Tolerance induction to human stem cell transplants with extension to their differentiated progeny.

abstract：:Stable water isotope records from Antarctica are key for our understanding of Quaternary climate variations. However, the exact quantitative interpretation of these important climate proxy records in terms of surface temperature, ice sheet height and other climatic changes is still a matter of debate. Here we report r...

journal_title：Nature communications

authors： Werner M,Jouzel J,Masson-Delmotte V,Lohmann G

更新日期：2018-08-30 00:00:00

abstract：:Artificially improving traits of cultivated alfalfa (Medicago sativa L.), one of the most important forage crops, is challenging due to the lack of a reference genome and an efficient genome editing protocol, which mainly result from its autotetraploidy and self-incompatibility. Here, we generate an allele-aware chrom...

journal_title：Nature communications

authors： Chen H,Zeng Y,Yang Y,Huang L,Tang B,Zhang H,Hao F,Liu W,Li Y,Liu Y,Zhang X,Zhang R,Zhang Y,Li Y,Wang K,He H,Wang Z,Fan G,Yang H,Bao A,Shang Z,Chen J,Wang W,Qiu Q

更新日期：2020-05-19 00:00:00

abstract：:Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) is widely used to study protein-protein interactions (PPI), protein structures, and even protein dynamics. However, structural information provided by CXMS is still limited, partly because most CXMS experiments use lysine-lysine (K-K) cr...

journal_title：Nature communications

authors： Jones AX,Cao Y,Tang YL,Wang JH,Ding YH,Tan H,Chen ZL,Fang RQ,Yin J,Chen RC,Zhu X,She Y,Huang N,Shao F,Ye K,Sun RX,He SM,Lei X,Dong MQ

更新日期：2019-09-02 00:00:00

abstract：:Cystic fibrosis (CF) is a genetic disorder caused by defective CF Transmembrane Conductance Regulator (CFTR) function. Insulin producing pancreatic islets are located in close proximity to the pancreatic duct and there is a possibility of impaired cell-cell signaling between pancreatic ductal epithelial cells (PDECs) ...

journal_title：Nature communications

authors： Shik Mun K,Arora K,Huang Y,Yang F,Yarlagadda S,Ramananda Y,Abu-El-Haija M,Palermo JJ,Appakalai BN,Nathan JD,Naren AP

更新日期：2019-07-16 00:00:00

abstract：:Laboratory spectroscopy of atomic hydrogen in a magnetic flux density of 10(5) T (1 gigagauss), the maximum observed on high-field magnetic white dwarfs, is impossible because practically available fields are about a thousand times less. In this regime, the cyclotron and binding energies become equal. Here we demonstr...

journal_title：Nature communications

authors： Murdin BN,Li J,Pang ML,Bowyer ET,Litvinenko KL,Clowes SK,Engelkamp H,Pidgeon CR,Galbraith I,Abrosimov NV,Riemann H,Pavlov SG,Hübers HW,Murdin PG

更新日期：2013-01-01 00:00:00

abstract：:When immersed into water, most solids develop a surface charge, which is neutralized by an accumulation of dissolved counterions at the interface. Although the density distribution of counterions perpendicular to the interface obeys well-established theories, little is known about counterions' lateral organization at ...

journal_title：Nature communications

authors： Ricci M,Spijker P,Voïtchovsky K

更新日期：2014-07-16 00:00:00

abstract：:It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct ske...

journal_title：Nature communications

authors： Li M,Wu H,Luo Z,Xia Y,Guan J,Wang T,Gu Y,Chen L,Zhang K,Ma J,Liu Y,Zhong Z,Nie J,Zhou S,Mu Z,Wang X,Qu J,Jing L,Wang H,Huang S,Yi N,Wang Z,Xi D,Wang J,Yin G,Wang L,Li N,Jiang Z,Lang Q,Xiao H,Ji

更新日期：2012-05-22 00:00:00

abstract：:The transdifferentiation of pancreatic acinar cells to a ductal phenotype (acinar-to-ductal metaplasia, ADM) occurs after injury or inflammation of the pancreas and is a reversible process. However, in the presence of activating Kras mutations or persistent epidermal growth factor receptor (EGF-R) signalling, cells th...

journal_title：Nature communications

authors： Liou GY,Döppler H,Braun UB,Panayiotou R,Scotti Buzhardt M,Radisky DC,Crawford HC,Fields AP,Murray NR,Wang QJ,Leitges M,Storz P

更新日期：2015-02-20 00:00:00

abstract：:The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant ...

journal_title：Nature communications

authors： Song W,Wang JH,Wu J,Liu J,Chen XL,Liu LM

更新日期：2018-09-19 00:00:00

abstract：:Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action potential that also possesses an initial spike followed by prolonged depolarization. Here we show that hERG channel proteins (α-conducting and ...

