, P, C, O) with formation of new, strong C-E and C-H bonds. Although subsequent transformations of the products represent an attractive strategy for metal-fre...

journal_title：Nature communications

authors： Oldroyd NL,Chitnis SS,Annibale VT,Arz MI,Sparkes HA,Manners I

更新日期：2019-03-26 00:00:00

abstract：:Single-nucleotide variants that underlie phenotypic variation can affect chromatin occupancy of transcription factors (TFs). To delineate determinants of in vivo TF binding and chromatin accessibility, we introduce an approach that compares ChIP-seq and DNase-seq data sets from genetically divergent murine erythroid c...

journal_title：Nature communications

authors： Behera V,Evans P,Face CJ,Hamagami N,Sankaranarayanan L,Keller CA,Giardine B,Tan K,Hardison RC,Shi J,Blobel GA

更新日期：2018-02-22 00:00:00

abstract：:The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effect...

journal_title：Nature communications

authors： Kim JH,Matsubara T,Lee J,Fenollar-Ferrer C,Han K,Kim D,Jia S,Chang CJ,Yang H,Nagano T,Krausz KW,Yim SH,Gonzalez FJ

更新日期：2021-01-12 00:00:00

abstract：:Coordination of outer membrane constriction with septation is critical to faithful division in Gram-negative bacteria and vital to the barrier function of the membrane. This coordination requires the recruitment of the peptidoglycan-binding outer-membrane lipoprotein Pal at division sites by the Tol system. Here, we s...

journal_title：Nature communications

authors： Szczepaniak J,Holmes P,Rajasekar K,Kaminska R,Samsudin F,Inns PG,Rassam P,Khalid S,Murray SM,Redfield C,Kleanthous C

更新日期：2020-03-11 00:00:00

abstract：:The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data. We identify a total of 201 transc...

journal_title：Nature communications

authors： Whisnant AW,Jürges CS,Hennig T,Wyler E,Prusty B,Rutkowski AJ,L'hernault A,Djakovic L,Göbel M,Döring K,Menegatti J,Antrobus R,Matheson NJ,Künzig FWH,Mastrobuoni G,Bielow C,Kempa S,Liang C,Dandekar T,Zimmer R,Landth

更新日期：2020-04-27 00:00:00

abstract：:While many tools exist for identifying and quantifying individual cell types, few methods are available to assess the relationships between cell types in organs and tissues and how these relationships change during aging or disease states. We present a quantitative method for evaluating cellular organization, using th...

journal_title：Nature communications

authors： Sornborger A,Li J,Timmons C,Lupu F,Eggenschwiler J,Takahama Y,Manley NR

更新日期：2017-05-30 00:00:00

abstract：:The Barbier reaction, a widely utilized reaction for carbon-carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an...

journal_title：Nature communications

authors： Sun XL,Liu DM,Tian D,Zhang XY,Wu W,Wan WM

更新日期：2017-10-31 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Hirata M,Asano N,Katayama K,Yoshida A,Tsuda Y,Sekimizu M,Mitani S,Kobayashi E,Komiyama M,Fujimoto H,Goto T,Iwamoto Y,Naka N,Iwata S,Nishida Y,Hiruma T,Hiraga H,Kawano H,Motoi T,Oda Y,Matsubara D,Fujita M,Shiba

更新日期：2020-02-19 00:00:00

abstract：:In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. We present the high-resolution cryo-EM structure of the human processive Pol δ-DNA-PCNA comple...

journal_title：Nature communications

authors： Lancey C,Tehseen M,Raducanu VS,Rashid F,Merino N,Ragan TJ,Savva CG,Zaher MS,Shirbini A,Blanco FJ,Hamdan SM,De Biasio A

更新日期：2020-02-28 00:00:00

abstract：:Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme cGAS may act anti-inflammatory. Here we report the discovery of ...

journal_title：Nature communications

authors： Lama L,Adura C,Xie W,Tomita D,Kamei T,Kuryavyi V,Gogakos T,Steinberg JI,Miller M,Ramos-Espiritu L,Asano Y,Hashizume S,Aida J,Imaeda T,Okamoto R,Jennings AJ,Michino M,Kuroita T,Stamford A,Gao P,Meinke P,Glickman

