Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders.

abstract：:There has been much research on renewable energy-harvesting techniques. However, owing to increasing energy demands, significant energy-related issues remain to be solved. Efforts aimed at reducing the amount of energy loss in electric/electronic systems are essential for reducing energy consumption and protecting the...

journal_title：Nature communications

authors： Kim T,Yong H,Kim B,Kim D,Choi D,Park YT,Lee S

更新日期：2018-04-12 00:00:00

abstract：:Theory predicts a trade-off between investments in precopulatory (ornaments and armaments) and postcopulatory (testes and ejaculates) sexual traits due to the costs associated with their growth and maintenance within the finite energy resources available. Empirical studies, however, have revealed considerable inconsis...

journal_title：Nature communications

authors： Lüpold S,Tomkins JL,Simmons LW,Fitzpatrick JL

更新日期：2014-01-01 00:00:00

abstract：:High-speed light emitters integrated on silicon chips can enable novel architectures for silicon-based optoelectronics, such as on-chip optical interconnects, and silicon photonics. However, conventional light sources based on compound semiconductors face major challenges for their integration with a silicon-based pla...

journal_title：Nature communications

authors： Miyoshi Y,Fukazawa Y,Amasaka Y,Reckmann R,Yokoi T,Ishida K,Kawahara K,Ago H,Maki H

更新日期：2018-03-29 00:00:00

abstract：:RNA-binding proteins (RBPs) integrate the processing of RNAs into post-transcriptional gene regulation, but the direct contribution of them to myeloid cell specification is poorly understood. Here, we report the first global RBP transcriptomic analysis of myeloid differentiation by combining RNA-seq analysis with myel...

journal_title：Nature communications

authors： Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J

更新日期：2017-11-10 00:00:00

abstract：:Biodiversity-ecosystem functioning (BEF) experiments have shown that local species richness promotes ecosystem functioning and stability. Whether this also applies under real-world conditions is still debated. Here, we focus on larger scales of space, time and ecological organization. We develop a quasi-experimental d...

journal_title：Nature communications

authors： Oehri J,Schmid B,Schaepman-Strub G,Niklaus PA

更新日期：2020-01-09 00:00:00

abstract：:Pair production can be triggered by high-intensity lasers via the Breit-Wheeler process. However, the straightforward laser-laser colliding for copious numbers of pair creation requires light intensities several orders of magnitude higher than possible with the ongoing laser facilities. Despite the numerous proposed a...

journal_title：Nature communications

authors： Zhu XL,Yu TP,Sheng ZM,Yin Y,Turcu IC,Pukhov A

更新日期：2016-12-14 00:00:00

abstract：:In genome editing with CRISPR-Cas9, transgene integration often remains challenging. Here, we present an approach for increasing the efficiency of transgene integration by homology-dependent repair (HDR). CtIP, a key protein in early steps of homologous recombination, is fused to Cas9 and stimulates transgene integrat...

journal_title：Nature communications

authors： Charpentier M,Khedher AHY,Menoret S,Brion A,Lamribet K,Dardillac E,Boix C,Perrouault L,Tesson L,Geny S,De Cian A,Itier JM,Anegon I,Lopez B,Giovannangeli C,Concordet JP

更新日期：2018-03-19 00:00:00

abstract：:Caffeine is a major component of xanthine alkaloids and commonly consumed in many popular beverages. Due to its occasional side effects, reduction of caffeine in a natural way is of great importance and economic significance. Recent studies reveal that caffeine can be converted into non-stimulatory theacrine in the ra...

journal_title：Nature communications

authors： Zhang YH,Li YF,Wang Y,Tan L,Cao ZQ,Xie C,Xie G,Gong HB,Sun WY,Ouyang SH,Duan WJ,Lu X,Ding K,Kurihara H,Hu D,Zhang ZM,Abe I,He RR

更新日期：2020-03-19 00:00:00

abstract：:For COVID-19, it is vital to understand if quarantines shorter than 14 days can be equally effective with judiciously deployed testing. Here, we develop a mathematical model that quantifies the probability of post-quarantine transmission incorporating testing into travel quarantine, quarantine of traced contacts with ...

journal_title：Nature communications

authors： Wells CR,Townsend JP,Pandey A,Moghadas SM,Krieger G,Singer B,McDonald RH,Fitzpatrick MC,Galvani AP

更新日期：2021-01-07 00:00:00

abstract：:Van der Waals materials exhibit intriguing structural, electronic, and photonic properties. Electron energy loss spectroscopy within scanning transmission electron microscopy allows for nanoscale mapping of such properties. However, its detection is typically limited to energy losses in the eV range-too large for prob...