journal_title：Nature communications

authors： Parkington HC,Stevenson J,Tonta MA,Paul J,Butler T,Maiti K,Chan EC,Sheehan PM,Brennecke SP,Coleman HA,Smith R

更新日期：2014-06-17 00:00:00

abstract：:Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the d...

journal_title：Nature communications

authors： Dutertre S,Jin AH,Vetter I,Hamilton B,Sunagar K,Lavergne V,Dutertre V,Fry BG,Antunes A,Venter DJ,Alewood PF,Lewis RJ

更新日期：2014-03-24 00:00:00

abstract：:Tissue injury and the healing response lead to the release of endogenous danger signals including Toll-like receptor (TLR) and interleukin-1 receptor, type 1 (IL-1R1) ligands, which modulate the immune microenvironment. Because TLRs and IL-1R1 have been shown to influence the repair process of various tissues, we expl...

journal_title：Nature communications

authors： Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S

更新日期：2016-03-22 00:00:00

abstract：:In the original version of this Article, an incorrect sample size was provided for the number of relict species (443 instead of 442) and the number of relict forests (423 instead of 422). These errors have been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Tang CQ,Matsui T,Ohashi H,Dong YF,Momohara A,Herrando-Moraira S,Qian S,Yang Y,Ohsawa M,Luu HT,Grote PJ,Krestov PV,LePage B,Werger M,Robertson K,Hobohm C,Wang CY,Peng MC,Chen X,Wang HC,Su WH,Zhou R,Li S,He LY

更新日期：2018-12-04 00:00:00

abstract：:During centriole duplication, a single daughter centriole is formed next to the mother centriole. The molecular mechanism that determines a single duplication site remains a long-standing question. Here, we show that intrinsic self-organization of Plk4 is implicated in symmetry breaking in the process of centriole dup...

journal_title：Nature communications

authors： Yamamoto S,Kitagawa D

更新日期：2019-04-18 00:00:00

abstract：:Bone tissue, by definition, is an organic-inorganic nanocomposite, where metabolically active cells are embedded within a matrix that is heavily calcified on the nanoscale. Currently, there are no strategies that replicate these definitive characteristics of bone tissue. Here we describe a biomimetic approach where a ...

journal_title：Nature communications

authors： Thrivikraman G,Athirasala A,Gordon R,Zhang L,Bergan R,Keene DR,Jones JM,Xie H,Chen Z,Tao J,Wingender B,Gower L,Ferracane JL,Bertassoni LE

更新日期：2019-08-06 00:00:00

abstract：:Semiconductor-based surface-enhanced Raman spectroscopy (SERS) substrates represent a new frontier in the field of SERS. However, the application of semiconductor materials as SERS substrates is still seriously impeded by their low SERS enhancement and inferior detection sensitivity, especially for non-metal-oxide sem...

journal_title：Nature communications

authors： Zheng Z,Cong S,Gong W,Xuan J,Li G,Lu W,Geng F,Zhao Z

更新日期：2017-12-08 00:00:00

abstract：:Mutations in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulation of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardation. Here, we present the crystallographic structure of human FALDH, t...

journal_title：Nature communications

authors： Keller MA,Zander U,Fuchs JE,Kreutz C,Watschinger K,Mueller T,Golderer G,Liedl KR,Ralser M,Kräutler B,Werner ER,Marquez JA

更新日期：2014-07-22 00:00:00

abstract：:Coelacanths are known for their evolutionary conservatism, and the body plan seen in Latimeria can be traced to late Middle Devonian Diplocercides, Holopterygius and presumably Euporosteus. However, the group's early history is unclear because of an incomplete fossil record. Until now, the only Early Devonian coelacan...

journal_title：Nature communications

authors： Zhu M,Yu X,Lu J,Qiao T,Zhao W,Jia L

更新日期：2012-04-10 00:00:00

abstract：:PIWI-interacting RNAs (piRNAs) are effectors of transposable element (TE) silencing in the reproductive apparatus. In Drosophila ovarian somatic cells, piRNAs arise from longer single-stranded RNA precursors that are processed in the cytoplasm presumably within the Yb-bodies. piRNA precursors encoded by the flamenco (...

journal_title：Nature communications

authors： Dennis C,Brasset E,Sarkar A,Vaury C

更新日期：2016-12-08 00:00:00

abstract：:Trypanosoma brucei is a protozoan parasite that evades its host's adaptive immune response by repeatedly replacing its dense variant surface glycoprotein (VSG) coat from its large genomic VSG repertoire. While the mechanisms regulating VSG gene expression and diversification have been examined extensively, the dynamic...

journal_title：Nature communications

authors： Pinger J,Chowdhury S,Papavasiliou FN

更新日期：2017-10-10 00:00:00

abstract：:Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression-methylation quantitative trait loci (emQTL) analysis between DNA methylation and gene expression. On a w...