更新日期：2019-05-21 00:00:00

abstract：:Recent studies of thermal transport in nanomaterials have demonstrated the breakdown of Fourier's law through observations of ballistic transport. Despite its unique features, another instance of the breakdown of Fourier's law, hydrodynamic phonon transport, has drawn less attention because it has been observed only a...

journal_title：Nature communications

authors： Lee S,Broido D,Esfarjani K,Chen G

更新日期：2015-02-18 00:00:00

abstract：:NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible for sensing danger si...

journal_title：Nature communications

authors： Hafner-Bratkovič I,Sušjan P,Lainšček D,Tapia-Abellán A,Cerović K,Kadunc L,Angosto-Bazarra D,Pelegrin P,Jerala R

更新日期：2018-12-05 00:00:00

abstract：:CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...

journal_title：Nature communications

authors： Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

更新日期：2016-02-04 00:00:00

abstract：:The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...

journal_title：Nature communications

authors： Marissal T,Bonifazi P,Picardo MA,Nardou R,Petit LF,Baude A,Fishell GJ,Ben-Ari Y,Cossart R

更新日期：2012-01-01 00:00:00

abstract：:Perovskite solar cells have received worldwide interests due to swiftly improved efficiency but the poor stability of the perovskite component hampers the device fabrication under normal condition. Herein, we develop a reliable nonstoichiometric acid-base reaction route to stable perovskite films by intermediate chemi...

journal_title：Nature communications

authors： Long M,Zhang T,Chai Y,Ng CF,Mak TC,Xu J,Yan K

更新日期：2016-11-15 00:00:00

abstract：:6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusi...

journal_title：Nature communications

authors： Liu R,Li W,Tao B,Wang X,Yang Z,Zhang Y,Wang C,Liu R,Gao H,Liang J,Yang W

更新日期：2019-03-01 00:00:00

abstract：:Flexible barrier films preventing permeation of gases and moistures are important for many industries ranging from food to medical and from chemical to electronic. From this perspective, graphene has recently attracted particular interest because its defect-free monolayers are impermeable to all atoms and molecules. H...

journal_title：Nature communications

authors： Su Y,Kravets VG,Wong SL,Waters J,Geim AK,Nair RR

更新日期：2014-09-11 00:00:00

abstract：:Highly pure semiconducting single-walled carbon nanotubes (SWNTs) are essential for the next generation of electronic devices, such as field-effect transistors and photovoltaic applications; however, contamination by metallic SWNTs reduces the efficiency of their associated devices. Here we report a simple and efficie...

journal_title：Nature communications

authors： Toshimitsu F,Nakashima N

更新日期：2014-10-03 00:00:00

abstract：:Natriuretic peptides (NPs) are important hormones that regulate multiple cellular functions including cardiovascular physiology. In the heart, two natriuretic peptide receptors NPR1 and NPR2 act as membrane guanylyl cyclases to produce 3',5'-cyclic guanosine monophosphate (cGMP). Although both receptors protect from c...

journal_title：Nature communications

authors： Subramanian H,Froese A,Jönsson P,Schmidt H,Gorelik J,Nikolaev VO

更新日期：2018-06-22 00:00:00

abstract：:Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However, the precise molecular mechanisms of arterial remodelling re...

journal_title：Nature communications

authors： Sumida T,Naito AT,Nomura S,Nakagawa A,Higo T,Hashimoto A,Okada K,Sakai T,Ito M,Yamaguchi T,Oka T,Akazawa H,Lee JK,Minamino T,Offermanns S,Noda T,Botto M,Kobayashi Y,Morita H,Manabe I,Nagai T,Shiojima I,Komuro

更新日期：2015-02-26 00:00:00

abstract：:Device performance and in particular device stability for blue perovskite light-emitting diodes (PeLEDs) remain considerable challenges for the whole community. In this manuscript, we conceive an approach by tuning the 'A-site' cation composition of perovskites to develop blue-emitters. We herein report a Rubidium-Ces...

journal_title：Nature communications

authors： Jiang Y,Qin C,Cui M,He T,Liu K,Huang Y,Luo M,Zhang L,Xu H,Li S,Wei J,Liu Z,Wang H,Kim GH,Yuan M,Chen J

更新日期：2019-04-23 00:00:00