Shape-memory effects in molecular crystals.

abstract：:Current knowledge on chromosomal mosaicism in human cell cultures is mostly based on cytogenetic banding methods. The recent development of high-resolution full-genome analysis methods applicable to single cells is providing new insights into genetic and cellular diversity. Here we study the genetic content of 92 indi...

journal_title：Nature communications

authors： Jacobs K,Mertzanidou A,Geens M,Nguyen HT,Staessen C,Spits C

更新日期：2014-06-27 00:00:00

abstract：:Regulatory T (Treg) cells derived from the thymus (tTreg) and periphery (pTreg) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of Treg subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpectedly supports the homeostasis...

journal_title：Nature communications

authors： Chapman NM,Zeng H,Nguyen TM,Wang Y,Vogel P,Dhungana Y,Liu X,Neale G,Locasale JW,Chi H

更新日期：2018-05-29 00:00:00

abstract：:During homologous recombination, eukaryotic RecA homologue Rad51 assembles into a nucleoprotein filament on single-stranded DNA to catalyse homologous pairing and DNA-strand exchange with a homologous template. Rad51 nucleoprotein filaments are highly dynamic and regulated via the coordinated actions of various access...

journal_title：Nature communications

authors： Sasanuma H,Tawaramoto MS,Lao JP,Hosaka H,Sanda E,Suzuki M,Yamashita E,Hunter N,Shinohara M,Nakagawa A,Shinohara A

更新日期：2013-01-01 00:00:00

abstract：:Across phyla, body size is linked to climate. For example, rearing fruit flies at lower temperatures results in bigger body sizes than those observed at higher temperatures. The underlying molecular basis of this effect is poorly understood. Here we provide evidence that the temperature-dependent regulation of Drosoph...

journal_title：Nature communications

authors： Li Q,Gong Z

更新日期：2015-12-09 00:00:00

abstract：:Non-Abelian quasiparticles have been predicted to exist in a variety of condensed matter systems. Their defining property is that an adiabatic braid between two of them results in a non-trivial change of the quantum state of the system. The simplest non-Abelian quasiparticles--the Majorana bound states--can occur in o...

journal_title：Nature communications

authors： Li J,Neupert T,Bernevig BA,Yazdani A

更新日期：2016-01-21 00:00:00

abstract：:The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contac...

journal_title：Nature communications

authors： Siqueira JD,Dominguez-Bello MG,Contreras M,Lander O,Caballero-Arias H,Xutao D,Noya-Alarcon O,Delwart E

更新日期：2018-10-15 00:00:00

abstract：:Scintillation based X-ray detection has received great attention for its application in a wide range of areas from security to healthcare. Here, we report highly efficient X-ray scintillators with state-of-the-art performance based on an organic metal halide, ethylenebis-triphenylphosphonium manganese (II) bromide ((C...

journal_title：Nature communications

authors： Xu LJ,Lin X,He Q,Worku M,Ma B

更新日期：2020-08-28 00:00:00

abstract：:Although networks are extensively used to visualize information flow in biological, social and technological systems, translating topology into dynamic flow continues to challenge us, as similar networks exhibit fundamentally different flow patterns, driven by different interaction mechanisms. To uncover a network's a...

journal_title：Nature communications

authors： Harush U,Barzel B

更新日期：2017-12-19 00:00:00

abstract：:Optical spectroscopy is a fundamental tool in numerous areas of science and technology. Much effort has focused on miniaturizing spectrometers, but thus far at the cost of spectral resolution and broad operating range. Here we describe a compact spectrometer that achieves both high spectral resolution and broad bandwi...

journal_title：Nature communications

authors： Wan NH,Meng F,Schröder T,Shiue RJ,Chen EH,Englund D

更新日期：2015-07-23 00:00:00

abstract：:Unusual features of the vibrational density of states D(ω) of glasses allow one to rationalize their peculiar low-temperature properties. Simulational studies of D(ω) have been restricted to studying poorly annealed glasses that may not be relevant to experiments. Here we report on D(ω) of zero-temperature glasses wit...

journal_title：Nature communications

authors： Wang L,Ninarello A,Guan P,Berthier L,Szamel G,Flenner E

更新日期：2019-01-03 00:00:00

abstract：:Horizontal gene transfer is a major contributor to the evolution of bacterial genomes and can facilitate the dissemination of antibiotic resistance genes between environmental reservoirs and potential pathogens. Wastewater treatment plants (WWTPs) are believed to play a central role in the dissemination of antibiotic ...