journal_title：Nature communications

authors： Fleischer T,Tekpli X,Mathelier A,Wang S,Nebdal D,Dhakal HP,Sahlberg KK,Schlichting E,Oslo Breast Cancer Research Consortium (OSBREAC).,Børresen-Dale AL,Borgen E,Naume B,Eskeland R,Frigessi A,Tost J,Hurtado A,Kristensen VN

更新日期：2017-11-09 00:00:00

abstract：:The realization that mitigation efforts to reduce carbon dioxide emissions have, until now, been relatively ineffective has led to an increasing interest in climate engineering as a possible means of preventing the potentially catastrophic consequences of climate change. While many studies have addressed the potential...

journal_title：Nature communications

authors： Keller DP,Feng EY,Oschlies A

更新日期：2014-02-25 00:00:00

abstract：:Efficient charge separation is of crucial importance for the improvement of photocatalytic activity for solar hydrogen evolution. Here we report efficient photo-generated charge separation by twin-induced one-dimensional homojunctions with type-II staggered band alignment, using a ternary chalcogenate, i.e. Cd0.5Zn0.5...

journal_title：Nature communications

authors： Liu M,Jing D,Zhou Z,Guo L

更新日期：2013-01-01 00:00:00

abstract：:Thoracian barnacles rely heavily upon their ability to adhere to surfaces and are environmentally and economically important as biofouling pests. Their adhesives have unique attributes that define them as targets for bio-inspired adhesive development. With the aid of multi-photon and broadband coherent anti-Stokes Ram...

journal_title：Nature communications

authors： Gohad NV,Aldred N,Hartshorn CM,Jong Lee Y,Cicerone MT,Orihuela B,Clare AS,Rittschof D,Mount AS

更新日期：2014-07-11 00:00:00

abstract：:Pattern-triggered immunity and effector-triggered immunity are two primary forms of innate immunity in land plants. The molecular components and connecting nodes of pattern-triggered immunity and effector-triggered immunity are not fully understood. Here, we report that the Arabidopsis calcium-dependent protein kinase...

journal_title：Nature communications

authors： Lu YJ,Li P,Shimono M,Corrion A,Higaki T,He SY,Day B

更新日期：2020-12-04 00:00:00

abstract：:Coherence in light-matter interaction is a necessary ingredient if light is used to control the quantum state of a material system. Coherent effects are firmly associated with isolated systems kept at low temperature. The exceedingly fast dephasing in condensed matter environments, in particular at elevated temperatur...

journal_title：Nature communications

authors： Kolarczik M,Owschimikow N,Korn J,Lingnau B,Kaptan Y,Bimberg D,Schöll E,Lüdge K,Woggon U

更新日期：2013-01-01 00:00:00

abstract：:Cholinergic neurons in the basal forebrain project heavily to the main olfactory bulb, the first processing station in the olfactory pathway. The projections innervate multiple layers of the main olfactory bulb and strongly influence odor discrimination, detection, and learning. The precise underlying circuitry of thi...

journal_title：Nature communications

authors： Case DT,Burton SD,Gedeon JY,Williams SG,Urban NN,Seal RP

更新日期：2017-09-21 00:00:00

abstract：:Elucidating the factors governing the functional compatibility of horizontally transferred genes is important to understand bacterial evolution, including the emergence and spread of antibiotic resistance, and to successfully engineer biological systems. In silico efforts and work using single-gene libraries have sugg...

journal_title：Nature communications

authors： Porse A,Schou TS,Munck C,Ellabaan MMH,Sommer MOA

更新日期：2018-02-06 00:00:00

abstract：:Cancer evolution is fueled by epigenetic as well as genetic diversity. In chronic lymphocytic leukemia (CLL), intra-tumoral DNA methylation (DNAme) heterogeneity empowers evolution. Here, to comprehensively study the epigenetic dimension of cancer evolution, we integrate DNAme analysis with histone modification mappin...

journal_title：Nature communications

authors： Pastore A,Gaiti F,Lu SX,Brand RM,Kulm S,Chaligne R,Gu H,Huang KY,Stamenova EK,Béguelin W,Jiang Y,Schulman RC,Kim KT,Alonso A,Allan JN,Furman RR,Gnirke A,Wu CJ,Melnick AM,Meissner A,Bernstein BE,Abdel-Wahab O,L

更新日期：2019-04-23 00:00:00

abstract：:The strong metal-support interaction (SMSI) has long been studied in heterogonous catalysis on account of its importance in stabilizing active metals and tuning catalytic performance. As a dynamic process taking place at the metal-support interface, the SMSI is closely related to the metal surface properties which are...

journal_title：Nature communications

authors： Du X,Huang Y,Pan X,Han B,Su Y,Jiang Q,Li M,Tang H,Li G,Qiao B

更新日期：2020-11-16 00:00:00