Recent strengthening of the stratospheric Arctic vortex response to warming in the central North Pacific.

abstract：:The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which targets substrates...

journal_title：Nature communications

authors： Xu Y,Plechanovová A,Simpson P,Marchant J,Leidecker O,Kraatz S,Hay RT,Matthews SJ

更新日期：2014-06-27 00:00:00

abstract：:Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share re...

journal_title：Nature communications

authors： Notti RQ,Bhattacharya S,Lilic M,Stebbins CE

更新日期：2015-05-21 00:00:00

abstract：:Amyloid aggregation of α-synuclein (α-syn) is closely associated with Parkinson's disease (PD) and other synucleinopathies. Several single amino-acid mutations (e.g. E46K) of α-syn have been identified causative to the early onset of familial PD. Here, we report the cryo-EM structure of an α-syn fibril formed by N-ter...

journal_title：Nature communications

authors： Zhao K,Li Y,Liu Z,Long H,Zhao C,Luo F,Sun Y,Tao Y,Su XD,Li D,Li X,Liu C

更新日期：2020-05-26 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this transformation occurs are still unclear. Here, hyperpolyploidization of ...

journal_title：Nature communications

authors： Lin H,Huang YS,Fustin JM,Doi M,Chen H,Lai HH,Lin SH,Lee YL,King PC,Hou HS,Chen HW,Young PY,Chao HW

更新日期：2021-01-28 00:00:00

abstract：:International corporations in an increasingly globalized economy exert a major influence on the planet's land use and resources through their product design and material sourcing decisions. Many companies use life cycle assessment (LCA) to evaluate their sustainability, yet commonly-used LCA methodologies lack the spa...

journal_title：Nature communications

authors： Chaplin-Kramer R,Sim S,Hamel P,Bryant B,Noe R,Mueller C,Rigarlsford G,Kulak M,Kowal V,Sharp R,Clavreul J,Price E,Polasky S,Ruckelshaus M,Daily G

更新日期：2017-04-21 00:00:00

abstract：:High-altitude pulmonary hypertension (HAPH) has heritable features and is a major cause of death in cattle in the Rocky Mountains, USA. Although multiple genes are likely involved in the genesis of HAPH, to date no major gene variant has been identified. Using whole-exome sequencing, we report the high association of ...

journal_title：Nature communications

authors： Newman JH,Holt TN,Cogan JD,Womack B,Phillips JA 3rd,Li C,Kendall Z,Stenmark KR,Thomas MG,Brown RD,Riddle SR,West JD,Hamid R

更新日期：2015-04-15 00:00:00

abstract：:Deformation twins are three-dimensional domains, traditionally viewed as ellipsoids because of their two-dimensional lenticular sections. In this work, we performed statistical analysis of twin shapes viewing along three orthogonal directions: the 'dark side' (DS) view along the twin shear direction (η1), the twinning...

journal_title：Nature communications

authors： Liu Y,Tang PZ,Gong MY,McCabe RJ,Wang J,Tomé CN

更新日期：2019-07-25 00:00:00

abstract：:The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read 'µm' rather than the correct 'nm.' This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Babakhanova G,Turiv T,Guo Y,Hendrikx M,Wei QH,Schenning APHJ,Broer DJ,Lavrentovich OD

更新日期：2018-03-14 00:00:00

abstract：:Meso/micro-porous solids, such as zeolites, are complex materials used in an impressive range of applications. Here we photo-polymerized ethylene using non-catalytic high-pressure techniques at 0.5-1.5 GPa under ultraviolet (351-364 nm) irradiation on a sub-nanometre scale in the channels of a pure SiO2 zeolite, silic...

journal_title：Nature communications

authors： Santoro M,Gorelli FA,Bini R,Haines J,van der Lee A

更新日期：2013-01-01 00:00:00

abstract：:Although chemically very simple, Fe2O3 is known to undergo a series of enigmatic structural, electronic and magnetic transformations at high pressures and high temperatures. So far, these transformations have neither been correctly described nor understood because of the lack of structural data. Here we report a syste...

journal_title：Nature communications

authors： Bykova E,Dubrovinsky L,Dubrovinskaia N,Bykov M,McCammon C,Ovsyannikov SV,Liermann HP,Kupenko I,Chumakov AI,Rüffer R,Hanfland M,Prakapenka V