journal_title：Nature communications

authors： Munck C,Albertsen M,Telke A,Ellabaan M,Nielsen PH,Sommer MOA

更新日期：2015-09-30 00:00:00

abstract：:Pladienolide, herboxidiene and spliceostatin have been identified as splicing modulators that target SF3B1 in the SF3b subcomplex. Here we report that PHF5A, another component of this subcomplex, is also targeted by these compounds. Mutations in PHF5A-Y36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 confer resistance to ...

journal_title：Nature communications

authors： Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ

更新日期：2017-05-25 00:00:00

abstract：:Transition metal oxides host a wealth of exotic phenomena ranging from charge, orbital and magnetic order to nontrivial topological phases and superconductivity. In order to translate these unique materials properties into device functionalities these materials must be doped; however, the nature of carriers and their ...

journal_title：Nature communications

authors： Verdi C,Caruso F,Giustino F

更新日期：2017-06-08 00:00:00

abstract：:Pulses of tree mortality caused by drought have been reported recently in forests around the globe, but large-scale quantitative evidence is lacking for Europe. Analyzing high-resolution annual satellite-based canopy mortality maps from 1987 to 2016 we here show that excess forest mortality (i.e., canopy mortality exc...

journal_title：Nature communications

authors： Senf C,Buras A,Zang CS,Rammig A,Seidl R

更新日期：2020-12-03 00:00:00

abstract：:Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. Here we apply an in silico-guided multiple knockout approach to engi...

journal_title：Nature communications

authors： Meyer F,Keller P,Hartl J,Gröninger OG,Kiefer P,Vorholt JA

更新日期：2018-04-17 00:00:00

abstract：:The original version of this Article contained an error in the spelling of the author Woochul Song, which was incorrectly given as Woochul C. Song. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Shen YX,Song W,Barden DR,Ren T,Lang C,Feroz H,Henderson CB,Saboe PO,Tsai D,Yan H,Butler PJ,Bazan GC,Phillip WA,Hickey RJ,Cremer PS,Vashisth H,Kumar M

更新日期：2018-08-14 00:00:00

abstract：:Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the ...

journal_title：Nature communications

authors： Jin L,Feng X,Rong H,Pan Z,Inaba Y,Qiu L,Zheng W,Lin S,Wang R,Wang Z,Wang S,Liu H,Li S,Xie W,Li Y

更新日期：2013-01-01 00:00:00

abstract：:TP53 mutations are the most frequent genetic alterations in breast cancer and are associated with more aggressive disease and worse overall survival. We have created two conditional mutant Trp53 alleles in the mouse that allow expression of Trp53R172H or Trp53R245W missense mutations in single cells surrounded by a no...

journal_title：Nature communications

authors： Zhang Y,Xiong S,Liu B,Pant V,Celii F,Chau G,Elizondo-Fraire AC,Yang P,You MJ,El-Naggar AK,Navin NE,Lozano G

更新日期：2018-09-27 00:00:00

abstract：:Liquids cooled towards the glass transition temperature transform into amorphous solids that have a wide range of applications. While the nature of this transformation is understood rigorously in the mean-field limit of infinite spatial dimensions, the problem remains wide open in physical dimensions. Nontrivial finit...

journal_title：Nature communications

authors： Berthier L,Charbonneau P,Ninarello A,Ozawa M,Yaida S

更新日期：2019-04-03 00:00:00

abstract：:Phylogenetic trees are essential for studying biology, but their reproducibility under identical parameter settings remains unexplored. Here, we find that 3515 (18.11%) IQ-TREE-inferred and 1813 (9.34%) RAxML-NG-inferred maximum likelihood (ML) gene trees are topologically irreproducible when executing two replicates ...

journal_title：Nature communications

authors： Shen XX,Li Y,Hittinger CT,Chen XX,Rokas A

更新日期：2020-11-30 00:00:00

abstract：:Phonons are the main source of relaxation in molecular nanomagnets, and different mechanisms have been proposed in order to explain the wealth of experimental findings. However, very limited experimental investigations on phonons in these systems have been performed so far, yielding no information about their dispersi...

journal_title：Nature communications

authors： Garlatti E,Tesi L,Lunghi A,Atzori M,Voneshen DJ,Santini P,Sanvito S,Guidi T,Sessoli R,Carretta S

