Terahertz-driven linear electron acceleration.

Abstract:

:The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30-50 MeV m(-1) gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradients orders of magnitude above that achievable with conventional radio-frequency structures. However, laser-driven wakefield accelerators require intense femtosecond sources and direct laser-driven accelerators suffer from low bunch charge, sub-micron tolerances and sub-femtosecond timing requirements due to the short wavelength of operation. Here we demonstrate linear acceleration of electrons with keV energy gain using optically generated terahertz pulses. Terahertz-driven accelerating structures enable high-gradient electron/proton accelerators with simple accelerating structures, high repetition rates and significant charge per bunch. These ultra-compact terahertz accelerators with extremely short electron bunches hold great potential to have a transformative impact for free electron lasers, linear colliders, ultrafast electron diffraction, X-ray science and medical therapy with X-rays and electron beams.

journal_name

Nat Commun

journal_title

Nature communications

authors

Nanni EA,Huang WR,Hong KH,Ravi K,Fallahi A,Moriena G,Miller RJ,Kärtner FX

doi

10.1038/ncomms9486

subject

Has Abstract

pub_date

2015-10-06 00:00:00

pages

8486

issn

2041-1723

pii

ncomms9486

journal_volume

6

pub_type

杂志文章
  • Chromatin remodeller Fun30Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

    abstract::Previous studies have revealed that nucleosomes impede elongation of RNA polymerase II (RNAPII). Recent observations suggest a role for ATP-dependent chromatin remodellers in modulating this process, but direct in vivo evidence for this is unknown. Here using fission yeast, we identify Fun30Fft3 as a chromatin remodel...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14527

    authors: Lee J,Choi ES,Seo HD,Kang K,Gilmore JM,Florens L,Washburn MP,Choe J,Workman JL,Lee D

    更新日期:2017-02-20 00:00:00

  • Boosting the catalysis of gold by O2 activation at Au-SiO2 interface.

    abstract::Supported gold (Au) nanocatalysts have attracted extensive interests in the past decades because of their unique catalytic properties for a number of key chemical reactions, especially in (selective) oxidations. The activation of O2 on Au nanocatalysts is crucial and remains a challenge because only small Au nanoparti...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-14241-8

    authors: Zhang Y,Zhang J,Zhang B,Si R,Han B,Hong F,Niu Y,Sun L,Li L,Qiao B,Sun K,Huang J,Haruta M

    更新日期:2020-01-28 00:00:00

  • Quantitative optical assessment of photonic and electronic properties in halide perovskite.

    abstract::The development of high efficiency solar cells relies on the management of electronic and optical properties that need to be accurately measured. As the conversion efficiencies increase, there is a concomitant electronic and photonic contribution that affects the overall performances. Here we show an optical method to...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-09527-w

    authors: Bercegol A,Ory D,Suchet D,Cacovich S,Fournier O,Rousset J,Lombez L

    更新日期:2019-04-08 00:00:00

  • Aqueous multiphoton lithography with multifunctional silk-centred bio-resists.

    abstract::Silk and silk fibroin, the biomaterial from nature, nowadays are being widely utilized in many cutting-edge micro/nanodevices/systems via advanced micro/nanofabrication techniques. Herein, for the first time to our knowledge, we report aqueous multiphoton lithography of diversiform-regenerated-silk-fibroin-centric ink...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms9612

    authors: Sun YL,Li Q,Sun SM,Huang JC,Zheng BY,Chen QD,Shao ZZ,Sun HB

    更新日期:2015-10-16 00:00:00

  • Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.

    abstract::Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clustering of gene expression profiles and canonical markers. The...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20059-6

    authors: Zhou Y,Yang D,Yang Q,Lv X,Huang W,Zhou Z,Wang Y,Zhang Z,Yuan T,Ding X,Tang L,Zhang J,Yin J,Huang Y,Yu W,Wang Y,Zhou C,Su Y,He A,Sun Y,Shen Z,Qian B,Meng W,Fei J,Yao Y,Pan X,Chen P,Hu H

    更新日期:2020-12-10 00:00:00

  • Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation.

    abstract::CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6909

    authors: Wang L,Liu R,Ye P,Wong C,Chen GY,Zhou P,Sakabe K,Zheng X,Wu W,Zhang P,Jiang T,Bassetti MF,Jube S,Sun Y,Zhang Y,Zheng P,Liu Y