更新日期：2016-02-11 00:00:00

abstract：:Medulloblastoma (MB) is the most common malignant brain tumor in children and among the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient-specific screen leading to the identification of Otx2 and c-MYC as strong Group 3 MB inducers. We validated our findings in human cerebellar organoids...

journal_title：Nature communications

authors： Ballabio C,Anderle M,Gianesello M,Lago C,Miele E,Cardano M,Aiello G,Piazza S,Caron D,Gianno F,Ciolfi A,Pedace L,Mastronuzzi A,Tartaglia M,Locatelli F,Ferretti E,Giangaspero F,Tiberi L

更新日期：2020-01-29 00:00:00

abstract：:In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia. Here, we show in mice that loss of Piezo2 expression in the proprioceptive system recapitulates several human skeletal abnormalities. While lo...

journal_title：Nature communications

authors： Assaraf E,Blecher R,Heinemann-Yerushalmi L,Krief S,Carmel Vinestock R,Biton IE,Brumfeld V,Rotkopf R,Avisar E,Agar G,Zelzer E

更新日期：2020-06-23 00:00:00

abstract：:Loss of seed dispersal is a key agronomical trait targeted by ancient human selection and has been regarded as a milestone of crop domestication. In this study, in the legume crop soybean Glycine max (L.) Merr. which provides vegetable oils and proteins for humans, we show that the key cellular feature of the shatteri...

journal_title：Nature communications

authors： Dong Y,Yang X,Liu J,Wang BH,Liu BL,Wang YZ

更新日期：2014-01-01 00:00:00

abstract：:Microbial communities mediating anaerobic ammonium oxidation (anammox) represent one of the most energy-efficient environmental biotechnologies for nitrogen removal from wastewater. However, little is known about the functional role heterotrophic bacteria play in anammox granules. Here, we use genome-centric metagenom...

journal_title：Nature communications

authors： Lawson CE,Wu S,Bhattacharjee AS,Hamilton JJ,McMahon KD,Goel R,Noguera DR

更新日期：2017-05-31 00:00:00

abstract：:Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein aggregates from PD...

journal_title：Nature communications

authors： Strohäker T,Jung BC,Liou SH,Fernandez CO,Riedel D,Becker S,Halliday GM,Bennati M,Kim WS,Lee SJ,Zweckstetter M

更新日期：2019-12-04 00:00:00

abstract：:Insects have presented human society with some of its greatest development challenges by spreading diseases, consuming crops and damaging infrastructure. Despite the massive human and financial toll of invasive insects, cost estimates of their impacts remain sporadic, spatially incomplete and of questionable quality. ...

journal_title：Nature communications

authors： Bradshaw CJ,Leroy B,Bellard C,Roiz D,Albert C,Fournier A,Barbet-Massin M,Salles JM,Simard F,Courchamp F

更新日期：2016-10-04 00:00:00

abstract：:Heterostructured material systems devoid of ferroic components are presumed not to display ordering associated with ferroelectricity. In heterostructures composed of transition metal oxides, however, the disruption introduced by an interface can affect the balance of the competing interactions among electronic spins, ...

journal_title：Nature communications

authors： Rogdakis K,Seo JW,Viskadourakis Z,Wang Y,Qune LF,Choi E,Burton JD,Tsymbal EY,Lee J,Panagopoulos C

更新日期：2012-01-01 00:00:00

abstract：:Black phosphorus, a fast emerging two-dimensional material, has been configured as field effect transistors, showing a hole-transport-dominated ambipolar characteristic. Here we report an effective modulation on ambipolar characteristics of few-layer black phosphorus transistors through in situ surface functionalizati...

journal_title：Nature communications

authors： Xiang D,Han C,Wu J,Zhong S,Liu Y,Lin J,Zhang XA,Ping Hu W,Özyilmaz B,Neto AH,Wee AT,Chen W

更新日期：2015-03-12 00:00:00

abstract：:Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA copy-number heterogeneity in colorectal cancer (CRC) by targeted high-depth sequencing of 100 most frequently altered genes. In 97 samples, with primary tumours ...

journal_title：Nature communications

authors： Mamlouk S,Childs LH,Aust D,Heim D,Melching F,Oliveira C,Wolf T,Durek P,Schumacher D,Bläker H,von Winterfeld M,Gastl B,Möhr K,Menne A,Zeugner S,Redmer T,Lenze D,Tierling S,Möbs M,Weichert W,Folprecht G,Blanc E,

更新日期：2017-01-25 00:00:00

abstract：:Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3'-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-in mouse model carry...