journal_title：Nature communications

authors： Govyadinov AA,Konečná A,Chuvilin A,Vélez S,Dolado I,Nikitin AY,Lopatin S,Casanova F,Hueso LE,Aizpurua J,Hillenbrand R

更新日期：2017-07-21 00:00:00

abstract：:Supported atomic clusters with uniform metal sites and definite low-nuclearity are intermediate states between single-atom catalysts (SACs) and nanoparticles in size. Benefiting from the presence of metal-metal bonds, supported atomic clusters can trigger synergistic effects among every metal atom, which contributes t...

journal_title：Nature communications

authors： Rong H,Ji S,Zhang J,Wang D,Li Y

更新日期：2020-11-18 00:00:00

abstract：:Weyl semimetals (WSMs) are topological quantum states wherein the electronic bands disperse linearly around pairs of nodes with fixed chirality, the Weyl points. In WSMs, nonorthogonal electric and magnetic fields induce an exotic phenomenon known as the chiral anomaly, resulting in an unconventional negative longitud...

journal_title：Nature communications

authors： Arnold F,Shekhar C,Wu SC,Sun Y,Dos Reis RD,Kumar N,Naumann M,Ajeesh MO,Schmidt M,Grushin AG,Bardarson JH,Baenitz M,Sokolov D,Borrmann H,Nicklas M,Felser C,Hassinger E,Yan B

更新日期：2016-05-17 00:00:00

abstract：:Investigating the susceptibility of oestrogen receptor-positive (ER(pos)) normal human breast epithelial cells (HBECs) for clinical purposes or basic research awaits a proficient cell-based assay. Here we set out to identify markers for isolating ER(pos) cells and to expand what appear to be post-mitotic primary cells...

journal_title：Nature communications

authors： Fridriksdottir AJ,Kim J,Villadsen R,Klitgaard MC,Hopkinson BM,Petersen OW,Rønnov-Jessen L

更新日期：2015-11-13 00:00:00

abstract：:There is no agnostic GWAS evidence for the genetic control of IL-1β expression in periodontal disease. Here we report a GWAS for "high" gingival crevicular fluid IL-1β expression among 4910 European-American adults and identify association signals in the IL37 locus. rs3811046 at this locus (p = 3.3 × 10-22) is associa...

journal_title：Nature communications

authors： Offenbacher S,Jiao Y,Kim SJ,Marchesan J,Moss KL,Jing L,Divaris K,Bencharit S,Agler CS,Morelli T,Zhang S,Sun L,Seaman WT,Cowley D,Barros SP,Beck JD,Munz M,Schaefer AS,North KE

更新日期：2018-09-11 00:00:00

abstract：:The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs...

journal_title：Nature communications

authors： Miyawaki S,Kawamura Y,Oiwa Y,Shimizu A,Hachiya T,Bono H,Koya I,Okada Y,Kimura T,Tsuchiya Y,Suzuki S,Onishi N,Kuzumaki N,Matsuzaki Y,Narita M,Ikeda E,Okanoya K,Seino K,Saya H,Okano H,Miura K

更新日期：2016-05-10 00:00:00

abstract：:The change of global-mean precipitation under global warming and interannual variability is predominantly controlled by the change of atmospheric longwave radiative cooling. Here we show that tightening of the ascending branch of the Hadley Circulation coupled with a decrease in tropical high cloud fraction is key in ...

journal_title：Nature communications

authors： Su H,Jiang JH,Neelin JD,Shen TJ,Zhai C,Yue Q,Wang Z,Huang L,Choi YS,Stephens GL,Yung YL

更新日期：2017-06-07 00:00:00

abstract：:Actin-based vesicular trafficking of Cdc42, leading to a polarized concentration of the GTPase, has been implicated in cell polarization, but it was recently debated whether this mechanism allows stable maintenance of cell polarity. Here we show that endocytosis and exocytosis are spatially segregated in the polar pla...

journal_title：Nature communications

authors： Slaughter BD,Unruh JR,Das A,Smith SE,Rubinstein B,Li R

更新日期：2013-01-01 00:00:00

abstract：:Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in ...

journal_title：Nature communications

authors： Qiu L,Liu JZ,Chang SL,Wu Y,Li D

更新日期：2012-01-01 00:00:00

abstract：:The excellent mechanical properties of carbon nanofibers bring promise for energy-related applications. Through in silico studies and continuum elasticity theory, here we show that the ultra-thin carbon nanothreads-based bundles exhibit a high mechanical energy storage density. Specifically, the gravimetric energy den...

journal_title：Nature communications

authors： Zhan H,Zhang G,Bell JM,Tan VBC,Gu Y

更新日期：2020-04-20 00:00:00

abstract：:Akin to single-site homogeneous catalysis, a long sought-after goal is to achieve reaction site precision in heterogeneous catalysis for chemical control over patterns of activity, selectivity and stability. Herein, we report on metal phosphides as a class of material capable of realizing these attributes and unlock t...