更新日期：2020-04-09 00:00:00

abstract：:To fulfill its role in protein biogenesis, the endoplasmic reticulum (ER) depends on the Hsp70-type molecular chaperone BiP, which requires a constant ATP supply. However, the carrier that catalyzes ATP uptake into the ER was unknown. Here, we report that our screen of gene expression datasets for member(s) of the fam...

journal_title：Nature communications

authors： Klein MC,Zimmermann K,Schorr S,Landini M,Klemens PAW,Altensell J,Jung M,Krause E,Nguyen D,Helms V,Rettig J,Fecher-Trost C,Cavalié A,Hoth M,Bogeski I,Neuhaus HE,Zimmermann R,Lang S,Haferkamp I

更新日期：2018-08-28 00:00:00

abstract：:Complex tissue-specific and cell-specific signaling by the estrogen receptor (ER) frequently leads to the development of resistance to endocrine therapy for breast cancer. Pure ER antagonists, which completely lack tissue-specific agonist activity, hold promise for preventing and treating endocrine resistance, however...

journal_title：Nature communications

authors： Fanning SW,Hodges-Gallagher L,Myles DC,Sun R,Fowler CE,Plant IN,Green BD,Harmon CL,Greene GL,Kushner PJ

更新日期：2018-06-18 00:00:00

abstract：:The ability to identify cause-effect relations is an essential component of the scientific method. The identification of causal relations is generally accomplished through statistical trials where alternative hypotheses are tested against each other. Traditionally, such trials have been based on classical statistics. ...

journal_title：Nature communications

authors： Chiribella G,Ebler D

更新日期：2019-04-01 00:00:00

abstract：:The plausibility of any model in science comes from the extent of its interconnections to other models that are grounded in different premises and reasoning. Focusing research on paradoxes in those models, logic whereby they appear to generate unacceptable conclusions from seemingly indisputable premises, helps find t...

journal_title：Nature communications

authors： Benner SA

更新日期：2018-12-12 00:00:00

abstract：:The growth of atomically dispersed metal catalysts (ADMCs) remains a great challenge owing to the thermodynamically driven atom aggregation. Here we report a surface-limited electrodeposition technique that uses site-specific substrates for the rapid and room-temperature synthesis of ADMCs. We obtained ADMCs by the un...

journal_title：Nature communications

authors： Shi Y,Huang WM,Li J,Zhou Y,Li ZQ,Yin YC,Xia XH

更新日期：2020-09-11 00:00:00

abstract：:Mutations disrupting regulatory T (Treg) cell function can cause IPEX and IPEX-related disorders, but whether established disease can be reversed by correcting these mutations is unclear. Treg-specific deletion of the chromatin remodeling factor Brg1 impairs Treg cell activation and causes fatal autoimmunity in mice. ...

journal_title：Nature communications

authors： Li Y,Chen Y,Mao S,Kaundal R,Jing Z,Chen Q,Wang X,Xia J,Liu D,Sun J,Wang H,Chi T

更新日期：2020-06-03 00:00:00

abstract：:Translationally controlled tumour protein (TCTP) is implicated in growth regulation and cancer. Recently, human TCTP has been suggested to play a role in the DNA damage response by forming a complex with ataxia telangiectasia-mutated (ATM) kinase . However, the exact nature of this interaction and its roles in vivo re...

journal_title：Nature communications

authors： Hong ST,Choi KW

更新日期：2013-01-01 00:00:00

abstract：:Acid sphingomyelinase (ASMase, ASM, SMPD1) converts sphingomyelin into ceramide, modulating membrane properties and signal transduction. Inactivating mutations in ASMase cause Niemann-Pick disease, and its inhibition is also beneficial in models of depression and cancer. To gain a better understanding of this critical...

journal_title：Nature communications

authors： Gorelik A,Illes K,Heinz LX,Superti-Furga G,Nagar B

更新日期：2016-07-20 00:00:00

abstract：:O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can enhance the expression, stability and function of Yes-associated protein (YAP), the downstream transcriptional regulator of the Hippo p...

journal_title：Nature communications

authors： Zhang X,Qiao Y,Wu Q,Chen Y,Zou S,Liu X,Zhu G,Zhao Y,Chen Y,Yu Y,Pan Q,Wang J,Sun F

更新日期：2017-05-05 00:00:00