    更新日期:2015-01-20 00:00:00

  • Arabidopsis ERF109 mediates cross-talk between jasmonic acid and auxin biosynthesis during lateral root formation.

    abstract::Jasmonic acid (JA) is well known to promote lateral root formation but the mechanisms by which JA signalling is integrated into the pathways responsible for lateral root formation, and how it interacts with auxin in this process remains poorly understood. Here, we report that the highly JA-responsive ethylene response...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6833

    authors: Cai XT,Xu P,Zhao PX,Liu R,Yu LH,Xiang CB

    更新日期:2014-12-19 00:00:00

  • LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.

    abstract::Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway, have been shown to exert tumor suppressive activities, here we report a pro-survival role of LATS1 but not LATS2 in hepatocellular carcinoma (HCC) cells. Speci...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13591-7

    authors: Tang F,Gao R,Jeevan-Raj B,Wyss CB,Kalathur RKR,Piscuoglio S,Ng CKY,Hindupur SK,Nuciforo S,Dazert E,Bock T,Song S,Buechel D,Morini MF,Hergovich A,Matthias P,Lim DS,Terracciano LM,Heim MH,Hall MN,Christofori G

    更新日期:2019-12-17 00:00:00

  • A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome.

    abstract::Compartmentalization of the gut microbiota is thought to be important to system function, but the extent of spatial organization in the gut ecosystem remains poorly understood. Here, we profile the murine colonic microbiota along longitudinal and lateral axes using laser capture microdissection. We found fine-scale sp...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-12413-0

    authors: Riva A,Kuzyk O,Forsberg E,Siuzdak G,Pfann C,Herbold C,Daims H,Loy A,Warth B,Berry D

    更新日期:2019-09-25 00:00:00

  • A subunit of the oligosaccharyltransferase complex is required for interspecific gametophyte recognition in Arabidopsis.

    abstract::Species-specific gamete recognition is a key premise to ensure reproductive success and the maintenance of species boundaries. During plant pollen tube (PT) reception, gametophyte interactions likely allow the species-specific recognition of signals from the PT (male gametophyte) by the embryo sac (female gametophyte)...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms10826

    authors: Müller LM,Lindner H,Pires ND,Gagliardini V,Grossniklaus U

    更新日期:2016-03-11 00:00:00

  • Mass spectrometry and Monte Carlo method mapping of nanoparticle ligand shell morphology.

    abstract::Janus, patchy, stripe-like, or random arrangements of molecules within the ligand shell of nanoparticles affect many properties. Among all existing ligand shell morphology characterization methods, the one based on mass spectroscopy is arguably the simplest. Its greatest limitation is that the results are qualitative....

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06939-y

    authors: Luo Z,Zhao Y,Darwish T,Wang Y,Hou J,Stellacci F

    更新日期:2018-10-26 00:00:00

  • Oxide-ion conduction in the Dion-Jacobson phase CsBi2Ti2NbO10-δ.

    abstract::Oxide-ion conductors have found applications in various electrochemical devices, such as solid-oxide fuel cells, gas sensors, and separation membranes. Dion-Jacobson phases are known for their rich magnetic and electrical properties; however, there have been no reports on oxide-ion conduction in this family of materia...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-15043-z

    authors: Zhang W,Fujii K,Niwa E,Hagihala M,Kamiyama T,Yashima M

    更新日期:2020-03-06 00:00:00

  • A generalized non-local optical response theory for plasmonic nanostructures.

    abstract::Metallic nanostructures exhibit a multitude of optical resonances associated with localized surface plasmon excitations. Recent observations of plasmonic phenomena at the sub-nanometre to atomic scale have stimulated the development of various sophisticated theoretical approaches for their description. Here instead we...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4809

    authors: Mortensen NA,Raza S,Wubs M,Søndergaard T,Bozhevolnyi SI

    更新日期:2014-05-02 00:00:00

  • Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.

    abstract::Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases, including cancer and neurological disorders. While BER is well studied on naked DNA, it remains uncl...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13394-w

    authors: Montaldo NP,Bordin DL,Brambilla A,Rösinger M,Fordyce Martin SL,Bjørås KØ,Bradamante S,Aas PA,Furrer A,Olsen LC,Kunath N,Otterlei M,Sætrom P,Bjørås M,Samson LD,van Loon B

