Abstract:
:The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contact. Numerous human enteric viruses, mainly from the Picornaviridae and Caliciviridae families, were sequenced from each of the sites. Multiple children from the same villages shed closely related viruses reflecting frequent transmission clusters. Feces of isolated villagers also contained multiple viral genomes of unknown cellular origin from the Picornavirales order and CRESS-DNA group and higher levels of nematode and protozoan DNA. Despite cultural and geographic isolation, the diversity of enteric human viruses was therefore not reduced in these Amazonian villages. Frequent viral introductions and/or increased susceptibility to enteric infections may account for the complex fecal virome of Amerindian children in isolated villages.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Siqueira JD,Dominguez-Bello MG,Contreras M,Lander O,Caballero-Arias H,Xutao D,Noya-Alarcon O,Delwart Edoi
10.1038/s41467-018-06502-9subject
Has Abstractpub_date
2018-10-15 00:00:00pages
4270issue
1issn
2041-1723pii
10.1038/s41467-018-06502-9journal_volume
9pub_type
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