Abstract:
:The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant challenge. Herein, we report an artificially designed chiral-group-resetting biocatalytic process, which uses simple achiral glycine and aldehydes to synthesize stereodefined α-functionalized organic acids. This cascade biocatalysis comprises a basic module and three different extender modules and operates in a modular assembly manner. The engineered Escherichia coli catalysts, which contained different module(s), provide access to α-keto acids, α-hydroxy acids, and α-amino acids with excellent conversion and enantioselectivities. Therefore, this biocatalytic process provides an attractive strategy for the conversion of low-cost achiral starting materials to high-value α-functionalized organic acids.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Song W,Wang JH,Wu J,Liu J,Chen XL,Liu LMdoi
10.1038/s41467-018-06241-xsubject
Has Abstractpub_date
2018-09-19 00:00:00pages
3818issue
1issn
2041-1723pii
10.1038/s41467-018-06241-xjournal_volume
9pub_type
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