    更新日期:2019-11-29 00:00:00

  • A genetically encoded probe for imaging nascent and mature HA-tagged proteins in vivo.

    abstract::To expand the toolbox of imaging in living cells, we have engineered a single-chain variable fragment binding the linear HA epitope with high affinity and specificity in vivo. The resulting probe, called the HA frankenbody, can light up in multiple colors HA-tagged nuclear, cytoplasmic, membrane, and mitochondrial pro...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-10846-1

    authors: Zhao N,Kamijo K,Fox PD,Oda H,Morisaki T,Sato Y,Kimura H,Stasevich TJ

    更新日期:2019-07-03 00:00:00

  • Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions.

    abstract::The Satb1 genome organizer regulates multiple cellular and developmental processes. It is not yet clear how Satb1 selects different sets of targets throughout the genome. Here we have used live-cell single molecule imaging and deep sequencing to assess determinants of Satb1 binding-site selectivity. We have found that...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-11118-8

    authors: Ghosh RP,Shi Q,Yang L,Reddick MP,Nikitina T,Zhurkin VB,Fordyce P,Stasevich TJ,Chang HY,Greenleaf WJ,Liphardt JT

    更新日期:2019-07-19 00:00:00

  • Molecular structure of promoter-bound yeast TFIID.

    abstract::Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. Here we present the cryo-electron microscopy structure of promot...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07096-y

    authors: Kolesnikova O,Ben-Shem A,Luo J,Ranish J,Schultz P,Papai G

    更新日期:2018-11-07 00:00:00

  • Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.

    abstract::Ryanodine receptors (RyRs) form calcium release channels located in the membranes of the sarcoplasmic and endoplasmic reticulum. RyRs play a major role in excitation-contraction coupling and other Ca(2+)-dependent signalling events, and consist of several globular domains that together form a large assembly. Here we d...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms8947

    authors: Yuchi Z,Yuen SM,Lau K,Underhill AQ,Cornea RL,Fessenden JD,Van Petegem F

    更新日期:2015-08-06 00:00:00

  • Measurement of the first ionization potential of astatine by laser ionization spectroscopy.

    abstract::The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy req...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2819

    authors: Rothe S,Andreyev AN,Antalic S,Borschevsky A,Capponi L,Cocolios TE,De Witte H,Eliav E,Fedorov DV,Fedosseev VN,Fink DA,Fritzsche S,Ghys L,Huyse M,Imai N,Kaldor U,Kudryavtsev Y,Köster U,Lane JF,Lassen J,Liberati V,

    更新日期:2013-01-01 00:00:00

  • Amplification and generation of ultra-intense twisted laser pulses via stimulated Raman scattering.

    abstract::Twisted Laguerre-Gaussian lasers, with orbital angular momentum and characterized by doughnut-shaped intensity profiles, provide a transformative set of tools and research directions in a growing range of fields and applications, from super-resolution microcopy and ultra-fast optical communications to quantum computin...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms10371

    authors: Vieira J,Trines RM,Alves EP,Fonseca RA,Mendonça JT,Bingham R,Norreys P,Silva LO

    更新日期:2016-01-28 00:00:00

  • T cell costimulation blockade blunts pressure overload-induced heart failure.

    abstract::Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual cytokines. Searching for better cardiac inflammation targets, here we link T cells with HF developmen...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14680

    authors: Kallikourdis M,Martini E,Carullo P,Sardi C,Roselli G,Greco CM,Vignali D,Riva F,Ormbostad Berre AM,Stølen TO,Fumero A,Faggian G,Di Pasquale E,Elia L,Rumio C,Catalucci D,Papait R,Condorelli G

    更新日期:2017-03-06 00:00:00

  • Solid-phase hetero epitaxial growth of α-phase formamidinium perovskite.

    abstract::Conventional epitaxy of semiconductor films requires a compatible single crystalline substrate and precisely controlled growth conditions, which limit the price competitiveness and versatility of the process. We demonstrate substrate-tolerant nano-heteroepitaxy (NHE) of high-quality formamidinium-lead-tri-iodide (FAPb...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19237-3

    authors: Lee JW,Tan S,Han TH,Wang R,Zhang L,Park C,Yoon M,Choi C,Xu M,Liao ME,Lee SJ,Nuryyeva S,Zhu C,Huynh K,Goorsky MS,Huang Y,Pan X,Yang Y