journal_title：Nature communications

authors： Xu YF,Duchesne PN,Wang L,Tavasoli A,Jelle AA,Xia M,Liao JF,Kuang DB,Ozin GA

更新日期：2020-10-13 00:00:00

abstract：:The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30-50 MeV m(-1) gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradi...

journal_title：Nature communications

authors： Nanni EA,Huang WR,Hong KH,Ravi K,Fallahi A,Moriena G,Miller RJ,Kärtner FX

更新日期：2015-10-06 00:00:00

abstract：:Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is nee...

journal_title：Nature communications

authors： Muhammad K,Reddy-Alla S,Driller JH,Schreiner D,Rey U,Böhme MA,Hollmann C,Ramesh N,Depner H,Lützkendorf J,Matkovic T,Götz T,Bergeron DD,Schmoranzer J,Goettfert F,Holt M,Wahl MC,Hell SW,Scheiffele P,Walter AM,Loll B

更新日期：2015-10-16 00:00:00

abstract：:Bcl9 and Pygo are Wnt enhanceosome components that effect β-catenin-dependent transcription. Whether they mediate β-catenin-dependent neoplasia is unclear. Here we assess their roles in intestinal tumourigenesis initiated by Apc loss-of-function (ApcMin), or by Apc1322T encoding a partially-functional Apc truncation c...

journal_title：Nature communications

authors： Mieszczanek J,van Tienen LM,Ibrahim AEK,Winton DJ,Bienz M

更新日期：2019-02-13 00:00:00

abstract：:The ability to suppress unwanted emotional memories is crucial for human mental health. Through consolidation over time, emotional memories often become resistant to change. However, how consolidation impacts the effectiveness of emotional memory suppression is still unknown. Using event-related fMRI while concurrentl...

journal_title：Nature communications

authors： Liu Y,Lin W,Liu C,Luo Y,Wu J,Bayley PJ,Qin S

更新日期：2016-11-29 00:00:00

abstract：:Phosphorylation is a major post-translational mechanism of regulation that frequently targets disordered protein domains, but it remains unclear how phosphorylation modulates disordered states of proteins. Here we determine the kinetics and energetics of a disordered protein domain the kinase-inducible domain (KID) of...

journal_title：Nature communications

authors： Stanley N,Esteban-Martín S,De Fabritiis G

更新日期：2014-10-28 00:00:00

abstract：:Intercellular signaling is indispensable for single cells to form complex biological structures, such as biofilms, tissues and organs. The genetic tools available for engineering intercellular signaling, however, are quite limited. Here we exploit the chemical diversity of biological small molecules to de novo design ...

journal_title：Nature communications

authors： Du P,Zhao H,Zhang H,Wang R,Huang J,Tian Y,Luo X,Luo X,Wang M,Xiang Y,Qian L,Chen Y,Tao Y,Lou C

更新日期：2020-08-24 00:00:00

abstract：:Interactions between a protein and a ligand are essential to all biological processes. Binding and dissociation are the two fundamental steps of ligand-protein interactions, and determine the binding affinity. Intrinsic conformational dynamics of proteins have been suggested to play crucial roles in ligand binding and...

journal_title：Nature communications

authors： Seo MH,Park J,Kim E,Hohng S,Kim HS

更新日期：2014-04-24 00:00:00

abstract：:The primary productivity of the Southern Ocean ecosystem is limited by iron availability. Away from benthic and aeolian sources, iron reaches phytoplankton primarily when iron-rich subsurface waters enter the euphotic zone. Here, eddy-resolving physical/biogeochemical simulations of a seasonally-forced, open-Southern-...

journal_title：Nature communications

authors： Uchida T,Balwada D,P Abernathey R,A McKinley G,K Smith S,Lévy M

更新日期：2020-02-28 00:00:00

abstract：:Chirality and liquid crystals are both widely expressed in nature and biology. Helical assembly of mesophasic molecules and colloids may produce intriguing chiral liquid crystals. To date, chiral liquid crystals of 2D colloids have not been explored. As a typical 2D colloid, graphene is now receiving unprecedented att...

journal_title：Nature communications

authors： Xu Z,Gao C

更新日期：2011-12-06 00:00:00

abstract：:Molecular crystals can be bent elastically by expansion or plastically by delamination into slabs that glide along slip planes. Here we report that upon bending, terephthalic acid crystals can undergo a mechanically induced phase transition without delamination and their overall crystal integrity is retained. Such pla...

journal_title：Nature communications

authors： Ahmed E,Karothu DP,Warren M,Naumov P

更新日期：2019-08-19 00:00:00