journal_title：Nature communications

authors： Nagata K,Takahashi M,Matsuba Y,Okuyama-Uchimura F,Sato K,Hashimoto S,Saito T,Saido TC

更新日期：2018-05-04 00:00:00

abstract：:The development of integrated photonics and lab-on-a-chip platforms for environmental and biomedical diagnostics demands ultraviolet electroluminescent materials with high mechanical, chemical and environmental stability and almost complete compatibility with existing silicon technology. Here we report the realization...

journal_title：Nature communications

authors： Brovelli S,Chiodini N,Lorenzi R,Lauria A,Romagnoli M,Paleari A

更新日期：2012-02-21 00:00:00

abstract：:Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathw...

journal_title：Nature communications

authors： Yeh I,Lang UE,Durieux E,Tee MK,Jorapur A,Shain AH,Haddad V,Pissaloux D,Chen X,Cerroni L,Judson RL,LeBoit PE,McCalmont TH,Bastian BC,de la Fouchardière A

更新日期：2017-09-21 00:00:00

abstract：:Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells...

journal_title：Nature communications

authors： Bicker F,Vasic V,Horta G,Ortega F,Nolte H,Kavyanifar A,Keller S,Stankovic ND,Harter PN,Benedito R,Lutz B,Bäuerle T,Hartwig J,Baumgart J,Krüger M,Radyushkin K,Alberi L,Berninger B,Schmidt MHH

更新日期：2017-06-28 00:00:00

abstract：:Processive chitinase is a linear molecular motor which moves on the surface of crystalline chitin driven by processive hydrolysis of single chitin chain. Here, we analyse the mechanism underlying unidirectional movement of Serratia marcescens chitinase A (SmChiA) using high-precision single-molecule imaging, X-ray cry...

journal_title：Nature communications

authors： Nakamura A,Okazaki KI,Furuta T,Sakurai M,Iino R

更新日期：2018-09-19 00:00:00

abstract：:The global urbanization rate is accelerating; however, data limitations have far prevented robust estimations of either global urban expansion or its effects on terrestrial net primary productivity (NPP). Here, using a high resolution dataset of global land use/cover (GlobeLand30), we show that global urban areas expa...

journal_title：Nature communications

authors： Liu X,Pei F,Wen Y,Li X,Wang S,Wu C,Cai Y,Wu J,Chen J,Feng K,Liu J,Hubacek K,Davis SJ,Yuan W,Yu L,Liu Z

更新日期：2019-12-05 00:00:00

abstract：:In the original version of this Article, the sixth sentence of the abstract incorrectly read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model undergo the same change.', and should have read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model ...

journal_title：Nature communications

authors： Arechederra M,Daian F,Yim A,Bazai SK,Richelme S,Dono R,Saurin AJ,Habermann BH,Maina F

更新日期：2018-09-25 00:00:00

abstract：:GFI1 is a transcriptional regulator expressed in lymphoid cells, and an "oncorequisite" factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing radiation, for which the molecular mechanism remains unknown. Here, we demonstrate that GFI1 is required in T...

journal_title：Nature communications

authors： Vadnais C,Chen R,Fraszczak J,Yu Z,Boulais J,Pinder J,Frank D,Khandanpour C,Hébert J,Dellaire G,Côté JF,Richard S,Orthwein A,Drobetsky E,Möröy T

更新日期：2018-04-12 00:00:00

abstract：:Locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest animal genome sequenced so far. Our findings indicate that the large genome size of L. migratoria is likely to...

journal_title：Nature communications

authors： Wang X,Fang X,Yang P,Jiang X,Jiang F,Zhao D,Li B,Cui F,Wei J,Ma C,Wang Y,He J,Luo Y,Wang Z,Guo X,Guo W,Wang X,Zhang Y,Yang M,Hao S,Chen B,Ma Z,Yu D,Xiong Z,Zhu Y,Fan D,Han L,Wang B,Chen Y,Wang J

更新日期：2014-01-01 00:00:00

abstract：:R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases such as neurodegeneration and cancer. Although excessive R-lo...

journal_title：Nature communications

authors： Chakraborty P,Huang JTJ,Hiom K

更新日期：2018-10-19 00:00:00

abstract：:Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extens...

journal_title：Nature communications

authors： Tay TL,Ronneberger O,Ryu S,Nitschke R,Driever W

更新日期：2011-01-25 00:00:00