    更新日期:2020-11-02 00:00:00

  • TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes.

    abstract::The accumulation of protein aggregates is involved in the onset of many neurodegenerative diseases. Aggrephagy is a selective type of autophagy that counteracts neurodegeneration by degrading such aggregates. In this study, we found that LC3C cooperates with lysosomal TECPR1 to promote the degradation of disease-relat...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-16689-5

    authors: Wetzel L,Blanchard S,Rama S,Beier V,Kaufmann A,Wollert T

    更新日期:2020-06-12 00:00:00

  • Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells.

    abstract::Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple sclerosis. To improve our understanding of human oligodendrocyte development, which could facilitate development of remyelination-based treatment strategies, here we describe time-course single-cell-transcriptomic analysis of develop...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-021-20892-3

    authors: Chamling X,Kallman A,Fang W,Berlinicke CA,Mertz JL,Devkota P,Pantoja IEM,Smith MD,Ji Z,Chang C,Kaushik A,Chen L,Whartenby KA,Calabresi PA,Mao HQ,Ji H,Wang TH,Zack DJ

    更新日期:2021-01-28 00:00:00

  • ERG induces taxane resistance in castration-resistant prostate cancer.

    abstract::Taxanes are the only chemotherapies used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Despite the initial efficacy of taxanes in treating CRPC, all patients ultimately fail due to the development of drug resistance. In this study, we show that ERG overexpression in in vitro and in viv...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6548

    authors: Galletti G,Matov A,Beltran H,Fontugne J,Miguel Mosquera J,Cheung C,MacDonald TY,Sung M,O'Toole S,Kench JG,Suk Chae S,Kimovski D,Tagawa ST,Nanus DM,Rubin MA,Horvath LG,Giannakakou P,Rickman DS

    更新日期:2014-11-25 00:00:00

  • PPARγ is an E3 ligase that induces the degradation of NFκB/p65.

    abstract::Nuclear factor-κB (NFκB) and peroxisome proliferator activated receptor-γ (PPARγ) are both transcription factors that perform distinct but overlapping roles in cellular regulation. Here we report that PPARγ acts as an E3 ubiquitin ligase, physically interacting with p65 to induce its ubiquitination and degradation. Th...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2270

    authors: Hou Y,Moreau F,Chadee K

    更新日期:2012-01-01 00:00:00

  • Artificial van der Waals hybrid synapse and its application to acoustic pattern recognition.

    abstract::Brain-inspired parallel computing, which is typically performed using a hardware neural-network platform consisting of numerous artificial synapses, is a promising technology for effectively handling large amounts of informational data. However, the reported nonlinear and asymmetric conductance-update characteristics ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-17849-3

    authors: Seo S,Kang BS,Lee JJ,Ryu HJ,Kim S,Kim H,Oh S,Shim J,Heo K,Oh S,Park JH

    更新日期:2020-08-07 00:00:00

  • Dietary diversity and evolution of the earliest flying vertebrates revealed by dental microwear texture analysis.

    abstract::Pterosaurs, the first vertebrates to evolve active flight, lived between 210 and 66 million years ago. They were important components of Mesozoic ecosystems, and reconstructing pterosaur diets is vital for understanding their origins, their roles within Mesozoic food webs and the impact of other flying vertebrates (i....

    journal_title:Nature communications

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41467-020-19022-2

    authors: Bestwick J,Unwin DM,Butler RJ,Purnell MA

    更新日期:2020-10-28 00:00:00

  • Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.

    abstract::Huntington's Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery by heat shock transcription factor 1 (HSF1) ameliorates biochemical and neurobiological defec...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14405

    authors: Gomez-Pastor R,Burchfiel ET,Neef DW,Jaeger AM,Cabiscol E,McKinstry SU,Doss A,Aballay A,Lo DC,Akimov SS,Ross CA,Eroglu C,Thiele DJ

    更新日期:2017-02-13 00:00:00

  • Intraoperative intravital microscopy permits the study of human tumour vessels.

    abstract::Tumour vessels have been studied extensively as they are critical sites for drug delivery, anti-angiogenic therapies and immunotherapy. As a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of vessels at the cellular level. However, to date there are no reports of intravita...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms10684

    authors: Fisher DT,Muhitch JB,Kim M,Doyen KC,Bogner PN,Evans SS,Skitzki JJ

    更新日期:2016-02-17 00:00:00